The Gain-of-Function p53 R248W Mutant Promotes Migration by STAT3 Deregulation in Human Pancreatic Cancer Cells
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Title
The Gain-of-Function p53 R248W Mutant Promotes Migration by STAT3 Deregulation in Human Pancreatic Cancer Cells
Authors
Keywords
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Journal
Frontiers in Oncology
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-06-11
DOI
10.3389/fonc.2021.642603
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Note: Only part of the references are listed.- Hsp90-stabilized MIF supports tumor progression via macrophage recruitment and angiogenesis in colorectal cancer
- (2021) Luisa Klemke et al. Cell Death & Disease
- Cancer statistics, 2020
- (2020) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic
- (2020) Eliran Kadosh et al. NATURE
- A Driver Never Works Alone—Interplay Networks of Mutant p53, MYC, RAS, and Other Universal Oncogenic Drivers in Human Cancer
- (2020) Maria Grzes et al. Cancers
- p53 tetramerization: at the center of the dominant-negative effect of mutant p53
- (2020) Jovanka Gencel-Augusto et al. GENES & DEVELOPMENT
- Targeting STAT3 in Cancer Immunotherapy
- (2020) Sailan Zou et al. Molecular Cancer
- Cancer therapeutic targeting using mutant–p53-specific siRNAs
- (2019) Ifeoma Ubby et al. ONCOGENE
- Inflammatory regulatory network mediated by the joint action of NF-kB, STAT3, and AP-1 factors is involved in many human cancers
- (2019) Zhe Ji et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- IL-6 promotes endometrial cancer cells invasion and migration through signal transducers and activators of transcription 3 signaling pathway
- (2019) Qi Che et al. PATHOLOGY RESEARCH AND PRACTICE
- A gain-of-function p53 mutant oncogene promotes cell fate plasticity and myeloid leukemia through the pluripotency factor Foxh1
- (2019) Evangelia Loizou et al. Cancer Discovery
- Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches
- (2019) Michael Orth et al. Radiation Oncology
- Chaperoning the guardian of the genome. The two-faced role of molecular chaperones in p53 tumor suppressor action
- (2018) Bartosz Wawrzynow et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42
- (2018) Gina L. Razidlo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Gain-of-Function (GOF) Mutant p53 as Actionable Therapeutic Target
- (2018) Ramona Schulz-Heddergott et al. Cancers
- Targeting Pancreatic Cancer Cell Plasticity: The Latest in Therapeutics
- (2018) Jacob Smigiel et al. Cancers
- Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion
- (2018) Ramona Schulz-Heddergott et al. CANCER CELL
- Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer
- (2018) Nagaraj S Nagathihalli et al. CANCER RESEARCH
- Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases
- (2018) Yun Zhang et al. Nature Communications
- Mutant p53 as a guardian of the cancer cell
- (2018) Fiamma Mantovani et al. CELL DEATH AND DIFFERENTIATION
- Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others
- (2017) Kanaga Sabapathy et al. Nature Reviews Clinical Oncology
- p53 loss-of-heterozygosity is a necessary prerequisite for mutant p53 stabilization and gain-of-function in vivo
- (2017) Evguenia M Alexandrova et al. Cell Death & Disease
- KRAS, TP53, CDKN2A, SMAD4, BRCA1, and BRCA2 Mutations in Pancreatic Cancer
- (2017) Jonas Cicenas et al. Cancers
- Molecular Biomarkers of Pancreatic Intraepithelial Neoplasia and Their Implications in Early Diagnosis and Therapeutic Intervention of Pancreatic Cancer
- (2016) Junli Guo et al. International Journal of Biological Sciences
- STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells
- (2016) Li Lin et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Genomic analyses identify molecular subtypes of pancreatic cancer
- (2016) Peter Bailey et al. NATURE
- DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway
- (2016) Alejandro Parrales et al. NATURE CELL BIOLOGY
- Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells
- (2016) Nagaraj S. Nagathihalli et al. Oncotarget
- Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer
- (2015) Nagaraj S. Nagathihalli et al. GASTROENTEROLOGY
- Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment
- (2015) E. M. Alexandrova et al. NATURE
- Oncostatin-M Differentially Regulates Mesenchymal and Proneural Signature Genes in Gliomas via STAT3 Signaling
- (2015) Kumar Natesh et al. NEOPLASIA
- Mutant p53: Multiple Mechanisms Define Biologic Activity in Cancer
- (2015) Michael Paul Kim et al. Frontiers in Oncology
- Mutant p53: One, No One, and One Hundred Thousand
- (2015) Dawid Walerych et al. Frontiers in Oncology
- P53 Mutations in Advanced Cancers: Clinical Characteristics, Outcomes, and Correlation between Progression-Free Survival and Bevacizumab-Containing Therapy
- (2015) Rabih Said et al. Oncotarget
- Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors
- (2014) Kodappully Sivaraman Siveen et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Mutant p53 in Cancer: New Functions and Therapeutic Opportunities
- (2014) Patricia A.J. Muller et al. CANCER CELL
- MicroRNA let-7 downregulates STAT3 phosphorylation in pancreatic cancer cells by increasing SOCS3 expression
- (2014) Kripa Patel et al. CANCER LETTERS
- UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib
- (2014) H Landmann et al. Cell Death & Disease
- Unequal prognostic potentials of p53 gain-of-function mutations in human cancers associate with drug-metabolizing activity
- (2014) J Xu et al. Cell Death & Disease
- Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer
- (2013) Tomer Cooks et al. CANCER CELL
- Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis
- (2013) W Hanel et al. CELL DEATH AND DIFFERENTIATION
- STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapyin vitroandin vivo
- (2013) Melanie Spitzner et al. INTERNATIONAL JOURNAL OF CANCER
- Activation of the IL-6R/Jak/Stat Pathway is Associated with a Poor Outcome in Resected Pancreatic Ductal Adenocarcinoma
- (2013) Simon M. Denley et al. JOURNAL OF GASTROINTESTINAL SURGERY
- Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
- (2013) J. Gao et al. Science Signaling
- SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells
- (2013) M Herreros-Villanueva et al. Oncogenesis
- Cell-type, Dose, and Mutation-type Specificity Dictate Mutant p53 Functions In Vivo
- (2012) Ming Kei Lee et al. CANCER CELL
- Mutant p53: one name, many proteins
- (2012) W. A. Freed-Pastor et al. GENES & DEVELOPMENT
- p53 mutations in cancer
- (2012) Patricia A. J. Muller et al. NATURE CELL BIOLOGY
- Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2
- (2012) Milena Wiech et al. PLoS One
- APE1/Ref-1 Regulates STAT3 Transcriptional Activity and APE1/Ref-1–STAT3 Dual-Targeting Effectively Inhibits Pancreatic Cancer Cell Survival
- (2012) Angelo A. Cardoso et al. PLoS One
- The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.
- (2012) Ethan Cerami et al. Cancer Discovery
- STAT3 Is Necessary for Proliferation and Survival in Colon Cancer-Initiating Cells
- (2011) L. Lin et al. CANCER RESEARCH
- The role of mutant p53 in human cancer
- (2010) Amanda M Goh et al. JOURNAL OF PATHOLOGY
- Mutant p53 Drives Invasion by Promoting Integrin Recycling
- (2009) Patricia A.J. Muller et al. CELL
- A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis
- (2009) Maddalena Adorno et al. CELL
- Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer
- (2009) Sergei I. Grivennikov et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions
- (2009) D Walerych et al. ONCOGENE
- Mutant p53 Gain-of-Function in Cancer
- (2009) M. Oren et al. Cold Spring Harbor Perspectives in Biology
- Tumor Suppressive Functions of p53
- (2009) J. T. Zilfou et al. Cold Spring Harbor Perspectives in Biology
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