Awakening the “guardian of genome”: reactivation of mutant p53

Small-Molecule Prodigiosin Restores p53 Tumor Suppressor Activity in Chemoresistant Colorectal Cancer Stem Cells via c-Jun-Mediated ΔNp73 Inhibition and p73 Activation

(2016) Varun V. Prabhu et al.   CANCER RESEARCH

Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth

(2016) M Aggarwal et al.   CELL DEATH AND DIFFERENTIATION

p53 Reactivation by PRIMA-1Met (APR-246) sensitises V600E/KBRAF melanoma to vemurafenib

(2016) Mohammad Krayem et al.   EUROPEAN JOURNAL OF CANCER

Design and synthesis of a C7-aryl piperlongumine derivative with potent antimicrotubule and mutant p53-reactivating properties

(2016) Surendra R. Punganuru et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Piperlongumine exerts cytotoxic effects against cancer cells with mutant p53 proteins at least in part by restoring the biological functions of the tumor suppressor

(2016) DEBASISH BASAK et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Strong synergy with APR-246 and DNA-damaging drugs in primary cancer cells from patients with TP53 mutant High-Grade Serous ovarian cancer

(2016) Åsa Fransson et al.   Journal of Ovarian Research

Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides

(2016) Perry Tal et al.   Oncotarget

Lead Phytochemicals for Anticancer Drug Development

(2016) Sukhdev Singh et al.   Frontiers in Plant Science

Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

(2016) Vladimir J. N. Bykov et al.   Frontiers in Oncology

Zn(II)-curc targets p53 in thyroid cancer cells

(2015) ALESSIA GARUFI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Prodigiosin and its potential applications

(2015) N. Darshan et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment

(2015) E. M. Alexandrova et al.   NATURE

RITA enhances irradiation-induced apoptosis in p53-defective cervical cancer cells via upregulation of IRE1α/XBP1 signaling

(2015) HONG ZHU et al.   ONCOLOGY REPORTS

Targeting Oncogenic Mutant p53 for Cancer Therapy

(2015) Alejandro Parrales et al.   Frontiers in Oncology

Chemopreventive Effects of the p53-Modulating Agents CP-31398 and Prima-1 in Tobacco Carcinogen-Induced Lung Tumorigenesis in A/J Mice

(2015) Chinthalapally V. Rao et al.   NEOPLASIA

Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents

(2014) M N Saha et al.   BRITISH JOURNAL OF CANCER

p53 as a target for the treatment of cancer

(2014) Michael J. Duffy et al.   CANCER TREATMENT REVIEWS

Mutant p53 reactivation by small molecules makes its way to the clinic

(2014) Vladimir J.N. Bykov et al.   FEBS LETTERS

Functional interplay between MDM2, p63/p73 and mutant p53

(2014) M H Stindt et al.   ONCOGENE

Degradation of mutant p53H175 protein by Zn(II) through autophagy

(2014) A Garufi et al.   Cell Death & Disease

Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer

(2013) Tomer Cooks et al.   CANCER CELL

Prodigiosin Rescues Deficient p53 Signaling and Antitumor Effects via Upregulating p73 and Disrupting Its Interaction with Mutant p53

(2013) B. Hong et al.   CANCER RESEARCH

Dual Targeting of Wild-Type and Mutant p53 by Small Molecule RITA Results in the Inhibition of N-Myc and Key Survival Oncogenes and Kills Neuroblastoma Cells In Vivo and In Vitro

(2013) M. Burmakin et al.   CLINICAL CANCER RESEARCH

A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells

(2013) Alessia Garufi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Small molecule induced reactivation of mutant p53 in cancer cells

(2013) Xiangrui Liu et al.   NUCLEIC ACIDS RESEARCH

Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells

(2013) S Masciarelli et al.   ONCOGENE

Effect of Y220C Mutation on p53 and Its Rescue Mechanism: A Computer Chemistry Approach

(2013) Shah Md. Abdur Rauf et al.   PROTEIN JOURNAL

Plants vs. Cancer: A Review on Natural Phytochemicals in Preventing and Treating Cancers and Their Druggability

(2012) Hu Wang et al.   Anti-Cancer Agents in Medicinal Chemistry

Autophagy induced by p53-reactivating molecules protects pancreatic cancer cells from apoptosis

(2012) Claudia Fiorini et al.   APOPTOSIS

Allele-Specific p53 Mutant Reactivation

(2012) Xin Yu et al.   CANCER CELL

The p53-reactivating small-molecule RITA enhances cisplatin-induced cytotoxicity and apoptosis in head and neck cancer

(2012) Jong-Lyel Roh et al.   CANCER LETTERS

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

The substitutions G245C and G245D in the Zn2+-binding pocket of the p53 protein result in differences of conformational flexibility of the DNA-binding domain

(2012) S.S. Pintus et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer

(2012) Sören Lehmann et al.   JOURNAL OF CLINICAL ONCOLOGY

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs

(2011) Rosa Puca et al.   CELL CYCLE

PRIMA-1Met/APR-246 Induces Apoptosis and Tumor Growth Delay in Small Cell Lung Cancer Expressing Mutant p53

(2011) R. Zandi et al.   CLINICAL CANCER RESEARCH

Zinc supplementation augments in vivo antitumor effect of chemotherapy by restoring p53 function

(2011) Ofer Margalit et al.   INTERNATIONAL JOURNAL OF CANCER

p53 and its mutants in tumor cell migration and invasion

(2011) Patricia A. J. Muller et al.   JOURNAL OF CELL BIOLOGY

Selective Depletion of Mutant p53 by Cancer Chemopreventive Isothiocyanates and Their Structure−Activity Relationships

(2011) Xiantao Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Mutant p53 exhibits trivial effects on mitochondrial functions which can be reactivated by ellipticine in lymphoma cells

(2010) Fei Wang et al.   APOPTOSIS

Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies

(2010) I Goldstein et al.   CANCER GENE THERAPY

Rescue of the apoptotic-inducing function of mutant p53 by small molecule RITA

(2010) Carolyn Y. Zhao et al.   CELL CYCLE

SCH529074, a Small Molecule Activator of Mutant p53, Which Binds p53 DNA Binding Domain (DBD), Restores Growth-suppressive Function to Mutant p53 and Interrupts HDM2-mediated Ubiquitination of Wild Type p53

(2010) Mark Demma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactivation of p53: from peptides to small molecules

(2010) Christopher J. Brown et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Ablation of Key Oncogenic Pathways by RITA-Reactivated p53 Is Required for Efficient Apoptosis

(2009) Vera V. Grinkevich et al.   CANCER CELL

PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

(2009) Jeremy M.R. Lambert et al.   CANCER CELL

Peptide Aptamers Targeting Mutant p53 Induce Apoptosis in Tumor Cells

(2008) E. Guida et al.   CANCER RESEARCH

Suppression of Familial Adenomatous Polyposis by CP-31398, a TP53 Modulator, in APCmin/+ Mice

(2008) C. V. Rao et al.   CANCER RESEARCH

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

(2008) T. Terzian et al.   GENES & DEVELOPMENT

Mutant p53 targeting by the low molecular weight compound STIMA-1

(2008) Nicole Zache et al.   Molecular Oncology

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

(2008) F. M. Boeckler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA