p53 Affects PGC1α Stability Through AKT/GSK-3β to Enhance Cisplatin Sensitivity in Non-Small Cell Lung Cancer

Homeostasis of SLC4A11 protein is mediated by endoplasmic reticulum-associated degradation

(2019) Susumu Hara et al.   EXPERIMENTAL EYE RESEARCH

p53 and metabolism: from mechanism to therapeutics

(2018) Fernando M. Simabuco et al.   Oncotarget

Epigenetic silencing of miR-493 increases the resistance to cisplatin in lung cancer by targeting tongue cancer resistance-related protein 1(TCRP1)

(2017) Yixue Gu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Endostatin sensitizes p53-deficient non-small-cell lung cancer to genotoxic chemotherapy by targeting DNA-dependent protein kinase catalytic subunit

(2017) Lin Jia et al.   JOURNAL OF PATHOLOGY

Loss of Uracil DNA Glycosylase Selectively Resensitizes p53-Mutant and -Deficient Cells to 5-FdU

(2017) Yan Yan et al.   MOLECULAR CANCER RESEARCH

Targeting the MDM2–p53 Protein–Protein Interaction for New Cancer Therapy: Progress and Challenges

(2017) Shaomeng Wang et al.   Cold Spring Harbor Perspectives in Medicine

p53 as guardian of the mitochondrial genome

(2016) Ji-Hoon Park et al.   FEBS LETTERS

Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors

(2016) Gao Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

AKT/GSK3β Signaling in Glioblastoma

(2016) Ewelina Majewska et al.   NEUROCHEMICAL RESEARCH

SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage

(2016) Xuehui Hong et al.   NUCLEIC ACIDS RESEARCH

Regulation of Cellular Metabolism and Hypoxia by p53

(2016) Timothy J. Humpton et al.   Cold Spring Harbor Perspectives in Medicine

p53: Protection against Tumor Growth beyond Effects on Cell Cycle and Apoptosis

(2015) X. Wang et al.   CANCER RESEARCH

SIRT1/PGC1 -Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer

(2015) T. T. Vellinga et al.   CLINICAL CANCER RESEARCH

Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation

(2015) Patrick Seale   DIABETES

Overexpression of PGC-1α enhances cell proliferation and tumorigenesis of HEK293 cells through the upregulation of Sp1 and Acyl-CoA binding protein

(2015) SUNG-WON SHIN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Circadian Rhythmicity of Active GSK3 Isoforms Modulates Molecular Clock Gene Rhythms in the Suprachiasmatic Nucleus

(2015) Rachel C. Besing et al.   JOURNAL OF BIOLOGICAL RHYTHMS

P53 suppresses cell proliferation, metastasis, and angiogenesis of osteosarcoma through inhibition of the PI3K/AKT/mTOR pathway

(2015) Ruipeng Song et al.   International Journal of Surgery

p53 attenuates AKT signaling by modulating membrane phospholipid composition

(2015) Natalia Rueda-Rincon et al.   Oncotarget

p53 and mitochondrial function in neurons

(2014) David B. Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents

(2014) Minh Truong Do et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF

(2013) Rizwan Haq et al.   CANCER CELL

p53 Orchestrates the PGC-1α-Mediated Antioxidant Response Upon Mild Redox and Metabolic Imbalance

(2012) Katia Aquilano et al.   ANTIOXIDANTS & REDOX SIGNALING

p53-PGC-1α Pathway Mediates Oxidative Mitochondrial Damage and Cardiomyocyte Necrosis Induced by Monoamine Oxidase-A Upregulation: Role in Chronic Left Ventricular Dysfunction in Mice

(2012) Christelle Villeneuve et al.   ANTIOXIDANTS & REDOX SIGNALING

The F-box Protein FBXO44 Mediates BRCA1 Ubiquitination and Degradation

(2012) Yunzhe Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

PGC-1 family coactivators and cell fate: Roles in cancer, neurodegeneration, cardiovascular disease and retrograde mitochondria–nucleus signalling

(2011) Aleck W.E. Jones et al.   MITOCHONDRION

PGC-1α, a Key Modulator of p53, Promotes Cell Survival upon Metabolic Stress

(2011) Nirmalya Sen et al.   MOLECULAR CELL

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin

(2010) Tilman Schneider-Poetsch et al.   Nature Chemical Biology

Dynamic regulation of PGC-1α localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response

(2009) Rozalyn M. Anderson et al.   AGING CELL

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

PH Domain-Only Protein PHLDA3 Is a p53-Regulated Repressor of Akt

(2009) Tatsuya Kawase et al.   CELL

Kinetic Cell-Based Morphological Screening: Prediction of Mechanism of Compound Action and Off-Target Effects

(2009) Yama A. Abassi et al.   CHEMISTRY & BIOLOGY

Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway

(2009) Peixin Dong et al.   Molecular Cancer