Curaxins: Anticancer Compounds That Simultaneously Suppress NF- B and Activate p53 by Targeting FACT

A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice

(2010) Katerina I. Leonova et al.   CELL CYCLE

NFκB signaling in carcinogenesis and as a potential molecular target for cancer therapy

(2009) Han-Ming Shen et al.   APOPTOSIS

Impaired DNA damage response — An Achilles' heel sensitizing cancer to chemotherapy and radiotherapy

(2009) Zbigniew Darzynkiewicz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

New molecular targets in radiotherapy: DNA damage signalling and repair in targeted and non-targeted cells

(2009) Susanne Burdak-Rothkamm et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

New hopes from old drugs: revisiting DNA-binding small molecules as anticancer agents

(2009) Katerina Gurova   Future Oncology

Phosphorylated Intrinsically Disordered Region of FACT Masks Its Nucleosomal DNA Binding Elements

(2009) Yasuo Tsunaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for SSRP1 in recombination-mediated DNA damage response

(2009) Anuradha Kumari et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Structure-Specific Recognition Protein 1 Facilitates Microtubule Growth and Bundling Required for Mitosis

(2009) S. X. Zeng et al.   MOLECULAR AND CELLULAR BIOLOGY

DNA-Dependent Protein Kinase (DNA-PK)-Dependent Cisplatin-Induced Loss of Nucleolar Facilitator of Chromatin Transcription (FACT) and Regulation of Cisplatin Sensitivity by DNA-PK and FACT

(2009) J. Dejmek et al.   MOLECULAR CANCER RESEARCH

9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-κB and p53 pathways

(2009) C Guo et al.   ONCOGENE

Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation

(2008) Amit Kulkarni et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Small-Molecule Inhibitor Which Reactivates p53 in Human T-Cell Leukemia Virus Type 1-Transformed Cells

(2008) K.-J. Jung et al.   JOURNAL OF VIROLOGY

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

(2008) Wataru Sakai et al.   NATURE

Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-κB pathways

(2008) Anwesha Dey et al.   NATURE REVIEWS DRUG DISCOVERY