Resolution of inflammation in bone regeneration: From understandings to therapeutic applications

Age‐related changes to macrophages are detrimental to fracture healing in mice

(2020) Daniel Clark et al.   AGING CELL

Macrophage subtype and cytokine expression characterization during the acute inflammatory phase of mouse bone fracture repair

(2020) James McCauley et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration

(2020) Lisha Zhu et al.   International Journal of Oral Science

Time Course of Immune Response and Immunomodulation During Normal and Delayed Healing of Musculoskeletal Wounds

(2020) Preeti J. Muire et al.   Frontiers in Immunology

Modulation of the Inflammatory Response and Bone Healing

(2020) Masahiro Maruyama et al.   Frontiers in Endocrinology

CDllb+ targeted depletion of macrophages negatively affects bone fracture healing

(2020) Sarah Hozain et al.   BONE

Maresin 1 resolves aged‐associated macrophage inflammation to improve bone regeneration

(2020) Rong Huang et al.   FASEB JOURNAL

Similarities and interplay between senescent cells and macrophages

(2020) Jacques Behmoaras et al.   JOURNAL OF CELL BIOLOGY

Different experimental multiple trauma models induce comparable inflammation and organ injury

(2020) Borna Relja et al.   Scientific Reports

Bone Extracts Immunomodulate and Enhance the Regenerative Performance of Dicalcium Phosphates Bioceramics

(2019) Alaa Mansour et al.   Acta Biomaterialia

Biomaterial-assisted local and systemic delivery of bioactive agents for bone repair

(2019) Yuze Zeng et al.   Acta Biomaterialia

Building capacity for macrophage modulation and stem cell recruitment in high-stiffness hydrogels for complex periodontal regeneration: Experimental studies in vitro and in rats

(2019) Xiao-Tao He et al.   Acta Biomaterialia

Repair of Critical‐Sized Long Bone Defects Using Dipyridamole‐Augmented 3D Printed Bioactive Ceramic Scaffolds

(2019) Lukasz Witek et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

(2019) Hamed Amani et al.   Advanced Materials Interfaces

Immune Modulation to Enhance Bone Healing—A New Concept to Induce Bone Using Prostacyclin to Locally Modulate Immunity

(2019) Sebastian Wendler et al.   Frontiers in Immunology

Immune Modulation by Transplanted Calcium Phosphate Biomaterials and Human Mesenchymal Stromal Cells in Bone Regeneration

(2019) Paul Humbert et al.   Frontiers in Immunology

Diabetes-Induced NF-κB Dysregulation in Skeletal Stem Cells Prevents Resolution of Inflammation

(2019) Kang I. Ko et al.   DIABETES

Individual Effector/Regulator T Cell Ratios Impact Bone Regeneration

(2019) Claudia Schlundt et al.   Frontiers in Immunology

Dysregulation of ectonucleotidase-mediated extracellular adenosine during postmenopausal bone loss

(2019) Yu-Ru V. Shih et al.   Science Advances

Biomimetic anti-inflammatory nano-capsule serves as a cytokine blocker and M2 polarization inducer for bone tissue repair

(2019) Chengcheng Yin et al.   Acta Biomaterialia

Compromised Bone Healing in Aged Rats Is Associated With Impaired M2 Macrophage Function

(2019) Julia Löffler et al.   Frontiers in Immunology

More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis

(2019) Martha Gschwandtner et al.   Frontiers in Immunology

Inflammatory Profile and Osteogenic Potential of Fracture Haematoma in Humans

(2019) Ippokratis Pountos et al.   Journal of Clinical Medicine

Immunomodulatory ECM-like Microspheres for Accelerated Bone Regeneration in Diabetes Mellitus

(2018) Zhiai Hu et al.   ACS Applied Materials & Interfaces

Effect of Age on Biomaterial-mediated in situ Bone Tissue Regeneration

(2018) Mengqian Liu et al.   Acta Biomaterialia

Therapeutic interleukin-6 blockade reverses transforming growth factor-beta pathway activation in dermal fibroblasts: insights from the faSScinate clinical trial in systemic sclerosis

(2018) Christopher P Denton et al.   ANNALS OF THE RHEUMATIC DISEASES

Macrophages in bone fracture healing: Their essential role in endochondral ossification

(2018) Claudia Schlundt et al.   BONE

Insulin-Like Growth Factor-1 as a Possible Alternative to Bone Morphogenetic Protein-7 to Induce Osteogenic Differentiation of Human Mesenchymal Stem Cells in Vitro

(2018) Bruno Reible et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A thermoresponsive, citrate-based macromolecule for bone regenerative engineering

(2018) Simona Morochnik et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Chitosan porous 3D scaffolds embedded with resolvin D1 to improve in vivo bone healing

(2018) Daniela P. Vasconcelos et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

(2018) Charles N. Serhan et al.   JOURNAL OF CLINICAL INVESTIGATION

The effect of two locally administered anti-resorptive agents on bone regeneration in a rat fibula model: Alendronate and 15-deoxy-Δ 12,14 -prostaglandin J₂

(2018) Jung Woo Nam et al.   JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY

LRP1: A chameleon receptor of lung inflammation and repair

(2018) Lukasz Wujak et al.   MATRIX BIOLOGY

Cellular Senescence and Inflammaging in Age-Related Diseases

(2018) Fabiola Olivieri et al.   MEDIATORS OF INFLAMMATION

Maresins: Specialized Proresolving Lipid Mediators and Their Potential Role in Inflammatory-Related Diseases

(2018) Shi Tang et al.   MEDIATORS OF INFLAMMATION

Wnt5a suppresses inflammation-driven intervertebral disc degeneration via a TNF-α/NF-κB–Wnt5a negative-feedback loop

(2018) Z. Li et al.   OSTEOARTHRITIS AND CARTILAGE

Pharmacology of Adenosine Receptors: The State of the Art

(2018) Pier Andrea Borea et al.   PHYSIOLOGICAL REVIEWS

Mineralized Biomaterials Mediated Repair of Bone Defects Through Endogenous Cells

(2018) Eva C. González Díaz et al.   TISSUE ENGINEERING PART A

Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus

(2018) Xavier Palomer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

(2018) Oliver Werz et al.   Nature Communications

Effects of obesity on the healing of bone fracture in mice

(2018) Feng Gao et al.   Journal of Orthopaedic Surgery and Research

Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes

(2018) Ilkka S. Junttila   Frontiers in Immunology

Transforming Growth Factor-β and Interleukin-10 Synergistically Regulate Humoral Immunity via Modulating Metabolic Signals

(2018) Toshihiko Komai et al.   Frontiers in Immunology

Rheumatoid arthritis

(2018) Josef S. Smolen et al.   Nature Reviews Disease Primers

Macrophage response to hydrophilic biomaterials regulates MSC recruitment and T-helper cell populations

(2018) Kelly M. Hotchkiss et al.   BIOMATERIALS

Transplanted interleukin-4--secreting mesenchymal stromal cells show extended survival and increased bone mineral density in the murine femur

(2018) TZUHUA LIN et al.   CYTOTHERAPY

Effect of NSAIDs on Bone Healing Rates

(2018) Benjamin M. Wheatley et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

Cellular biology of fracture healing

(2018) Chelsea S. Bahney et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Stimuli-Responsive Supramolecular Hydrogels and Their Applications in Regenerative Medicine

(2018) Jiaul Hoque et al.   MACROMOLECULAR BIOSCIENCE

Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice

(2018) Linda Vi et al.   Nature Communications

Bioinformatics Analysis of the Molecular Mechanism of Aging on Fracture Healing

(2018) Shu-Jie Zhao et al.   Biomed Research International

Fatty acid is a potential agent for bone tissue induction: In vitro and in vivo approach

(2017) Guinea BC Cardoso et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Polyurethane conjugating TGF-β on surface impacts local inflammation and endoplasmic reticulum stress in skeletal muscle

(2017) Dandan Shi et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

IGF1 potentiates the pro-inflammatory response in human peripheral blood mononuclear cells via MAPK

(2017) Thalijn Liliana Catharina Wolters et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Ecto-5′-nucleotidase (CD73) regulates bone formation and remodeling during intramembranous bone repair in aging mice

(2017) Vivian Bradaschia-Correa et al.   TISSUE & CELL

Heparinization of Beta Tricalcium Phosphate: Osteo-immunomodulatory Effects

(2017) Anna Diez-Escudero et al.   Advanced Healthcare Materials

Insulin-Like Growth Factor-1 and Neuroinflammation

(2017) Jose L. Labandeira-Garcia et al.   Frontiers in Aging Neuroscience

Endogenous Production of n-3 Polyunsaturated Fatty Acids Promotes Fracture Healing in Mice

(2017) Yuhui Chen et al.   Journal of Healthcare Engineering

RANKL-induced M1 macrophages are involved in bone formation

(2017) Rong Huang et al.   Bone Research

Effects of Aging on Fracture Healing

(2017) Dan Clark et al.   Current Osteoporosis Reports

Type 1 Diabetes: A Chronic Anti-Self-Inflammatory Response

(2017) Matthew Clark et al.   Frontiers in Immunology

Potential Role of Chemokines in Fracture Repair

(2017) Bouchra Edderkaoui   Frontiers in Endocrinology

Poly(ethylene glycol) hydrogels with cell cleavable groups for autonomous cell delivery

(2016) Mrityunjoy Kar et al.   BIOMATERIALS

Transforming growth factor-beta 1 delivery from microporous scaffolds decreases inflammation post-implant and enhances function of transplanted islets

(2016) Jeffrey M.H. Liu et al.   BIOMATERIALS

Defective Bone Repair in C57Bl6 Mice With Acute Systemic Inflammation

(2016) D. A. Behrends et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

LDL receptor-related protein-1 regulates NFκB and microRNA-155 in macrophages to control the inflammatory response

(2016) Elisabetta Mantuano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response

(2016) Ajaykumar Vishwakarma et al.   TRENDS IN BIOTECHNOLOGY

Tailoring biomaterial surface properties to modulate host-implant interactions: implication in cardiovascular and bone therapy

(2016) Settimio Pacelli et al.   Journal of Materials Chemistry B

Epidemiology of Fracture Nonunion in 18 Human Bones

(2016) Robert Zura et al.   JAMA Surgery

Resolution of Inflammation: What Controls Its Onset?

(2016) Michelle A. Sugimoto et al.   Frontiers in Immunology

Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts

(2016) H. Kang et al.   Science Advances

The Anti-Inflammatory Effects of Prostaglandins

(2016) Jose U. Scher et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Controlled Drug Release and Hydrolysis Mechanism of Polymer–Magnetic Nanoparticle Composite

(2015) Fang Yang et al.   ACS Applied Materials & Interfaces

Stretch-Triggered Drug Delivery from Wearable Elastomer Films Containing Therapeutic Depots

(2015) Jin Di et al.   ACS Nano

Biomineralized Matrices Dominate Soluble Cues To Direct Osteogenic Differentiation of Human Mesenchymal Stem Cells through Adenosine Signaling

(2015) Heemin Kang et al.   BIOMACROMOLECULES

Lipoxins and aspirin-triggered lipoxins in resolution of inflammation

(2015) Mario Romano et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Direct or indirect stimulation of adenosine A2A receptors enhances bone regeneration as well as bone morphogenetic protein-2

(2015) Aránzazu Mediero et al.   FASEB JOURNAL

Bone regeneration in critical bone defects using three-dimensionally printed β-tricalcium phosphate/hydroxyapatite scaffolds is enhanced by coating scaffolds with either dipyridamole or BMP-2

(2015) Stephanie Ishack et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification

(2015) Masato Yuasa et al.   JOURNAL OF CLINICAL INVESTIGATION

Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms

(2015) Tamás Rőszer   MEDIATORS OF INFLAMMATION

Monocyte/Macrophage-derived IGF-1 Orchestrates Murine Skeletal Muscle Regeneration and Modulates Autocrine Polarization

(2015) Joanne Tonkin et al.   MOLECULAR THERAPY

Diabetes and Its Effect on Bone and Fracture Healing

(2015) Hongli Jiao et al.   Current Osteoporosis Reports

Influence of antiTNF-alpha antibody treatment on fracture healing under chronic inflammation

(2014) Melanie Timmen et al.   BMC MUSCULOSKELETAL DISORDERS

Design of growth factor sequestering biomaterials

(2014) David G. Belair et al.   CHEMICAL COMMUNICATIONS

Proresolving Nanomedicines Activate Bone Regeneration in Periodontitis

(2014) T.E. Van Dyke et al.   JOURNAL OF DENTAL RESEARCH

Modulation of Macrophage Activity During Fracture Repair Has Differential Effects in Young Adult and Elderly Mice

(2014) Jesse Alan Slade Shantz et al.   JOURNAL OF ORTHOPAEDIC TRAUMA

Fracture Healing and Biomarker Expression in a Diabetic Zucker Rat Model

(2014) Javier La Fontaine et al.   JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

The Pro-Inflammatory Cytokine, Interleukin-6, Enhances the Polarization of Alternatively Activated Macrophages

(2014) Maria Ruweka Fernando et al.   PLoS One

Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling

(2014) Y.-R. V. Shih et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An optimized Protocol for Human M2 Macrophages using M-CSF and IL-4/IL-10/TGF-βYields a Dominant Immunosuppressive Phenotype

(2014) S. Mia et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

NSAIDs and fracture healing

(2013) Piet Geusens et al.   CURRENT OPINION IN RHEUMATOLOGY

TGF- : Guardian of T Cell Function

(2013) S. A. Oh et al.   JOURNAL OF IMMUNOLOGY

Inflammatory and apoptotic alterations in serum and injured tissue after experimental polytrauma in mice

(2013) Sebastian Weckbach et al.   Journal of Trauma and Acute Care Surgery

Systemic inflammation induced by a thoracic trauma alters the cellular composition of the early fracture callus

(2013) Stefan Recknagel et al.   Journal of Trauma and Acute Care Surgery

15-Deoxy-Δ12,14-Prostaglandin J2 Inhibits Macrophage Colonization by Salmonella enterica Serovar Typhimurium

(2013) Michelle M. C. Buckner et al.   PLoS One

NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies

(2013) Carmela R Balistreri et al.   Immunity & Ageing

Regulation of Inflammation by Adenosine

(2013) György Haskó et al.   Frontiers in Immunology

Regulation of Adaptive Immunity; The Role of Interleukin-10

(2013) T. H. Sky Ng et al.   Frontiers in Immunology

Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations

(2013) Jeremy Sokolove et al.   Therapeutic Advances in Musculoskeletal Disease

Inflammatory cell response to calcium phosphate biomaterial particles: An overview

(2012) Frédéric Velard et al.   Acta Biomaterialia

PEG-co-PCL nanoparticles modified with MMP-2/9 activatable low molecular weight protamine for enhanced targeted glioblastoma therapy

(2012) Guangzhi Gu et al.   BIOMATERIALS

TGFβ signaling plays a critical role in promoting alternative macrophage activation

(2012) Dapeng Gong et al.   BMC IMMUNOLOGY

The Insulin-Like Growth Factor System in Bone

(2012) Masanobu Kawai et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Interleukin-6 induces the generation of IL-10-producing Tr1 cells and suppresses autoimmune tissue inflammation

(2012) Jun-O Jin et al.   JOURNAL OF AUTOIMMUNITY

A2B Adenosine Receptor Promotes Mesenchymal Stem Cell Differentiation to Osteoblasts and Bone Formationin Vivo

(2012) Shannon H. Carroll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Local effect of IL-4 delivery on polyethylene particle induced osteolysis in the murine calvarium

(2012) Allison J. Rao et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Neutrophil-Mediated Inhibition of Proinflammatory Cytokine Responses

(2012) M. S. Gresnigt et al.   JOURNAL OF IMMUNOLOGY

Resolvin E1 and Chemokine-like Receptor 1 Mediate Bone Preservation

(2012) L. Gao et al.   JOURNAL OF IMMUNOLOGY

PGI2as a Regulator of Inflammatory Diseases

(2012) Stacy L. Dorris et al.   MEDIATORS OF INFLAMMATION

Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

(2012) Dong Sohn et al.   ARTHRITIS RESEARCH & THERAPY

Mineral Coatings for Temporally Controlled Delivery of Multiple Proteins

(2011) Jae Sung Lee et al.   ADVANCED MATERIALS

15-Deoxy-Δ12,14-prostaglandin J2, an electrophilic lipid mediator of anti-inflammatory and pro-resolving signaling

(2011) Young-Joon Surh et al.   BIOCHEMICAL PHARMACOLOGY

Engineering the cell–material interface for controlling stem cell adhesion, migration, and differentiation

(2011) Ramses Ayala et al.   BIOMATERIALS

Inflammatory phase of bone healing initiates the regenerative healing cascade

(2011) Katharina Schmidt-Bleek et al.   CELL AND TISSUE RESEARCH

NF-κB, Inflammation, and Metabolic Disease

(2011) Rebecca G. Baker et al.   Cell Metabolism

Adenosine promotes alternative macrophage activation via A2A and A2B receptors

(2011) Balázs Csóka et al.   FASEB JOURNAL

Angiogenesis in bone regeneration

(2011) Kurt D. Hankenson et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

The biology of fracture healing

(2011) Richard Marsell et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Adenosine receptor subtype expression and activation influence the differentiation of mesenchymal stem cells to osteoblasts and adipocytes

(2011) Borzo Gharibi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

CD73-generated adenosine promotes osteoblast differentiation

(2011) Masahide Takedachi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Adenosine A1receptors regulate bone resorption in mice: Adenosine A1receptor blockade or deletion increases bone density and prevents ovariectomy-induced bone loss in adenosine A1receptor-knockout mice

(2010) Firas M. Kara et al.   ARTHRITIS AND RHEUMATISM

TNF-α mediates diabetes-enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis Through FOXO1

(2010) Rayyan A Kayal et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Fracture healing is accelerated in the absence of the adaptive immune system

(2010) Daniel Toben et al.   JOURNAL OF BONE AND MINERAL RESEARCH

On the role of subtype selective adenosine receptor agonists during proliferation and osteogenic differentiation of human primary bone marrow stromal cells

(2010) M. Adelina Costa et al.   JOURNAL OF CELLULAR PHYSIOLOGY

High Levels of Tumor Necrosis Factor-α Contribute to Accelerated Loss of Cartilage in Diabetic Fracture Healing

(2009) Jazia Alblowi et al.   AMERICAN JOURNAL OF PATHOLOGY

Potential roles of growth factor PDGF-BB in the bony repair of injured growth plate

(2009) Rosa Chung et al.   BONE

Mesenchymal stem cell differentiation and roles in regenerative medicine

(2009) Nathaniel S. Hwang et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Bone formation in interleukin‐4 and interleukin‐13 depleted mice

(2008) Carl–Johan Silfverswärd et al.   Acta Orthopaedica

Mechanical induction of critically delayed bone healing in sheep: Radiological and biomechanical results

(2008) Hanna Schell et al.   JOURNAL OF BIOMECHANICS

Adenosine A2A receptors play an active role in mouse bone marrow-derived mesenchymal stem cell development

(2008) Majid Katebi et al.   JOURNAL OF LEUKOCYTE BIOLOGY