Similarities and interplay between senescent cells and macrophages

Cysteine Toxicity Drives Age-Related Mitochondrial Decline by Altering Iron Homeostasis

(2020) Casey E. Hughes et al.   CELL

Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence

(2020) Maria Grazia Vizioli et al.   GENES & DEVELOPMENT

Autolysosomal degradation of cytosolic chromatin fragments antagonizes oxidative stress–induced senescence

(2020) Xiaojuan Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation

(2020) Ross A. Weber et al.   MOLECULAR CELL

Mitochondrial TCA cycle metabolites control physiology and disease

(2020) Inmaculada Martínez-Reyes et al.   Nature Communications

Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

(2020) Estela González‐Gualda et al.   AGING CELL

BRD4 contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake

(2020) Hui Wang et al.   Aging-US

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

(2020) Min Zheng et al.   CELL

Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan

(2020) Laurent Grosse et al.   Cell Metabolism

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

(2020)   NATURE

The Transcriptional Network That Controls Growth Arrest and Macrophage Differentiation in the Human Myeloid Leukemia Cell Line THP-1

(2020) Iveta Gažová et al.   Frontiers in Cell and Developmental Biology

A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart

(2020) José A. Nicolás-Ávila et al.   CELL

Lysosome Fusion Maintains Phagosome Integrity during Fungal Infection

(2020) Johannes Westman et al.   Cell Host & Microbe

Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence

(2020) Ioana Olan et al.   Nature Communications

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

(2019) Mikolaj Ogrodnik et al.   Cell Metabolism

Emergence of Microglia Bearing Senescence Markers During Paralysis Progression in a Rat Model of Inherited ALS

(2019) Emiliano Trias et al.   Frontiers in Aging Neuroscience

Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence

(2019) Jie-Yu Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model

(2019) Ziv Erlich et al.   NATURE IMMUNOLOGY

Elevated Local Senescence in Diabetic Wound Healing Is Linked to Pathological Repair via CXCR2

(2019) Holly N. Wilkinson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin

(2019) Laura C. Burzynski et al.   IMMUNITY

IL‐1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence‐associated secretory phenotype

(2019) Kimberley A. Wiggins et al.   AGING CELL

Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism

(2019) Mara Mazzoni et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Acute Iron Deprivation Reprograms Human Macrophage Metabolism and Reduces Inflammation In Vivo

(2019) Marie Pereira et al.   Cell Reports

Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival

(2019) Crystal A. Tonnessen-Murray et al.   JOURNAL OF CELL BIOLOGY

Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer

(2019) Diletta Di Mitri et al.   Cell Reports

SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells

(2019) Christopher D. Wiley et al.   Cell Reports

Caspase-11-dependent IL-1α release boosts Th17 immunity against Paracoccidioides brasiliensis

(2019) Natália Ketelut-Carneiro et al.   PLoS Pathogens

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation

(2019) Victoria E. B. Hipolito et al.   PLOS BIOLOGY

Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo

(2019) King Faisal Yambire et al.   eLife

A versatile drug delivery system targeting senescent cells

(2018) Daniel Muñoz‐Espín et al.   EMBO Molecular Medicine

CD36 initiates the secretory phenotype during the establishment of cellular senescence

(2018) Mengyang Chong et al.   EMBO REPORTS

Mechanisms and functions of cellular senescence

(2018) Nicolás Herranz et al.   JOURNAL OF CLINICAL INVESTIGATION

NLRP3 inflammasome activation in inflammaging

(2018) Eicke Latz et al.   SEMINARS IN IMMUNOLOGY

mTOR as a central hub of nutrient signalling and cell growth

(2018) Joungmok Kim et al.   NATURE CELL BIOLOGY

F4/80+ Macrophages Contribute to Clearance of Senescent Cells in the Mouse Postpartum Uterus

(2017) Mahiro Egashira et al.   ENDOCRINOLOGY

Senescence and aging: Causes, consequences, and therapeutic avenues

(2017) Domhnall McHugh et al.   JOURNAL OF CELL BIOLOGY

Phagocytosis imprints heterogeneity in tissue-resident macrophages

(2017) Noelia A-Gonzalez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease

(2017) J. Kenneth Baillie et al.   PLoS Genetics

Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?

(2017) Viktor I. Korolchuk et al.   EBioMedicine

Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

(2016) Brandon M. Hall et al.   Aging-US

Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

(2016) Haoran Tai et al.   Autophagy

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Phagocytosis: An Immunobiologic Process

(2016) Siamon Gordon   IMMUNITY

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence

(2016) Olga Spadaro et al.   Cell Reports

Macrophages and iron trafficking at the birth and death of red cells

(2015) T. Korolnek et al.   BLOOD

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Innate Host Defense Requires TFEB-Mediated Transcription of Cytoprotective and Antimicrobial Genes

(2014) Orane Visvikis et al.   IMMUNITY

Macrophage heterogeneity in tissues: phenotypic diversity and functions

(2014) Siamon Gordon et al.   IMMUNOLOGICAL REVIEWS

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity

(2014) Alberto Toso et al.   Cell Reports

Cytokine Secretion in Macrophages: SNAREs, Rabs, and Membrane Trafficking

(2014) Rachael Zoe Murray et al.   Frontiers in Immunology

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Non-Cell-Autonomous Tumor Suppression by p53

(2013) Amaia Lujambio et al.   CELL

Aging-related changes in the iron status of skeletal muscle

(2013) Keith C. DeRuisseau et al.   EXPERIMENTAL GERONTOLOGY

Lysosome-mediated processing of chromatin in senescence

(2013) Andre Ivanov et al.   JOURNAL OF CELL BIOLOGY

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

(2013) Joanna Kaplon et al.   NATURE

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice

(2011) Anca Sindrilaru et al.   JOURNAL OF CLINICAL INVESTIGATION

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

The Identification of Markers of Macrophage Differentiation in PMA-Stimulated THP-1 Cells and Monocyte-Derived Macrophages

(2010) Marc Daigneault et al.   PLoS One

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

(2009) O. Moiseeva et al.   MOLECULAR AND CELLULAR BIOLOGY

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells

(2009) Chinnaswamy Jagannath et al.   NATURE MEDICINE

Hepatocyte Necrosis Induced by Oxidative Stress and IL-1α Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis

(2008) Toshiharu Sakurai et al.   CANCER CELL

Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival

(2008) Nancie J. MacIver et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice

(2008) I. Murano et al.   JOURNAL OF LIPID RESEARCH

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE