Pharmacology of Adenosine Receptors: The State of the Art

Allosteric Coupling of Drug Binding and Intracellular Signaling in the A 2A Adenosine Receptor

(2018) Matthew T. Eddy et al.   CELL

The Role of Adenosine Receptors in Psychostimulant Addiction

(2018) Inmaculada Ballesteros-Yáñez et al.   Frontiers in Pharmacology

Astrocytic Adenosine A2A Receptors Control the Amyloid-β Peptide-Induced Decrease of Glutamate Uptake

(2018) Marco Matos et al.   JOURNAL OF ALZHEIMERS DISEASE

Targeting A2 adenosine receptors in cancer

(2017) David Allard et al.   IMMUNOLOGY AND CELL BIOLOGY

Adenosine and adenosine receptors in the immunopathogenesis and treatment of cancer

(2017) Mohammad H. Kazemi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

(2017) Paul A. Beavis et al.   JOURNAL OF CLINICAL INVESTIGATION

Deregulation of Adenosine Receptors in Psoriatic Epidermis: An Option for Therapeutic Treatment

(2017) Stefania Merighi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Adenosine A 2A and A 2B Receptors Differentially Modulate Keratinocyte Proliferation: Possible Deregulation in Psoriatic Epidermis

(2017) Rosa M. Andrés et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Adenosine receptors regulate gap junction coupling of the human cerebral microvascular endothelial cells hCMEC/D3 by Ca2+ influx through cyclic nucleotide-gated channels

(2017) Almke Bader et al.   JOURNAL OF PHYSIOLOGY-LONDON

Hypoxic postconditioning attenuates apoptosis via activation of adenosine A 2a receptors on dermal microvascular endothelial cells of human flaps

(2017) Jiankun Cao et al.   JOURNAL OF SURGICAL RESEARCH

Adenosine Receptors as a Biological Pathway for the Anti-Inflammatory and Beneficial Effects of Low Frequency Low Energy Pulsed Electromagnetic Fields

(2017) Katia Varani et al.   MEDIATORS OF INFLAMMATION

A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy

(2017) Kenneth A. Jacobson et al.   MEDICINAL RESEARCH REVIEWS

Pharmacological targeting of adenosine receptor signaling

(2017) Maria Peleli et al.   MOLECULAR ASPECTS OF MEDICINE

Adenosine signaling in diabetes mellitus and associated cardiovascular and renal complications

(2017) Maria Peleli et al.   MOLECULAR ASPECTS OF MEDICINE

Hypothermia in mouse is caused by adenosine A1 and A3 receptor agonists and AMP via three distinct mechanisms

(2017) Jesse Lea Carlin et al.   NEUROPHARMACOLOGY

A 2B adenosine receptors stimulate IL-6 production in primary murine microglia through p38 MAPK kinase pathway

(2017) Stefania Merighi et al.   PHARMACOLOGICAL RESEARCH

Adenosine A1 receptor activation increases myocardial protein S-nitrosothiols and elicits protection from ischemia-reperfusion injury in male and female hearts

(2017) Qin Shao et al.   PLoS One

Crystal structure of the adenosine A2Areceptor bound to an antagonist reveals a potential allosteric pocket

(2017) Bingfa Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adenosine A 2A receptors are up-regulated and control the activation of human alveolar macrophages

(2017) Tiago M. Alfaro et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Inhibition of SDF-1 receptors CXCR4 and CXCR7 attenuates acute pulmonary inflammation via the adenosine A2B-receptor on blood cells

(2017) Franziska Magdalena Konrad et al.   Cell Death & Disease

Adenosine A2A  receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction

(2017) Jaqueline da Silva et al.   Drug Design Development and Therapy

The adenosine A2b receptor promotes tumor progression of bladder urothelial carcinoma by enhancing MAPK signaling pathway

(2017) Yihong Zhou et al.   Oncotarget

Pharmacological Activity and Clinical Use of PDRN

(2017) Francesco Squadrito et al.   Frontiers in Pharmacology

Caffeine Suppresses Amyloid-β Levels in Plasma and Brain of Alzheimer's Disease Transgenic Mice

(2017) Chuanhai Cao et al.   JOURNAL OF ALZHEIMERS DISEASE

Caffeine Intake is Associated with a Lower Risk of Cognitive Decline: A Cohort Study from Portugal

(2017) Catarina Santos et al.   JOURNAL OF ALZHEIMERS DISEASE

Electroacupuncture Attenuates CFA-induced Inflammatory Pain by suppressing Nav1.8 through S100B, TRPV1, Opioid and Adenosine Pathways in Mice

(2017) Hsien-Yin Liao et al.   Scientific Reports

Macrophage A2A Adenosine Receptors Are Essential to Protect from Progressive Kidney Injury

(2016) Luan D. Truong et al.   AMERICAN JOURNAL OF PATHOLOGY

Adenosine influences myeloid cells to inhibit aeroallergen sensitization

(2016) Hong Pei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A1 adenosine receptor-induced phosphorylation and modulation of transglutaminase 2 activity in H9c2 cells: A role in cell survival

(2016) Falguni S. Vyas et al.   BIOCHEMICAL PHARMACOLOGY

The hybrid molecule, VCP746, is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling

(2016) Elizabeth A. Vecchio et al.   BIOCHEMICAL PHARMACOLOGY

Adenosine A2A receptor signaling attenuates LPS-induced pro-inflammatory cytokine formation of mouse macrophages by inducing the expression of DUSP1

(2016) Krisztina Köröskényi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs

(2016) Gemma Navarro et al.   BMC BIOLOGY

Identification of A3adenosine receptor agonists as novel non-narcotic analgesics

(2016) K Janes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Adenosine A2A receptor promotes collagen type III synthesis via β-catenin activation in human dermal fibroblasts

(2016) Gibran Shaikh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Diagnosis and management of supraventricular tachycardias

(2016) Lior Bibas et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses

(2016) Arabella Young et al.   CANCER CELL

Adenosine 2B Receptor Expression on Cancer Cells Promotes Metastasis

(2016) D. Mittal et al.   CANCER RESEARCH

Structurally Enabled Discovery of Adenosine A2A Receptor Antagonists

(2016) Ali Jazayeri et al.   CHEMICAL REVIEWS

Adenosine-Induced Atrial FibrillationClinical Perspective

(2016) Ning Li et al.   CIRCULATION

VCP746, a novel A1adenosine receptor biased agonist, reduces hypertrophy in a rat neonatal cardiac myocyte model

(2016) Chung H Chuo et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The A3 adenosine receptor (A3AR): therapeutic target and predictive biological marker in rheumatoid arthritis

(2016) Pnina Fishman et al.   CLINICAL RHEUMATOLOGY

A2A adenosine receptor antagonists to weaken the hypoxia-HIF-1α driven immunosuppression and improve immunotherapies of cancer

(2016) Stephen M Hatfield et al.   CURRENT OPINION IN PHARMACOLOGY

Immunosuppressive activities of adenosine in cancer

(2016) Bertrand Allard et al.   CURRENT OPINION IN PHARMACOLOGY

Aberrant adenosine A2A receptor signaling contributes to neurodegeneration and cognitive impairments in a mouse model of synucleinopathy

(2016) Qidi Hu et al.   EXPERIMENTAL NEUROLOGY

Adenosine A2A receptor plays an important role in radiation-induced dermal injury

(2016) Miguel Perez-Aso et al.   FASEB JOURNAL

CD73–adenosine: a next-generation target in immuno-oncology

(2016) David Allard et al.   Immunotherapy

The role of adenosine and adenosine receptors in the immunopathogenesis of multiple sclerosis

(2016) Elham Safarzadeh et al.   INFLAMMATION RESEARCH

Enhanced A2A adenosine receptor-mediated increase in coronary flow in type I diabetic mice

(2016) Hicham Labazi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

How does adenosine control neuronal dysfunction and neurodegeneration?

(2016) Rodrigo A. Cunha   JOURNAL OF NEUROCHEMISTRY

Dual roles of the adenosine A2a receptor in autoimmune neuroinflammation

(2016) J. Ingwersen et al.   Journal of Neuroinflammation

A Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of 2 and 4 Weeks of Twice-Daily Ocular Trabodenoson in Adults with Ocular Hypertension or Primary Open-Angle Glaucoma

(2016) Jonathan S. Myers et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

A Randomized Phase 1 Dose Escalation Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Trabodenoson in Healthy Adult Volunteers

(2016) Alan Laties et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

A1 Adenosine Receptor Activation Modulates Central Nervous System Development and Repair

(2016) Shirin Kashfi et al.   MOLECULAR NEUROBIOLOGY

Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses

(2016) Nuno J. Machado et al.   MOLECULAR NEUROBIOLOGY

Structure of the adenosine A2A receptor bound to an engineered G protein

(2016) Byron Carpenter et al.   NATURE

Activation of the A2A adenosine G-protein-coupled receptor by conformational selection

(2016) Libin Ye et al.   NATURE

Adenosine and adenosine receptors in the pathogenesis and treatment of rheumatic diseases

(2016) Bruce N. Cronstein et al.   Nature Reviews Rheumatology

Purinergic signalling in brain ischemia

(2016) Felicita Pedata et al.   NEUROPHARMACOLOGY

Purinergic signaling in Parkinson's disease. Relevance for treatment

(2016) Gemma Navarro et al.   NEUROPHARMACOLOGY

Purinergic receptors in psychiatric disorders

(2016) Ute Krügel   NEUROPHARMACOLOGY

Positive allosteric modulation of A1 adenosine receptors as a novel and promising therapeutic strategy for anxiety

(2016) Fabrizio Vincenzi et al.   NEUROPHARMACOLOGY

Purinergic receptors as potential therapeutic targets in Alzheimer's disease

(2016) Lucas T. Woods et al.   NEUROPHARMACOLOGY

Adenosine A2A Receptors in the Amygdala Control Synaptic Plasticity and Contextual Fear Memory

(2016) Ana Patrícia Simões et al.   NEUROPSYCHOPHARMACOLOGY

Neuroprotection by caffeine in the MPTP model of parkinson’s disease and its dependence on adenosine A 2A receptors

(2016) K. Xu et al.   NEUROSCIENCE

Adenosine receptor targets for pain

(2016) J. Sawynok   NEUROSCIENCE

Pharmacology of the Adenosine A3 Receptor in the Vasculature and Essential Hypertension

(2016) Ming-Fen Ho et al.   PLoS One

Specific Activation of A3, A2A and A1 Adenosine Receptors in CD73-Knockout Mice Affects B16F10 Melanoma Growth, Neovascularization, Angiogenesis and Macrophage Infiltration

(2016) Patrycja Koszałka et al.   PLoS One

Adenosine arrests breast cancer cell motility by A3 receptor stimulation

(2016) Carola Ledderose et al.   Purinergic Signalling

Signaling pathways involving adenosine A2A and A2B receptors in wound healing and fibrosis

(2016) Gibran Shaikh et al.   Purinergic Signalling

Selective A2A receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure–induced transient ischemic injury

(2016) Maria H. Madeira et al.   Translational Research

Adenosine as a Multi-Signalling Guardian Angel in Human Diseases: When, Where and How Does it Exert its Protective Effects?

(2016) Pier Andrea Borea et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors

(2016) Silvia Viana da Silva et al.   Nature Communications

Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells

(2016) Angelo Torres et al.   Oncotarget

Anxiolytic properties of A1 adenosine receptor PAMs

(2016) Fabrizio Vincenzi et al.   Oncotarget

Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction

(2016) Xia Hu et al.   Cell Reports

The Adenosinergic System in Diabetic Retinopathy

(2016) J. Vindeirinho et al.   Journal of Diabetes Research

Adenosine Receptor Stimulation by Polydeoxyribonucleotide Improves Tissue Repair and Symptomology in Experimental Colitis

(2016) Giovanni Pallio et al.   Frontiers in Pharmacology

A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment

(2016) Akio Ohta   Frontiers in Immunology

Anti-CD73 immunotherapy: A viable way to reprogram the tumor microenvironment

(2016) Luca Antonioli et al.   OncoImmunology

Adenosine A2B Receptor: From Cell Biology to Human Diseases

(2016) Ying Sun et al.   Frontiers in Chemistry

Prevention of adenosine A2A receptor activation diminishes beat-to-beat alternation in human atrial myocytes

(2015) Cristina E. Molina et al.   BASIC RESEARCH IN CARDIOLOGY

The infarct-sparing effect of IB-MECA against myocardial ischemia/reperfusion injury in mice is mediated by sequential activation of adenosine A3 and A2A receptors

(2015) Yikui Tian et al.   BASIC RESEARCH IN CARDIOLOGY

Adenosine A1 receptor activation modulates N-methyl-d-aspartate (NMDA) preconditioning phenotype in the brain

(2015) Leandra C. Constantino et al.   BEHAVIOURAL BRAIN RESEARCH

Adenosine signaling in reserpine-induced depression in rats

(2015) Thomas R. Minor et al.   BEHAVIOURAL BRAIN RESEARCH

A2b adenosine signaling represses CIITA transcription via an epigenetic mechanism in vascular smooth muscle cells

(2015) Jun Xia et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Spinal neuroimmune activation is independent of T-cell infiltration and attenuated by A3 adenosine receptor agonists in a model of oxaliplatin-induced peripheral neuropathy

(2015) Kali Janes et al.   BRAIN BEHAVIOR AND IMMUNITY

Adenosine A1receptor activation attenuates cardiac hypertrophy and fibrosis in response to α1-adrenoceptor stimulationin vivo

(2015) S-L Puhl et al.   BRITISH JOURNAL OF PHARMACOLOGY

Selective A3 adenosine receptor agonist protects against doxorubicin-induced cardiotoxicity

(2015) Aya Galal et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

CD73 Is Associated with Poor Prognosis in High-Grade Serous Ovarian Cancer

(2015) Martin Turcotte et al.   CANCER RESEARCH

The mutual regulation between miR-214 and A2AR signaling plays an important role in inflammatory response

(2015) Li Zhao et al.   CELLULAR SIGNALLING

Adenosine A2AReceptors Modulate α-Synuclein Aggregation and Toxicity

(2015) Diana G. Ferreira et al.   CEREBRAL CORTEX

Association of Coffee Consumption With Total and Cause-Specific Mortality in 3 Large Prospective CohortsClinical Perspective

(2015) Ming Ding et al.   CIRCULATION

CD39+regulatory T cells attenuate allergic airway inflammation

(2015) P. Li et al.   CLINICAL AND EXPERIMENTAL ALLERGY

CD73 Expression Is an Independent Prognostic Factor in Prostate Cancer

(2015) B. G. Leclerc et al.   CLINICAL CANCER RESEARCH

Abrogation of adenosine A1 receptor signalling improves metabolic regulation in mice by modulating oxidative stress and inflammatory responses

(2015) Ting Yang et al.   DIABETOLOGIA

Direct or indirect stimulation of adenosine A2A receptors enhances bone regeneration as well as bone morphogenetic protein-2

(2015) Aránzazu Mediero et al.   FASEB JOURNAL

Different danger signals differently impact on microglial proliferation through alterations of ATP release and extracellular metabolism

(2015) Jimmy George et al.   GLIA

A2aand a2badenosine receptors affect HIF-1α signaling in activated primary microglial cells

(2015) Stefania Merighi et al.   GLIA

Promotion of Wound Healing by an Agonist of Adenosine A2A Receptor Is Dependent on Tissue Plasminogen Activator

(2015) M. Carmen Montesinos et al.   INFLAMMATION

Alveolar Epithelial A2B Adenosine Receptors in Pulmonary Protection during Acute Lung Injury

(2015) Sandra Hoegl et al.   JOURNAL OF IMMUNOLOGY

Differential Tissue-Specific Function of Adora2b in Cardioprotection

(2015) Seong-wook Seo et al.   JOURNAL OF IMMUNOLOGY

History and Perspectives of A2AAdenosine Receptor Antagonists as Potential Therapeutic Agents

(2015) Delia Preti et al.   MEDICINAL RESEARCH REVIEWS

Sex Difference in Coronary Endothelial Dysfunction in Apolipoprotein E Knockout Mouse: Role of NO and A2AAdenosine Receptor

(2015) Xueping Zhou et al.   MICROCIRCULATION

Down-regulation of the A3 adenosine receptor in human mast cells upregulates mediators of angiogenesis and remodeling

(2015) Noam Rudich et al.   MOLECULAR IMMUNOLOGY

Effects of A2BR on the biological behavior of mouse renal fibroblasts during hypoxia

(2015) JIN TANG et al.   Molecular Medicine Reports

Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis

(2015) C M Aherne et al.   Mucosal Immunology

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory

(2015) Anna G Orr et al.   NATURE NEUROSCIENCE

Inactivation of adenosine A 2A receptors reverses working memory deficits at early stages of Huntington's disease models

(2015) Wei Li et al.   NEUROBIOLOGY OF DISEASE

Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease

(2015) Shiraz Tyebji et al.   NEUROBIOLOGY OF DISEASE

Time-course of protection by the selective A2A receptor antagonist SCH58261 after transient focal cerebral ischemia

(2015) Alessia Melani et al.   NEUROLOGICAL SCIENCES

Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats

(2015) Theresa A. Lusardi et al.   NEUROPHARMACOLOGY

Adenosine receptors and diabetes: Focus on the A2B adenosine receptor subtype

(2015) Stefania Merighi et al.   PHARMACOLOGICAL RESEARCH

An A2B Adenosine Receptor Agonist Promotes Th17 Autoimmune Responses in Experimental Autoimmune Uveitis (EAU) via Dendritic Cell Activation

(2015) Mingjiazi Chen et al.   PLoS One

Allosteric interactions between agonists and antagonists within the adenosine A2Areceptor-dopamine D2receptor heterotetramer

(2015) Jordi Bonaventura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis

(2015) Raphael Sanches Peres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caffeine acts through neuronal adenosine A2Areceptors to prevent mood and memory dysfunction triggered by chronic stress

(2015) Manuella P. Kaster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of adenosine receptor subclasses in malignant and adjacent normal human prostate tissues

(2015) Samira Mousavi et al.   PROSTATE

Involvement of NADPH oxidase in A2A adenosine receptor-mediated increase in coronary flow in isolated mouse hearts

(2015) Zhichao Zhou et al.   Purinergic Signalling

Potentiation of temozolomide antitumor effect by purine receptor ligands able to restrain the in vitro growth of human glioblastoma stem cells

(2015) Iolanda D’Alimonte et al.   Purinergic Signalling

Ticagrelor potentiates adenosine-induced stimulation of neutrophil chemotaxis and phagocytosis

(2015) Khalaf F. Alsharif et al.   VASCULAR PHARMACOLOGY

Preladenant as an Adjunctive Therapy With Levodopa in Parkinson Disease

(2015) Robert A. Hauser et al.   JAMA Neurology

A2B and A3 Adenosine Receptors Modulate Vascular Endothelial Growth Factor and Interleukin-8 Expression in Human Melanoma Cells Treated with Etoposide and Doxorubicin

(2015) Stefania Merighi et al.   NEOPLASIA

Adenosine A3 Receptor Suppresses Prostate Cancer Metastasis by Inhibiting NADPH Oxidase Activity

(2015) Sarvesh Jajoo et al.   NEOPLASIA

Adenosine receptors and renal ischaemia reperfusion injury

(2014) M. M. Rabadi et al.   Acta Physiologica

Extracellular adenosine regulates colitis through effects on lymphoid and nonlymphoid cells

(2014) Courtney C. Kurtz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states

(2014) Joshua W. Little et al.   BRAIN

Low doses of the selective adenosine A2A receptor agonist CGS21680 are protective in a rat model of transient cerebral ischemia

(2014) Alessia Melani et al.   BRAIN RESEARCH

G-Protein-Coupled Receptor Heteromers as Key Players in the Molecular Architecture of the Central Nervous System

(2014) Marc Brugarolas et al.   CNS Neuroscience & Therapeutics

Adenosine and inflammation: what's new on the horizon?

(2014) Luca Antonioli et al.   DRUG DISCOVERY TODAY

Adenosine A1 receptor antagonist, L-97-1, improves survival and protects the kidney in a rat model of cecal ligation and puncture induced sepsis

(2014) Constance N. Wilson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Targeting adenosine receptors to prevent inflammatory skin diseases

(2014) Stefania Gessi et al.   EXPERIMENTAL DERMATOLOGY

Topical application of the adenosine A2Areceptor agonist CGS-21680 prevents phorbol-induced epidermal hyperplasia and inflammation in mice

(2014) Jorge Arasa et al.   EXPERIMENTAL DERMATOLOGY

Dopamine heteroreceptor complexes as therapeutic targets in Parkinson’s disease

(2014) Kjell Fuxe et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The Effect of PDRN, an Adenosine Receptor A2AAgonist, on the Healing of Chronic Diabetic Foot Ulcers: Results of a Clinical Trial

(2014) Francesco Squadrito et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Effect of A2B Adenosine Receptor Gene Ablation on Proinflammatory Adenosine Signaling in Mast Cells

(2014) S. Ryzhov et al.   JOURNAL OF IMMUNOLOGY

Identification of Hypoxia-Inducible Factor HIF-1A as Transcriptional Regulator of the A2B Adenosine Receptor during Acute Lung Injury

(2014) T. Eckle et al.   JOURNAL OF IMMUNOLOGY

Tozadenant (SYN115) in patients with Parkinson's disease who have motor fluctuations on levodopa: a phase 2b, double-blind, randomised trial

(2014) Robert A Hauser et al.   LANCET NEUROLOGY

A2A adenosine receptor deletion is protective in a mouse model of Tauopathy

(2014) C Laurent et al.   MOLECULAR PSYCHIATRY

Beneficial effects of caffeine in a transgenic model of Alzheimer's disease-like tau pathology

(2014) Cyril Laurent et al.   NEUROBIOLOGY OF AGING

TRR469, a potent A1 adenosine receptor allosteric modulator, exhibits anti-nociceptive properties in acute and neuropathic pain models in mice

(2014) Fabrizio Vincenzi et al.   NEUROPHARMACOLOGY

A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways

(2014) Kali Janes et al.   PAIN

Purinergic Signaling on Leukocytes Infiltrating the LPS-Injured Lung

(2014) Daniela Friebe et al.   PLoS One

Antidepressant activity of the adenosine A2A receptor antagonist, istradefylline (KW-6002) on learned helplessness in rats

(2014) Koji Yamada et al.   PSYCHOPHARMACOLOGY

The role of activated adenosine receptors in degranulation of human LAD2 mast cells

(2014) Chi Ting Leung et al.   Purinergic Signalling

Role of adenosine A2B receptor signaling in contribution of cardiac mesenchymal stem-like cells to myocardial scar formation

(2014) Sergey Ryzhov et al.   Purinergic Signalling

Cardiac purinergic signalling in health and disease

(2014) Geoffrey Burnstock et al.   Purinergic Signalling

Modulation of A1 and A2B adenosine receptor activity: a new strategy to sensitise glioblastoma stem cells to chemotherapy

(2014) S Daniele et al.   Cell Death & Disease

Adenosine A2B Receptors on Cardiac Stem Cell Antigen (Sca)-1–Positive Stromal Cells Play a Protective Role in Myocardial Infarction

(2013) Sergey Ryzhov et al.   AMERICAN JOURNAL OF PATHOLOGY

Differential effect of adenosine receptors on growth of human colon cancer HCT 116 and HT-29 cell lines

(2013) Monika Sakowicz-Burkiewicz et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Activation of adenosine A2Areceptor reduces osteoclast formation via PKA- and ERK1/2-mediated suppression of NFκB nuclear translocation

(2013) Aránzazu Mediero et al.   BRITISH JOURNAL OF PHARMACOLOGY

Allosteric interactions at adenosine A1and A3receptors: new insights into the role of small molecules and receptor dimerization

(2013) Stephen J Hill et al.   BRITISH JOURNAL OF PHARMACOLOGY

Caspase Inhibition Via A3 Adenosine Receptors: A New Cardioprotective Mechanism Against Myocardial Infarction

(2013) Afthab Hussain et al.   CARDIOVASCULAR DRUGS AND THERAPY

Apoptosis-Related Gene Transcription in Human A549 Lung Cancer Cells via A3Adenosine Receptor

(2013) Hitomi Kamiya et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes

(2013) Ross Corriden et al.   EMBO REPORTS

Adenosine signaling pathways as potential therapeutic targets in respiratory disease

(2013) Massimo Caruso et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis

(2013) Rebecca L. Williams-Karnesky et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-Human CD73 Monoclonal Antibody Inhibits Metastasis Formation in Human Breast Cancer by Inducing Clustering and Internalization of CD73 Expressed on the Surface of Cancer Cells

(2013) M. G. Terp et al.   JOURNAL OF IMMUNOLOGY

Adenosine A2A Receptor as a Drug Discovery Target

(2013) Manuel de Lera Ruiz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia

(2013) Catarina Gomes et al.   Journal of Neuroinflammation

Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi

(2013) LiZe Gu et al.   Journal of Neuroinflammation

Adenosine receptors as drug targets — what are the challenges?

(2013) Jiang-Fan Chen et al.   NATURE REVIEWS DRUG DISCOVERY

CF102 for the Treatment of Hepatocellular Carcinoma: A Phase I/II, Open-Label, Dose-Escalation Study

(2013) S. M. Stemmer et al.   ONCOLOGIST

A1 and A3 adenosine receptors inhibit LPS-induced hypoxia-inducible factor-1 accumulation in murine astrocytes

(2013) Stefania Gessi et al.   PHARMACOLOGICAL RESEARCH

Cardiovascular adenosine receptors: Expression, actions and interactions

(2013) John P. Headrick et al.   PHARMACOLOGY & THERAPEUTICS

Pulsed Electromagnetic Fields Increased the Anti-Inflammatory Effect of A2A and A3 Adenosine Receptors in Human T/C-28a2 Chondrocytes and hFOB 1.19 Osteoblasts

(2013) Fabrizio Vincenzi et al.   PLoS One

CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer

(2013) S. Loi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blockade of A2Areceptors potently suppresses the metastasis of CD73+tumors

(2013) Paul A. Beavis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis

(2013) C. J. Desmet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes

(2013) Sofia Cristóvão-Ferreira et al.   Purinergic Signalling

An Adenosine-Mediated Signaling Pathway Suppresses Prenylation of the GTPase Rap1B and Promotes Cell Scattering

(2013) E. Ntantie et al.   Science Signaling

Functional Tissue Engineering in Articular Cartilage Repair: Is There a Role for Electromagnetic Biophysical Stimulation?

(2013) Milena Fini et al.   TISSUE ENGINEERING PART B-REVIEWS

Adenosine and bone metabolism

(2013) Aránzazu Mediero et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regulation of Inflammation by Adenosine

(2013) György Haskó et al.   Frontiers in Immunology

Adora2b Signaling on Bone Marrow Derived Cells Dampens Myocardial Ischemia-Reperfusion Injury

(2012) Michael Koeppen et al.   ANESTHESIOLOGY

CD73-Deficient Mice Are Resistant to Carcinogenesis

(2012) J. Stagg et al.   CANCER RESEARCH

A3Adenosine Receptor Mediates Apoptosis in 5637 Human Bladder Cancer Cells by GqProtein/PKC-Dependent AIF Upregulation

(2012) Takeshi Kanno et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

A3Adenosine Receptor-Mediated p53-Dependent Apoptosis in Lu-65 Human Lung Cancer Cells

(2012) Tai-ichiro Otsuki et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

AMP Converted from Intracellularly Transported Adenosine Upregulates p53 Expression to Induce Malignant Pleural Mesothelioma Cell Apoptosis

(2012) Yoshitaka Nogi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

A2BAR expression in non-immune cells plays an important role in the development of murine colitis

(2012) Sarah A. Ingersoll et al.   DIGESTIVE AND LIVER DISEASE

The stimulation of A3 adenosine receptors reduces bone-residing breast cancer in a rat preclinical model

(2012) Katia Varani et al.   EUROPEAN JOURNAL OF CANCER

Impairment of adenosine A3 receptor activity disrupts neutrophil migratory capacity and impacts innate immune function in vivo

(2012) Matt Butler et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Enhancing pigmentation via activation of A3 adenosine receptors in B16 melanoma cells and in human skin explants

(2012) Lea Madi et al.   EXPERIMENTAL DERMATOLOGY

Controlling murine and rat chronic pain through A3 adenosine receptor activation

(2012) Zhoumou Chen et al.   FASEB JOURNAL

The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors

(2012) Eduard Gracia et al.   FASEB JOURNAL

Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors

(2012) Schuichi Koizumi et al.   GLIA

Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes

(2012) Marco Matos et al.   GLIA

Amphiregulin, an Epidermal Growth Factor Receptor Ligand, Plays an Essential Role in the Pathogenesis of Transforming Growth Factor-β-induced Pulmonary Fibrosis

(2012) Yang Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel mechanism of control of NF B activation and inflammation involving A2B adenosine receptors

(2012) Y. Sun et al.   JOURNAL OF CELL SCIENCE

Dendritic cells tolerized with adenosine A2AR agonist attenuate acute kidney injury

(2012) Li Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Blocking A2B Adenosine Receptor Alleviates Pathogenesis of Experimental Autoimmune Encephalomyelitis via Inhibition of IL-6 Production and Th17 Differentiation

(2012) W. Wei et al.   JOURNAL OF IMMUNOLOGY

Adenosine A3 receptor-induced proliferation of primary human coronary smooth muscle cells involving the induction of early growth response genes

(2012) A.V. Hinze et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Adenosine A3 receptor is involved in ADP-induced microglial process extension and migration

(2012) Keiko Ohsawa et al.   JOURNAL OF NEUROCHEMISTRY

Blockade of adenosine A2A receptors prevents interleukin-1β-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway

(2012) Ana Patrícia Simões et al.   Journal of Neuroinflammation

Autocrine Adenosine Signaling Promotes Regulatory T Cell-Mediated Renal Protection

(2012) G. R. Kinsey et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A3 Adenosine Receptor Mediates Apoptosis in In Vitro RCC4-VHL Human Renal Cancer Cells by Up-Regulating AMID Expression

(2012) Hisao Nagaya et al.   JOURNAL OF UROLOGY

Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia

(2012) Tobias Eckle et al.   NATURE MEDICINE

The Anti-Tumor Effect of A3 Adenosine Receptors Is Potentiated by Pulsed Electromagnetic Fields in Cultured Neural Cancer Cells

(2012) Fabrizio Vincenzi et al.   PLoS One

The A2b Adenosine Receptor Modulates Glucose Homeostasis and Obesity

(2012) Hillary Johnston-Cox et al.   PLoS One

Adoptive Immunotherapy with Cl-IB-MECA-Treated CD8+ T Cells Reduces Melanoma Growth in Mice

(2012) Antonella Montinaro et al.   PLoS One

Adenosine A2A Receptor Activation Prevents Wear Particle-Induced Osteolysis

(2012) A. Mediero et al.   Science Translational Medicine

Selective Activation of Adenosine A2A Receptors on Immune Cells by a CD73-Dependent Prodrug Suppresses Joint Inflammation in Experimental Rheumatoid Arthritis

(2012) U. Flogel et al.   Science Translational Medicine

A3 Adenosine Receptor Agonist Reduces Brain Ischemic Injury and Inhibits Inflammatory Cell Migration in Rats

(2011) In-Young Choi et al.   AMERICAN JOURNAL OF PATHOLOGY

Purinergic regulation of high-glucose-induced caspase-1 activation in the rat retinal Müller cell line rMC-1

(2011) Katherine E. Trueblood et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Essential role of EGFR in cardioprotection and signaling responses to A1 adenosine receptors and ischemic preconditioning

(2011) Grant Williams-Pritchard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Adenosine A2A receptor gene disruption protects in an α-synuclein model of Parkinson's disease

(2011) Anil Kachroo et al.   ANNALS OF NEUROLOGY

CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death

(2011) S. Serra et al.   BLOOD

CD73-Deficient Mice Have Increased Antitumor Immunity and Are Resistant to Experimental Metastasis

(2011) J. Stagg et al.   CANCER RESEARCH

A 2b Adenosine Receptor Regulates Hyperlipidemia and Atherosclerosis

(2011) Milka Koupenova et al.   CIRCULATION

Cl-IB-MECA enhances TNF-α release in peritoneal macrophages stimulated with LPS

(2011) Giovanni Forte et al.   CYTOKINE

Links Between Insulin Resistance, Adenosine A2B Receptors, and Inflammatory Markers in Mice and Humans

(2011) R. A. Figler et al.   DIABETES

Pharmacological and therapeutic effects of A3 adenosine receptor agonists

(2011) Pnina Fishman et al.   DRUG DISCOVERY TODAY

Enhanced actions of adenosine in medial entorhinal cortex layer II stellate neurons in temporal lobe epilepsy are mediated via A1-receptor activation

(2011) Nicholas J. Hargus et al.   EPILEPSIA

Caffeine prevents acute mortality after TBI in rats without increased morbidity

(2011) Theresa A. Lusardi et al.   EXPERIMENTAL NEUROLOGY

Investigational A3adenosine receptor targeting agents

(2011) Balázs Koscsó et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Adenosine receptor targeting in health and disease

(2011) Stefania Gessi et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Adenosine promotes alternative macrophage activation via A2A and A2B receptors

(2011) Balázs Csóka et al.   FASEB JOURNAL

Cholesterol 27-Hydroxylase but Not Apolipoprotein apoE Contributes to A2A Adenosine Receptor Stimulated Reverse Cholesterol Transport

(2011) Taiese Crystal Bingham et al.   INFLAMMATION

A novel post-exposure medical countermeasure L-97-1 improves survival and acute lung injury following intratracheal infection with Yersinia pestis

(2011) Constance N Wilson et al.   Innate Immunity

Molecular mechanisms of A3 adenosine receptor-induced G1 cell cycle arrest and apoptosis in androgen-dependent and independent prostate cancer cell lines: involvement of intrinsic pathway

(2011) Mahmoud Aghaei et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Disparity in FcεRI-Induced Degranulation of Primary Human Lung and Skin Mast Cells Exposed to Adenosine

(2011) Gregorio Gomez et al.   JOURNAL OF CLINICAL IMMUNOLOGY

A ketogenic diet suppresses seizures in mice through adenosine A1 receptors

(2011) Susan A. Masino et al.   JOURNAL OF CLINICAL INVESTIGATION

The A2B Adenosine Receptor Promotes Th17 Differentiation via Stimulation of Dendritic Cell IL-6

(2011) J. M. Wilson et al.   JOURNAL OF IMMUNOLOGY

Adenosinergic Regulation of the Expansion and Immunosuppressive Activity of CD11b+Gr1+ Cells

(2011) S. Ryzhov et al.   JOURNAL OF IMMUNOLOGY

Adenosine A2B Receptor Blockade Slows Growth of Bladder and Breast Tumors

(2011) C. Cekic et al.   JOURNAL OF IMMUNOLOGY

Adenosine Augments IL-10 Production by Microglial Cells through an A2B Adenosine Receptor-Mediated Process

(2011) B. Koscso et al.   JOURNAL OF IMMUNOLOGY

Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction

(2011) Nelson Rebola et al.   JOURNAL OF NEUROCHEMISTRY

CGS 21680, an Agonist of the Adenosine (A2A) Receptor, Reduces Progression of Murine Type II Collagen-induced Arthritis

(2011) EMANUELA MAZZON et al.   JOURNAL OF RHEUMATOLOGY

Treatment of plaque-type psoriasis with oral CF101: data from an exploratory randomized phase 2 clinical trial

(2011) M. David et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

(2011) Guillaume Lebon et al.   NATURE

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update

(2011) B. B. Fredholm et al.   PHARMACOLOGICAL REVIEWS

Partial adenosine A1 receptor agonists for cardiovascular therapies

(2011) Barbara E. Albrecht-Küpper et al.   Purinergic Signalling

Structure of an Agonist-Bound Human A2A Adenosine Receptor

(2011) F. Xu et al.   SCIENCE

A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release

(2011) Katia Varani et al.   ARTHRITIS RESEARCH & THERAPY

Involvement of A1 adenosine receptors in altered vascular responses and inflammation in an allergic mouse model of asthma

(2010) Dovenia S. Ponnoth et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Myocardial adenosine A1-receptor-mediated adenoprotection involves phospholipase C, PKC-ε, and p38 MAPK, but not HSP27

(2010) Richard A. Fenton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A3Receptors Are Overexpressed in Pleura from Patients with Mesothelioma and Reduce Cell Growth via Akt/Nuclear Factor-κB Pathway

(2010) Katia Varani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Characterization of the A2AR–D2R interface: Focus on the role of the C-terminal tail and the transmembrane helices

(2010) Dasiel O. Borroto-Escuela et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modulation of metalloproteinase-9 in U87MG glioblastoma cells by A3 adenosine receptors

(2010) Stefania Gessi et al.   BIOCHEMICAL PHARMACOLOGY

Adenosine receptors and brain diseases: Neuroprotection and neurodegeneration

(2010) Catarina V. Gomes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Adenosine receptors and cancer

(2010) Stefania Gessi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Adenosine and its receptors in the heart: Regulation, retaliation and adaptation

(2010) John P. Headrick et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Control of enteric neuromuscular functions by purinergic A3 receptors in normal rat distal colon and experimental bowel inflammation

(2010) L Antonioli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Adenosine-cannabinoid receptor interactions. Implications for striatal function

(2010) Sergi Ferré et al.   BRITISH JOURNAL OF PHARMACOLOGY

Allosteric Enhancers of A1 Adenosine Receptors: State of the Art and New Horizons for Drug Development

(2010) R. Romagnoli et al.   CURRENT MEDICINAL CHEMISTRY

A3 Receptor Ligands: Past, Present and Future Trends

(2010) S. Taliani et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Abnormal calcium handling in atrial fibrillation is linked to up-regulation of adenosine A2A receptors

(2010) A. Llach et al.   EUROPEAN HEART JOURNAL

Adenosine A2A Receptor Is Involved in Cell Surface Expression of A2B Receptor

(2010) Kengo Moriyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions between Intracellular Domains as Key Determinants of the Quaternary Structure and Function of Receptor Heteromers

(2010) Gemma Navarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CF102 an A3 adenosine receptor agonist mediates anti-tumor and anti-inflammatory effects in the liver

(2010) S. Cohen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A3 adenosine receptor activation during reperfusion reduces infarct size through actions on bone marrow-derived cells

(2010) Zhi-Dong Ge et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Blockade of Adenosine Deaminase Ameliorates Chronic Experimental Colitis through the Recruitment of Adenosine A2A and A3 Receptors

(2010) L. Antonioli et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Methotrexate—how does it really work?

(2010) Edwin S. L. Chan et al.   Nature Reviews Rheumatology

Alterations in Adenosine Metabolism and Signaling in Patients with Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis

(2010) Yang Zhou et al.   PLoS One

Direct involvement of  -1 receptors in the dopamine D1 receptor-mediated effects of cocaine

(2010) G. Navarro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

(2010) J. Stagg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of PLCβ2 by Endotoxin Plays a Role in the Adenosine A2A Receptor-Mediated Switch of Macrophages from an Inflammatory to an Angiogenic Phenotype

(2009) Stan Grinberg et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of β-arrestin1/ERK MAP kinase pathway in regulating adenosine A1 receptor desensitization and recovery

(2009) Sarvesh Jajoo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Inactivation of the Adenosine A 2A Receptor Protects Apolipoprotein E–Deficient Mice From Atherosclerosis

(2009) Huan Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Adenosine Modulates HIF-1α, VEGF, IL-8, and Foam Cell Formation in a Human Model of Hypoxic Foam Cells

(2009) Stefania Gessi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Induction of an antiinflammatory effect and prevention of cartilage damage in rat knee osteoarthritis by CF101 treatment

(2009) S. Bar-Yehuda et al.   ARTHRITIS AND RHEUMATISM

The anti-inflammatory target A3 adenosine receptor is over-expressed in rheumatoid arthritis, psoriasis and Crohn’s disease

(2009) A. Ochaion et al.   CELLULAR IMMUNOLOGY

Increased Ectonucleotidase Expression and Activity in Regulatory T Cells of Patients with Head and Neck Cancer

(2009) M. Mandapathil et al.   CLINICAL CANCER RESEARCH

Adenosine A1 receptors in neointimal hyperplasia and in-stent stenosis in Ossabaw miniature swine

(2009) Jason M. Edwards et al.   CORONARY ARTERY DISEASE

Tuning and Fine-Tuning of Synapses with Adenosine

(2009) A. Sebastiao et al.   Current Neuropharmacology

Generation and Accumulation of Immunosuppressive Adenosine by Human CD4+CD25highFOXP3+Regulatory T Cells

(2009) Magis Mandapathil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cl-IB-MECA enhances TRAIL-induced apoptosis via the modulation of NF-κB signalling pathway in thyroid cancer cells

(2009) Silvana Morello et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Adenosine signaling contributes to ethanol-induced fatty liver in mice

(2009) Zhongsheng Peng et al.   JOURNAL OF CLINICAL INVESTIGATION

Adenosine Blocks IFN- -Induced Phosphorylation of STAT1 on Serine 727 to Reduce Macrophage Activation

(2009) K. E. Barnholt et al.   JOURNAL OF IMMUNOLOGY

Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts

(2009) Jinkun Xi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Hypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia

(2009) Peter Rosenberger et al.   NATURE IMMUNOLOGY

Adenosine A2A receptor mediates microglial process retraction

(2009) Anna G Orr et al.   NATURE NEUROSCIENCE

T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response

(2009) Michail V. Sitkovsky   TRENDS IN IMMUNOLOGY

Adenosine receptors as targets for therapeutic intervention in asthma and chronic obstructive pulmonary disease

(2009) Riccardo Polosa et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Adenosine A2A receptor activation reduces infarct size in the isolated, perfused mouse heart by inhibiting resident cardiac mast cell degranulation

(2008) Tyler H. Rork et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The A 3 adenosine receptor agonist CF502 inhibits the PI3K, PKB/Akt and NF-κB signaling pathway in synoviocytes from rheumatoid arthritis patients and in adjuvant-induced arthritis rats

(2008) A. Ochaion et al.   BIOCHEMICAL PHARMACOLOGY

Adenosine receptors in regulation of dendritic cell differentiation and function

(2008) S. V. Novitskiy et al.   BLOOD

Blockade of adenosine A2Breceptors ameliorates murine colitis

(2008) V L Kolachala et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activation of the adenosine-A3 receptor stimulates matrix metalloproteinase-9 secretion by macrophages

(2008) Emilie Velot et al.   CARDIOVASCULAR RESEARCH

Adenosine Receptor Antagonists:  Translating Medicinal Chemistry and Pharmacology into Clinical Utility

(2008) Pier Giovanni Baraldi et al.   CHEMICAL REVIEWS

Loss of Myocardial Ischemic Postconditioning in Adenosine A1 and Bradykinin B2 Receptors Gene Knockout Mice

(2008) L. Xi et al.   CIRCULATION

Hypoxia-Adenosinergic Immunosuppression: Tumor Protection by T Regulatory Cells and Cancerous Tissue Hypoxia

(2008) M. V. Sitkovsky et al.   CLINICAL CANCER RESEARCH

A2B Adenosine Receptor Gene Deletion Attenuates Murine Colitis

(2008) Vasantha L. Kolachala et al.   GASTROENTEROLOGY

Caffeine, cognitive failures and health in a non-working community sample

(2008) Andrew P Smith   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Major Histocompatibility Class II Transactivator Expression in Smooth Muscle Cells from A2b Adenosine Receptor Knock-out Mice

(2008) Yong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ecto-nucleoside Triphosphate Diphosphohydrolase 1 (E-NTPDase1/CD39) Regulates Neutrophil Chemotaxis by Hydrolyzing Released ATP to Adenosine

(2008) Ross Corriden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous A1 adenosine receptors protect against hepatic ischemia reperfusion injury in mice

(2008) Jeehee Kim et al.   LIVER TRANSPLANTATION

Activation of the A3 Adenosine Receptor Suppresses Superoxide Production and Chemotaxis of Mouse Bone Marrow Neutrophils

(2008) D. van der Hoeven et al.   MOLECULAR PHARMACOLOGY

A positive inotropic effect of adenosine in cardiac preparations of right atria from diseased human hearts

(2008) Ulrich Gergs et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Regulation of enteric functions by adenosine: Pathophysiological and pharmacological implications

(2008) Luca Antonioli et al.   PHARMACOLOGY & THERAPEUTICS

The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

(2008) V.-P. Jaakola et al.   SCIENCE

Repetitive stimulation of adenosine A1 receptors in vivo: Changes in receptor numbers, G-proteins and A1 receptor agonist-induced hypothermia

(2007) Viktor Roman et al.   BRAIN RESEARCH

Short-term TNF-Alpha treatment induced A2B adenosine receptor desensitization in human astroglial cells

(2007) Maria Letizia Trincavelli et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Characterization of adenosine receptors in bovine chondrocytes and fibroblast-like synoviocytes exposed to low frequency low energy pulsed electromagnetic fields

(2007) K. Varani et al.   OSTEOARTHRITIS AND CARTILAGE