Article
Immunology
Yehuda Klein, Offir Levin-Talmor, Jaime Garber Berkstein, Sharon Wald, Yaron Meirow, Avi Maimon, Avi Leibovich, Yechezkel Barenholz, David Polak, Stella Chaushu
Summary: The study investigated the role of RvD1 in acute and prolonged sterile inflammation and bone remodeling, and found that RvD1 significantly inhibited bone remodeling and reduced inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Noy Pinto, Yehuda Klein, Eilon David, David Polak, Daniel Steinberg, Gilad Mizrahi, Yasmin Khoury, Yechezkel Barenholz, Stella Chaushu
Summary: In this study, the effect of endogenous lipid RvD1 on allograft osteointegration in alveolar bone regeneration was investigated. Repeated administrations of RvD1 were found to promote bone regeneration through enhancing osteoblasts' differentiation and reducing osteoclastogenesis. This suggests that RvD1 may be a potential therapeutic bioagent for osseous regeneration following allograft implantation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Engineering, Biomedical
Ni Su, Cassandra Villicana, Fan Yang
Summary: This review discusses the progress in immunomodulation research for bone applications using biomaterials and cell-based strategies, with a focus on different disease types. The role of the immune system in orthopedic applications, including prolonging orthopaedic implant lifetime and enhancing fracture healing, is reviewed. Recent research progress in harnessing immunomodulatory strategies for regenerating critical-sized, long bone or cranial bone defects, and treating osteolytic bone diseases is also discussed.
Article
Biochemistry & Molecular Biology
Karoline M. L. Pacheco, Bruno B. M. Torres, Rafaela C. Sanfelice, Mardoqueu M. da Costa, Livia Assis, Rosemarie Brandim Marques, Antonio Luiz Martins Maia Filho, Carla R. Tim, Adriana Pavinatto
Summary: Chitosan and chitosan/turmeric-based membranes were produced and found to be applicable for skin wound repair. The membranes containing glycerol were more flexible and hydrophilic compared to those formed with pure chitosan. In vivo experiments showed that the chitosan/glycerol/turmeric membrane had a significant effect on reducing the injured area and promoting healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Engineering, Biomedical
Mojtaba Farahani, Abbas Shafiee
Summary: The universal increase in the number of patients with nonhealing skin wounds imposes a huge social and economic burden. The recent advances in materials and fabrication technologies have led to the development of smart wound dressings, such as 3D-printed dressings and biomolecule-loaded dressings, which accelerate wound healing and provide effective wound care management strategies.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Clinical Neurology
Daniela P. Vasconcelos, Madalena Costa, Joaquim L. Reis, Vasco S. Pinto, Ana B. Sousa, Artur P. aguas, Mario A. Barbosa, Judite N. Barbosa
Summary: This pilot study evaluated the feasibility of chitosan porous 3D scaffolds incorporated with resolvin D1 as an alternative to iliac bone autograft. The results showed that the chitosan scaffolds with resolvin D1 demonstrated potential in inhibiting inflammation and promoting new bone formation, suggesting their usefulness for bone tissue repair applications.
EUROPEAN SPINE JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Anisha Apte, Kenneth W. Liechty, Carlos Zgheib
Summary: Normal wound healing involves the secretion of chemokines by immune cells in response to injury, which recruit suitable immune cell types to the site of injury. Dysregulation of chemokine signaling may contribute to delayed wound healing and chronic wounds in diseased states. Research on the effects of biomaterials on chemokine signaling in wound healing is limited, but understanding these effects can help develop new biomaterial therapies.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qing Yu, Yonggan Yan, Jun Huang, Qianyu Liang, Jianhua Li, Bing Wang, Baojin Ma, Alberto Bianco, Shaohua Ge, Jinlong Shao
Summary: Chitosan-based composite hydrogels have desirable mechanical properties and excellent antibacterial abilities, and may be promising as wound dressings. However, their immunomodulatory abilities were rarely evaluated. In this study, a multifunctional CS/PMETAC hydrogel was developed and demonstrated its self-healing ability, biocompatibility, immunomodulatory effects, and antibacterial activity in vitro and in vivo. This work revealed the potential immunomodulatory effect of CS-based wound dressings and may provide a novel target for developing efficient wound healing tools.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Ni Su, Cassandra Villicana, Danial Barati, Peyton Freeman, Ying Luo, Fan Yang
Summary: A new method for treating critical size cranial bone defects by using mesenchymal stem cell membrane (MSCM)-coated microribbon (mu RB) scaffolds via targeting immunomodulation is reported. The study shows that MSCM coating promotes macrophage polarization, induces CD8+ T cell apoptosis, and enhances regulatory T cell differentiation. These results establish cell membrane-coated microribbon scaffolds as a promising strategy for treating critical size bone defects via immunomodulation.
ADVANCED MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Emad Molaei, Ali Molaei, A. Wallace Hayes, Gholamreza Karimi
Summary: Studies have shown that Resolvin D1 has the potential to inhibit inflammation, promote resolution and modulation of inflammation, and may have potential therapeutic value in treating acute lung injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ahmed E. Zarrough, Hatice Hasturk, Danielle N. Stephens, Thomas E. Van Dyke, Alpdogan Kantarci
Summary: The study found that RvD1 has a significant impact on wound healing and proliferation, receptor expression, and cytokine expression and release in PDLFs. RvD1 can reverse the inhibitory effects of IL-1beta, promote wound healing and proliferation in PDLFs, and inhibit inflammatory reactions.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Bo Yuan, Mintao Xue, Yin Zhao, Qunfeng Guo, Gang Zheng, Zheng Xu, Fengning Li, Xiongsheng Chen, Zhixin Chen, Jianlin Shi, Han Lin, Xiang Guo
Summary: Bionic functional coating is important for promoting bone fracture healing, but the post-traumatic microenvironment weakens the established coatings. In this study, a H-Si@HA composite coating was developed by anchoring two-dimensional H-silicene nanosheet (H-Si) onto hydroxyapatite (HA) coated metal implant. The coating exhibits pH-responsive characteristics, maintains stability in acidic conditions, simulates enzyme activities, reduces oxidative stress, and reverses the acidic microenvironment. The coating also induces cellular autophagy and promotes fracture healing through the release of Si4+ in a neutral environment.
Article
Engineering, Environmental
Jinfeng Huang, Quan-Chang Tan, Hao Bai, Jing Wang, Pooyan Makvandi, Moonis Ali Khan, Xiaofan Hu, Zixiang Wu
Summary: Osteoimmunology and immune microenvironments are crucial for bone tissue regeneration. A multifunctional hydrogel with M2 phenotype was developed to enhance bone regeneration. The hydrogel, made of tannic acid (TA)-Mg2+ chelate networks coated on black phosphorus (BP) nanosheets, improves the stability of BP and enhances its osteogenesis and osteoimmunomodulation ability. The modified hydrogel also enhances the bonding between BP nanosheets and the hydrogel matrix. In vivo experiments demonstrate that the hydrogel significantly enhances bone regeneration by modulating the immune microenvironment and macrophage phenotype.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Hunter Newman, Yuru Vernon Shih, Shyni Varghese
Summary: Impaired bone healing affects 5-10% of cases after injury, with timely resolution of inflammation being crucial for normal healing. Modulating the initial inflammatory phase and promoting its resolution can create a pro-regenerative environment for bone regeneration.
Article
Biochemistry & Molecular Biology
Maryam Shafique, Muhammad Sohail, Muhammad Usman Minhas, Touba Khaliq, Mubeen Kousar, Shahzeb Khan, Zahid Hussain, Arshad Mahmood, Mudassir Abbasi, Heather C. Aziz, Syed Ahmed Shah
Summary: This study developed a novel wound dressing based on hydrogel membranes loaded with cefepime nanoparticles, which showed promising potential for accelerating wound healing process. The in vitro analysis indicated that the developed membrane has ideal water vapor transmission rate and oxygen permeability, along with sustained drug release and high zone of inhibition against various bacteria.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Immunology
Daniela P. Vasconcelos, Clive Jabangwe, Meriem Lamghari, Cecilia J. Alves
Summary: This article discusses the role of neuroimmune crosstalk in joint disorders, with a focus on the role of macrophages in chronic pain. It explores the impact of the interaction between inflammatory response and nerve fibers on the genesis and maintenance of pain, and describes the alteration in joint innervation pattern and inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
M. Bessa-Goncalves, C. Ribeiro-Machado, M. Costa, C. C. Ribeiro, J. N. Barbosa, M. A. Barbosa, S. G. Santos
Summary: This study demonstrated that the incorporation of 10mM of magnesium sulfate improved the mechanical properties of the fibrinogen scaffold and promoted macrophage polarization to M2 phenotype. In vivo experiments showed that FgMg10 scaffolds reduced inflammatory mediators and increased M2 macrophage polarization.
ACTA BIOMATERIALIA
(2023)
Review
Cell & Tissue Engineering
Daniela P. Vasconcelos, Artur P. Aguas, Judite N. Barbosa
Summary: Inflammasomes are intracellular structures that play a crucial role in innate immune responses as key players in host defense. They are assembled upon the perception of pathogens or danger signals and activate the production of pro-inflammatory cytokines. The inflammasome is involved in various inflammatory processes and tissue repair, making it a potential target for regenerative medicine.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Clinical Neurology
Daniela P. Vasconcelos, Madalena Costa, Joaquim L. Reis, Vasco S. Pinto, Ana B. Sousa, Artur P. aguas, Mario A. Barbosa, Judite N. Barbosa
Summary: This pilot study evaluated the feasibility of chitosan porous 3D scaffolds incorporated with resolvin D1 as an alternative to iliac bone autograft. The results showed that the chitosan scaffolds with resolvin D1 demonstrated potential in inhibiting inflammation and promoting new bone formation, suggesting their usefulness for bone tissue repair applications.
EUROPEAN SPINE JOURNAL
(2023)
Article
Cell & Tissue Engineering
Sara Reis Moura, Jaime Freitas, Claudia Ribeiro-Machado, Jorge Lopes, Nuno Neves, Helena Canhao, Ana Maria Rodrigues, Mario Adolfo Barbosa, Maria Ines Almeida
Summary: This study decodes the regulatory network of the lncRNA H19 on the extracellular matrix (ECM) and reveals its impact on bone regeneration. Inhibition of H19 expression results in decreased ECM density and collagen content, and promotes adipogenic differentiation of bone marrow-derived stem cells. Furthermore, H19 is targeted by miR-29c, which is downregulated in osteoporotic bone tissue and affects MSC proliferation and collagen production. These findings suggest that H19 is a potential therapeutic target for controlling cell behavior and engineering the bone ECM.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Carlota M. Relvas, Susana G. Santos, Maria J. Oliveira, Fernao D. Magalhaes, Artur M. Pinto
Summary: Skin cancer is a common and increasing type of cancer with two main categories: melanoma and non-melanoma. Current treatments, including surgery, radiation therapy, and chemotherapy, have limitations in terms of mortality and recurrence rates. Recent studies have focused on new approaches, such as immunotherapy and various forms of phototherapy. Among these, photoimmunotherapy has gained attention for its potential outcomes in combining photodynamic and/or photothermal therapy with a systemic immune response. This review critically discusses the properties and mechanisms of action of different nanomaterials in skin cancer photoimmunotherapy and presents important results in the field.
Review
Engineering, Biomedical
Ana Beatriz Sousa, Judite N. Barbosa
Summary: Tissue engineering and regenerative medicine aim to find clinical valid solutions for repairing and restoring the function of damaged tissues or organs, either by promoting endogenous tissue repair or by using biomaterials or medical devices. Understanding the interactions between the immune system and biomaterials, as well as the role of immune cells in wound healing, is critical for the development of successful solutions.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Engineering, Biomedical
Ana Beatriz Sousa, Judite N. Barbosa
Summary: The implantation of biomaterials triggers an acute inflammatory response, which is crucial for the repair process. The resolution of the inflammatory response is an active and highly regulated process involving specialized pro-resolving mediators (SPMs) that play a fundamental role in terminating inflammation. SPMs have anti-inflammatory and pro-resolving actions and can be used in the development of immunomodulatory biomaterials to create a pro-regenerative microenvironment.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Materials Science, Biomaterials
Morena Francesca Fiordalisi, Joana Rita Ferreira, Marta Laranjeiro Pinto, Claudia Ribeiro-Machado, Marta Teixeira Pinto, Maria Jose Oliveira, Mario Adolfo Barbosa, Raquel Madeira Goncalves, Joana Caldeira
Summary: This study evaluated the impact of extracellular matrix (ECM) donor age on intervertebral disc (IVD) regeneration/degeneration and found that younger ECM scaffolds have better repopulation efficiency and the ability to restore a functional IVD microenvironment.
BIOMATERIALS ADVANCES
(2022)
Review
Materials Science, Biomaterials
Ana Beatriz Sousa, Artur P. Aguas, Mario A. Barbosa, Judite N. Barbosa
Summary: Successful wound healing involves three phases: inflammatory, proliferative, and remodeling. Chronic wounds are characterized by persistent inflammation that hampers the healing process. Macrophages play a crucial role in wound healing, promoting cleaning and phagocytosis at the early stage and then facilitating the resolution of inflammation, as well as expressing growth factors and cytokines needed for cell proliferation and tissue repair. In chronic wounds, the presence of pro-inflammatory M1 macrophages inhibits tissue repair. Immunomodulatory biomaterials are being explored as potential solutions to overcome the continued inflammatory phase that impairs chronic wound healing.
REGENERATIVE BIOMATERIALS
(2022)
Meeting Abstract
Cell & Tissue Engineering
Ana Luisa Castro, Claudia Ribeiro-Machado, Carla Oliveira, Paulo Pereira, Rui Vaz, Graciosa Quelhas Teixeira, Cornelia Neidlinger-Wilke, Mario Adolfo Barbosa, Raquel Madureira Goncalves
TISSUE ENGINEERING PART A
(2022)
