Effects of Aging on Fracture Healing

Osteoimmunology in Bone Fracture Healing

(2017) Takehito Ono et al.   Current Osteoporosis Reports

Absence of CCR2 results in an inflammaging environment in young mice with age-independent impairments in muscle regeneration

(2016) David W. Melton et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Identification and characterization of an injury-induced skeletal progenitor

(2015) Owen Marecic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Muscle Stem Cells During Skeletal Regeneration

(2015) Rana Abou-Khalil et al.   STEM CELLS

Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin

(2015) Gurpreet S. Baht et al.   Nature Communications

Stem and progenitor cells: advancing bone tissue engineering

(2015) R. Tevlin et al.   Drug Delivery and Translational Research

The ins and outs of muscle stem cell aging

(2015) Andrew S. Brack et al.   Skeletal Muscle

T and B cells participate in bone repair by infiltrating the fracture callus in a two-wave fashion

(2014) Ireen Könnecke et al.   BONE

Bone marrow blood vessel ossification and “microvascular dead space” in rat and human long bone

(2014) Rhonda D. Prisby   BONE

Fractures in Geriatric Mice Show Decreased Callus Expansion and Bone Volume

(2014) Luke A. Lopas et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Role of Fas and Treg Cells in Fracture Healing as Characterized in the Fas-Deficient (lpr) Mouse Model of Lupus

(2014) Maisa O Al-Sebaei et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo

(2014) M. K. Chang et al.   JOURNAL OF IMMUNOLOGY

Modulation of Macrophage Activity During Fracture Repair Has Differential Effects in Young Adult and Elderly Mice

(2014) Jesse Alan Slade Shantz et al.   JOURNAL OF ORTHOPAEDIC TRAUMA

Fracture healing: mechanisms and interventions

(2014) Thomas A. Einhorn et al.   Nature Reviews Rheumatology

Interaction of Age and Mechanical Stability on Bone Defect Healing: An Early Transcriptional Analysis of Fracture Hematoma in Rat

(2014) Andrea Ode et al.   PLoS One

Human Periosteal Derived Stem Cell Potential: The Impact of age

(2014) Concetta Ferretti et al.   Stem Cell Reviews and Reports

Aging disrupts cell subpopulation dynamics and diminishes the function of mesenchymal stem cells

(2014) Dominik Duscher et al.   Scientific Reports

Stem Cell-Derived Endochondral Cartilage Stimulates Bone Healing by Tissue Transformation

(2013) Chelsea S Bahney et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Serum Chitotriosidase, a Putative Marker of Chronically Activated Macrophages, Increases With Normal Aging

(2013) R. Ramanathan et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Systemic Inhibition of Canonical Notch Signaling Results in Sustained Callus Inflammation and Alters Multiple Phases of Fracture Healing

(2013) Michael I. Dishowitz et al.   PLoS One

T-Lymphocytes Enable Osteoblast Maturation via IL-17F during the Early Phase of Fracture Repair

(2012) Diane Nam et al.   PLoS One

Regulation of Macrophage Polarization and Wound Healing

(2012) Christopher J. Ferrante et al.   Advances in Wound Care

Inflammatory phase of bone healing initiates the regenerative healing cascade

(2011) Katharina Schmidt-Bleek et al.   CELL AND TISSUE RESEARCH

The MSC: An Injury Drugstore

(2011) Arnold I. Caplan et al.   Cell Stem Cell

Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model

(2011) Kylie A Alexander et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Infection, Inflammation, and Bone Regeneration: a Paradoxical Relationship

(2011) M.V. Thomas et al.   JOURNAL OF DENTAL RESEARCH

Mesenchymal Stem/Stromal Cells (MSCs): Role as Guardians of Inflammation

(2011) Darwin J Prockop et al.   MOLECULAR THERAPY

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Multiple roles for CCR2 during fracture healing

(2010) Z. Xing et al.   Disease Models & Mechanisms

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Age-related changes in osteogenic stem cells in mice

(2010) R.J. Bergman et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inflammaging: The driving force in osteoporosis?

(2010) P. Lencel et al.   MEDICAL HYPOTHESES

Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: a noninvasive therapeutic regimen

(2009) Arsalan Shabbir et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mesenchymal stem cell–educated macrophages: A novel type of alternatively activated macrophages

(2009) Jaehyup Kim et al.   EXPERIMENTAL HEMATOLOGY

Telomere Shortening and Oxidative Stress in Aged Macrophages Results in Impaired STAT5a Phosphorylation

(2009) C. Sebastian et al.   JOURNAL OF IMMUNOLOGY

Orthopaedic Surgeon Workforce and Volume Assessment for Total Hip and Knee Replacement in the United States: Preparing for an Epidemic

(2008) Richard Iorio et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Bone Formation During Distraction Osteogenesis Is Dependent on Both VEGFR1 and VEGFR2 Signaling

(2008) Kimberly A Jacobsen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inflammaging as a prodrome to Alzheimer's disease

(2008) Brian Giunta et al.   Journal of Neuroinflammation

Effect of age on vascularization during fracture repair

(2008) Chuanyong Lu et al.   JOURNAL OF ORTHOPAEDIC RESEARCH