Recent Advances in Microfluidic-Based Microphysiological Systems

Multicellular modeling of ciliopathy by combining iPS cells and microfluidic airway-on-a-chip technology

(2021) Naoyuki Sone et al.   Science Translational Medicine

Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection

(2021) Kunal Sharma et al.   eLife

Beyond PDMS and Membranes: New Materials for Organ-on-a-Chip Devices

(2021) Milica Radisic et al.   ACS Biomaterials-Science & Engineering

Probing prodrug metabolism and reciprocal toxicity with an integrated and humanized multi-tissue organ-on-a-chip platform

(2020) Shiny Amala Priya Rajan et al.   Acta Biomaterialia

Organ-on-a-chip: recent breakthroughs and future prospects

(2020) Qirui Wu et al.   Biomedical Engineering Online

3D Pancreatic Tissue Modeling in vitro: Advances and Prospects

(2020) Myungji Kim et al.   BioChip Journal

h-FIBER: Microfluidic Topographical Hollow Fiber for Studies of Glomerular Filtration Barrier

(2020) Ruoxiao Xie et al.   ACS Central Science

Synthetic alternatives to Matrigel

(2020) Elizabeth A. Aisenbrey et al.   Nature Reviews Materials

Alginate Microencapsulation for Three-Dimensional In Vitro Cell Culture

(2020) Sung-Min Kang et al.   ACS Biomaterials-Science & Engineering

Microfluidic organ-on-a-chip models of human liver tissue

(2020) Ehsanollah Moradi et al.   Acta Biomaterialia

Modular operation of microfluidic chips for highly parallelized cell culture and liquid dosing via a fluidic circuit board

(2020) A. R. Vollertsen et al.   Microsystems & Nanoengineering

Organ-on-a-Chip: A New Paradigm for Drug Development

(2020) Chao Ma et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Flow-enhanced vascularization and maturation of kidney organoids in vitro

(2019) Kimberly A. Homan et al.   NATURE METHODS

A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor

(2019) Stefan Florian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multivascular networks and functional intravascular topologies within biocompatible hydrogels

(2019) Bagrat Grigoryan et al.   SCIENCE

A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

(2019) Sasan Jalili-Firoozinezhad et al.   Nature Biomedical Engineering

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies

(2019) Tae-Eun Park et al.   Nature Communications

Investigation of mechanical properties and applications of polylactic acids—a review

(2019) S Divakara Shetty et al.   Materials Research Express

Engineered materials for organoid systems

(2019) Michael J. Kratochvil et al.   Nature Reviews Materials

Pulsatile Flow in Microfluidic Systems

(2019) Brian Dincau et al.   Small

Hydrogel-integrated Microfluidic Systems for Advanced Stem Cell Engineering

(2019) Soohwan An et al.   BioChip Journal

Connections Between Metabolism and Epigenetics in Programming Cellular Differentiation

(2018) Danielle A. Chisolm et al.   Annual Review of Immunology

Antimicrobial additives for poly(lactic acid) materials and their applications: current state and perspectives

(2018) Roberto Scaffaro et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Facile fabrication of sulfated alginate electrospun nanofibers

(2018) Hamed Daemi et al.   CARBOHYDRATE POLYMERS

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

(2018) Kacey Ronaldson-Bouchard et al.   Cell Stem Cell

Liver ‘organ on a chip’

(2018) Colin H. Beckwitt et al.   EXPERIMENTAL CELL RESEARCH

A review on chitosan centred scaffolds and their applications in tissue engineering

(2018) Shakeel Ahmed et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

A review on chitosan and its nanocomposites in drug delivery

(2018) Akbar Ali et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform

(2018) T. Satoh et al.   LAB ON A CHIP

Powering ex vivo tissue models in microfluidic systems

(2018) Ian C. McLean et al.   LAB ON A CHIP

Human brain organoid-on-a-chip to model prenatal nicotine exposure

(2018) Yaqing Wang et al.   LAB ON A CHIP

Microfluidic lung airway-on-a-chip with arrayable suspended gels for studying epithelial and smooth muscle cell interactions

(2018) Mouhita Humayun et al.   LAB ON A CHIP

UniChip enables long-term recirculating unidirectional perfusion with gravity-driven flow for microphysiological systems

(2018) Ying I. Wang et al.   LAB ON A CHIP

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

(2018) Collin D. Edington et al.   Scientific Reports

Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids

(2018) Magdalena Kasendra et al.   Scientific Reports

Establishing normal metabolism and differentiation in hepatocellular carcinoma cells by culturing in adult human serum

(2018) Rineke Steenbergen et al.   Scientific Reports

Advances in organ-on-a-chip engineering

(2018) Boyang Zhang et al.   Nature Reviews Materials

Glass-based organ-on-a-chip device for restricting small molecular absorption

(2018) Hirotada Hirama et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

A bacterial immunomodulatory protein with lipocalin-like domains facilitates host–bacteria mutualism in larval zebrafish

(2018) Annah S Rolig et al.   eLife

Stereolithographic hydrogel printing of 3D culture chips with biofunctionalized complex 3D perfusion networks

(2017) Rujing Zhang et al.   LAB ON A CHIP

A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice

(2017) Li Wang et al.   LAB ON A CHIP

Integration and application of optical chemical sensors in microbioreactors

(2017) Pia Gruber et al.   LAB ON A CHIP

A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as a blood–brain barrier

(2017) Giulia Adriani et al.   LAB ON A CHIP

Organs-on-chips with integrated electrodes for trans-epithelial electrical resistance (TEER) measurements of human epithelial barrier function

(2017) Olivier Y. F. Henry et al.   LAB ON A CHIP

Paper-based cell culture platform and its emerging biomedical applications

(2017) Kelvin Ng et al.   Materials Today

Metabolic origins of spatial organization in the tumor microenvironment

(2017) Carlos Carmona-Fontaine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

3D Miniaturization of Human Organs for Drug Discovery

(2017) Joseph Park et al.   Advanced Healthcare Materials

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

(2017) Aleksander Skardal et al.   Scientific Reports

Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling

(2016) Aleksander Skardal et al.   DRUG DISCOVERY TODAY

Organoids: A historical perspective of thinking in three dimensions

(2016) Marina Simian et al.   JOURNAL OF CELL BIOLOGY

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing

(2016) Johan U. Lind et al.   NATURE MATERIALS

Liver and kidney cells cultures in a new perfluoropolyether biochip

(2016) Rachid Jellali et al.   SENSORS AND ACTUATORS B-CHEMICAL

Organ-on-a-Chip Systems: Microengineering to Biomimic Living Systems

(2016) Fuyin Zheng et al.   Small

A microfluidics-based in vitro model of the gastrointestinal human–microbe interface

(2016) Pranjul Shah et al.   Nature Communications

Personalized Disease Models on a Chip

(2016) Nalin Tejavibulya et al.   Cell Systems

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

(2016) Anna Herland et al.   PLoS One

Investigating Nonalcoholic Fatty Liver Disease in a Liver-on-a-Chip Microfluidic Device

(2016) Manuele Gori et al.   PLoS One

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

(2016) Carlota Oleaga et al.   Scientific Reports

Recapitulation of in vivo-like paracrine signals of human mesenchymal stem cells for functional neuronal differentiation of human neural stem cells in a 3D microfluidic system

(2015) Kisuk Yang et al.   BIOMATERIALS

A microfluidically perfused three dimensional human liver model

(2015) Knut Rennert et al.   BIOMATERIALS

On-chip three-dimensional cell culture in phaseguides improves hepatocyte functions in vitro

(2015) Mi Jang et al.   Biomicrofluidics

Long-term maintenance of a microfluidic 3D human liver sinusoid

(2015) Ljupcho Prodanov et al.   BIOTECHNOLOGY AND BIOENGINEERING

Co-culture of 3D tumor spheroids with fibroblasts as a model for epithelial–mesenchymal transition in vitro

(2015) Sun-Ah Kim et al.   EXPERIMENTAL CELL RESEARCH

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

(2015) Hasan Erbil Abaci et al.   Integrative Biology

A Rapidly Fabricated Microfluidic Chip for Cell Culture

(2015) Rui Li et al.   JOURNAL OF CHROMATOGRAPHIC SCIENCE

A lung-on-a-chip array with an integrated bio-inspired respiration mechanism

(2015) Andreas O. Stucki et al.   LAB ON A CHIP

Multi-layered, membrane-integrated microfluidics based on replica molding of a thiol–ene epoxy thermoset for organ-on-a-chip applications

(2015) Drago Sticker et al.   LAB ON A CHIP

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling human carcinomas: Physiologically relevant 3D models to improve anti-cancer drug development

(2014) Christine Unger et al.   ADVANCED DRUG DELIVERY REVIEWS

Dynamic interplay of flow and collagen stabilizes primary hepatocytes culture in a microfluidic platform

(2014) Manjunath Hegde et al.   LAB ON A CHIP

Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury

(2014) Mandy B. Esch et al.   LAB ON A CHIP

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Three-dimensional organotypic culture: experimental models of mammalian biology and disease

(2014) Eliah R. Shamir et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Cell and tissue engineering for liver disease

(2014) S. N. Bhatia et al.   Science Translational Medicine

Micropatterned Cell–Cell Interactions Enable Functional Encapsulation of Primary Hepatocytes in Hydrogel Microtissues

(2014) Cheri Y. Li et al.   TISSUE ENGINEERING PART A

Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis

(2014) Olivier Frey et al.   Nature Communications

Platform for High-Throughput Testing of the Effect of Soluble Compounds on 3D Cell Cultures

(2013) Frédérique Deiss et al.   ANALYTICAL CHEMISTRY

Animal microsurgery using microfluidics

(2013) Jeffrey N Stirman et al.   CURRENT OPINION IN BIOTECHNOLOGY

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

Environmental tobacco smoke exposure and brain development: The case of attention deficit/hyperactivity disorder

(2013) Linda S. Pagani   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The zebrafish issue of Development

(2012) C. Nusslein-Volhard   DEVELOPMENT

Photopolymerization of a perfluoropolyether oligomer and photolithographic processes for the fabrication of microfluidic devices

(2012) Alessandra Vitale et al.   EUROPEAN POLYMER JOURNAL

Caenorhabditis elegans Immune Conditioning with the Probiotic Bacterium Lactobacillus acidophilus Strain NCFM Enhances Gram-Positive Immune Responses

(2012) Younghoon Kim et al.   INFECTION AND IMMUNITY

In vitro formation and characterization of a perfusable three-dimensional tubular capillary network in microfluidic devices

(2012) Ju Hun Yeon et al.   LAB ON A CHIP

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Indirect Co-Culture with Tendons or Tenocytes Can Program Amniotic Epithelial Cells towards Stepwise Tenogenic Differentiation

(2012) Barbara Barboni et al.   PLoS One

Poly-lactic acid synthesis for application in biomedical devices — A review

(2011) Astrid J.R. Lasprilla et al.   BIOTECHNOLOGY ADVANCES

Biomimetic tissues on a chip for drug discovery

(2011) Amir M. Ghaemmaghami et al.   DRUG DISCOVERY TODAY

Generation of oxygen gradients in microfluidic devices for cell culture using spatially confined chemical reactions

(2011) Yung-Ann Chen et al.   LAB ON A CHIP

Alginate: Properties and biomedical applications

(2011) Kuen Yong Lee et al.   PROGRESS IN POLYMER SCIENCE

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

A hydrophobic perfluoropolyether elastomer as a patternable biomaterial for cell culture and tissue engineering

(2010) Vera A. Schulte et al.   BIOMATERIALS

Fundamentals of microfluidic cell culture in controlled microenvironments

(2010) Edmond W. K. Young et al.   CHEMICAL SOCIETY REVIEWS

A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices

(2010) Paul M. van Midwoud et al.   LAB ON A CHIP

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

(2009) Gretchen J. Mahler et al.   BIOTECHNOLOGY AND BIOENGINEERING

Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes

(2009) Matteo Ricchi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells

(2009) Kyung-Jin Jang et al.   LAB ON A CHIP

The end of the era of generosity? Global health amid economic crisis

(2009) Kammerle Schneider et al.   Philosophy Ethics and Humanities in Medicine

Microfeature guided skeletal muscle tissue engineering for highly organized 3-dimensional free-standing constructs

(2008) Mai T. Lam et al.   BIOMATERIALS

In vitro analysis of a hepatic device with intrinsic microvascular-based channels

(2008) Amedeo Carraro et al.   BIOMEDICAL MICRODEVICES

Recognition between symbioticVibrio fischeriand the haemocytes ofEuprymna scolopes

(2008) Spencer V. Nyholm et al.   ENVIRONMENTAL MICROBIOLOGY

The role of matrix stiffness in regulating cell behavior

(2008) Rebecca G. Wells   HEPATOLOGY

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

(2004) Aaron Sin et al.   BIOTECHNOLOGY PROGRESS