Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection

Rapid endotheliitis and vascular damage characterize SARS‐CoV‐2 infection in a human lung‐chip model

(2021) Vivek V Thacker et al.   EMBO REPORTS

A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics

(2021) Longlong Si et al.   Nature Biomedical Engineering

Early invasion of the bladder wall by solitary bacteria protects UPEC from antibiotics and neutrophil swarms in an organoid model

(2021) Kunal Sharma et al.   Cell Reports

Urinary tract infections: microbial pathogenesis, host–pathogen interactions and new treatment strategies

(2020) Roger D. Klein et al.   NATURE REVIEWS MICROBIOLOGY

A shear stress micromodel of urinary tract infection by the Escherichia coli producing Dr adhesin

(2020) Beata Zalewska-Piątek et al.   PLoS Pathogens

Robotic fluidic coupling and interrogation of multiple vascularized organ chips

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A Micro-Engineered Airway Lung-Chip Models Key Features of Viral-Induced Exacerbation of Asthma

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Distinct morphological fates of uropathogenic E. coli intracellular bacterial communities: dependency on urine composition and pH

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A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth

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Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis

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A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

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Directed differentiation of human induced pluripotent stem cells into mature stratified bladder urothelium

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Bioengineered Human Organ-on-Chip Reveals Intestinal Microenvironment and Mechanical Forces Impacting Shigella Infection

(2019) Alexandre Grassart et al.   Cell Host & Microbe

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

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A virus-induced kidney disease model based on organ-on-a-chip: Pathogenesis exploration of virus-related renal dysfunctions

(2019) Ji Wang et al.   BIOMATERIALS

Engineering of human brain organoids with a functional vascular-like system

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Reproducing human and cross-species drug toxicities using a Liver-Chip

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Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

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Purification of Intracellular Bacterial Communities during Experimental Urinary Tract Infection Reveals an Abundant and Viable Bacterial Reservoir

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A urine-dependent human urothelial organoid offers a potential alternative to rodent models of infection

(2018) Harry Horsley et al.   Scientific Reports

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(2018) Giuliana Rossi et al.   NATURE REVIEWS GENETICS

The inflation of viscoelastic balloons and hollow viscera

(2018) Riccardo De Pascalis et al.   PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Improved recovery of functionally active eosinophils and neutrophils using novel immunomagnetic technology

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Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist

(2017) Caitlin N. Spaulding et al.   NATURE

Characterization of Early-Phase Neutrophil Extracellular Traps in Urinary Tract Infections

(2017) Yanbao Yu et al.   PLoS Pathogens

Human Liver Sinusoid on a Chip for Hepatitis B Virus Replication Study

(2017) Young Kang et al.   Micromachines

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Neutrophil swarming: an essential process of the neutrophil tissue response

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A microfluidics-based in vitro model of the gastrointestinal human–microbe interface

(2016) Pranjul Shah et al.   Nature Communications

Development of a Functional Glomerulus at the Organ Level on a Chip to Mimic Hypertensive Nephropathy

(2016) Mengying Zhou et al.   Scientific Reports

Phenotypic Heterogeneity Enables Uropathogenic Escherichia coli To Evade Killing by Antibiotics and Serum Complement

(2015) Marta Putrinš et al.   INFECTION AND IMMUNITY

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

Dysregulation ofEscherichia coliα-hemolysin expression alters the course of acute and persistent urinary tract infection

(2015) Kanna Nagamatsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular Bacterial Communities: A Potential Etiology for Chronic Lower Urinary Tract Symptoms

(2015) Victoria C.S. Scott et al.   UROLOGY

Rapid Cytolysis of Mycobacterium tuberculosis by Faropenem, an Orally Bioavailable β-Lactam Antibiotic

(2014) Neeraj Dhar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

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(2013) Kyung-Jin Jang et al.   Integrative Biology

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

(2013) Tim Lämmermann et al.   NATURE

Detection of intracellular bacterial communities in a child withEscherichia colirecurrent urinary tract infections

(2013) Luciana Robino et al.   Pathogens and Disease

Escherichia coli UropathogenesisIn Vitro: Invasion, Cellular Escape, and Secondary Infection Analyzed in a Human Bladder Cell Infection Model

(2012) Thomas E. Andersen et al.   INFECTION AND IMMUNITY

Population Dynamics and Niche Distribution of Uropathogenic Escherichia coli during Acute and Chronic Urinary Tract Infection

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Intracellular Lifestyles and Immune Evasion Strategies of UropathogenicEscherichia coli

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Persistence of Uropathogenic Escherichia coli in the Face of Multiple Antibiotics

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Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity

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Ex vivo deformations of the urinary bladder wall during whole bladder filling: Contributions of extracellular matrix and smooth muscle

(2010) Aron Parekh et al.   JOURNAL OF BIOMECHANICS

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

Breaching multiple barriers: leukocyte motility through venular walls and the interstitium

(2010) Sussan Nourshargh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The epidemiology of urinary tract infection

(2010) Betsy Foxman   Nature Reviews Urology

In vivo two-photon imaging reveals monocyte-dependent neutrophil extravasation during pulmonary inflammation

(2010) D. Kreisel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Mouse Neutrophil Extracellular Traps in Microbial Infections

(2009) David Ermert et al.   Journal of Innate Immunity

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

A murine model of urinary tract infection

(2009) Chia-Suei Hung et al.   Nature Protocols

Catch-Bond Mechanism of Force-Enhanced Adhesion: Counterintuitive, Elusive, but … Widespread?

(2008) Evgeni V. Sokurenko et al.   Cell Host & Microbe