The multifaceted roles of gasdermins in cancer biology and oncologic therapies

Downregulation of miR-155-5p enhances the anti-tumor effect of cetuximab on triple-negative breast cancer cells via inducing cell apoptosis and pyroptosis

(2021) Wen Xu et al.   Aging-US

Switching from Apoptosis to Pyroptosis: Gasdermin-Elicited Inflammation and Antitumor Immunity

(2021) Kohsuke Tsuchiya   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NINJ1 mediates plasma membrane rupture during lytic cell death

(2021) Nobuhiko Kayagaki et al.   NATURE

Channelling inflammation: gasdermins in physiology and disease

(2021) Xing Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity

(2021) Xiujin Shen et al.   Cell Death & Disease

Tetraarsenic hexoxide enhances generation of mitochondrial ROS to promote pyroptosis by inducing the activation of caspase-3/GSDME in triple-negative breast cancer cells

(2021) Haein An et al.   Cell Death & Disease

The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8

(2021) Jia-yuan Zhang et al.   CELL RESEARCH

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

(2021) Damien Bertheloot et al.   Cellular & Molecular Immunology

Involvement of TFAP2A in the activation of GSDMD gene promoter in hyperoxia-induced ALI

(2021) Qian Cao et al.   EXPERIMENTAL CELL RESEARCH

Posttranslational and Therapeutic Control of Gasdermin-Mediated Pyroptosis and Inflammation

(2021) Fabian A. Fischer et al.   Frontiers in Immunology

A novel defined pyroptosis-related gene signature for predicting the prognosis of ovarian cancer

(2021) Ying Ye et al.   Cell Death Discovery

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

(2021) Charles L. Evavold et al.   CELL

Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions

(2021) Justin M. Hansen et al.   CELL

Long non‑coding RNA nuclear paraspeckle assembly transcript 1 regulates ionizing radiation‑induced pyroptosis via microRNA‑448/gasdermin E in colorectal cancer cells

(2021) Fei Su et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ

(2021) Jing Cai et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Up-regulation of gasdermin C in mouse small intestine is associated with lytic cell death in enterocytes in worm-induced type 2 immunity

(2021) Ranhui Xi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Punching Holes in Cellular Membranes: Biology and Evolution of Gasdermins

(2021) Elke De Schutter et al.   TRENDS IN CELL BIOLOGY

The role of Caspase-1/GSDMD-mediated pyroptosis in Taxol-induced cell death and a Taxol-resistant phenotype in nasopharyngeal carcinoma regulated by autophagy

(2020) Xianyao Wang et al.   CELL BIOLOGY AND TOXICOLOGY

Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

(2020) Yuying Liu et al.   Science Immunology

FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells

(2020) Robin Schwarzer et al.   IMMUNITY

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

A bioorthogonal system reveals antitumour immune function of pyroptosis

(2020) Qinyang Wang et al.   NATURE

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

(2020) Jun Jacob Hu et al.   NATURE IMMUNOLOGY

Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate

(2020) Lei Hu et al.   Cell Death & Disease

N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis

(2020) Mausita Karmakar et al.   Nature Communications

Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis

(2020) Xiaowei Zhang et al.   Acta Pharmaceutica Sinica B

Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy

(2020) Pengfei Zhao et al.   BIOMATERIALS

Ultraviolet B induces proteolytic cleavage of the pyroptosis inducer gasdermin E in keratinocytes

(2020) Yujie Chen et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

(2020) Junwei Hou et al.   NATURE CELL BIOLOGY

Succination inactivates gasdermin D and blocks pyroptosis

(2020) Fiachra Humphries et al.   SCIENCE

Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition

(2020) Wanfeng Xu et al.   Cell Metabolism

GSDME and its role in cancer: From behind the scenes to the front of the stage

(2020) Elke De Schutter et al.   INTERNATIONAL JOURNAL OF CANCER

P4HA1 regulates human colorectal cancer cells through HIF1α‑mediated Wnt signaling

(2020) Qiang Zhang et al.   Oncology Letters

Vitamin D/VDR attenuate cisplatin-induced AKI by down-regulating NLRP3/Caspase-1/GSDMD pyroptosis pathway

(2020) Siqing Jiang et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Schwannoma gene therapy by adeno-associated virus delivery of the pore-forming protein Gasdermin-D

(2019) Sherif G. Ahmed et al.   CANCER GENE THERAPY

A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma

(2019) Mengjiao Wu et al.   EBioMedicine

Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells

(2019) Junhui Yu et al.   Cell Death & Disease

Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation

(2019) Cheng-cheng Zhang et al.   APOPTOSIS

Eukaryotic elongation factor-2 kinase regulates the cross-talk between autophagy and pyroptosis in doxorubicin-treated human melanoma cells in vitro

(2019) Pian Yu et al.   ACTA PHARMACOLOGICA SINICA

Metformin induces human esophageal carcinoma cell pyroptosis by targeting the miR-497/PELP1 axis

(2019) Lu Wang et al.   CANCER LETTERS

Intracellular delivery of an antibody targeting Gasdermin-B reduces HER2 breast cancer aggressiveness

(2019) Angela Molina-Crespo et al.   CLINICAL CANCER RESEARCH

Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization

(2019) Zhonghua Liu et al.   IMMUNITY

Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage

(2019) Jean Defourny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRF2 transcriptionally induces GSDMD expression for pyroptosis

(2019) Nobuhiko Kayagaki et al.   Science Signaling

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

Methylation analysis of Gasdermin E shows great promise as a biomarker for colorectal cancer

(2019) Joe Ibrahim et al.   Cancer Medicine

Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation

(2019) Sabrina Sofia Burgener et al.   Cell Reports

α-NETA induces pyroptosis of epithelial ovarian cancer cells through the GSDMD/caspase-4 pathway

(2019) Lianqiao Qiao et al.   FASEB JOURNAL

Mechanism and Regulation of Gasdermin-Mediated Cell Death

(2019) Shiyu Xia et al.   Cold Spring Harbor Perspectives in Biology

Determination of the Potential Tumor-Suppressive Effects of Gsdme in a Chemically Induced and in a Genetically Modified Intestinal Cancer Mouse Model

(2019) Lieselot Croes et al.   Cancers

The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma

(2019) Yang Kong et al.   Frontiers in Oncology

Epigenetics-Based Tumor Cells Pyroptosis for Enhancing the Immunological Effect of Chemotherapeutic Nanocarriers

(2019) Jin-Xuan Fan et al.   NANO LETTERS

The Gasdermin E gene Potential as a Pan-Cancer Biomarker, While Discriminating between Different Tumor Types

(2019) Joe Ibrahim et al.   Cancers

Inactivation of the Cytoprotective Major Vault Protein by Caspase-1 and -9 in Epithelial Cells during Apoptosis

(2019) Serena Grossi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis

(2019) Dan A. Erkes et al.   Cancer Discovery

GSDME mediates caspase-3-dependent pyroptosis in gastric cancer

(2018) Yubin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture

(2018) Nathalia M. de Vasconcelos et al.   CELL DEATH AND DIFFERENTIATION

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle

(2018) Michelle M. Stein et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis

(2018) Ronald A. Panganiban et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Gasdermin C is induced by ultraviolet light and contributes to MMP-1 expression via activation of ERK and JNK pathways

(2018) Novi Kusumaningrum et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Downregulation of gasdermin D promotes gastric cancer proliferation by regulating cell cycle-related proteins

(2018) Wei Jie Wang et al.   Journal of Digestive Diseases

DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia

(2018) Darren C. Johnson et al.   NATURE MEDICINE

Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death

(2018) Hiroto Kambara et al.   Cell Reports

Large-scale analysis of DFNA5 methylation reveals its potential as biomarker for breast cancer

(2018) Lieselot Croes et al.   Clinical Epigenetics

Cryo-EM structure of the gasdermin A3 membrane pore

(2018) Jianbin Ruan et al.   NATURE

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 

(2018) Bo Zhou et al.   CELL RESEARCH

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

(2018) Sebastian Rühl et al.   SCIENCE

Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue

(2017) Zhenjiang Liu et al.   JOURNAL OF PINEAL RESEARCH

Enterovirus 71 Inhibits Pyroptosis through Cleavage of Gasdermin D

(2017) Xiaobo Lei et al.   JOURNAL OF VIROLOGY

Analysis of rs8067378 Polymorphism in the Risk of Uterine Cervical Cancer from a Polish Population and its Impact on Gasdermin B Expression

(2017) Anna Lutkowska et al.   Molecular Diagnosis & Therapy

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein

(2017) Kinlin L. Chao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis

(2017) Siyun Kuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

DFNA5 promoter methylation a marker for breast tumorigenesis

(2017) Lieselot Croes et al.   Oncotarget

Pro-necrotic molecules impact local immunosurveillance in human breast cancer

(2017) Gautier Stoll et al.   OncoImmunology

Role of DNA methylation in expression control of the IKZF3-GSDMA region in human epithelial cells

(2017) Sanny Moussette et al.   PLoS One

Epidermal cornification is preceded by the expression of a keratinocyte-specific set of pyroptosis-related genes

(2017) Julia Lachner et al.   Scientific Reports

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation

(2016) Sudipta Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer

(2016) Marta Hergueta-Redondo et al.   Oncotarget

Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation

(2016) Masashi Miguchi et al.   PLoS One

Loss of conservedGsdma3self-regulation causes autophagy and cell death

(2015) Peiliang Shi et al.   BIOCHEMICAL JOURNAL

A GSDMB enhancer-driven HSV thymidine kinase-expressing vector for controlling occult peritoneal dissemination of gastric cancer cells

(2015) Norihisa Saeki et al.   BMC CANCER

Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes

(2015) Sedigheh Delmaghani et al.   CELL

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Gasdermin-B Promotes Invasion and Metastasis in Breast Cancer Cells

(2014) Marta Hergueta-Redondo et al.   PLoS One

Expression of GSDML Associates with Tumor Progression in Uterine Cervix Cancer

(2014) Qiao Sun et al.   Translational Oncology

The splice site variant rs11078928 may be associated with a genotype-dependent alteration in expression of GSDMB transcripts

(2013) Faer S Morrison et al.   BMC GENOMICS

The expression and regulation of DFNA5 in human hepatocellular carcinoma DFNA5 in hepatocellular carcinoma

(2013) Cong-Jun Wang et al.   MOLECULAR BIOLOGY REPORTS

Alu-derived cis-element regulates tumorigenesis-dependent gastric expression of GASDERMIN B (GSDMB)

(2010) Hiromitsu Komiyama et al.   GENES & GENETIC SYSTEMS

Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer

(2009) Tomoko Fujikane et al.   BREAST CANCER RESEARCH AND TREATMENT

Transcriptional regulation of GSDML gene by antisense-oriented HERV-H LTR element

(2008) J.-W. Huh et al.   ARCHIVES OF VIROLOGY

Methylation of the DFNA5 increases risk of lymph node metastasis in human breast cancer

(2008) Myoung Sook Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Distinctive expression and function of fourGSDMfamily genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium

(2008) Norihisa Saeki et al.   GENES CHROMOSOMES & CANCER

Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma

(2008) M S Kim et al.   ONCOGENE

Differential expression and localisation of gasdermin-like (GSDML), a novel member of the cancer-associated GSDMDC protein family, in neoplastic and non-neoplastic gastric, hepatic, and colon tissues

(2007) Stacy Carl-McGrath et al.   PATHOLOGY