Eukaryotic elongation factor-2 kinase regulates the cross-talk between autophagy and pyroptosis in doxorubicin-treated human melanoma cells in vitro

Thymoquinone inhibits cell proliferation, migration, and invasion by regulating the elongation factor 2 kinase (eEF-2K) signaling axis in triple-negative breast cancer

(2018) Nashwa Kabil et al.   BREAST CANCER RESEARCH AND TREATMENT

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions

(2017) Robin A. Aglietti et al.   TRENDS IN IMMUNOLOGY

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Roles of Caspases in Necrotic Cell Death

(2016) Junying Yuan et al.   CELL

Role of Beclin-1-Mediated Autophagy in the Survival of Pediatric Leukemia Cells

(2016) Xiaoli Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Therapeutic Targeting of Autophagy

(2016) Christina G. Towers et al.   EBioMedicine

TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy

(2015) Yu Matsuzawa et al.   Autophagy

Src/STAT3-dependent heme oxygenase-1 induction mediates chemoresistance of breast cancer cells to doxorubicin by promoting autophagy

(2015) Qixing Tan et al.   CANCER SCIENCE

Caspase target drives pyroptosis

(2015) Petr Broz   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Ghrelin inhibits doxorubicin cardiotoxicity by inhibiting excessive autophagy through AMPK and p38-MAPK

(2014) Xue Wang et al.   BIOCHEMICAL PHARMACOLOGY

eEF2K--a new target in breast cancers with combined inactivation of p53 and PTEN

(2014) H. G. Russnes et al.   EMBO Molecular Medicine

Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells

(2013) Ahmed A. Ashour et al.   APOPTOSIS

Autophagy is used as a survival program in unfertilized sea urchin eggs that are destined to die by apoptosis after inactivation of MAPK1/3 (ERK2/1)

(2013) Ludivine Houel-Renault et al.   Autophagy

The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation

(2013) Gabriel Leprivier et al.   CELL

The role of autophagy in doxorubicin-induced cardiotoxicity

(2013) Amie J. Dirks-Naylor   LIFE SCIENCES

Inflammasome Components Coordinate Autophagy and Pyroptosis as Macrophage Responses to Infection

(2013) B. G. Byrne et al.   mBio

MAPK14/p38α confers irinotecan resistance to TP53-defective cells by inducing survival autophagy

(2012) Salome Paillas et al.   Autophagy

Berberine Inhibits Doxorubicin-Triggered Cardiomyocyte Apoptosis via Attenuating Mitochondrial Dysfunction and Increasing Bcl-2 Expression

(2012) Xiuxiu Lv et al.   PLoS One

eEF-2 Kinase Dictates Cross-Talk between Autophagy and Apoptosis Induced by Akt Inhibition, Thereby Modulating Cytotoxicity of Novel Akt Inhibitor MK-2206

(2011) Y. Cheng et al.   CANCER RESEARCH

Inhibition of doxorubicin-induced autophagy in hepatocellular carcinoma Hep3B cells by sorafenib - the role of extracellular signal-regulated kinase counteraction

(2011) Irena Manov et al.   FEBS Journal

Cytoprotective Effect of the Elongation Factor-2 Kinase-Mediated Autophagy in Breast Cancer Cells Subjected to Growth Factor Inhibition

(2010) Yan Cheng et al.   PLoS One

Cardiomyocyte death in doxorubicin-induced cardiotoxicity

(2009) Yi-Wei Zhang et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Silencing of Elongation Factor-2 Kinase Potentiates the Effect of 2-Deoxy-D-Glucose against Human Glioma Cells through Blunting of Autophagy

(2009) H. Wu et al.   CANCER RESEARCH

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure

(2008) Lihe Lu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY