White matter microglia heterogeneity in the CNS

Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease

(2021) Emma Gerrits et al.   ACTA NEUROPATHOLOGICA

White matter aging drives microglial diversity

(2021) Shima Safaiyan et al.   NEURON

Viscoelastic properties of white and gray matter-derived microglia differentiate upon treatment with lipopolysaccharide but not upon treatment with myelin

(2021) Thecla A. van Wageningen et al.   Journal of Neuroinflammation

A lymphocyte–microglia–astrocyte axis in chronic active multiple sclerosis

(2021) Martina Absinta et al.   NATURE

Neuroinflammatory astrocyte subtypes in the mouse brain

(2021) Philip Hasel et al.   NATURE NEUROSCIENCE

C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation

(2021) Deepti Lall et al.   NEURON

Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer’s disease

(2021) Jing-Fei Chen et al.   NEURON

Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system

(2020) Khalil S. Rawji et al.   ACTA NEUROPATHOLOGICA

Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology

(2020) Annerieke Sierksma et al.   EMBO Molecular Medicine

Reactive oxygen species-mediated cytoplasmic stiffening impairs the phagocytic ability of the macrophage

(2020) Mahesh Agarwal et al.   JOURNAL OF CELL SCIENCE

Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits

(2020) Rebecca J. Henry et al.   JOURNAL OF NEUROSCIENCE

Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory

(2020) Fei Wang et al.   NATURE NEUROSCIENCE

Microglia Heterogeneity in the Single-Cell Era

(2020) Takahiro Masuda et al.   Cell Reports

Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion

(2020) Jason R. Plemel et al.   Science Advances

Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner

(2020) Emily F. Willis et al.   CELL

Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy

(2020) Liam Kempthorne et al.   Acta Neuropathologica Communications

Synaptic Loss in Multiple Sclerosis Spinal Cord

(2020) Natalia Petrova et al.   ANNALS OF NEUROLOGY

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

(2020) Wei-Ting Chen et al.   CELL

Novel Hexb-based tools for studying microglia in the CNS

(2020) Takahiro Masuda et al.   NATURE IMMUNOLOGY

Human fetal microglia acquire homeostatic immune-sensing properties early in development

(2020) L. Kracht et al.   SCIENCE

Investigating Microglia in Health and Disease: Challenges and Opportunities

(2020) Veronique E. Miron et al.   TRENDS IN IMMUNOLOGY

To Kill a Microglia: A Case for CSF1R Inhibitors

(2020) Kim N. Green et al.   TRENDS IN IMMUNOLOGY

Overview of General and Discriminating Markers of Differential Microglia Phenotypes

(2020) Agnieszka M. Jurga et al.   Frontiers in Cellular Neuroscience

A new genetic strategy for targeting microglia in development and disease

(2020) Gabriel L McKinsey et al.   eLife

Motor cortex transcriptome reveals microglial key events in amyotrophic lateral sclerosis

(2020) Oriol Dols-Icardo et al.   Neurology-Neuroimmunology & Neuroinflammation

Negative feedback control of neuronal activity by microglia

(2020) Ana Badimon et al.   NATURE

Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection

(2020) Alan Sariol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type I interferon‐activated microglia are critical for neuromyelitis optica pathology

(2020) Agnieszka Wlodarczyk et al.   GLIA

Glial cells in the driver seat of leukodystrophy pathogenesis

(2020) Luis M. Garcia et al.   NEUROBIOLOGY OF DISEASE

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes

(2019) Marlijn van der Poel et al.   Nature Communications

Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury

(2019) Victor Bellver-Landete et al.   Nature Communications

Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation

(2019) Marta Joana Costa Jordão et al.   SCIENCE

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

(2019) Takahiro Masuda et al.   NATURE

Transforming growth factor-beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors

(2019) Roey Baror et al.   GLIA

Microglia damage precedes major myelin breakdown in X-linked adrenoleukodystrophy and metachromatic leukodystrophy

(2019) Caroline G. Bergner et al.   GLIA

Impaired behavioural flexibility related to white matter microgliosis in the TgAPP21 rat model of Alzheimer disease

(2019) Alexander Levit et al.   BRAIN BEHAVIOR AND IMMUNITY

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

(2019) Hannah Van Hove et al.   NATURE NEUROSCIENCE

Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis

(2019) Silas Maniatis et al.   SCIENCE

The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

(2019) Carlo Sala Frigerio et al.   Cell Reports

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

(2019) Diego Adhemar Jaitin et al.   CELL

Microglial Depletion Causes Region-Specific Changes to Developmental Neuronal Cell Death in the Mouse Brain

(2019) Andrew J. Jacobs et al.   Developmental Neurobiology

Neuronal vulnerability and multilineage diversity in multiple sclerosis

(2019) Lucas Schirmer et al.   NATURE

Central nervous system regeneration is driven by microglia necroptosis and repopulation

(2019) Amy F. Lloyd et al.   NATURE NEUROSCIENCE

The pro-remyelination properties of microglia in the central nervous system

(2019) Amy F. Lloyd et al.   Nature Reviews Neurology

Loss of USP18 in microglia induces white matter pathology

(2019) Marius Schwabenland et al.   Acta Neuropathologica Communications

Mapping microglia states in the human brain through the integration of high-dimensional techniques

(2019) Roman Sankowski et al.   NATURE NEUROSCIENCE

Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice

(2019) Patrick E. Steadman et al.   NEURON

Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease

(2019) Sebastian Werneburg et al.   IMMUNITY

Regulation of microglial TMEM119 and P2RY12 immunoreactivity in multiple sclerosis white and grey matter lesions is dependent on their inflammatory environment

(2019) Thecla A. van Wageningen et al.   Acta Neuropathologica Communications

B-cell Therapy for Multiple Sclerosis: Entering an era

(2018) Ariele L. Greenfield et al.   ANNALS OF NEUROLOGY

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

Microglia and Aging: The Role of the TREM2–DAP12 and CX3CL1-CX3CR1 Axes

(2018) Carmen Mecca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP): Integrating the literature on hereditary diffuse leukoencephalopathy with spheroids (HDLS) and pigmentary orthochromatic leukodystrophy (POLD)

(2018) Scott J. Adams et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia

(2018) James C. Cronk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reassessing B cell contributions in multiple sclerosis

(2018) Rui Li et al.   NATURE IMMUNOLOGY

Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models

(2018) Bahareh Ajami et al.   NATURE NEUROSCIENCE

A transcriptomic atlas of aged human microglia

(2018) Marta Olah et al.   Nature Communications

Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945

(2018) Nicolau Beckmann et al.   Acta Neuropathologica Communications

Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau

(2018) Silvia S. Kang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Animal models of neurodegenerative diseases

(2018) Ted M. Dawson et al.   NATURE NEUROSCIENCE

Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo

(2018) Nynke Oosterhof et al.   Cell Reports

Multimodal Enhancement of Remyelination by Exercise with a Pivotal Role for Oligodendroglial PGC1α

(2018) Samuel K. Jensen et al.   Cell Reports

The Kaleidoscope of Microglial Phenotypes

(2018) Marissa L. Dubbelaar et al.   Frontiers in Immunology

Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice

(2018) Monica R. P. Elmore et al.   AGING CELL

Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment

(2018) Erin M. Gibson et al.   CELL

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry

(2018) Chotima Böttcher et al.   NATURE NEUROSCIENCE

Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing

(2018) Qingyun Li et al.   NEURON

Region-Specific Phenotypes of Microglia: The Role of Local Regulatory Cues

(2018) Lindsay M. De Biase et al.   NEUROSCIENTIST

A Single-Cell Sequencing Guide for Immunologists

(2018) Peter See et al.   Frontiers in Immunology

Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain

(2017) Maria I. Fonseca et al.   Journal of Neuroinflammation

Implications of white matter damage in amyotrophic lateral sclerosis

(2017) Ting Zhou et al.   Molecular Medicine Reports

A new fate mapping system reveals context-dependent random or clonal expansion of microglia

(2017) Tuan Leng Tay et al.   NATURE NEUROSCIENCE

Regenerating CNS myelin — from mechanisms to experimental medicines

(2017) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

A novel mutation in TREM2 gene causing Nasu-Hakola disease and review of the literature

(2017) Efthimios Dardiotis et al.   NEUROBIOLOGY OF AGING

Ocrelizumab and Other CD20+ B-Cell-Depleting Therapies in Multiple Sclerosis

(2017) Jeffrey M. Gelfand et al.   Neurotherapeutics

An environment-dependent transcriptional network specifies human microglia identity

(2017) David Gosselin et al.   SCIENCE

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

(2017) Katharine Askew et al.   Cell Reports

Increased White Matter Inflammation in Aging- and Alzheimer’s Disease Brain

(2017) Divya Raj et al.   Frontiers in Molecular Neuroscience

The Role of Microglia and Macrophages in CNS Homeostasis, Autoimmunity, and Cancer

(2017) Jie Yin et al.   Journal of Immunology Research

Analysis of Microglia and Monocyte-derived Macrophages from the Central Nervous System by Flow Cytometry

(2017) Elodie Martin et al.   Jove-Journal of Visualized Experiments

Molecular Mechanisms Modulating the Phenotype of Macrophages and Microglia

(2017) Stephanie A. Amici et al.   Frontiers in Immunology

Massive transcriptome sequencing of human spinal cord tissues provides new insights into motor neuron degeneration in ALS

(2017) Anna Maria D’Erchia et al.   Scientific Reports

Correlations between Gray Matter and White Matter Degeneration in Pure Alzheimer’s Disease, Pure Subcortical Vascular Dementia, and Mixed Dementia

(2017) Hyemin Jang et al.   Scientific Reports

Characteristic microglial features in patients with hereditary diffuse leukoencephalopathy with spheroids

(2016) Mari Tada et al.   ANNALS OF NEUROLOGY

The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting

(2016) Christopher S. von Bartheld et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome

(2016) Marije E.C. Meuwissen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Brain trauma elicits non-canonical macrophage activation states

(2016) Charles C. Kim et al.   Journal of Neuroinflammation

Is involvement of inflammation underestimated in Pelizaeus-Merzbacher disease?

(2016) Antoine Marteyn et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning

(2016) Lin Xiao et al.   NATURE NEUROSCIENCE

Microglial brain region−dependent diversity and selective regional sensitivities to aging

(2016) Kathleen Grabert et al.   NATURE NEUROSCIENCE

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualization and analysis of gene expression in tissue sections by spatial transcriptomics

(2016) P. L. Stahl et al.   SCIENCE

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

(2016) Gergely Szalay et al.   Nature Communications

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination

(2015) Muktha S. Natrajan et al.   BRAIN

Mouse Models of Multiple Sclerosis: Lost in Translation?

(2015) David Baker et al.   CURRENT PHARMACEUTICAL DESIGN

Poised for action: USP18 restrains microglial activation in the white matter

(2015) K. Takata et al.   EMBO JOURNAL

USP18 lack in microglia causes destructive interferonopathy of the mouse brain

(2015) T. Goldmann et al.   EMBO JOURNAL

Activation Status of Human Microglia Is Dependent on Lesion Formation Stage and Remyelination in Multiple Sclerosis

(2015) Laura A.N. Peferoen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

(2015) Nicholas Butowski et al.   NEURO-ONCOLOGY

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Motor skill learning requires active central myelination

(2014) I. A. McKenzie et al.   SCIENCE

Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons

(2013) Shailender Singh et al.   ACTA NEUROPATHOLOGICA

Innate Immune Activation in the Pathogenesis of a Murine Model of Globoid Cell Leukodystrophy

(2013) Eric R. Snook et al.   AMERICAN JOURNAL OF PATHOLOGY

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status

(2013) Daphne YS Vogel et al.   Journal of Neuroinflammation

Update on the diagnosis and treatment of neuromyelitis optica: Recommendations of the Neuromyelitis Optica Study Group (NEMOS)

(2013) Corinna Trebst et al.   JOURNAL OF NEUROLOGY

A Dramatic Increase of C1q Protein in the CNS during Normal Aging

(2013) A. H. Stephan et al.   JOURNAL OF NEUROSCIENCE

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

(2013) Tobias Goldmann et al.   NATURE NEUROSCIENCE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Fractalkine: A Survivor's Guide

(2012) Gemma E. White et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Innate Immunity in multiple sclerosis white matter lesions: expression of natural cytotoxicity triggering receptor 1 (NCR1)

(2012) Pascal F Durrenberger et al.   Journal of Neuroinflammation

Microglial Activation Correlates with Disease Progression and Upper Motor Neuron Clinical Symptoms in Amyotrophic Lateral Sclerosis

(2012) Johannes Brettschneider et al.   PLoS One

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits

(2011) Bryna Erblich et al.   PLoS One

OSTEODYSPLASIA POLYCYSTICA HEREDITARIA COMBINED WITH SCLEROSING LEUCOENCEPHALOPATHY

(2010) H. P. A. Hakola et al.   ACTA NEUROLOGICA SCANDINAVICA

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Regional differences between grey and white matter in cuprizone induced demyelination

(2009) Viktoria Gudi et al.   BRAIN RESEARCH

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

(2009) Carol A. Colton   Journal of Neuroimmune Pharmacology

Selective reduction in microglia density and function in the white matter of colony-stimulating factor-1-deficient mice

(2009) Yoichi Kondo et al.   JOURNAL OF NEUROSCIENCE RESEARCH