Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

(2016) Hansen Lui et al.   CELL

A complement–microglial axis drives synapse loss during virus-induced memory impairment

(2016) Michael J. Vasek et al.   NATURE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation

(2016) Roberta Bulla et al.   Nature Communications

Periodontitis and Cognitive Decline in Alzheimer’s Disease

(2016) Mark Ide et al.   PLoS One

Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline

(2015) Q. Shi et al.   JOURNAL OF NEUROSCIENCE

Neurodegeneration by Activation of the Microglial Complement-Phagosome Pathway

(2014) L.-G. Bodea et al.   JOURNAL OF NEUROSCIENCE

Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma

(2014) Gareth R. Howell et al.   NEUROBIOLOGY OF DISEASE

C1q as a unique player in angiogenesis with therapeutic implication in wound healing

(2014) F. Bossi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation

(2014) Julie A. Harris et al.   Frontiers in Neural Circuits

Complement, C1q, and C1q-Related Molecules Regulate Macrophage Polarization

(2014) Suzanne S. Bohlson et al.   Frontiers in Immunology

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms

(2013) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Distinct development and functions of resident and recruited liver Kupffer cells/macrophages

(2013) Masami Ikarashi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A Dramatic Increase of C1q Protein in the CNS during Normal Aging

(2013) A. H. Stephan et al.   JOURNAL OF NEUROSCIENCE

TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement

(2013) Allison R Bialas et al.   NATURE NEUROSCIENCE

Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration

(2013) V. Hugh Perry et al.   Seminars in Immunopathology

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

C1q-induced LRP1B and GPR6 Proteins Expressed Early in Alzheimer Disease Mouse Models, Are Essential for the C1q-mediated Protection against Amyloid-β Neurotoxicity

(2012) Marie E. Benoit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement Protein C1q Directs Macrophage Polarization and Limits Inflammasome Activity during the Uptake of Apoptotic Cells

(2012) M. E. Benoit et al.   JOURNAL OF IMMUNOLOGY

Local Complement-Targeted Intervention in Periodontitis: Proof-of-Concept Using a C5a Receptor (CD88) Antagonist

(2012) T. Abe et al.   JOURNAL OF IMMUNOLOGY

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

(2012) David H Cribbs et al.   Journal of Neuroinflammation

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Functional Complement C1q Abnormality Leads to Impaired Immune Complexes and Apoptotic Cell Clearance

(2011) Lubka T. Roumenina et al.   JOURNAL OF IMMUNOLOGY

Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease

(2011) Maria I Fonseca et al.   Journal of Neuroinflammation

Complement Protein C1q-Mediated Neuroprotection Is Correlated with Regulation of Neuronal Gene and MicroRNA Expression

(2011) M. E. Benoit et al.   JOURNAL OF NEUROSCIENCE

Complement in the brain

(2011) Robert Veerhuis et al.   MOLECULAR IMMUNOLOGY

Enhanced synaptic connectivity and epilepsy in C1q knockout mice

(2010) Yunxiang Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crosstalk pathways between Toll-like receptors and the complement system

(2010) George Hajishengallis et al.   TRENDS IN IMMUNOLOGY

Acquisition of chemiluminescent signals from immunoblots with a digital single-lens reflex camera

(2009) Mitri K. Khoury et al.   ANALYTICAL BIOCHEMISTRY

Treatment with a C5aR Antagonist Decreases Pathology and Enhances Behavioral Performance in Murine Models of Alzheimer's Disease

(2009) M. I. Fonseca et al.   JOURNAL OF IMMUNOLOGY

C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production

(2009) Deborah A. Fraser et al.   JOURNAL OF NEUROCHEMISTRY

The role of the anaphylatoxins in health and disease

(2009) Andreas Klos et al.   MOLECULAR IMMUNOLOGY

Complement activation and inhibition: a delicate balance

(2009) A.P. Sjöberg et al.   TRENDS IN IMMUNOLOGY

Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer’s disease

(2008) Jun Zhou et al.   JOURNAL OF NEUROCHEMISTRY

The complement cascade: Yin-Yang in neuroinflammation - neuro-protection and -degeneration

(2008) Jessy John Alexander et al.   JOURNAL OF NEUROCHEMISTRY

Single-neuron labeling with inducible Cre-mediated knockout in transgenic mice

(2008) Paul Young et al.   NATURE NEUROSCIENCE

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cells

(2008) Lionel M. L. Chow et al.   TRANSGENIC RESEARCH