Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes

Progressive multiple sclerosis patients show substantial lesion activity that correlates with clinical disease severity and sex: a retrospective autopsy cohort analysis

(2018) Sabina Luchetti et al.   ACTA NEUROPATHOLOGICA

Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice

(2018) R. Holland et al.   BRAIN BEHAVIOR AND IMMUNITY

A Combination of Ontogeny and CNS Environment Establishes Microglial Identity

(2018) F. Chris Bennett et al.   NEURON

A transcriptomic atlas of aged human microglia

(2018) Marta Olah et al.   Nature Communications

Microglial Phenotypes and Functions in Multiple Sclerosis

(2018) Elaine O’Loughlin et al.   Cold Spring Harbor Perspectives in Medicine

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology

(2017) Debbie A.E. Hendrickx et al.   JOURNAL OF NEUROIMMUNOLOGY

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

(2017) Thais F Galatro et al.   NATURE NEUROSCIENCE

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

(2017) Katharine Askew et al.   Cell Reports

Gene Expression Profiling of Multiple Sclerosis Pathology Identifies Early Patterns of Demyelination Surrounding Chronic Active Lesions

(2017) Debbie A. E. Hendrickx et al.   Frontiers in Immunology

Isolation of primary microglia from the human post-mortem brain: effects of ante- and post-mortem variables

(2017) Mark R. Mizee et al.   Acta Neuropathologica Communications

Fine-tuning of type I IFN-signaling in microglia — implications for homeostasis, CNS autoimmunity and interferonopathies

(2016) Tobias Goldmann et al.   CURRENT OPINION IN NEUROBIOLOGY

Microglial Physiology and Pathophysiology: Insights from Genome-wide Transcriptional Profiling

(2016) Andrea Crotti et al.   IMMUNITY

Cerebrospinal fluid biomarkers as a measure of disease activity and treatment efficacy in relapsing-remitting multiple sclerosis

(2016) Lenka Novakova et al.   JOURNAL OF NEUROCHEMISTRY

Microglial brain region−dependent diversity and selective regional sensitivities to aging

(2016) Kathleen Grabert et al.   NATURE NEUROSCIENCE

Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons

(2016) Suguna Rani Krishnaswami et al.   Nature Protocols

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

The brain parenchyma has a type I interferon response that can limit virus spread

(2016) Eugene Drokhlyansky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Adhesion G Protein-Coupled Receptor GPR56/ADGRG1 Is an Inhibitory Receptor on Human NK Cells

(2016) Gin-Wen Chang et al.   Cell Reports

The contribution of NF-κB signalling to immune regulation and tolerance

(2015) Myrthe A. M. van Delft et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

(2015) Antoine Lampron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Lipoprotein lipase: From gene to atherosclerosis

(2014) Yuan Li et al.   ATHEROSCLEROSIS

DOSE: an R/Bioconductor package for disease ontology semantic and enrichment analysis

(2014) Guangchuang Yu et al.   BIOINFORMATICS

Chitinase 3-Like 1 Suppresses Injury and Promotes Fibroproliferative Responses in Mammalian Lung Fibrosis

(2014) Y. Zhou et al.   Science Translational Medicine

Dynamic regulation of genome-wide pre-mRNA splicing and stress tolerance by the Sm-like protein LSm5 in Arabidopsis

(2014) Peng Cui et al.   GENOME BIOLOGY

Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons

(2013) Shailender Singh et al.   ACTA NEUROPATHOLOGICA

From development to dysfunction: Microglia and the complement cascade in CNS homeostasis

(2013) Matthew K. Zabel et al.   AGEING RESEARCH REVIEWS

Microglia in normal appearing white matter of multiple sclerosis are alerted but immunosuppressed

(2013) Jeroen Melief et al.   GLIA

Interferons in the central nervous system: A few instruments play many tunes

(2013) Trevor Owens et al.   GLIA

Selective Upregulation of Scavenger Receptors in and Around Demyelinating Areas in Multiple Sclerosis

(2013) Debbie A.E. Hendrickx et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology

(2013) Conor Mc Guire et al.   TRENDS IN MOLECULAR MEDICINE

The sva package for removing batch effects and other unwanted variation in high-throughput experiments

(2012) Jeffrey T. Leek et al.   BIOINFORMATICS

Increased iron accumulation occurs in the earliest stages of demyelinating disease: an ultra-high field susceptibility mapping study in Clinically Isolated Syndrome

(2012) Ali M Al-Radaideh et al.   Multiple Sclerosis Journal

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

C3-dependent mechanism of microglial priming relevant to multiple sclerosis

(2012) V. Ramaglia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific expression of GPR56 by human cytotoxic lymphocytes

(2011) Yen-Ming Peng et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Pathogenic implications of iron accumulation in multiple sclerosis

(2011) Rachel Williams et al.   JOURNAL OF NEUROCHEMISTRY

Inflammation, demyelination, and degeneration — Recent insights from MS pathology

(2010) Christine Stadelmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Injury-Induced Type I IFN Signaling Regulates Inflammatory Responses in the Central Nervous System

(2010) R. Khorooshi et al.   JOURNAL OF IMMUNOLOGY

Effects of pioglitazone on diffusion tensor imaging indices in multiple sclerosis patients

(2010) Dinesh K. Shukla et al.   NEUROSCIENCE LETTERS

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis

(2008) David Wheeler et al.   BRAIN