The Dual Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Atherosclerosis

Neutrophils as regulators of cardiovascular inflammation

(2020) Carlos Silvestre-Roig et al.   Nature Reviews Cardiology

Roles of Perivascular adipose tissue in hypertension and atherosclerosis

(2020) Hengjing Hu et al.   ANTIOXIDANTS & REDOX SIGNALING

The Research Progress of Vascular Macrophages and Atherosclerosis

(2020) Yeqing Tong et al.   Oxidative Medicine and Cellular Longevity

sLRP1 (Soluble Low-Density Lipoprotein Receptor-Related Protein 1)

(2020) Jiefang Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Recombinant Tissue Plasminogen Activator (r-tPA) Induces In-Vitro Human Neutrophil Migration via Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1)

(2020) Luca Liberale et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Developing LRP1 Agonists into a Therapeutic Strategy in Acute Myocardial Infarction

(2019) Nicola Potere et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Matrix metalloproteinase-2: Not (just) a “hero” of the past

(2019) Patrick Henriet et al.   BIOCHIMIE

Atherosclerosis

(2019) Peter Libby et al.   Nature Reviews Disease Primers

Single-cell immune landscape of human atherosclerotic plaques

(2019) Dawn M. Fernandez et al.   NATURE MEDICINE

Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-β1 from ECM stores

(2019) Jennifer Schnieder et al.   MATRIX BIOLOGY

Plasminogen Activator Inhibitor-1 Promotes Neutrophil Infiltration and Tissue Injury on Ischemia–ReperfusionHighlights

(2018) Marc Praetner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases CCR7 Expression in Plaque Macrophages

(2018) Paul A. Mueller et al.   CIRCULATION

The Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Lipid Metabolism, Glucose Homeostasis and Inflammation

(2018) Virginia Actis Dato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Membrane-Associated Proteinase 3 on Granulocytes and Acute Myeloid Leukemia Inhibits T Cell Proliferation

(2018) Tian-Hui Yang et al.   JOURNAL OF IMMUNOLOGY

LRP1: A chameleon receptor of lung inflammation and repair

(2018) Lukasz Wujak et al.   MATRIX BIOLOGY

LRP1 expression in colon cancer predicts clinical outcome

(2018) Camille Boulagnon-Rombi et al.   Oncotarget

Soluble LRP1 is an independent biomarker of epicardial fat volume in patients with type 1 diabetes mellitus

(2018) David de Gonzalo-Calvo et al.   Scientific Reports

Impaired Lipoprotein Receptor-Mediated Peripheral Binding of Plasma Amyloid-β is an Early Biomarker for Mild Cognitive Impairment Preceding Alzheimer's Disease

(2018) Abhay P. Sagare et al.   JOURNAL OF ALZHEIMERS DISEASE

T-cell regulation through a basic suppressive mechanism targeting low-density lipoprotein receptor-related protein 1

(2017) Jeneen Panezai et al.   IMMUNOLOGY

Shedding of membrane-associated LDL receptor-related protein-1 from microglia amplifies and sustains neuroinflammation

(2017) Coralie Brifault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ

(2017) Hua Mao et al.   Nature Communications

LRP in Endothelial Cells

(2016) Dudley K. Strickland et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Loss of Macrophage Low-Density Lipoprotein Receptor–Related Protein 1 Confers Resistance to the Antiatherogenic Effects of Tumor Necrosis Factor-α InhibitionHighlights

(2016) Lin Zhu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Vascular Smooth Muscle Cells in Atherosclerosis

(2016) Martin R. Bennett et al.   CIRCULATION RESEARCH

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

(2016) Yoko Kojima et al.   NATURE

Vascular smooth muscle cell in atherosclerosis

(2015) D. A. Chistiakov et al.   Acta Physiologica

LRP1 Regulates Retinal Angiogenesis by Inhibiting PARP-1 Activity and Endothelial Cell ProliferationSignificance

(2015) Hua Mao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Matrix Metalloproteinases Promote Arterial Remodeling in Aging, Hypertension, and Atherosclerosis

(2015) M. Wang et al.   HYPERTENSION

Circulating soluble low-density lipoprotein receptor-related protein 1 (sLRP1) concentration is associated with hypercholesterolemia: A new potential biomarker for atherosclerosis

(2015) D. de Gonzalo-Calvo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Low-density Lipoprotein Receptor-related Proteins in a Novel Mechanism of Axon Guidance and Peripheral Nerve Regeneration

(2015) Lila M. Landowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

K Domain CR9 of Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1) Is Critical for Aggregated LDL-induced Foam Cell Formation from Human Vascular Smooth Muscle Cells

(2015) Paula Costales et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LDL Receptor-Related Protein-1 (LRP1) Regulates Cholesterol Accumulation in Macrophages

(2015) Anna P. Lillis et al.   PLoS One

Low-Density Lipoprotein Receptor–Related Protein-1

(2014) Dudley K. Strickland et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Proinflammatory Phenotype of Perivascular Adipocytes

(2014) Abdullah Omar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via  2 integrins (CD11/CD18)

(2014) L. T. Weckbach et al.   BLOOD

Role of vascular smooth muscle cell in the inflammation of atherosclerosis

(2014) Soyeon Lim et al.   BMB Reports

Cerebrospinal fluid levels of Alzheimer’s disease biomarkers in middle-aged patients with type 1 diabetes

(2014) D. Margriet Ouwens et al.   DIABETOLOGIA

LRP1-dependent pepsin clearance induced by 2′-hydroxycinnamaldehyde attenuates breast cancer cell invasion

(2014) Hye Suk Kang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inverse relationship between raft LRP1 localization and non-raft ERK1,2/MMP9 activation in idiopathic dilated cardiomyopathy: Potential impact in ventricular remodeling

(2014) Santiago Roura et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis

(2014) Yoko Kojima et al.   JOURNAL OF CLINICAL INVESTIGATION

Murine Low-Density Lipoprotein Receptor-Related Protein 1 (LRP) Is Required for Phagocytosis of Targets Bearing LRP Ligands but Is Not Required for C1q-Triggered Enhancement of Phagocytosis

(2014) A. P. Lillis et al.   JOURNAL OF IMMUNOLOGY

LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins

(2014) B. Schorch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LDL Receptor–Related Protein-1

(2013) Steven L. Gonias et al.   AMERICAN JOURNAL OF PATHOLOGY

LRP1 Protects the Vasculature by Regulating Levels of Connective Tissue Growth Factor and HtrA1

(2013) Selen C. Muratoglu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hepatic Remnant Lipoprotein Clearance by Heparan Sulfate Proteoglycans and Low-Density Lipoprotein Receptors Depend on Dietary Conditions in Mice

(2013) Erin M. Foley et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Low density receptor-related protein 1 (LRP1) promotes anti-inflammatory phenotype in murine macrophages

(2013) Petra May et al.   CELL AND TISSUE RESEARCH

A cytokine-controlled mechanism for integrated regulation of T-lymphocyte motility, adhesion and activation

(2013) Sten-Erik Bergström et al.   IMMUNOLOGY

LRP1 Assembles Unique Co-receptor Systems to Initiate Cell Signaling in Response to Tissue-type Plasminogen Activator and Myelin-associated Glycoprotein

(2013) Elisabetta Mantuano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular Heat Shock Protein 90 Signals through Subdomain II and the NPVY Motif of LRP-1 Receptor to Akt1 and Akt2: a Circuit Essential for Promoting Skin Cell Migration In Vitro and Wound Healing In Vivo

(2013) F. Tsen et al.   MOLECULAR AND CELLULAR BIOLOGY

Decreased Expression of Hepatic Low-Density Lipoprotein Receptor–Related Protein 1 in Hypothyroidism: A Novel Mechanism of Atherogenic Dyslipidemia in Hypothyroidism

(2013) Jae Hoon Moon et al.   THYROID

LRP-1: A Checkpoint for the Extracellular Matrix Proteolysis

(2013) Nicolas Etique et al.   Biomed Research International

Aggregated Low-Density Lipoprotein Induces LRP1 Stabilization Through E3 Ubiquitin Ligase CHFR Downregulation in Human Vascular Smooth Muscle Cells

(2012) Roi Cal et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophage LRP1 contributes to the clearance of von Willebrand factor

(2012) G. Rastegarlari et al.   BLOOD

Low-density lipoprotein receptor-related protein 1 mediates hypoxia-induced very low density lipoprotein-cholesteryl ester uptake and accumulation in cardiomyocytes

(2012) Roi Cal et al.   CARDIOVASCULAR RESEARCH

LRP1-Dependent Endocytic Mechanism Governs the Signaling Output of the Bmp System in Endothelial Cells and in Angiogenesis

(2012) Xinchun Pi et al.   CIRCULATION RESEARCH

LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin

(2012) Travis L. Stiles et al.   JOURNAL OF CELL SCIENCE

LRP1 mediates Hedgehog-induced endocytosis of the GPC3-Hedgehog complex

(2012) M. I. Capurro et al.   JOURNAL OF CELL SCIENCE

Low density lipoprotein receptor-related protein 1 expression correlates with cholesteryl ester accumulation in the myocardium of ischemic cardiomyopathy patients

(2012) Roi Cal et al.   Journal of Translational Medicine

Low-density lipoprotein receptor-related protein 1: A physiological Aβ homeostatic mechanism with multiple therapeutic opportunities

(2012) Abhay P. Sagare et al.   PHARMACOLOGY & THERAPEUTICS

TNFα-Induced Apoptosis Enabled by CCN1/CYR61: Pathways of Reactive Oxygen Species Generation and Cytochrome c Release

(2012) Vladislava Juric et al.   PLoS One

Abdominal Aortic Aneurysm Is Associated with a Variant in Low-Density Lipoprotein Receptor-Related Protein 1

(2011) Matthew J. Bown et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Shedding of Low-Density Lipoprotein Receptor–related Protein-1 in Acute Respiratory Distress Syndrome

(2011) Malgorzata Wygrecka et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hypoxia Stimulates Low-Density Lipoprotein Receptor–Related Protein-1 Expression Through Hypoxia-Inducible Factor-1α in Human Vascular Smooth Muscle Cells

(2011) Jose Castellano et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Activation of TRPV1 reduces vascular lipid accumulation and attenuates atherosclerosis

(2011) Liqun Ma et al.   CARDIOVASCULAR RESEARCH

Low-Density Lipoprotein Receptor–Related Protein 1 Prevents Early Atherosclerosis by Limiting Lesional Apoptosis and Inflammatory Ly-6C high Monocytosis

(2011) Patricia G. Yancey et al.   CIRCULATION

Low-density lipoprotein receptor-related protein 1: new functions for an old molecule

(2011) Massimo Franchini et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function

(2011) Charlotte Selvais et al.   FASEB JOURNAL

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Atherosclerosis: current pathogenesis and therapeutic options

(2011) Christian Weber et al.   NATURE MEDICINE

Cathepsin D is partly endocytosed by the LRP1 receptor and inhibits LRP1-regulated intramembrane proteolysis

(2011) D Derocq et al.   ONCOGENE

Macrophage LRP1 Suppresses Neo-Intima Formation during Vascular Remodeling by Modulating the TGF-β Signaling Pathway

(2011) Selen Catania Muratoglu et al.   PLoS One

Neutrophils and clinical outcomes in patients with acute coronary syndromes and/or cardiac revascularisation

(2011) Luigina Guasti et al.   THROMBOSIS AND HAEMOSTASIS

Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System

(2011) Qiang Liu et al.   PLOS BIOLOGY

Macrophage LRP-1 Controls Plaque Cellularity by Regulating Efferocytosis and Akt Activation

(2010) Patricia G. Yancey et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Perivascular adipose tissue as a cause of atherosclerosis

(2010) Sandra N. Verhagen et al.   ATHEROSCLEROSIS

Signaling through LRP1: Protection from atherosclerosis and beyond

(2010) Philippe Boucher et al.   BIOCHEMICAL PHARMACOLOGY

Hyperlipidemia-Triggered Neutrophilia Promotes Early Atherosclerosis

(2010) Maik Drechsler et al.   CIRCULATION

The role of low-density receptor-related protein 1 (LRP1) as a competitive substrate of the amyloid precursor protein (APP) for BACE1

(2010) Bjoern von Einem et al.   EXPERIMENTAL NEUROLOGY

Low Density Lipoprotein Receptor-related Protein-1 (LRP1) Regulates Thrombospondin-2 (TSP2) Enhancement of Notch3 Signaling

(2010) He Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Forms a Signaling Complex with Platelet-derived Growth Factor Receptor-β in Endosomes and Regulates Activation of the MAPK Pathway

(2010) Selen Catania Muratoglu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages

(2010) Matvey Gorovoy et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β-peptide elimination from the brain

(2010) Berislav V. Zlokovic et al.   JOURNAL OF NEUROCHEMISTRY

Matrix-Metalloproteinases as Imaging Targets for Inflammatory Activity in Atherosclerotic Plaques

(2010) M. Schafers et al.   JOURNAL OF NUCLEAR MEDICINE

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Inactivation of the LRP1 Intracellular NPxYxxL Motif in LDLR-Deficient Mice Enhances Postprandial Dyslipidemia and Atherosclerosis

(2009) Philip L.S.M. Gordts et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Smooth Muscle LDL Receptor-Related Protein-1 Inactivation Reduces Vascular Reactivity and Promotes Injury-Induced Neointima Formation

(2009) Joshua E. Basford et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Metalloproteinase-Dependent Shedding of Low-Density Lipoprotein Receptor-Related Protein-1 Ectodomain Decreases Endocytic Clearance of Endometrial Matrix Metalloproteinase-2 and -9 at Menstruation

(2009) Charlotte Selvais et al.   ENDOCRINOLOGY

Low Density Lipoprotein Receptor-related Protein 1 Promotes Anti-apoptotic Signaling in Neurons by Activating Akt Survival Pathway

(2009) Rodrigo A. Fuentealba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis

(2009) A. Gaultier et al.   JOURNAL OF CELL SCIENCE

Proteomic Analysis of Src Family Kinases Signaling Complexes in Golgi/Endosomal Fractions Using a Site-Selective Anti-Phosphotyrosine Antibody: Identification of LRP1-Insulin Receptor Complexes

(2009) Nicolas Bilodeau et al.   JOURNAL OF PROTEOME RESEARCH

LRP1 shedding in human brain: roles of ADAM10 and ADAM17

(2009) Qiang Liu et al.   Molecular Neurodegeneration

LRP1 Controls cPLA2 Phosphorylation, ABCA1 Expression and Cellular Cholesterol Export

(2009) Li Zhou et al.   PLoS One

LRP1 Regulates Architecture of the Vascular Wall by Controlling PDGFRβ-Dependent Phosphatidylinositol 3-Kinase Activation

(2009) Li Zhou et al.   PLoS One

LRP1 Receptor Controls Adipogenesis and Is Up-Regulated In Human and Mouse Obese Adipose Tissue

(2009) Olivier Masson et al.   PLoS One

Metalloproteinase Expression in Monocytes and Macrophages and its Relationship to Atherosclerotic Plaque Instability

(2008) Andrew C. Newby   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of tumor necrosis factor receptor-1 and the IKK-NF- B pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor

(2008) A. Gaultier et al.   BLOOD

Contribution of Macromolecular Structure to the Retention of Low-Density Lipoprotein at Arterial Branch Points

(2008) Gina P. Kwon et al.   CIRCULATION

Cellular uptake of C4b-binding protein is mediated by heparan sulfate proteoglycans and CD91/LDL receptor-related protein

(2008) Patricia P. Spijkers et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

LRP1 Controls Intracellular Cholesterol Storage and Fatty Acid Synthesis through Modulation of Wnt Signaling

(2008) Jérome Terrand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

(2008) Anna P. Lillis et al.   PHYSIOLOGICAL REVIEWS

 -Secretase Limits the Inflammatory Response Through the Processing of LRP1

(2008) K. Zurhove et al.   Science Signaling

Heart Disease and Stroke Statistics—2008 Update

(2007) et al.   CIRCULATION