LRP-1: A Checkpoint for the Extracellular Matrix Proteolysis

A crucial role for Lyn in TIMP-1 erythroid cell survival signalling pathway

(2013) Lucie Bridoux et al.   FEBS LETTERS

Who decides when to cleave an ectodomain?

(2013) Monika Hartmann et al.   TRENDS IN BIOCHEMICAL SCIENCES

LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage

(2012) Kazuhiro Yamamoto et al.   FASEB JOURNAL

Differential Regulation of Extracellular Tissue Inhibitor of Metalloproteinases-3 Levels by Cell Membrane-bound and Shed Low Density Lipoprotein Receptor-related Protein 1

(2012) Simone D. Scilabra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Surface Remodeling by Plasmin: A New Function for an Old Enzyme

(2012) Elena I. Deryugina et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

LRP-1-CD44, a New Cell Surface Complex Regulating Tumor Cell Adhesion

(2012) G. Perrot et al.   MOLECULAR AND CELLULAR BIOLOGY

Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model

(2012) Yifeng Xia et al.   NATURE CELL BIOLOGY

Shedding of Low-Density Lipoprotein Receptor–related Protein-1 in Acute Respiratory Distress Syndrome

(2011) Malgorzata Wygrecka et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Matrix metalloproteinases in tumorigenesis: an evolving paradigm

(2011) Hui Hua et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function

(2011) Charlotte Selvais et al.   FASEB JOURNAL

Cathepsin D is partly endocytosed by the LRP1 receptor and inhibits LRP1-regulated intramembrane proteolysis

(2011) D Derocq et al.   ONCOGENE

Tissue inhibitors of metalloproteinases

(2011) Gillian Murphy   GENOME BIOLOGY

The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity

(2010) Keith Brew et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis

(2010) Uri Barash et al.   FEBS Journal

Pro-cathepsin D interacts with the extracellular domain of the   chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth

(2010) M. Beaujouin et al.   JOURNAL OF CELL SCIENCE

Activated α2 macroglobulin induces matrix metalloproteinase 9 expression by low-density lipoprotein receptor-related protein 1 through MAPK-ERK1/2 and NF-κB activation in macrophage-derived cell lines

(2010) Leandro C. Cáceres et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

LRP-1 Promotes Cancer Cell Invasion by Supporting ERK and Inhibiting JNK Signaling Pathways

(2010) Benoit Langlois et al.   PLoS One

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion

(2010) Dimitra Bourboulia et al.   SEMINARS IN CANCER BIOLOGY

Low-Density Lipoprotein Receptor-Related Protein 1 Promotes Cancer Cell Migration and Invasion by Inducing the Expression of Matrix Metalloproteinases 2 and 9

(2009) H. Song et al.   CANCER RESEARCH

The Serine Protease Inhibitor Protease Nexin-1 Controls Mammary Cancer Metastasis through LRP-1-Mediated MMP-9 Expression

(2009) B. Fayard et al.   CANCER RESEARCH

Metalloproteinase-Dependent Shedding of Low-Density Lipoprotein Receptor-Related Protein-1 Ectodomain Decreases Endocytic Clearance of Endometrial Matrix Metalloproteinase-2 and -9 at Menstruation

(2009) Charlotte Selvais et al.   ENDOCRINOLOGY

LRP1 shedding in human brain: roles of ADAM10 and ADAM17

(2009) Qiang Liu et al.   Molecular Neurodegeneration

Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein induce Akt phosphorylation in the ischemic brain

(2008) J. An et al.   BLOOD

Activation of Matrix Metalloproteinase-2 (MMP-2) by Membrane Type 1 Matrix Metalloproteinase through an Artificial Receptor for ProMMP-2 Generates Active MMP-2

(2008) Yuki Nishida et al.   CANCER RESEARCH

Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases

(2008) Linda Troeberg et al.   FASEB JOURNAL

TIMP-1 binding to proMMP-9/CD44 complex localized at the cell surface promotes erythroid cell survival

(2008) Elise Lambert et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

LRP-1 Silencing Prevents Malignant Cell Invasion despite Increased Pericellular Proteolytic Activities

(2008) S. Dedieu et al.   MOLECULAR AND CELLULAR BIOLOGY

Progress in matrix metalloproteinase research

(2008) G MURPHY et al.   MOLECULAR ASPECTS OF MEDICINE

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

(2008) Anna P. Lillis et al.   PHYSIOLOGICAL REVIEWS

Tissue Inhibitors of Metalloproteinases in Cell Signaling: Metalloproteinase-Independent Biological Activities

(2008) W. G. Stetler-Stevenson   Science Signaling