Shedding of membrane-associated LDL receptor-related protein-1 from microglia amplifies and sustains neuroinflammation

Ionotropic glutamate receptors activate cell signaling in response to glutamate in Schwann cells

(2017) Wendy M. Campana et al.   FASEB JOURNAL

Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis

(2017) Kazuhiro Yamamoto et al.   Arthritis & Rheumatology

LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways

(2016) Longyu Yang et al.   Journal of Neuroinflammation

Evidence that LDL receptor-related protein 1 acts as an early injury detection receptor and activates c-Jun in Schwann cells

(2016) Andreas Flütsch et al.   NEUROREPORT

LDL receptor-related protein-1 regulates NFκB and microRNA-155 in macrophages to control the inflammatory response

(2016) Elisabetta Mantuano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRP1 expression in microglia is protective during CNS autoimmunity

(2016) Tzu-Ying Chuang et al.   Acta Neuropathologica Communications

Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model

(2015) Edel Kavanagh et al.   Aging-US

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Innate Immunity Fights Alzheimer's Disease

(2015) Marie-Victoire Guillot-Sestier et al.   TRENDS IN NEUROSCIENCES

The Matricellular Receptor LRP1 Forms an Interface for Signaling and Endocytosis in Modulation of the Extracellular Tumor Environment

(2015) Bart Van Gool et al.   Frontiers in Pharmacology

Murine Low-Density Lipoprotein Receptor-Related Protein 1 (LRP) Is Required for Phagocytosis of Targets Bearing LRP Ligands but Is Not Required for C1q-Triggered Enhancement of Phagocytosis

(2014) A. P. Lillis et al.   JOURNAL OF IMMUNOLOGY

LDL Receptor–Related Protein-1

(2013) Steven L. Gonias et al.   AMERICAN JOURNAL OF PATHOLOGY

Lipopolysaccharide downregulates CD91/low-density lipoprotein receptor-related protein 1 expression through SREBP-1 overexpression in human macrophages

(2013) P. Costales et al.   ATHEROSCLEROSIS

Myeloid Cell Receptor LRP1/CD91 Regulates Monocyte Recruitment and Angiogenesis in Tumors

(2013) Nicole D. Staudt et al.   CANCER RESEARCH

Low density receptor-related protein 1 (LRP1) promotes anti-inflammatory phenotype in murine macrophages

(2013) Petra May et al.   CELL AND TISSUE RESEARCH

LRP1 Assembles Unique Co-receptor Systems to Initiate Cell Signaling in Response to Tissue-type Plasminogen Activator and Myelin-associated Glycoprotein

(2013) Elisabetta Mantuano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Upregulation of Scavenger Receptors in and Around Demyelinating Areas in Multiple Sclerosis

(2013) Debbie A.E. Hendrickx et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Identification of the Low Density Lipoprotein (LDL) Receptor-related Protein-1 Interactome in Central Nervous System Myelin Suggests a Role in the Clearance of Necrotic Cell Debris

(2012) Anthony Fernandez-Castaneda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Regulation of Extracellular Tissue Inhibitor of Metalloproteinases-3 Levels by Cell Membrane-bound and Shed Low Density Lipoprotein Receptor-related Protein 1

(2012) Simone D. Scilabra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Primary phagocytosis of viable neurons by microglia activated with LPS or Aβ is dependent on calreticulin/LRP phagocytic signalling

(2012) Michael Fricker et al.   Journal of Neuroinflammation

Shedding of Low-Density Lipoprotein Receptor–related Protein-1 in Acute Respiratory Distress Syndrome

(2011) Malgorzata Wygrecka et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Immune responses of microglia in the spinal cord: Contribution to pain states

(2011) Dominic Schomberg et al.   EXPERIMENTAL NEUROLOGY

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

CD91-dependent programming of T-helper cell responses following heat shock protein immunization

(2011) Sudesh Pawaria et al.   Nature Communications

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Direct interaction between CD91 and C1q

(2010) Karen Duus et al.   FEBS Journal

Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages

(2010) Matvey Gorovoy et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines

(2010) Paul J. Austin et al.   JOURNAL OF NEUROIMMUNOLOGY

Microglial low-density lipoprotein receptor-related protein 1 modulates c-Jun N-terminal kinase activation

(2009) Ana Pocivavsek et al.   JOURNAL OF NEUROIMMUNOLOGY

LRP1 shedding in human brain: roles of ADAM10 and ADAM17

(2009) Qiang Liu et al.   Molecular Neurodegeneration

Ligand Binding to LRP1 Transactivates Trk Receptors by a Src Family Kinase-Dependent Pathway

(2009) Y. Shi et al.   Science Signaling

Regulation of tumor necrosis factor receptor-1 and the IKK-NF- B pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor

(2008) A. Gaultier et al.   BLOOD

Low-density lipoprotein receptors regulate microglial inflammation through c-Jun N-terminal kinase

(2008) Ana Pocivavsek et al.   GLIA

A shed form of LDL receptor–related protein–1 regulates peripheral nerve injury and neuropathic pain in rodents

(2008) Alban Gaultier et al.   JOURNAL OF CLINICAL INVESTIGATION

 -Secretase Limits the Inflammatory Response Through the Processing of LRP1

(2008) K. Zurhove et al.   Science Signaling