Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

Genes and molecular pathways underpinning ciliopathies

(2017) Jeremy F. Reiter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK -Deficient Mice

(2017) Emilie Giaime et al.   NEURON

The Cilium: Cellular Antenna and Central Processing Unit

(2017) Jarema J. Malicki et al.   TRENDS IN CELL BIOLOGY

Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells

(2017) Kenneth Thirstrup et al.   Scientific Reports

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

(2016) G. Ito et al.   BIOCHEMICAL JOURNAL

Cellular functions of LRRK2 implicate vesicular trafficking pathways in Parkinson's disease

(2016) M. R. Cookson   BIOCHEMICAL SOCIETY TRANSACTIONS

Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion

(2016) Kai Liu et al.   JOURNAL OF CELL BIOLOGY

Rabs, Membrane Dynamics, and Parkinson's Disease

(2016) Bor Luen Tang   JOURNAL OF CELLULAR PHYSIOLOGY

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for posttranslational modifications by host and pathogen

(2016) Rebecca S. Levin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport

(2016) Victor L. Jensen et al.   PLoS Genetics

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

(2016) Martin Steger et al.   eLife

LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts

(2016) Tomoki Kuwahara et al.   Scientific Reports

The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis

(2015) A Onnis et al.   CELL DEATH AND DIFFERENTIATION

Genes associated with Parkinson's disease: regulation of autophagy and beyond

(2015) Alexandra Beilina et al.   JOURNAL OF NEUROCHEMISTRY

Systems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation

(2015) S. Satpathy et al.   Molecular Systems Biology

Mutations in RAB39B Cause X-Linked Intellectual Disability and Early-Onset Parkinson Disease with α-Synuclein Pathology

(2014) Gabrielle R. Wilson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy

(2014) J. Schapansky et al.   HUMAN MOLECULAR GENETICS

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

ProteomeXchange provides globally coordinated proteomics data submission and dissemination

(2014) Juan A Vizcaíno et al.   NATURE BIOTECHNOLOGY

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells

(2014) Nils A Kulak et al.   NATURE METHODS

LRRK2 Transport Is Regulated by Its Novel Interacting Partner Rab32

(2014) Dieter Waschbüsch et al.   PLoS One

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

(2014) A. Beilina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rab Proteins and the Compartmentalization of the Endosomal System

(2014) A. Wandinger-Ness et al.   Cold Spring Harbor Perspectives in Biology

Mutations in RAB28, Encoding a Farnesylated Small GTPase, Are Associated with Autosomal-Recessive Cone-Rod Dystrophy

(2013) Susanne Roosing et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis

(2013) T. Sato et al.   JOURNAL OF CELL SCIENCE

Expression Analysis of Lrrk1, Lrrk2 and Lrrk2 Splice Variants in Mice

(2013) Florian Giesert et al.   PLoS One

Loss of Leucine-Rich Repeat Kinase 2 (LRRK2) in Rats Leads to Progressive Abnormal Phenotypes in Peripheral Organs

(2013) Marco A. S. Baptista et al.   PLoS One

Reversible phosphocholination of Rab proteins byLegionella pneumophilaeffector proteins

(2012) Philip R Goody et al.   EMBO JOURNAL

The Rab Interacting Lysosomal Protein (RILP) Homology Domain Functions as a Novel Effector Domain for Small GTPase Rab36

(2012) Takahide Matsui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Rilp-like proteins Rilpl1 and Rilpl2 regulate ciliary membrane content

(2012) Johanna R. Schaub et al.   MOLECULAR BIOLOGY OF THE CELL

The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling

(2012) Nicolas Dzamko et al.   PLoS One

Posttranslational modifications of Rab proteins cause effective displacement of GDP dissociation inhibitor

(2012) L. K. Oesterlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations

(2012) Z. Sheng et al.   Science Translational Medicine

Brain Penetrant LRRK2 Inhibitor

(2012) Hwan Geun Choi et al.   ACS Medicinal Chemistry Letters

A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1

(2011) Xiaomin Hou et al.   EMBO JOURNAL

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Modulation of Rab GTPase function by a protein phosphocholine transferase

(2011) Shaeri Mukherjee et al.   NATURE

Genetic characteristics of leucine-rich repeat kinase 2 (LRRK2) associated Parkinson’s disease

(2011) Soraya Bardien et al.   PARKINSONISM & RELATED DISORDERS

Regulation of LRRK2 Expression Points to a Functional Role in Human Monocyte Maturation

(2011) Jonathan Thévenet et al.   PLoS One

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

(2010) R. Jeremy Nichols et al.   BIOCHEMICAL JOURNAL

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

(2010) Brendan MacLean et al.   BIOINFORMATICS

Differential role of Rab proteins in ciliary trafficking: Rab23 regulates Smoothened levels

(2010) C. Boehlke et al.   JOURNAL OF CELL SCIENCE

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

(2010) Mark R. Cookson   NATURE REVIEWS NEUROSCIENCE

Coordination of Rab8 and Rab11 in primary ciliogenesis

(2010) A. Knodler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Legionella Effector Protein DrrA AMPylates the Membrane Traffic Regulator Rab1b

(2010) M. P. Muller et al.   SCIENCE

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY