The Vps35 D620N Mutation Linked to Parkinson's Disease Disrupts the Cargo Sorting Function of Retromer

A global analysis of SNX27–retromer assembly and cargo specificity reveals a function in glucose and metal ion transport

(2013) Florian Steinberg et al.   NATURE CELL BIOLOGY

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

(2012) Nicole Exner et al.   EMBO JOURNAL

The retromer complex - endosomal protein recycling and beyond

(2012) M. N. J. Seaman   JOURNAL OF CELL SCIENCE

A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants

(2012) Manu Sharma et al.   JOURNAL OF MEDICAL GENETICS

Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks

(2012) Timothy S. Gomez et al.   MOLECULAR BIOLOGY OF THE CELL

VPS35mutation in Japanese patients with typical Parkinson's disease

(2012) Maya Ando et al.   MOVEMENT DISORDERS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Identification of VPS35 mutations replicated in French families with Parkinson disease

(2012) S. Lesage et al.   NEUROLOGY

Vacuolar protein sorting 35 Asp620Asn mutation is rare in the ethnic Chinese population with Parkinson's disease

(2012) Yu Zhang et al.   PARKINSONISM & RELATED DISORDERS

Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in thetrans-Golgi network

(2012) Regina Wai-Yan Choy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease

(2011) Alexander Zimprich et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Recruitment of the endosomal WASH complex is mediated by the extended ‘tail’ of Fam21 binding to the retromer protein Vps35

(2011) Michael E. Harbour et al.   BIOCHEMICAL JOURNAL

The Arp2/3 activator WASH regulates  5 1-integrin-mediated invasive migration

(2011) T. Zech et al.   JOURNAL OF CELL SCIENCE

Vps26A and Vps26B Subunits Define Distinct Retromer Complexes

(2011) Andrea Bugarcic et al.   TRAFFIC

Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella

(2010) Markus C Kerr et al.   EMBO JOURNAL

Genetic Animal Models of Parkinson's Disease

(2010) Ted M. Dawson et al.   NEURON

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

(2010) D. Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and thermodynamic analysis of the GFP:GFP-nanobody complex

(2010) Marta H. Kubala et al.   PROTEIN SCIENCE

Assembly and Solution Structure of the Core Retromer Protein Complex

(2010) Suzanne J. Norwood et al.   TRAFFIC

The Arp2/3 Activator WASH Controls the Fission of Endosomes through a Large Multiprotein Complex

(2009) Emmanuel Derivery et al.   DEVELOPMENTAL CELL

A FAM21-Containing WASH Complex Regulates Retromer-Dependent Sorting

(2009) Timothy S. Gomez et al.   DEVELOPMENTAL CELL

Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5

(2009) M. N. J. Seaman et al.   JOURNAL OF CELL SCIENCE

Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo

(2009) Valerie Cullen et al.   Molecular Brain

Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of α-Synuclein and Generation of Its Carboxy-Terminally Truncated Species†

(2008) Daniel Sevlever et al.   BIOCHEMISTRY

Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7

(2008) Raul Rojas et al.   JOURNAL OF CELL BIOLOGY

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

(2008) Liyan Qiao et al.   Molecular Brain