The proline-rich domain promotes Tau liquid–liquid phase separation in cells

Electrostatically Driven Complex Coacervation and Amyloid Aggregation of Tau Are Independent Processes with Overlapping Conditions

(2020) Yanxian Lin et al.   ACS Chemical Neuroscience

Composition-dependent thermodynamics of intracellular phase separation

(2020) Joshua A. Riback et al.   NATURE

RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43

(2019) Jacob R. Mann et al.   NEURON

Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death

(2019) Fatima Gasset-Rosa et al.   NEURON

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions

(2019) Yanxian Lin et al.   eLife

Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly

(2019) Xinrui Gui et al.   Nature Communications

Microtubules gate tau condensation to spatially regulate microtubule functions

(2019) Ruensern Tan et al.   NATURE CELL BIOLOGY

Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes

(2019) Valerie Siahaan et al.   NATURE CELL BIOLOGY

Independent tubulin binding and polymerization by the proline-rich region of Tau is regulated by Tau's N-terminal domain

(2019) Kristen M. McKibben et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Probing and engineering liquid-phase organelles

(2019) Dan Bracha et al.   NATURE BIOTECHNOLOGY

RNA buffers the phase separation behavior of prion-like RNA binding proteins

(2018) Shovamayee Maharana et al.   SCIENCE

Near-atomic model of microtubule-tau interactions

(2018) Elizabeth H. Kellogg et al.   SCIENCE

Spatial positioning of EB family proteins at microtubule tips involves distinct nucleotide-dependent binding properties

(2018) Daniel Roth et al.   JOURNAL OF CELL SCIENCE

Cofactors are essential constituents of stable and seeding-active tau fibrils

(2018) Yann Fichou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

(2017) Susmitha Ambadipudi et al.   Nature Communications

Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase

(2017) Amayra Hernández-Vega et al.   Cell Reports

RNA stores tau reversibly in complex coacervates

(2017) Xuemei Zhang et al.   PLOS BIOLOGY

Tau antagonizes end-binding protein tracking at microtubule ends through a phosphorylation-dependent mechanism

(2016) Sacnicte Ramirez-Rios et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins

(2015) Rui Zhang et al.   CELL

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

(2015) Yuan Lin et al.   MOLECULAR CELL

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

Polymer physics of intracellular phase transitions

(2015) Clifford P. Brangwynne et al.   Nature Physics

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics

(2015) Shana Elbaum-Garfinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical effects of EB1 on microtubules depend on GTP hydrolysis state and presence of paclitaxel

(2014) Benjamin J. Lopez et al.   Cytoskeleton

Reversible protein inactivation by optogenetic trapping in cells

(2014) Sangkyu Lee et al.   NATURE METHODS

An optimized optogenetic clustering tool for probing protein interaction and function

(2014) Amir Taslimi et al.   Nature Communications

Optogenetic protein clustering and signaling activation in mammalian cells

(2013) Lukasz J Bugaj et al.   NATURE METHODS

Tau protein kinases: Involvement in Alzheimer's disease

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Plus-End-Tracking Proteins and Their Interactions at Microtubule Ends

(2010) Niels Galjart   CURRENT BIOLOGY

Microtubule +TIPs at a glance

(2010) A. Akhmanova et al.   JOURNAL OF CELL SCIENCE

Field-theoretic simulations in the Gibbs ensemble

(2010) Robert A. Riggleman et al.   JOURNAL OF CHEMICAL PHYSICS

An EB1-Binding Motif Acts as a Microtubule Tip Localization Signal

(2009) Srinivas Honnappa et al.   CELL

Effect of GFP tags on the localization of EB1 and EB1 fragments in vivo

(2009) Susan B. Skube et al.   Cytoskeleton

Mammalian end binding proteins control persistent microtubule growth

(2009) Yulia Komarova et al.   JOURNAL OF CELL BIOLOGY

CLIP-170 tracks growing microtubule ends by dynamically recognizing composite EB1/tubulin-binding sites

(2008) Peter Bieling et al.   JOURNAL OF CELL BIOLOGY

EB1 regulates microtubule dynamics and tubulin sheet closure in vitro

(2008) Benjamin Vitre et al.   NATURE CELL BIOLOGY