Development of Efficient AAV2/DJ-Based Viral Vectors to Selectively Downregulate the Expression of Neuronal or Astrocytic Target Proteins in the Rat Central Nervous System

Severe Toxicity in Nonhuman Primates and Piglets Following High-Dose Intravenous Administration of an Adeno-Associated Virus Vector Expressing Human SMN

(2018) Christian Hinderer et al.   HUMAN GENE THERAPY

Neuronal Cell Death

(2018) Michael Fricker et al.   PHYSIOLOGICAL REVIEWS

Adeno-Associated Viral Vector Serotype DJ-Mediated Overexpression of N171-82Q-Mutant Huntingtin in the Striatum of Juvenile Mice Is a New Model for Huntington’s Disease

(2018) Minhee Jang et al.   Frontiers in Cellular Neuroscience

Emerging Issues in AAV-Mediated In Vivo Gene Therapy

(2018) Pasqualina Colella et al.   Molecular Therapy-Methods & Clinical Development

Neuroprotective effect of rLosac on supplement-deprived mouse cultured cortical neurons involves maintenance of monocarboxylate transporter MCT2 protein levels

(2018) Miryam P. Alvarez-Flores et al.   JOURNAL OF NEUROCHEMISTRY

Three-dimensional Ca2+imaging advances understanding of astrocyte biology

(2017) Erika Bindocci et al.   SCIENCE

The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes

(2017) Nicolas Merienne et al.   Cell Reports

A neuronal MCT2 knockdown in the rat somatosensory cortex reduces both the NMR lactate signal and the BOLD response during whisker stimulation

(2017) Leslie Mazuel et al.   PLoS One

Astrocytes are key but indirect contributors to the development of the symptomatology and pathophysiology of Huntington's disease

(2016) Cécile Meunier et al.   GLIA

Metabolic and Inflammatory Adaptation of Reactive Astrocytes: Role of PPARs

(2016) José Iglesias et al.   MOLECULAR NEUROBIOLOGY

Cell-specific modulation of monocarboxylate transporter expression contributes to the metabolic reprograming taking place following cerebral ischemia

(2016) K. Rosafio et al.   NEUROSCIENCE

Recombinant Adeno-Associated Virus Serotype 6 (rAAV6) Potently and Preferentially Transduces Rat Astrocytes In vitro and In vivo

(2016) Alexandra L. Schober et al.   Frontiers in Cellular Neuroscience

Microglia-specific targeting by novel capsid-modified AAV6 vectors

(2016) Awilda M Rosario et al.   Molecular Therapy-Methods & Clinical Development

Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis

(2015) Lawrence R. Gray et al.   Cell Metabolism

Adeno-associated viral serotypes produce differing titers and differentially transduce neurons within the rat basal and lateral amygdala

(2014) Roopashri Holehonnur et al.   BMC NEUROSCIENCE

Biosafety of Recombinant Adeno-associated Virus Vectors

(2014) David Dismuke et al.   CURRENT GENE THERAPY

Astrogliosis

(2014) Michael V. Sofroniew   Cold Spring Harbor Perspectives in Biology

Oxygen tension controls the expression of the monocarboxylate transporter MCT4 in cultured mouse cortical astrocytes via a hypoxia-inducible factor-1α-mediated transcriptional regulation

(2013) Katia Rosafio et al.   GLIA

The SLC16 gene family – Structure, role and regulation in health and disease

(2013) Andrew P. Halestrap   MOLECULAR ASPECTS OF MEDICINE

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

(2013) Tobias Goldmann et al.   NATURE NEUROSCIENCE

Glial Promoter Selectivity following AAV-Delivery to the Immature Brain

(2013) Georg von Jonquieres et al.   PLoS One

Analysis of Transduction Efficiency, Tropism and Axonal Transport of AAV Serotypes 1, 2, 5, 6, 8 and 9 in the Mouse Brain

(2013) Dominik F. Aschauer et al.   PLoS One

A survey of ex vivo/in vitro transduction efficiency of mammalian primary cells and cell lines with Nine natural adeno-associated virus (AAV1-9) and one engineered adeno-associated virus serotype

(2013) Brian L Ellis et al.   Virology Journal

An Optimized microRNA Backbone for Effective Single-Copy RNAi

(2013) Christof Fellmann et al.   Cell Reports

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Nitric oxide induces the expression of the monocarboxylate transporter MCT4 in cultured astrocytes by a cGMP-independent transcriptional activation

(2011) Fabrice Marcillac et al.   GLIA

Optimizing Promoters for Recombinant Adeno-Associated Virus-Mediated Gene Expression in the Peripheral and Central Nervous System Using Self-Complementary Vectors

(2011) Steven J. Gray et al.   HUMAN GENE THERAPY

Sweet Sixteen for ANLS

(2011) Luc Pellerin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

siRNA vs. shRNA: Similarities and differences

(2009) Donald D. Rao et al.   ADVANCED DRUG DELIVERY REVIEWS

Worldwide Epidemiology of Neutralizing Antibodies to Adeno‐Associated Viruses

(2009) Roberto Calcedo et al.   JOURNAL OF INFECTIOUS DISEASES

Gene Therapy Using Adeno-Associated Virus Vectors

(2008) S. Daya et al.   CLINICAL MICROBIOLOGY REVIEWS

GFAPpromoter elements required for region-specific and astrocyte-specific expression

(2008) Youngjin Lee et al.   GLIA

Basal and stimulated lactate fluxes in primary cultures of astrocytes are differentially controlled by distinct proteins

(2008) Fumihiko Maekawa et al.   JOURNAL OF NEUROCHEMISTRY

In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated Viruses

(2008) D. Grimm et al.   JOURNAL OF VIROLOGY

Artificial MicroRNAs as siRNA Shuttles: Improved Safety as Compared to shRNAs In vitro and In vivo

(2008) Ryan L Boudreau et al.   MOLECULAR THERAPY

Tropism and toxicity of adeno-associated viral vector serotypes 1, 2, 5, 6, 7, 8, and 9 in rat neurons and glia in vitro

(2007) Douglas B. Howard et al.   VIROLOGY