Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy

Pro-survival autophagy and cancer cell resistance to therapy

(2018) Chandan Kanta Das et al.   CANCER AND METASTASIS REVIEWS

Metformin suppresses retinal angiogenesis and inflammation in vitro and in vivo

(2018) Jing Han et al.   PLoS One

Challenges and perspectives in the treatment of diabetes associated breast cancer

(2018) Samson Mathews Samuel et al.   CANCER TREATMENT REVIEWS

Metformin inhibits ALK1-mediated angiogenesis via activation of AMPK

(2017) Ying Ying et al.   Oncotarget

Angiogenesis revisited from a metabolic perspective: role and therapeutic implications of endothelial cell metabolism

(2017) Nihed Draoui et al.   Open Biology

Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium

(2016) C. R. Triggle et al.   Acta Physiologica

Metformin as an adjuvant treatment for cancer: a systematic review and meta-analysis

(2016) C. Coyle et al.   ANNALS OF ONCOLOGY

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

(2016) Anna Rita Cantelmo et al.   CANCER CELL

Metformin improves the angiogenic functions of endothelial progenitor cells via activating AMPK/eNOS pathway in diabetic mice

(2016) Jia-Wen Yu et al.   Cardiovascular Diabetology

Cation-selective transporters are critical to the AMPK-mediated antiproliferative effects of metformin in human breast cancer cells

(2016) Hao Cai et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor angiogenesis—characteristics of tumor endothelial cells

(2016) Kyoko Hida et al.   International Journal of Clinical Oncology

Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan

(2016) Nako Maishi et al.   Scientific Reports

Metformin improves endothelial function in aortic tissue and microvascular endothelial cells subjected to diabetic hyperglycaemic conditions

(2015) Suparna Ghosh et al.   BIOCHEMICAL PHARMACOLOGY

Endothelial Cell Metabolism in Normal and Diseased Vasculature

(2015) Guy Eelen et al.   CIRCULATION RESEARCH

Glycolytic inhibitor 2-deoxyglucose simultaneously targets cancer and endothelial cells to suppress neuroblastoma growth in mice

(2015) Chao-Cheng Huang et al.   Disease Models & Mechanisms

Steady-state pharmacokinetics of metformin is independent of the OCT1 genotype in healthy volunteers

(2015) Mette Marie Hougaard Christensen et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium

(2015) Mustafa Kinaan et al.   MEDICAL PRINCIPLES AND PRACTICE

Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer

(2015) Lacey M. Litchfield et al.   Oncotarget

Suppression of tumor angiogenesis by metformin treatment via a mechanism linked to targeting of HER2/HIF-1α/VEGF secretion axis

(2015) Jichang Wang et al.   Oncotarget

Metabolic Targeting of Lactate Efflux by Malignant Glioma Inhibits Invasiveness and Induces Necrosis: An In Vivo Study

(2015) Chaim B Colen et al.   NEOPLASIA

Efficacy of Tie2 Receptor Antagonism in Angiosarcoma

(2015) Jason R. Hasenstein et al.   NEOPLASIA

2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy

(2014) Dongsheng Zhang et al.   CANCER LETTERS

Paradoxic effects of metformin on endothelial cells and angiogenesis

(2014) Katiuscia Dallaglio et al.   CARCINOGENESIS

Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease

(2014) J. Goveia et al.   EMBO Molecular Medicine

The AMPK Inhibitor Compound C Is a Potent AMPK-Independent Antiglioma Agent

(2014) X. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Thrombospondin-1 modulates VEGF signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in microvascular endothelial cells

(2013) L.-Y. Chu et al.   BLOOD

Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1

(2013) Gnanapragasam Arunachalam et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glucose promotes breast cancer aggression and reduces metformin efficacy

(2013) Reema Wahdan-Alaswad et al.   CELL CYCLE

Partial and Transient Reduction of Glycolysis by PFKFB3 Blockade Reduces Pathological Angiogenesis

(2013) Sandra Schoors et al.   Cell Metabolism

Pharmacogenetic Variation and Metformin Response

(2013) Suning Chen et al.   CURRENT DRUG METABOLISM

Endothelial cell metabolism and tumour angiogenesis: glucose and glutamine as essential fuels and lactate as the driving force

(2013) F. Polet et al.   JOURNAL OF INTERNAL MEDICINE

Metformin Therapy and Risk of Cancer in Patients with Type 2 Diabetes: Systematic Review

(2013) Monica Franciosi et al.   PLoS One

Metformin: an old but still the best treatment for type 2 diabetes

(2013) Lilian Beatriz Aguayo Rojas et al.   Diabetology & Metabolic Syndrome

Tumor Endothelial Cells

(2013) A. C. Dudley   Cold Spring Harbor Perspectives in Medicine

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Metformin is synthetically lethal with glucose withdrawal in cancer cells

(2012) Javier A. Menendez et al.   CELL CYCLE

Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects

(2012) Arian Emami Riedmaier et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

In vivo imaging of the molecular distribution of the VEGF receptor during angiogenesis in a mouse model of ischemia

(2011) Y. Hamada et al.   BLOOD

Diabetes and pancreatic cancer

(2011) Donghui Li   MOLECULAR CARCINOGENESIS

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

PI3K/AKT/mTOR Pathway in Angiogenesis

(2011) Jayashree Karar et al.   Frontiers in Molecular Neuroscience

Targeting the pro-death and pro-survival functions of autophagy as novel therapeutic strategies in cancer

(2010) Kevin Dalby et al.   Autophagy

The combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells

(2010) Issam Ben Sahra et al.   Autophagy

Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells

(2010) I. Ben Sahra et al.   CANCER RESEARCH

Metformin and cancer: Doses, mechanisms and the dandelion and hormetic phenomena

(2010) Begoña Martin-Castillo et al.   CELL CYCLE

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

Vascular Endothelial Growth Factor as an Anti-Angiogenic Target for Cancer Therapy

(2010) Gang Niu et al.   CURRENT DRUG TARGETS

Activation of AMP-activated Protein Kinase by Vascular Endothelial Growth Factor Mediates Endothelial Angiogenesis Independently of Nitric-oxide Synthase

(2010) Nadine Stahmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

(2010) I. Ben Sahra et al.   MOLECULAR CANCER THERAPEUTICS

Antiangiogenic Activity of 2-Deoxy-D-Glucose

(2010) Jaime R. Merchan et al.   PLoS One

Rapamycin Inhibition of the Akt/mTOR Pathway Blocks Select Stages of VEGF-A 164 –Driven Angiogenesis, in Part by Blocking S6Kinase

(2009) Qi Xue et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer

(2009) X B Trinh et al.   BRITISH JOURNAL OF CANCER

Metformin decreases angiogenesis via NF-κB and Erk1/2/Erk5 pathways by increasing the antiangiogenic thrombospondin-1

(2009) Bee K. Tan et al.   CARDIOVASCULAR RESEARCH

Clinical studies for improving radiotherapy with 2-deoxy-D-glucose: Present status and future prospects

(2009) BS Dwarakanath et al.   Journal of Cancer Research and Therapeutics

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

(2008) I Ben Sahra et al.   ONCOGENE

Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

(2008) James A. Dykens et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY