Therapeutic Potential of Metformin in COVID-19: Reasoning for Its Protective Role
Published 2021 View Full Article
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Title
Therapeutic Potential of Metformin in COVID-19: Reasoning for Its Protective Role
Authors
Keywords
blood glucose control, coronavirus, COVID-19, diabetes, endothelial dysfunction, metformin, SARS-CoV-2
Journal
TRENDS IN MICROBIOLOGY
Volume -, Issue -, Pages -
Publisher
Elsevier BV
Online
2021-03-15
DOI
10.1016/j.tim.2021.03.004
References
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Note: Only part of the references are listed.- Interim Results of a Phase 1–2a Trial of Ad26.COV2.S Covid-19 Vaccine
- (2021) Jerald Sadoff et al. NEW ENGLAND JOURNAL OF MEDICINE
- New mutations raise specter of ‘immune escape’
- (2021) Kai Kupferschmidt SCIENCE
- Metformin Use Is Associated With Reduced Mortality in a Diverse Population With COVID-19 and Diabetes
- (2021) Andrew B. Crouse et al. Frontiers in Endocrinology
- Prevalence of Asymptomatic SARS-CoV-2 Infection
- (2021) Daniel P. Oran et al. ANNALS OF INTERNAL MEDICINE
- Metformin Treatment Was Associated with Decreased Mortality in COVID-19 Patients with Diabetes in a Retrospective Analysis
- (2020) Pan Luo et al. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
- Why the endothelium? The endothelium as a target to reduce diabetes-associated vascular disease.’
- (2020) Christopher R. Triggle et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
- (2020) Markus Hoffmann et al. CELL
- Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes
- (2020) Lihua Zhu et al. Cell Metabolism
- Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China
- (2020) Bo Li et al. Clinical Research in Cardiology
- Clinical Characteristics and Outcomes of Patients With Diabetes and COVID-19 in Association With Glucose-Lowering Medication
- (2020) Yuchen Chen et al. DIABETES CARE
- Outcomes in Patients With Hyperglycemia Affected by Covid-19: Can We Do More on Glycemic Control?
- (2020) Celestino Sardu et al. DIABETES CARE
- The Clinical Characteristics and Outcomes of Diabetes Mellitus and Secondary Hyperglycaemia Patients with Coronavirus Disease 2019: a Single‐center, Retrospective, Observational Study in Wuhan
- (2020) Yang Zhang et al. DIABETES OBESITY & METABOLISM
- Association of Diabetes Mellitus with Disease Severity and Prognosis in COVID-19: A Retrospective Cohort Study
- (2020) Yan Zhang et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study
- (2020) Bertrand Cariou et al. DIABETOLOGIA
- CLINICAL CHARACTERISTICS OF 28 PATIENTS WITH DIABETES AND COVID-19 IN WUHAN, CHINA
- (2020) Feng Wang et al. Endocrine Practice
- Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis
- (2020) Wei-jie Guan et al. EUROPEAN RESPIRATORY JOURNAL
- Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis
- (2020) Jing Yang et al. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
- Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan
- (2020) Xiaochen Li et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy
- (2020) Ning Tang et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Endothelial cell infection and endotheliitis in COVID-19
- (2020) Zsuzsanna Varga et al. LANCET
- Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
- (2020) Fei Zhou et al. LANCET
- A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
- (2020) David E. Gordon et al. NATURE
- Prevalence and impact of diabetes among people infected with SARS-CoV-2
- (2020) G. P. Fadini et al. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
- Clinical characteristics and outcomes of patients with severe covid-19 with diabetes
- (2020) Yongli Yan et al. BMJ Open Diabetes Research & Care
- A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
- (2020) Liuliu Yang et al. Cell Stem Cell
- Metformin and COVID-19: From cellular mechanisms to reduced mortality
- (2020) A.J. Scheen DIABETES & METABOLISM
- A proposed mechanism for the possible therapeutic potential of Metformin in COVID-19
- (2020) Zohreh Esam DIABETES RESEARCH AND CLINICAL PRACTICE
- Metformin in COVID-19: A possible role beyond diabetes
- (2020) Swati Sharma et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Fasting blood glucose at admission is an independent predictor for 28-day mortality in patients with COVID-19 without previous diagnosis of diabetes: a multi-centre retrospective study
- (2020) Sufei Wang et al. DIABETOLOGIA
- Diabetic patients with COVID-19 infection are at higher risk of ICU admission and poor short-term outcome
- (2020) Loris Roncon et al. JOURNAL OF CLINICAL VIROLOGY
- Factors associated with COVID-19-related death using OpenSAFELY
- (2020) Elizabeth J. Williamson et al. NATURE
- New-Onset Diabetes in Covid-19
- (2020) Francesco Rubino et al. NEW ENGLAND JOURNAL OF MEDICINE
- COVID-19 in people with diabetes: understanding the reasons for worse outcomes
- (2020) Matteo Apicella et al. Lancet Diabetes & Endocrinology
- Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study
- (2020) Emma Barron et al. Lancet Diabetes & Endocrinology
- The COVID-19 Cytokine Storm; What We Know So Far
- (2020) Dina Ragab et al. Frontiers in Immunology
- Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study
- (2020) George Goshua et al. Lancet Haematology
- Diabetes and Novel Coronavirus Infection: Implications for Treatment
- (2020) David M. Williams et al. Diabetes Therapy
- COVID-19 and Diabetes: The Importance of Controlling RAGE
- (2020) Ernestina M. De Francesco et al. Frontiers in Endocrinology
- ACE2, Metformin, and COVID-19
- (2020) Atul Malhotra et al. iScience
- Sex differences in SARS-CoV-2 infection rates and the potential link to prostate cancer
- (2020) Dimple Chakravarty et al. Communications Biology
- Endothelial dysfunction in COVID-19: Current findings and therapeutic implications
- (2020) Matthias P. Nägele et al. ATHEROSCLEROSIS
- SARS-CoV-2 leading to acute pancreatitis: an unusual presentation
- (2020) Amanda Mandarino Alves et al. Brazilian Journal of Infectious Diseases
- Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes
- (2020) Xu Cheng et al. Cell Metabolism
- Risk of Metformin in Patients With Type 2 Diabetes With COVID‐19: A Preliminary Retrospective Report
- (2020) Yongchao Gao et al. CTS-Clinical and Translational Science
- Endothelial Dysfunction in COVID-19: Lessons Learned from Coronaviruses
- (2020) Eleni Gavriilaki et al. CURRENT HYPERTENSION REPORTS
- Sitagliptin Treatment at the Time of Hospitalization Was Associated With Reduced Mortality in Patients With Type 2 Diabetes and COVID-19: A Multicenter, Case-Control, Retrospective, Observational Study
- (2020) Sebastiano Bruno Solerte et al. DIABETES CARE
- Fasting Blood Glucose and COVID-19 Severity: Nonlinearity Matters
- (2020) Barrak Alahmad et al. DIABETES CARE
- New-Onset Type 1 Diabetes in Children During COVID-19: Multicenter Regional Findings in the U.K.
- (2020) Rebecca Unsworth et al. DIABETES CARE
- Hyperglycemia without diabetes and new-onset diabetes are both associated with poorer outcomes in COVID-19
- (2020) Awadhesh Kumar Singh et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Protective role of ACE2 and its downregulation in SARS-CoV-2 infection leading to Macrophage Activation Syndrome: Therapeutic implications
- (2020) Nehla Banu et al. LIFE SCIENCES
- Obesity and diabetes as comorbidities for COVID-19: Underlying mechanisms and the role of viral–bacterial interactions
- (2020) Ilja L Kruglikov et al. eLife
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- (2020) Minako Yamaoka-Tojo Biomedical Journal
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- (2020) Merryn Voysey et al. LANCET
- SARS-CoV-2 cell entry receptor ACE2 mediated endothelial dysfunction leads to vascular thrombosis in COVID-19 patients
- (2020) Ashutosh Kumar et al. MEDICAL HYPOTHESES
- Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
- (2020) Lindsey R. Baden et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
- (2020) Fernando P. Polack et al. NEW ENGLAND JOURNAL OF MEDICINE
- SARS-CoV-2, ACE2 expression, and systemic organ invasion
- (2020) Usman M Ashraf et al. PHYSIOLOGICAL GENOMICS
- Metformin: The Answer to Cancer in a Flower? Current Knowledge and Future Prospects of Metformin as an Anti-Cancer Agent in Breast Cancer
- (2019) Samson Mathews Samuel et al. Biomolecules
- The diabetes pandemic and associated infections
- (2018) Antonio Toniolo et al. REVIEWS IN MEDICAL MICROBIOLOGY
- Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium
- (2016) C. R. Triggle et al. Acta Physiologica
- Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release
- (2016) Guang Xin et al. Scientific Reports
- Metformin use in patients with type 2 diabetes mellitus is associated with reduced risk of deep vein thrombosis: a non-randomized, pair-matched cohort study
- (2015) Dai-Yin Lu et al. BMC Cardiovascular Disorders
- RAGE regulation and signaling in inflammation and beyond
- (2013) Katrin Kierdorf et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes
- (2009) Jin-Kui Yang et al. ACTA DIABETOLOGICA
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