Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet

Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans

(2018) Emily Tubbs et al.   DIABETES

Palmitic acid triggers inflammatory responses in N42 cultured hypothalamic cells partially via ceramide synthesis but not via TLR4

(2018) Domenico Sergi et al.   NUTRITIONAL NEUROSCIENCE

Omega-3 Fatty Acids and Insulin Resistance: Focus on the Regulation of Mitochondria and Endoplasmic Reticulum Stress

(2018) Marilena Lepretti et al.   Nutrients

Resveratrol improves ex vivo mitochondrial function but does not affect insulin sensitivity or brown adipose tissue in first degree relatives of patients with type 2 diabetes

(2018) Marlies de Ligt et al.   Molecular Metabolism

Preserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in β Cells

(2018) Enming Zhang et al.   Cell Metabolism

PDK4 Augments ER-Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity

(2018) Themis Thoudam et al.   DIABETES

Mitochondrial dysfunction and inhibition of myoblast differentiation in mice with high-fat-diet-induced pre-diabetes

(2018) Dengqiu Xu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Calorie Restriction-induced Weight Loss and Exercise Have Differential Effects on Skeletal Muscle Mitochondria Despite Similar Effects on Insulin Sensitivity

(2017) Elizaveta V Menshikova et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Disentangling the effect of dietary restriction on mitochondrial function using recombinant inbred mice

(2017) Lorna Mulvey et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Adiposity, Type 2 Diabetes, and Alzheimer's Disease

(2017) José A. Luchsinger et al.   JOURNAL OF ALZHEIMERS DISEASE

Respiratory supercomplexes and the functional segmentation of the CoQ pool

(2016) Raquel Moreno-Loshuertos et al.   FREE RADICAL BIOLOGY AND MEDICINE

EFFECTS OF 12 MONTHS OF CALORIC RESTRICTION ON MUSCLE MITOCHONDRIAL FUNCTION IN HEALTHY INDIVIDUALS

(2016) Lauren Marie Sparks et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

(2016) Varman T. Samuel et al.   JOURNAL OF CLINICAL INVESTIGATION

The Effects of Resveratrol Supplementation in Overweight and Obese Humans: A Systematic Review of Randomized Trials

(2016) Julia Christenson et al.   Metabolic Syndrome and Related Disorders

Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus

(2016) Matthijs K. C. Hesselink et al.   Nature Reviews Endocrinology

Mitochondrial Cristae: Where Beauty Meets Functionality

(2016) Sara Cogliati et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondrial Dynamics and Metabolic Regulation

(2016) Timothy Wai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver

(2016) Pierre Theurey et al.   Journal of Molecular Cell Biology

Insulin-Sensitizing Effects of Omega-3 Fatty Acids: Lost in Translation?

(2016) Antigoni Lalia et al.   Nutrients

Lipid-Induced Insulin Resistance in Skeletal Muscle: The Chase for the Culprit Goes from Total Intramuscular Fat to Lipid Intermediates, and Finally to Species of Lipid Intermediates

(2016) Soressa Kitessa et al.   Nutrients

SIRT1 Gain of Function Does Not Mimic or Enhance the Adaptations to Intermittent Fasting

(2016) Marie Boutant et al.   Cell Reports

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle

(2016) Orsolya M. Palacios et al.   Aging-US

Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective

(2016) Alessandra Valerio et al.   Aging-US

Carnitine supplementation in high-fat diet-fed rats does not ameliorate lipid-induced skeletal muscle mitochondrial dysfunction in vivo

(2015) Bart Wessels et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The molecular targets of resveratrol

(2015) Sameer S. Kulkarni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

Mechanism by which caloric restriction improves insulin sensitivity in sedentary obese adults

(2015) Matthew L. Johnson et al.   DIABETES

SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat–Fed Mice

(2015) Louise Lantier et al.   DIABETES

Impaired mitochondrial oxidative phosphorylation and supercomplex assembly in rectus abdominis muscle of diabetic obese individuals

(2015) Ghadi Antoun et al.   DIABETOLOGIA

Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels

(2015) Arnaud Mourier et al.   JOURNAL OF CELL BIOLOGY

Resveratrol improves high-fat diet induced insulin resistance by rebalancing subsarcolemmal mitochondrial oxidation and antioxidantion

(2015) Zhang Haohao et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Regulation of mitochondrial biogenesis through TFAM–mitochondrial DNA interactions

(2015) Anna Picca et al.   MITOCHONDRION

Short-chain fatty acids in control of body weight and insulin sensitivity

(2015) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Obesity, insulin resistance and comorbidities ? Mechanisms of association

(2014) Ana Valeria B. Castro et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Epigallocatechin gallate counteracts oxidative stress in docosahexaenoxic acid-treated myocytes

(2014) Ester Casanova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Activating HSP72 in Rodent Skeletal Muscle Increases Mitochondrial Number and Oxidative Capacity and Decreases Insulin Resistance

(2014) Darren C. Henstridge et al.   DIABETES

Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance

(2014) E. Tubbs et al.   DIABETES

Mitochondrial protein acetylation regulates metabolism

(2014) Kristin A. Anderson et al.   Essays in Biochemistry

Coumestrol Induces Mitochondrial Biogenesis by Activating Sirt1 in Cultured Skeletal Muscle Cells

(2014) Dae-Bang Seo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Insulin Receptor Activation with Transmembrane Domain Ligands

(2014) Jongsoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity

(2014) Ana Paula Arruda et al.   NATURE MEDICINE

Influence of fish oil on skeletal muscle mitochondrial energetics and lipid metabolites during high-fat diet

(2013) Ian R. Lanza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondrial fission mediates ceramide-induced metabolic disruption in skeletal muscle

(2013) Melissa E. Smith et al.   BIOCHEMICAL JOURNAL

Functional role of mitochondrial respiratory supercomplexes

(2013) Maria Luisa Genova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

(2013) Marc Liesa et al.   Cell Metabolism

The effects of dietary restriction on oxidative stress in rodents

(2013) Michael E. Walsh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dietary stimulators of the PGC-1 superfamily and mitochondrial biosynthesis in skeletal muscle. A mini-review

(2013) Roger A. Vaughan et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Alterations of Ultrastructural and Fission/Fusion Markers in Hepatocyte Mitochondria From Mice Following Calorie Restriction With Different Dietary Fats

(2013) H. Khraiwesh et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

(2013) E. Lapuente-Brun et al.   SCIENCE

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Chronic Caloric Restriction Preserves Mitochondrial Function in Senescence without Increasing Mitochondrial Biogenesis

(2012) Ian R. Lanza et al.   Cell Metabolism

Omega 3 Fatty Acids and GPR120

(2012) Da Young Oh et al.   Cell Metabolism

A Ceramide-Centric View of Insulin Resistance

(2012) Jose A. Chavez et al.   Cell Metabolism

High Oxidative Capacity Due to Chronic Exercise Training Attenuates Lipid-Induced Insulin Resistance

(2012) E. Phielix et al.   DIABETES

Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice

(2012) Pedro M Quirós et al.   EMBO JOURNAL

PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans

(2012) Timothy R. Koves et al.   JOURNAL OF LIPID RESEARCH

Exercise-induced AMPK activity in skeletal muscle: Role in glucose uptake and insulin sensitivity

(2012) Martin Friedrichsen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

(2012) D. Sebastian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New insights into ER stress-induced insulin resistance

(2012) Mélissa Flamment et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Late-onset intermittent fasting dietary restriction as a potential intervention to retard age-associated brain function impairments in male rats

(2011) Rumani Singh et al.   AGE

Insulin signaling to hepatic lipid metabolism in health and disease

(2011) Karla F. Leavens et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Alterations in Skeletal Muscle Indicators of Mitochondrial Structure and Biogenesis in Patients with Type 2 Diabetes and Heart Failure: Effects of Epicatechin Rich Cocoa

(2011) Pam R. Taub et al.   CTS-Clinical and Translational Science

Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1β involves reductions in long-chain acyl-CoA levels and oxidative stress

(2011) L. E. Wright et al.   DIABETOLOGIA

Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle

(2011) H.-F. Jheng et al.   MOLECULAR AND CELLULAR BIOLOGY

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

AMP-activated protein kinase (AMPK)  1 2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise

(2011) H. M. O'Neill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress

(2010) Larysa Yuzefovych et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

(2010) Simon A. Hawley et al.   Cell Metabolism

Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle

(2010) Carles Cantó et al.   Cell Metabolism

Branched-Chain Amino Acid Supplementation Promotes Survival and Supports Cardiac and Skeletal Muscle Mitochondrial Biogenesis in Middle-Aged Mice

(2010) Giuseppe D'Antona et al.   Cell Metabolism

Does calorie restriction induce mitochondrial biogenesis? A reevaluation

(2010) Chad R. Hancock et al.   FASEB JOURNAL

Comparative study between the effect of the peroxisome proliferator activated receptor-α ligands fenofibrate and n-3 polyunsaturated fatty acids on activation of 5′-AMP-activated protein kinase-α1 in high-fat fed rats

(2010) Tarek M. Kamal Motawi et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Lipid-induced insulin resistance: unravelling the mechanism

(2010) Varman T Samuel et al.   LANCET

Stimulation of AMP-activated protein kinase and enhancement of basal glucose uptake in muscle cells by quercetin and quercetin glycosides, active principles of the antidiabetic medicinal plant Vaccinium vitis-idaea

(2010) Hoda M. Eid et al.   MOLECULAR NUTRITION & FOOD RESEARCH

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Regulation of PPARγCoactivator-1αFunction and Expression in Muscle: Effect of Exercise

(2010) Giulia Uguccioni et al.   PPAR Research

Calorie restriction alters mitochondrial protein acetylation

(2009) Bjoern Schwer et al.   AGING CELL

A saturated fatty acid–rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome

(2009) Susan J van Dijk et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Obesity: Why be Concerned?

(2009) W. Virgil Brown et al.   AMERICAN JOURNAL OF MEDICINE

Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance

(2009) J. Mark Davis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Quercetin’s effect on cycling efficiency and substrate utilization

(2009) Charles L. Dumke et al.   Applied Physiology Nutrition and Metabolism

Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca2+and AMP

(2009) Sarah Fogarty et al.   BIOCHEMICAL JOURNAL

Transcriptional and post-transcriptional regulation of mitochondrial biogenesis in skeletal muscle: Effects of exercise and aging

(2009) Vladimir Ljubicic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondrial dysfunction and lipotoxicity

(2009) Patrick Schrauwen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity

(2009) R. C.R. Meex et al.   DIABETES

Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells

(2009) Sandro M. Hirabara et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Effect of Hyperglycemia on Mitochondrial Respiration in Type 2 Diabetes

(2009) Rasmus Rabøl et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Effect of Branched Chain Amino Acids on Skeletal Muscle Mitochondrial Function in Young and Elderly Adults

(2009) Laura L. Tatpati et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of muscle glycogen synthase phosphorylation and kinetic properties by insulin, exercise, adrenaline and role in insulin resistance

(2009) Jørgen Jensen et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Effects of complete whey-protein breakfasts versus whey without GMP-breakfasts on energy intake and satiety

(2008) Margriet A.B. Veldhorst et al.   APPETITE

Skeletal muscle “mitochondrial deficiency” does not mediate insulin resistance

(2008) John O Holloszy   AMERICAN JOURNAL OF CLINICAL NUTRITION

Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells

(2008) Gabriela Suchankova et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

(2008) Timothy R. Koves et al.   Cell Metabolism

Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients

(2008) E. Phielix et al.   DIABETES

Visceral Adiposity, Not Abdominal Subcutaneous Fat Area, Is Associated With an Increase in Future Insulin Resistance in Japanese Americans

(2008) T. Hayashi et al.   DIABETES

Increased Daily Walking Improves Lipid Oxidation Without Changes in Mitochondrial Function in Type 2 Diabetes

(2008) M. I. Trenell et al.   DIABETES CARE

Gain-of-function R225Q Mutation in AMP-activated Protein Kinase γ3 Subunit Increases Mitochondrial Biogenesis in Glycolytic Skeletal Muscle

(2008) Pablo M. Garcia-Roves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

High-fat diets cause insulin resistance despite an increase in muscle mitochondria

(2008) C. R. Hancock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA