T Cell Response in Ischemic Stroke: From Mechanisms to Translational Insights

Functional characterization of the dural sinuses as a neuroimmune interface

(2021) Justin Rustenhoven et al.   CELL

Platelets and lymphocytes drive progressive penumbral tissue loss during middle cerebral artery occlusion in mice

(2021) Michael K. Schuhmann et al.   Journal of Neuroinflammation

Delayed diapedesis of CD8 T cells contributes to long-term pathology after ischemic stroke in male mice

(2021) Uma Maheswari Selvaraj et al.   BRAIN BEHAVIOR AND IMMUNITY

Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke

(2021) Ligen Shi et al.   IMMUNITY

Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies

(2021) Steffanie Heindl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Local Leukocyte Invasion during Hyperacute Human Ischemic Stroke

(2020) Alexander M. Kollikowski et al.   ANNALS OF NEUROLOGY

The von Willebrand Factor A1 domain mediates thromboinflammation, aggravating ischemic stroke outcome in mice

(2020) Frederik Denorme et al.   HAEMATOLOGICA

Global, Regional and Country-Specific Burden of Ischaemic Stroke, Intracerebral Haemorrhage and Subarachnoid Haemorrhage: A Systematic Analysis of the Global Burden of Disease Study 2017

(2020) Rita V. Krishnamurthi et al.   NEUROEPIDEMIOLOGY

Management of acute ischemic stroke

(2020) Michael S Phipps et al.   BMJ-British Medical Journal

Efficacy of the sphingosine-1-phosphate receptor agonist fingolimod in animal models of stroke: an updated meta-analysis

(2020) Chun Dang et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

CD84 Links T Cell and Platelet Activity in Cerebral Thrombo-Inflammation in Acute Stroke

(2020) Michael K Schuhmann et al.   CIRCULATION RESEARCH

Temporal profile of lymphocyte counts and relationship with infections with fingolimod therapy in paediatric patients with multiple sclerosis: Results from the PARADIGMS study

(2020) Tanuja Chitnis et al.   Multiple Sclerosis Journal

Natalizumab in acute ischemic stroke (ACTION II): a randomized, placebo-controlled trial

(2020) Mitchell S. V. Elkind et al.   NEUROLOGY

Antigen-Dependent T Cell Response to Neural Peptides After Human Ischemic Stroke

(2020) Francesc Miró-Mur et al.   Frontiers in Cellular Neuroscience

Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons

(2020) Kalil Alves de Lima et al.   NATURE IMMUNOLOGY

China Stroke Statistics 2019: A Report From the National Center for Healthcare Quality Management in Neurological Diseases, China National Clinical Research Center for Neurological Diseases, the Chinese Stroke Association, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations

(2020) Yong-Jun Wang et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Lymphocyte recovery after fingolimod discontinuation in patients with MS

(2020) Sara Nagy et al.   Neurology-Neuroimmunology & Neuroinflammation

Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019

(2020) Gregory A. Roth et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Fingolimod: Lessons Learned and New Opportunities for Treating Multiple Sclerosis and Other Disorders

(2019) Jerold Chun et al.   Annual Review of Pharmacology and Toxicology

Double-negative T cells remarkably promote neuroinflammation after ischemic stroke

(2019) Hailan Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-Regulatory Cells Confer Increased Myelination and Stem Cell Activity after Stroke-Induced White Matter Injury

(2019) Sydney Zarriello et al.   Journal of Clinical Medicine

Thrombo-inflammation in acute ischaemic stroke — implications for treatment

(2019) Guido Stoll et al.   Nature Reviews Neurology

Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association

(2019) William J. Powers et al.   STROKE

FTY720 (Fingolimod) Ameliorates Brain Injury through Multiple Mechanisms and is a Strong Candidate for Stroke Treatment

(2019) Zifeng Wang et al.   CURRENT MEDICINAL CHEMISTRY

The diverse cellular responses of the choroid plexus during infection of the central nervous system

(2018) Alexa N. Lauer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A guide to chemokines and their receptors

(2018) Catherine E. Hughes et al.   FEBS Journal

Regulatory T-cells within bone marrow-derived stem cells actively confer immunomodulatory and neuroprotective effects against stroke

(2018) Elliot G Neal et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Multisociety Consensus Quality Improvement Revised Consensus Statement for Endovascular Therapy of Acute Ischemic Stroke

(2018) David Sacks et al.   JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY

Blood-brain barrier dysfunction and recovery after ischemic stroke

(2018) Xiaoyan Jiang et al.   PROGRESS IN NEUROBIOLOGY

Brain Ischemia Induces Diversified Neuroantigen-Specific T-Cell Responses That Exacerbate Brain Injury

(2018) Wei-Na Jin et al.   STROKE

Early Blood–Brain Barrier Disruption in Ischemic Stroke Initiates Multifocally Around Capillaries/Venules

(2018) Angelika Hoffmann et al.   STROKE

Experimental ischemic stroke induces long-term T cell activation in the brain

(2018) Luokun Xie et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Fingolimod enhances the efficacy of delayed alteplase administration in acute ischemic stroke by promoting anterograde reperfusion and retrograde collateral flow

(2018) De-Cai Tian et al.   ANNALS OF NEUROLOGY

In Vivo Expansion of Regulatory T Cells with IL-2/IL-2 Antibody Complex Protects against Transient Ischemic Stroke

(2018) Haiyue Zhang et al.   JOURNAL OF NEUROSCIENCE

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Spencer L James et al.   LANCET

Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery

(2018) Minako Ito et al.   NATURE

Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke

(2018) Changjun Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Blocking of platelet glycoprotein receptor Ib reduces “thrombo-inflammation” in mice with acute ischemic stroke

(2017) Michael K. Schuhmann et al.   Journal of Neuroinflammation

B cells do not have a major pathophysiologic role in acute ischemic stroke in mice

(2017) Michael K. Schuhmann et al.   Journal of Neuroinflammation

Safety and efficacy of natalizumab in patients with acute ischaemic stroke (ACTION): a randomised, placebo-controlled, double-blind phase 2 trial

(2017) Jacob Elkins et al.   LANCET NEUROLOGY

Partial MHC class II constructs as novel immunomodulatory therapy for stroke

(2017) Gil Benedek et al.   NEUROCHEMISTRY INTERNATIONAL

T-cells and macrophages peak weeks after experimental stroke: Spatial and temporal characteristics

(2017) Nina Vindegaard et al.   NEUROPATHOLOGY

CCR6 (CC Chemokine Receptor 6) Is Essential for the Migration of Detrimental Natural Interleukin-17–Producing γδ T Cells in Stroke

(2017) Priyadharshini Arunachalam et al.   STROKE

IL-23 (Interleukin-23)–Producing Conventional Dendritic Cells Control the Detrimental IL-17 (Interleukin-17) Response in Stroke

(2017) Mathias Gelderblom et al.   STROKE

C‐C Chemokine Receptor Type 5 (CCR5)‐Mediated Docking of Transferred Tregs Protects Against Early Blood‐Brain Barrier Disruption After Stroke

(2017) Peiying Li et al.   Journal of the American Heart Association

Dynamics of T cell responses after stroke

(2016) Dipender Gill et al.   CURRENT OPINION IN PHARMACOLOGY

Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume

(2016) Han Kyu Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation

(2016) Ángel Chamorro et al.   LANCET NEUROLOGY

Reduced Numbers and Impaired Function of Regulatory T Cells in Peripheral Blood of Ischemic Stroke Patients

(2016) Johanna Ruhnau et al.   MEDIATORS OF INFLAMMATION

Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid

(2016) Christian Schläger et al.   NATURE

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

(2016) Corinne Benakis et al.   NATURE MEDICINE

Antigen Presentation After Stroke

(2016) Francesc Miró-Mur et al.   Neurotherapeutics

Contribution of very late antigen-4 (VLA-4) integrin to cancer progression and metastasis

(2015) Martin Schlesinger et al.   CANCER AND METASTASIS REVIEWS

Combination of the Immune Modulator Fingolimod With Alteplase in Acute Ischemic StrokeCLINICAL PERSPECTIVE

(2015) Zilong Zhu et al.   CIRCULATION

Early Blood Brain Barrier Changes in Acute Ischemic Stroke: A Sequential MRI Study

(2015) Marc Giraud et al.   JOURNAL OF NEUROIMAGING

Regulatory T cells in cardiovascular diseases

(2015) Xiao Meng et al.   Nature Reviews Cardiology

Pivotal role of cerebral interleukin-23 during immunologic injury in delayed cerebral ischemia in mice

(2015) Y. Zheng et al.   NEUROSCIENCE

Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia

(2015) Gemma Llovera et al.   Science Translational Medicine

Activated regulatory T cell regulates neural stem cell proliferation in the subventricular zone of normal and ischemic mouse brain through interleukin 10

(2015) Jixian Wang et al.   Frontiers in Cellular Neuroscience

Perforin: structure, function, and role in human immunopathology

(2015) Ilia Voskoboinik et al.   IMMUNOLOGICAL REVIEWS

Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke

(2014) Jens Neumann et al.   ACTA NEUROPATHOLOGICA

Interleukin-10 may protect against progressing injury during the acute phase of ischemic stroke

(2014) Gustavo G. Protti et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

Timing and Dose Regimens of Marrow Mesenchymal Stem Cell Transplantation Affect the Outcomes and Neuroinflammatory Response After Ischemic Stroke

(2014) Liu-Qing Wang et al.   CNS Neuroscience & Therapeutics

TIM-1 Glycoprotein Binds the Adhesion Receptor P-Selectin and Mediates T Cell Trafficking during Inflammation and Autoimmunity

(2014) Stefano Angiari et al.   IMMUNITY

CD28 Superagonist-Mediated Boost of Regulatory T Cells Increases Thrombo-Inflammation and Ischemic Neurodegeneration during the Acute Phase of Experimental Stroke

(2014) Michael K Schuhmann et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

T cell–derived interleukin (IL)-21 promotes brain injury following stroke in mice

(2014) Benjamin D.S. Clarkson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pro-Inflammatory Interferon Gamma Signaling is Directly Associated with Stroke Induced Neurodegeneration

(2014) Hilary A. Seifert et al.   Journal of Neuroimmune Pharmacology

Antigen Dependently Activated Cluster of Differentiation 8-Positive T Cells Cause Perforin-Mediated Neurotoxicity in Experimental Stroke

(2014) E. Mracsko et al.   JOURNAL OF NEUROSCIENCE

Imbalance between IL-17A-Producing Cells and Regulatory T Cells during Ischemic Stroke

(2014) Yuehua Hu et al.   MEDIATORS OF INFLAMMATION

Intracerebral interleukin-10 injection modulates post-ischemic neuroinflammation: An experimental microarray study

(2014) Arthur Liesz et al.   NEUROSCIENCE LETTERS

Impact of an immune modulator fingolimod on acute ischemic stroke

(2014) Ying Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential Role of Program Death 1-Ligand 1 in Regulatory T-Cell–Afforded Protection Against Blood–Brain Barrier Damage After Stroke

(2014) Peiying Li et al.   STROKE

Blocking of α4 Integrin Does Not Protect From Acute Ischemic Stroke in Mice

(2014) Friederike Langhauser et al.   STROKE

Regulation of T cell trafficking by the T cell immunoglobulin and mucin domain 1 glycoprotein

(2014) Stefano Angiari et al.   TRENDS IN MOLECULAR MEDICINE

Afferent and efferent immunological pathways of the brain. Anatomy, Function and Failure

(2013) R.O. Carare et al.   BRAIN BEHAVIOR AND IMMUNITY

Immune Cell Infiltration in Malignant Middle Cerebral Artery Infarction: Comparison with Transient Cerebral Ischemia

(2013) Hannah X Chu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Spectratype analysis of clonal T cell expansion in murine experimental stroke

(2013) Arthur Liesz et al.   JOURNAL OF NEUROIMMUNOLOGY

Leukocyte infiltration in experimental stroke

(2013) Nina Vindegaard Grønberg et al.   Journal of Neuroinflammation

Boosting Regulatory T Cells Limits Neuroinflammation in Permanent Cortical Stroke

(2013) A. Liesz et al.   JOURNAL OF NEUROSCIENCE

Adoptive Regulatory T-Cell Therapy Preserves Systemic Immune Homeostasis After Cerebral Ischemia

(2013) Peiying Li et al.   STROKE

Fingolimod Reduces Hemorrhagic Transformation Associated With Delayed Tissue Plasminogen Activator Treatment in a Mouse Thromboembolic Model

(2013) Francisco Campos et al.   STROKE

FTY720 Ameliorates Acute Ischemic Stroke in Mice by Reducing Thrombo-Inflammation but Not by Direct Neuroprotection

(2013) Peter Kraft et al.   STROKE

Adoptive regulatory T-cell therapy protects against cerebral ischemia

(2012) Peiying Li et al.   ANNALS OF NEUROLOGY

Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke

(2012) M. Gelderblom et al.   BLOOD

Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature

(2012) C. Kleinschnitz et al.   BLOOD

Chemokine-triggered leukocyte arrest: force-regulated bi-directional integrin activation in quantal adhesive contacts

(2012) Ronen Alon et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of CCL20 expression in astrocytes by IL-6 and IL-17

(2012) Gordon P. Meares et al.   GLIA

Regulatory T Cells Accumulate and Proliferate in the Ischemic Hemisphere for up to 30 Days after MCAO

(2012) Tobias Stubbe et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain-Derived Antigens in Lymphoid Tissue of Patients with Acute Stroke

(2012) A. M. Planas et al.   JOURNAL OF IMMUNOLOGY

Capture, crawl, cross: the T cell code to breach the blood–brain barriers

(2012) Britta Engelhardt et al.   TRENDS IN IMMUNOLOGY

Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow

(2011) A. Zarbock et al.   BLOOD

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

(2011) Arthur Liesz et al.   BRAIN

Glucocorticoid-induced TNF receptor-triggered T cells are key modulators for survival/death of neural stem/progenitor cells induced by ischemic stroke

(2011) M Takata et al.   CELL DEATH AND DIFFERENTIATION

Therapy with recombinant T-cell receptor ligand reduces infarct size and infiltrating inflammatory cells in brain after middle cerebral artery occlusion in mice

(2011) Suzan Dziennis et al.   METABOLIC BRAIN DISEASE

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

FTY720 Reduces Post-Ischemic Brain Lymphocyte Influx but Does Not Improve Outcome in Permanent Murine Cerebral Ischemia

(2011) Arthur Liesz et al.   PLoS One

Blood–Brain Barrier Breakdown in Acute and Chronic Cerebrovascular Disease

(2011) Yi Yang et al.   STROKE

Recombinant T Cell Receptor Ligands Improve Outcome After Experimental Cerebral Ischemia

(2011) Kozaburo Akiyoshi et al.   Translational Stroke Research

Fingolimod provides long-term protection in rodent models of cerebral ischemia

(2010) Ying Wei et al.   ANNALS OF NEUROLOGY

Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation

(2010) C. Kleinschnitz et al.   BLOOD

Role of Cytotoxic Protease Granzyme-b in Neuronal Degeneration During Human Stroke

(2010) Ganta Vijay Chaitanya et al.   BRAIN PATHOLOGY

Induction of peripheral CD4+ T-cell tolerance and CD8+ T-cell cross-tolerance by dendritic cells

(2009) Manfred B. Lutz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Recombinant TCR Ligand Reverses Clinical Signs and CNS Damage of EAE Induced by Recombinant Human MOG

(2009) Sushmita Sinha et al.   Journal of Neuroimmune Pharmacology

IL-17 potentiates neuronal injury induced by oxygen–glucose deprivation and affects neuronal IL-17 receptor expression

(2009) Dan-dan Wang et al.   JOURNAL OF NEUROIMMUNOLOGY

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

(2009) Takashi Shichita et al.   NATURE MEDICINE

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

(2009) Arthur Liesz et al.   NATURE MEDICINE

Granzyme-b is involved in mediating post-ischemic neuronal death during focal cerebral ischemia in rat model

(2009) G.V. Chaitanya et al.   NEUROSCIENCE

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

(2009) Mathias Gelderblom et al.   STROKE

Recombinant T Cell Receptor Ligand Treats Experimental Stroke

(2009) Sandhya Subramanian et al.   STROKE

Activation of Sphingosine 1-Phosphate Receptor-1 by FTY720 Is Neuroprotective After Ischemic Stroke in Rats

(2009) Yu Hasegawa et al.   STROKE

Production and functions of IL-17 in microglia

(2008) Jun Kawanokuchi et al.   JOURNAL OF NEUROIMMUNOLOGY

Immune cell entry into the central nervous system: Involvement of adhesion molecules and chemokines

(2008) Britta Engelhardt   JOURNAL OF THE NEUROLOGICAL SCIENCES

Sensitization and tolerization to brain antigens in stroke

(2008) K.J. Becker   NEUROSCIENCE