Contribution of very late antigen-4 (VLA-4) integrin to cancer progression and metastasis

Constitutive Expression of the α4 Integrin Correlates with Tumorigenicity and Lymph Node Metastasis of the B16 Murine Melanoma

(2015) Robert B. Rebhun et al.   NEOPLASIA

Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF- B mediates chemoresistance

(2014) R. Jacamo et al.   BLOOD

Natalizumab: Risk Stratification of Individual Patients with Multiple Sclerosis

(2014) Carmen Tur et al.   CNS DRUGS

Inhibition of α4β1 integrin increases ovarian cancer response to carboplatin

(2014) Jennifer M. Scalici et al.   GYNECOLOGIC ONCOLOGY

Integrin  1 Regulates Phagosome Maturation in Macrophages through Rac Expression

(2014) Q.-Q. Wang et al.   JOURNAL OF IMMUNOLOGY

Lutheran/basal cell adhesion molecule accelerates progression of crescentic glomerulonephritis in mice

(2014) Jin Huang et al.   KIDNEY INTERNATIONAL

Does risk stratification decrease the risk of natalizumab-associated PML? Where is the evidence?

(2014) Gary R Cutter et al.   Multiple Sclerosis Journal

Rac2 Controls Tumor Growth, Metastasis and M1-M2 Macrophage Differentiation In Vivo

(2014) Shweta Joshi et al.   PLoS One

The Binding of Monomeric C-Reactive Protein (mCRP) to Integrins αvβ3 and α4β1 Is Related to Its Pro-Inflammatory Action

(2014) Masaaki Fujita et al.   PLoS One

The Chemokine Fractalkine Can Activate Integrins without CX3CR1 through Direct Binding to a Ligand-Binding Site Distinct from the Classical RGD-Binding Site

(2014) Masaaki Fujita et al.   PLoS One

The role of VLA-4 binding for experimental melanoma metastasis and its inhibition by heparin

(2014) Martin Schlesinger et al.   THROMBOSIS RESEARCH

The pathogenic relevance of the prognostic markers CD38 and CD49d in chronic lymphocytic leukemia

(2013) Gabriele Brachtl et al.   ANNALS OF HEMATOLOGY

VCAM-1 and VAP-1 recruit myeloid cells that promote pulmonary metastasis in mice

(2013) S. Ferjancic et al.   BLOOD

Origins of Metastatic Traits

(2013) Sakari Vanharanta et al.   CANCER CELL

The Membrane-Proximal KXGFFKR Motif of  -Integrin Mediates Chemoresistance

(2013) C.-C. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

PI3-Kinase γ Promotes Rap1a-Mediated Activation of Myeloid Cell Integrin α4β1, Leading to Tumor Inflammation and Growth

(2013) Michael C. Schmid et al.   PLoS One

The PI3-Kinase Delta Inhibitor Idelalisib (GS-1101) Targets Integrin-Mediated Adhesion of Chronic Lymphocytic Leukemia (CLL) Cell to Endothelial and Marrow Stromal Cells

(2013) Stefania Fiorcari et al.   PLoS One

PI3K  activates integrin  4 1 to establish a metastatic niche in lymph nodes

(2013) B. Garmy-Susini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil-mediated tumour angiogenesis: Subversion of immune responses to promote tumour growth

(2013) Simon Tazzyman et al.   SEMINARS IN CANCER BIOLOGY

Cyr61 is a target for heparin in reducing MV3 melanoma cell adhesion and migration via the integrin VLA-4

(2013) Norbert Schütze et al.   THROMBOSIS AND HAEMOSTASIS

Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis

(2013) Su Yin Lim et al.   OncoImmunology

Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice

(2012) A. M. Gil-Bernabe et al.   BLOOD

Molecular Pathways: VCAM-1 as a Potential Therapeutic Target in Metastasis

(2012) Q. Chen et al.   CLINICAL CANCER RESEARCH

Tumor necrosis factor-α enhanced fusions between oral squamous cell carcinoma cells and endothelial cells via VCAM-1/VLA-4 pathway

(2012) Kai Song et al.   EXPERIMENTAL CELL RESEARCH

Recruitment of a myeloid cell subset (CD11b/Gr1mid) via CCL2/CCR2 promotes the development of colorectal cancer liver metastasis*

(2012) Lei Zhao et al.   HEPATOLOGY

The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells

(2012) Dennis Lindau et al.   IMMUNOLOGY

Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment

(2012) Adam Byron et al.   PROTEOMICS

Proinflammatory Adhesion Molecules Facilitate Polychlorinated Biphenyl-Mediated Enhancement of Brain Metastasis Formation

(2012) E. Sipos et al.   TOXICOLOGICAL SCIENCES

Interleukin-8 associates with adhesion, migration, invasion and chemosensitivity of human gastric cancer cells

(2012) Wen-Xia Kuai   WORLD JOURNAL OF GASTROENTEROLOGY

Aspects of VLA-4 and LFA-1 regulation that may contribute to rolling and firm adhesion

(2012) Alexandre Chigaev et al.   Frontiers in Immunology

Nitric oxide/cGMP pathway signaling actively down-regulates α4β1-integrin affinity: an unexpected mechanism for inducing cell de-adhesion

(2011) Alexandre Chigaev et al.   BMC IMMUNOLOGY

The selective adhesion molecule inhibitor Natalizumab decreases multiple myeloma cell growth in the bone marrow microenvironment: therapeutic implications

(2011) Klaus Podar et al.   BRITISH JOURNAL OF HAEMATOLOGY

Metastatic Cells Will Take Any Help They Can Get

(2011) Richard O. Hynes   CANCER CELL

VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging α4β1-Positive Osteoclast Progenitors

(2011) Xin Lu et al.   CANCER CELL

Macrophage Binding to Receptor VCAM-1 Transmits Survival Signals in Breast Cancer Cells that Invade the Lungs

(2011) Qing Chen et al.   CANCER CELL

Combined Blockade of Integrin- 4 1 Plus Cytokines SDF-1  or IL-1  Potently Inhibits Tumor Inflammation and Growth

(2011) M. C. Schmid et al.   CANCER RESEARCH

Talin-1 and Kindlin-3 Regulate α 4 β 1 Integrin-Mediated Adhesion Stabilization, but Not G Protein-Coupled Receptor-Induced Affinity Upregulation

(2011) Sharon J. Hyduk et al.   JOURNAL OF IMMUNOLOGY

Mobilization of hematopoietic stem and progenitor cells using inhibitors of CXCR4 and VLA-4

(2011) M P Rettig et al.   LEUKEMIA

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Akt/Protein Kinase B Is Required for Lymphatic Network Formation, Remodeling, and Valve Development

(2010) Fei Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

Myeloid-Derived Suppressor Cells in Human Cancer

(2010) Srinivas Nagaraj et al.   CANCER JOURNAL

Integrin  4 1 Signaling Is Required for Lymphangiogenesis and Tumor Metastasis

(2010) B. Garmy-Susini et al.   CANCER RESEARCH

Neutrophils: key mediators of tumour angiogenesis

(2010) Simon Tazzyman et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Multiple functions of CXCL12 in a syngeneic model of breast cancer

(2010) Sharon A Williams et al.   Molecular Cancer

Diagnosis of melanoma under concomitant natalizumab therapy

(2010) Bettina M Prinz Vavricka et al.   Multiple Sclerosis Journal

BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells

(2009) P. Ramirez et al.   BLOOD

High CD49d protein and mRNA expression predicts poor outcome in chronic lymphocytic leukemia

(2009) Holger Nückel et al.   CLINICAL IMMUNOLOGY

Integrin-α9 Is Required for Fibronectin Matrix Assembly during Lymphatic Valve Morphogenesis

(2009) Eleni Bazigou et al.   DEVELOPMENTAL CELL

Dexamethasone enhances cell resistance to chemotherapy by increasing adhesion to extracellular matrix in human ovarian cancer cells

(2009) Yu-Xia Chen et al.   ENDOCRINE-RELATED CANCER

Tumor cell/endothelial cell tight contact upregulates endothelial adhesion molecule expression mediated by NFκB: Differential role of the shear stress

(2009) Oualid Haddad et al.   EXPERIMENTAL CELL RESEARCH

Real-time Analysis of Conformation-sensitive Antibody Binding Provides New Insights into Integrin Conformational Regulation

(2009) Alexandre Chigaev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of natalizumab on clinical and radiological disease activity in multiple sclerosis: a retrospective analysis of the Natalizumab Safety and Efficacy in Relapsing-Remitting Multiple Sclerosis (AFFIRM) study

(2009) Eva Havrdova et al.   LANCET NEUROLOGY

A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth

(2009) Binzhi Qian et al.   PLoS One

Markers for Microscopic Imaging of Lymphangiogenesis and Angiogenesis

(2008) Peter Baluk et al.   Annals of the New York Academy of Sciences

Galphas-coupled receptor signaling actively down-regulates α4β1-integrin affinity: A possible mechanism for cell de-adhesion

(2008) Alexandre Chigaev et al.   BMC IMMUNOLOGY

Integrins Put the Brakes on Microcluster Dynamics at the Immunological Synapse

(2008) Janis K. Burkhardt   IMMUNITY

T Cell Costimulation via the Integrin VLA-4 Inhibits the Actin-Dependent Centralization of Signaling Microclusters Containing the Adaptor SLP-76

(2008) Ken Nguyen et al.   IMMUNITY

Blocking α4-integrins — A small molecule approach to treatment of multiple sclerosis

(2008) Richard J. Davenport et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Roles of Integrins in Tumor Angiogenesis and Lymphangiogenesis

(2008) Barbara Garmy-Susini et al.   Lymphatic Research and Biology

Inflammation as a matchmaker: revisiting cell fusion

(2008) Ilyas Singec et al.   NATURE CELL BIOLOGY

Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion

(2008) Jens M. Nygren et al.   NATURE CELL BIOLOGY

Melanoma Complicating Treatment with Natalizumab for Multiple Sclerosis

(2008) John T. Mullen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia

(2007) V. Gattei et al.   BLOOD