Double-negative T cells remarkably promote neuroinflammation after ischemic stroke

TCRαβ + CD3 + CD4 − CD8 − (double negative) T cells in autoimmunity

(2018) D. Brandt et al.   AUTOIMMUNITY REVIEWS

Brain Ischemia Induces Diversified Neuroantigen-Specific T-Cell Responses That Exacerbate Brain Injury

(2018) Wei-Na Jin et al.   STROKE

TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation

(2018) Cun-Jin Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

PTPN2 regulates T cell lineage commitment and αβ versus γδ specification

(2017) Florian Wiede et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In situexpansion of T cells that recognize distinct self-antigens sustains autoimmunity in the CNS

(2016) Abdulraouf Ramadan et al.   BRAIN

Crosstalk between microglia and T cells contributes to brain damage and recovery after ischemic stroke

(2016) Sunwei Wang et al.   NEUROLOGICAL RESEARCH

DRα1-MOG-35-55 Reduces Permanent Ischemic Brain Injury

(2016) Jianyi Wang et al.   Translational Stroke Research

Targeting the Fas/FasL system in Rheumatoid Arthritis therapy: Promising or risky?

(2015) Flavia Calmon-Hamaty et al.   CYTOKINE

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

(2015) Nicola Gagliani et al.   NATURE

Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys

(2014) J. C. Crispin et al.   JOURNAL OF IMMUNOLOGY

Systemically administered anti-TNF therapy ameliorates functional outcomes after focal cerebral ischemia

(2014) Bettina Hjelm Clausen et al.   Journal of Neuroinflammation

MHC Class II Restricted Innate-Like Double Negative T Cells Contribute to Optimal Primary and Secondary Immunity to Leishmania major

(2014) Zhirong Mou et al.   PLoS Pathogens

Helper T cells down-regulate CD4 expression upon chronic stimulation giving rise to double-negative T cells

(2013) Inna V. Grishkan et al.   CELLULAR IMMUNOLOGY

cAMP-responsive Element Modulator α (CREMα)trans-Represses the Transmembrane Glycoprotein CD8 and Contributes to the Generation of CD3+CD4−CD8−T Cells in Health and Disease

(2013) Christian M. Hedrich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immune Cell Infiltration in Malignant Middle Cerebral Artery Infarction: Comparison with Transient Cerebral Ischemia

(2013) Hannah X Chu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Adoptive Regulatory T-Cell Therapy Preserves Systemic Immune Homeostasis After Cerebral Ischemia

(2013) Peiying Li et al.   STROKE

IL-17-producing CD4−CD8−T cells are expanded in the peripheral blood, infiltrate salivary glands and are resistant to corticosteroids in patients with primary Sjögren's syndrome

(2012) Alessia Alunno et al.   ANNALS OF THE RHEUMATIC DISEASES

Liver TCRγδ+ CD3+ CD4− CD8− T cells contribute to murine hepatitis virus strain 3-induced hepatic injury through a TNF-α-dependent pathway

(2012) Yulei Lu et al.   MOLECULAR IMMUNOLOGY

CD3+CD4−CD8− (double negative) T cells: Saviours or villains of the immune response?

(2011) Fulvio D’Acquisto et al.   BIOCHEMICAL PHARMACOLOGY

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

(2011) Arthur Liesz et al.   BRAIN

Targeted mutation of Fas ligand gene attenuates brain inflammation in experimental stroke

(2011) Feng-nan Niu et al.   BRAIN BEHAVIOR AND IMMUNITY

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

(2011) Florian Wiede et al.   JOURNAL OF CLINICAL INVESTIGATION

Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease

(2011) Julie Zikherman et al.   JOURNAL OF CLINICAL INVESTIGATION

Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation

(2010) C. Kleinschnitz et al.   BLOOD

T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis

(2010) Atsushi Fukushima et al.   DIABETES

Human Urinary Kallidinogenase Suppresses Cerebral Inflammation in Experimental Stroke and Downregulates Nuclear Factor-κB

(2010) Zhi-Bin Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Human TCR-  + CD4- CD8- T Cells Can Derive from CD8+ T Cells and Display an Inflammatory Effector Phenotype

(2009) J. C. Crispin et al.   JOURNAL OF IMMUNOLOGY

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

(2009) Takashi Shichita et al.   NATURE MEDICINE

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

(2009) Mathias Gelderblom et al.   STROKE

The effect of murine anti-thymocyte globulin on experimental kidney warm ischemia–reperfusion injury in mice

(2009) Hye Ryoun Jang et al.   TRANSPLANT IMMUNOLOGY

Immunoregulatory mechanisms and CD4−CD8− (double negative) T cell subpopulations in human cutaneous leishmaniasis: A balancing act between protection and pathology

(2008) Kenneth J. Gollob et al.   INTERNATIONAL IMMUNOPHARMACOLOGY