Perforin: structure, function, and role in human immunopathology

Delayed Contraction of the CD8+ T Cell Response toward Lymphocytic Choriomeningitis Virus Infection in Mice Lacking Serglycin

(2014) M. Grujic et al.   JOURNAL OF IMMUNOLOGY

Extending the C2 domain family: C2s in PKCs δ, ϵ,η,θ, phospholipases, GAPs, and perforin

(2010) C.P. Pointing et al.   PROTEIN SCIENCE

Familial Hemophagocytic Lymphohistiocytosis Type 5 (FHL-5) Is Caused by Mutations in Munc18-2 and Impaired Binding to Syntaxin 11

(2009) Udo zur Stadt et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Defective phosphorylation of interleukin-18 receptor β causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis

(2009) Wilco de Jager et al.   ARTHRITIS AND RHEUMATISM

A critical analysis of the tumour immunosurveillance controversy for 3-MCA-induced sarcomas

(2009) T H Schreiber et al.   BRITISH JOURNAL OF CANCER

Anti-perforin neutralizing antibody reduces myocardial injury in viral myocarditis

(2009) Guo Chun-yan et al.   CARDIOLOGY IN THE YOUNG

The Molecular Basis for Perforin Oligomerization and Transmembrane Pore Assembly

(2009) Katherine Baran et al.   IMMUNITY

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells

(2009) Marjorie Côte et al.   JOURNAL OF CLINICAL INVESTIGATION

Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer

(2009) J. Chia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations of the hemophagocytic lymphohistiocytosis–associated geneUNC13D in a patient with systemic juvenile idiopathic arthritis

(2008) Melissa M. Hazen et al.   ARTHRITIS AND RHEUMATISM

Functional assessment of perforin C2 domain mutations illustrates the critical role for calcium-dependent lipid binding in perforin cytotoxic function

(2008) R. Urrea Moreno et al.   BLOOD

The MACPF/CDC family of pore-forming toxins

(2008) Carlos J. Rosado et al.   CELLULAR MICROBIOLOGY

Variations of the Perforin Gene in Patients With Type 1 Diabetes

(2008) E. Orilieri et al.   DIABETES

Dihydrofuro[3,4-c]pyridinones as Inhibitors of the Cytolytic Effects of the Pore-Forming Glycoprotein Perforin

(2008) Gersande Lena et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structure of the MACPF Domain of Human Complement Protein C8α in Complex with the C8γ Subunit

(2008) Daniel J. Slade et al.   JOURNAL OF MOLECULAR BIOLOGY

Clinical and molecular aspects of Turkish familial hemophagocytic lymphohistiocytosis patients with perforin mutations

(2008) Hamza Okur et al.   LEUKEMIA RESEARCH

NS1 Specific CD8+ T-Cells with Effector Function and TRBV11 Dominance in a Patient with Parvovirus B19 Associated Inflammatory Cardiomyopathy

(2008) Mathias Streitz et al.   PLoS One

Hyperbaric Oxygen Prevents Early Death Caused by Experimental Cerebral Malaria

(2008) Yara C. Blanco et al.   PLoS One

A teenage boy with late onset hemophagocytic lymphohistiocytosis with predominant neurologic disease and perforin deficiency

(2007) Andrew D. Beaty et al.   PEDIATRIC BLOOD & CANCER