Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia

Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke

(2014) Jens Neumann et al.   ACTA NEUROPATHOLOGICA

Increasing value and reducing waste in research design, conduct, and analysis

(2014) John P A Ioannidis et al.   LANCET

Preclinical research: Make mouse studies work

(2014) Steve Perrin   NATURE

Journals unite for reproducibility

(2014) M. McNutt   SCIENCE

Changing the Mindset in Life Sciences Toward Translation: A Consensus

(2014) G. N. Duda et al.   Science Translational Medicine

Are We Ready to Translate T-Cell Transmigration in Stroke?

(2014) Wolf-Rüdiger Schäbitz et al.   STROKE

Blocking of α4 Integrin Does Not Protect From Acute Ischemic Stroke in Mice

(2014) Friederike Langhauser et al.   STROKE

Distinguishing between Exploratory and Confirmatory Preclinical Research Will Improve Translation

(2014) Jonathan Kimmelman et al.   PLOS BIOLOGY

Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

(2014) Gemma Llovera et al.   Jove-Journal of Visualized Experiments

Immune Cell Infiltration in Malignant Middle Cerebral Artery Infarction: Comparison with Transient Cerebral Ischemia

(2013) Hannah X Chu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Bringing rigour to translational medicine

(2013) David W. Howells et al.   Nature Reviews Neurology

Power failure: why small sample size undermines the reliability of neuroscience

(2013) Katherine S. Button et al.   NATURE REVIEWS NEUROSCIENCE

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Concerted Appeal for International Cooperation in Preclinical Stroke Research

(2013) Ulrich Dirnagl et al.   STROKE

Guidelines for the Early Management of Patients With Acute Ischemic Stroke

(2013) Edward C. Jauch et al.   STROKE

Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases

(2013) Konstantinos K. Tsilidis et al.   PLOS BIOLOGY

Postischemic Brain Infiltration of Leukocyte Subpopulations Differs among Murine Permanent and Transient Focal Cerebral Ischemia Models

(2012) Wei Zhou et al.   BRAIN PATHOLOGY

Targeting Mannose-Binding Lectin Confers Long-Lasting Protection With a Surprisingly Wide Therapeutic Window in Cerebral Ischemia

(2012) Franca Orsini et al.   CIRCULATION

Improving the Efficiency of the Development of Drugs for Stroke

(2012) David W. Howells et al.   International Journal of Stroke

International, Multicenter Randomized Preclinical Trials in Translational Stroke Research: It's Time to Act

(2012) Ulrich Dirnagl et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Two Pathophysiologies of Focal Brain Ischemia: Implications for Translational Stroke Research

(2012) Konstantin-Alexander Hossmann   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Assessing Post-Stroke Behavior in Mouse Models of Focal Ischemia

(2012) Mustafa Balkaya et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

The immunology of acute stroke

(2012) Ángel Chamorro et al.   Nature Reviews Neurology

Natalizumab

(2012) Richard Rudick et al.   JAMA Neurology

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

(2011) Arthur Liesz et al.   BRAIN

Development of an NIH Consortium for PreclinicAl AssESsment of CARdioprotective Therapies (CAESAR): A Paradigm Shift in Studies of Infarct Size Limitation

(2011) David J. Lefer et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Improving the efficacy of translational medicine by optimally integrating health care, academia and industry

(2011) Stefan R Bornstein et al.   NATURE MEDICINE

Stroke research at a crossroad: asking the brain for directions

(2011) Costantino Iadecola et al.   NATURE NEUROSCIENCE

Believe it or not: how much can we rely on published data on potential drug targets?

(2011) Florian Prinz et al.   NATURE REVIEWS DRUG DISCOVERY

Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation

(2010) C. Kleinschnitz et al.   BLOOD

Brain Protection: Maybe Yes, Maybe No

(2010) M. A. Moskowitz   STROKE

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Emulating Multicentre Clinical Stroke Trials: A New Paradigm for Studying Novel Interventions in Experimental Models of Stroke

(2009) P. M. W. Bath et al.   International Journal of Stroke

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

(2009) Takashi Shichita et al.   NATURE MEDICINE

The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice

(2009) Valentine Bouet et al.   Nature Protocols

The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction

(2009) Britta Engelhardt et al.   Seminars in Immunopathology

Improving Outcome after Stroke: Overcoming the Translational Roadblock

(2008) Matthias Endres et al.   CEREBROVASCULAR DISEASES

Stroke

(2008) Geoffrey A Donnan et al.   LANCET

Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke

(2008) Werner Hacke et al.   NEW ENGLAND JOURNAL OF MEDICINE

Empirical Evidence of Bias in the Design of Experimental Stroke Studies

(2008) Nicolas A. Crossley et al.   STROKE