Article
Oncology
Xin Nie, Dawo Liu, Mingjun Zheng, Xiao Li, Ouxuan Liu, Qian Guo, Liancheng Zhu, Bei Lin
Summary: HERPUD1 is highly expressed in ovarian cancer and positively correlated with the expression of Lewis y antigen. HERPUD1 promotes ovarian cancer by promoting cell proliferation, inhibiting apoptosis, affecting the cell cycle, promoting autophagy, and inhibiting multiple signaling pathways.
Article
Cell Biology
Wenqing Xie, Yue Shan, Zhuonan Wu, Nan Liu, Jinjin Yang, Hanlin Zhang, Shiming Sun, Jufang Chi, Weizhong Feng, Hui Lin, Hangyuan Guo
Summary: The study reveals the important role and therapeutic value of Homocysteine-inducible Endoplasmic Reticulum Stress Protein with Ubiquitin Like Domain 1 (Herpud1) in Homocysteine-induced Calcific Aortic Valve Disease (CAVD). It is found that Herpud1 deficiency inhibits the development of CAVD induced by homocysteine and activates cell autophagy to inhibit the osteogenic differentiation of AVICs. Moreover, inhibiting endoplasmic reticulum stress and Herpud1 biosynthesis can alleviate AVIC calcification induced by homocysteine and mitigate aortic valve calcification.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Oncology
Taewan Kim, Carlo M. Croce
Summary: Advancements in biological technologies have provided insights into the role of coding genes and noncoding RNAs in cancer cellular pathways, particularly highlighting the importance of understanding the ER stress pathway and its implications in cancer.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Cell Biology
Ruiyuan Xu, Jianlu Song, Rexiati Ruze, Yuan Chen, Xinpeng Yin, Chengcheng Wang, Yupei Zhao
Summary: This study reveals squalene epoxidase (SQLE) as a novel oncogene that promotes pancreatic cancer (PC) growth by mitigating endoplasmic reticulum stress and activating lipid raft-regulated Src/PI3K/Akt signaling pathway. SQLE facilitates cell proliferation, induces cell cycle progression, and inhibits apoptosis in vitro, while promoting tumor growth in vivo. SQLE inhibitors effectively suppress PC cell proliferation and xenograft tumor growth, highlighting the potential of SQLE as a therapeutic target for PC.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Ching-Yao Li, Tsui-Fen Chou, Yu-Li Lo
Summary: This study developed a novel approach for treating PDAC using CB-5083, miR-142, and R in nanotechnology. The nanoformulation showed pH-sensitive and targeted characteristics, inhibiting cell migration and immune evasion in the tumor microenvironment. Additionally, it induced immunogenic cell death in PDAC cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Cell Biology
Xin Wen, Bin Su, Mingming Gao, Jiaqi Chen, Donglei Zhou, Hui You, Nannan Li, Shuaikang Chang, Xiaoyun Cheng, Chunhua Qian, Jingyang Gao, Peng Yang, Shen Qu, Le Bu
Summary: Our study reveals that lipocalin 2 (LCN2) plays a protective role in obese individuals, inhibiting cell apoptosis and improving inflammatory state by repressing endoplasmic reticulum stress, thereby alleviating gastric injury associated with obesity.
CELL DEATH & DISEASE
(2021)
Article
Chemistry, Inorganic & Nuclear
Karampal Singh, Joshua Northcote-Smith, Kuldip Singh, Kogularamanan Suntharalingam
Summary: This study reports the synthesis, characterisation, and anti-breast cancer stem cell (CSC) properties of a series of copper(ii)-terpyridine complexes containing aryl sulfonamide groups. One of these complexes, with p-toluene sulfonamide, is more potent than established anti-CSC drug salinomycin and anticancer drug cisplatin. The complexes enter breast CSCs, generate intracellular reactive oxygen species (ROS), induce endoplasmic reticulum stress, and trigger apoptosis.
DALTON TRANSACTIONS
(2023)
Review
Immunology
Jana Messias Sandes, Regina Celia Bressan Queiroz de Figueiredo
Summary: The endoplasmic reticulum (ER) is an important organelle in higher eukaryotic cells responsible for protein folding and assembly. It undergoes strict quality control to ensure proper processing of proteins, with unfolded proteins being targeted for degradation through the ER-associated degradation (ERAD) complex. Additionally, the ER responds to stress through the unfolded protein response (UPR) to restore homeostasis or induce cell death. Protozoan parasites such as Trypanosoma cruzi, Trypanosoma brucei, and Leishmania spp. also have similar ER structures and stress response mechanisms, making them attractive targets for chemotherapy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Jianhuang Lin, Heng Liu, Takeshi Fukumoto, Joseph Zundell, Qingqing Yan, Chih-Hang Anthony Tang, Shuai Wu, Wei Zhou, Dajiang Guo, Sergey Karakashev, Chih-Chi Andrew Hu, Kavitha Sarma, Andrew Kossenkov, Rugang Zhang
Summary: The arginine methyltransferase CARM1 regulates the IRE1 alpha/XBP1 pathway in the unfolded protein response, affecting the growth of ovarian cancers expressing CARM1. Inhibition of this pathway shows selective sensitivity in CARM1-expressing ovarian cancer cells. Pharmacological inhibition of the IRE1 alpha/XBP1 pathway alone or in combination with immune checkpoint blockade represents a potential therapeutic strategy for CARM1-expressing cancers.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Gunes Parlakgul, Ana Paula Arruda, Song Pang, Erika Cagampan, Nina Min, Ekin Guney, Grace Yankun Lee, Karen Inouye, Harald F. Hess, C. Shan Xu, Gokhan S. Hotamisligil
Summary: This study reveals the complex structural organization of organelles in liver tissue and highlights the significant alterations in obese mice. The functional importance of these structural changes on cellular and systemic metabolism is also demonstrated.
Article
Pharmacology & Pharmacy
Dan Zhang, Shanzhuang Niu, Yicheng Ma, Hang Chen, Yu Wen, Mingke Li, Bo Zhou, Yi Deng, Chunjing Shi, Guangyu Pu, Meng Yang, Xianmei Wang, Chenggang Zou, Yuanli Chen, Lanqing Ma
Summary: This study found that fenofibrate can alleviate ER stress and improve the pathology of NAFLD by regulating the expression of let-7 miRNA and SERCA2b. This provides new insights into the specific mechanism of fenofibrate in treating NAFLD and improving lipid metabolism disorders.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Hang Huang, Ping Li, Xueting Ye, Fangyi Zhang, Qi Lin, Keming Wu, Wei Chen
Summary: This study found that combination treatment of isoalantolactone (IATL) and cisplatin showed significantly enhanced growth inhibition and apoptosis in human prostate cancer cells, potentially through excessive accumulation of intracellular reactive oxygen species (ROS) and activation of endoplasmic reticulum (ER) stress and the JNK signaling pathway. In vivo, the combined treatment also exhibited the strongest anti-tumor effects compared to single agents, suggesting that IATL and cisplatin combination therapy may be more effective for treating prostate cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Plant Sciences
Kyung Hyun Yoo, Dae-Hwan Kim, Sumin Oh, Myong-Suk Park, Hangun Kim, Hyung-Ho Ha, Sang-Hee Cho, Ik-Joo Chung, Woo Kyun Bae
Summary: Potassium usnate (KU) exerts cytotoxic effects in human gastric cancer (GC) and colorectal cancer (CRC) cells through the activation of endoplasmic reticulum (ER) stress-induced apoptosis via an ATF3 dependent pathway.
Article
Multidisciplinary Sciences
Ankang Hu, Jing Liu, Yonghui Wang, Maoyin Zhang, Yao Guo, Ying Qin, Tingya Liu, Yanjuan Men, Quangang Chen, Tingjun Liu
Summary: This study found that rafoxanide significantly inhibits the growth, invasion, and migration of non-small cell lung cancer cells by inducing apoptosis and cell cycle arrest. It also induces endoplasmic reticulum stress and activates the unfolded protein response. In vivo models showed that rafoxanide effectively inhibits tumor growth.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Qingqing Zhou, Tengfei Liu, Wenjing Qian, Jun Ji, Qu Cai, Yangbing Jin, Jinling Jiang, Jun Zhang
Summary: BAP31 is upregulated in gastric cancer tissues and high expression is associated with poor survival of patients. BAP31 knockdown inhibits cell growth, induces G1/S arrest, and promotes cellular ferroptosis by increasing membrane lipid peroxidation. BAP31 directly binds to VDAC1, affecting its oligomerization and polyubiquitination, and is regulated by HNF4A at the promoter. Knockdown of BAP31 sensitizes gastric cancer cells to 5-FU and the ferroptosis inducer erastin.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Shu-Ping Li, Quan-Lin Guan, Da Zhao, Guang-Jun Pei, Hong-Xin Su, Lan-Ning Du, Jin-Xiang He, Zhao-Chen Liu
MEDICAL SCIENCE MONITOR
(2016)
Article
Medicine, Research & Experimental
Shu-Ping Li, Hong-Xin Su, Da Zhao, Quan-Lin Guan
MEDICAL SCIENCE MONITOR
(2016)
Article
Medicine, Research & Experimental
Deng-Rui Liu, Quan-Lin Guan, Ming-Tai Gao, Lei Jiang, Hong-Xia Kang
MEDICAL SCIENCE MONITOR
(2016)
Article
Biotechnology & Applied Microbiology
Gang Yang, Yong-bin Lu, Quan-lin Guan
ONCOTARGETS AND THERAPY
(2019)
Article
Immunology
Yuanchao Shi, Jingwei Duan, Quanlin Guan, Penglong Xue, Ya Zheng
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Deng-Rui Liu, Quan-Lin Guan, Ming-Tai Gao, Lei Jiang, Hong-Xia Kang
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS
(2017)