MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions

Recent progress toward the use of circulating microRNAs as clinical biomarkers

(2016) Vikas Ghai et al.   ARCHIVES OF TOXICOLOGY

A dual inhibition: microRNA-552 suppresses both transcription and translation of cytochrome P450 2E1

(2016) Lingling Miao et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

miRISC and the CCR4–NOT complex silence mRNA targets independently of 43S ribosomal scanning

(2016) Duygu Kuzuoğlu‐Öztürk et al.   EMBO JOURNAL

Human Argonaute 2 Is Tethered to Ribosomal RNA through MicroRNA Interactions

(2016) Blake L. Atwood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA Target Recognition: Insights from Transcriptome-Wide Non-Canonical Interactions

(2016)   MOLECULES AND CELLS

Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP

(2016) Ryan M. Spengler et al.   NUCLEIC ACIDS RESEARCH

Stable association of RNAi machinery is conserved between the cytoplasm and nucleus of human cells

(2016) Roya Kalantari et al.   RNA

The Role of microRNAs in the Pathogenesis of Herpesvirus Infection

(2016) Diogo Piedade et al.   Viruses-Basel

Argonaute-associated short introns are a novel class of gene regulators

(2016) Thomas B. Hansen et al.   Nature Communications

Endogenous Mouse Dicer Is an Exclusively Cytoplasmic Protein

(2016) Christian Much et al.   PLoS Genetics

Circulating MicroRNAs: Potential and Emerging Biomarkers for Diagnosis of Human Infectious Diseases

(2016) Parmila Verma et al.   Frontiers in Microbiology

Towards a molecular understanding of microRNA-mediated gene silencing

(2015) Stefanie Jonas et al.   NATURE REVIEWS GENETICS

A-to-I editing of coding and non-coding RNAs by ADARs

(2015) Kazuko Nishikura   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Importin-β facilitates nuclear import of human GW proteins and balances cytoplasmic gene silencing protein levels

(2015) Daniel Schraivogel et al.   NUCLEIC ACIDS RESEARCH

Modulation of Splicing by Single-Stranded Silencing RNAs

(2015) Jing Liu et al.   Nucleic Acid Therapeutics

Transcriptional regulation mechanism mediated by miRNA–DNA•DNA triplex structure stabilized by Argonaute

(2014) Julia D. Toscano-Garibay et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Autoregulation oflin-4microRNA transcription by RNA activation (RNAa) inC. elegans

(2014) Michael Turner et al.   CELL CYCLE

Importin 8 Regulates the Transport of Mature MicroRNAs into the Cell Nucleus

(2014) Yao Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long Non-coding RNAHOTAIRIs Targeted and Regulated by miR-141 in Human Cancer Cells

(2014) Takeshi Chiyomaru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues

(2014) Stephen W. Eichhorn et al.   MOLECULAR CELL

Transcriptome-wide Discovery of microRNA Binding Sites in Human Brain

(2014) Ryan L. Boudreau et al.   NEURON

Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells

(2014) M. Allo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel HIV-1-encoded microRNA enhances its viral replication by targeting the TATA box region

(2014) Yijun Zhang et al.   Retrovirology

Cellular microRNAs up-regulate transcription via interaction with promoter TATA-box motifs

(2014) Yijun Zhang et al.   RNA

MicroRNA-206: a Promising Theranostic Marker

(2014) Jan Novák et al.   Theranostics

RNAi Factors Are Present and Active in Human Cell Nuclei

(2014) Keith T. Gagnon et al.   Cell Reports

A mRNA and Cognate MicroRNAs Localize in the Nucleolus

(2014) Pablo Reyes-Gutierrez et al.   Nucleus

Small RNA expression and deep sequencing analyses of the nucleolus reveal the presence of nucleolus-associated microRNAs

(2014) Baoyan Bai et al.   FEBS Open Bio

Negative regulation of lncRNA GAS5 by miR-21

(2013) Z Zhang et al.   CELL DEATH AND DIFFERENTIATION

The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis

(2013) M. Liu et al.   GENES & DEVELOPMENT

RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond

(2013) Stephane E. Castel et al.   NATURE REVIEWS GENETICS

Promoter RNA links transcriptional regulation of inflammatory pathway genes

(2013) Masayuki Matsui et al.   NUCLEIC ACIDS RESEARCH

Dynamic Localisation of Mature MicroRNAs in Human Nucleoli is Influenced by Exogenous Genetic Materials

(2013) Zhou Fang Li et al.   PLoS One

The double-stranded RNA binding domain of human Dicer functions as a nuclear localization signal

(2013) M. Doyle et al.   RNA

Translational Repression and eIF4A2 Activity Are Critical for MicroRNA-Mediated Gene Regulation

(2013) H. A. Meijer et al.   SCIENCE

microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus

(2013) Eleonora Leucci et al.   Scientific Reports

A comprehensive characterization of the nuclear microRNA repertoire of post-mitotic neurons

(2013) Sharof A. Khudayberdiev et al.   Frontiers in Molecular Neuroscience

Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression

(2012) G. Zardo et al.   BLOOD

Intracellular Localization and Routing of miRNA and RNAi Pathway Components

(2012) Thomas Ohrt et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review

(2012) Marilena V. Iorio et al.   EMBO Molecular Medicine

Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells

(2012) Julien Béthune et al.   EMBO REPORTS

DNA-RNA hybrid formation mediates RNAi-directed heterochromatin formation

(2012) Mina Nakama et al.   GENES TO CELLS

Autoregulation of microRNA biogenesis by let-7 and Argonaute

(2012) Dimitrios G. Zisoulis et al.   NATURE

Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation

(2012) Farzaneh Modarresi et al.   NATURE BIOTECHNOLOGY

Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells

(2012) Moussa Benhamed et al.   NATURE CELL BIOLOGY

Argonaute proteins couple chromatin silencing to alternative splicing

(2012) Maya Ameyar-Zazoua et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC

(2012) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An alternative mode of microRNA target recognition

(2012) Sung Wook Chi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Combinatorial Action of miRNAs Regulates Transcriptional and Post-Transcriptional Gene Silencing following in vivo PNS Injury

(2012) Tadepalli Adilakshmi et al.   PLoS One

Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus

(2012) K. Nishi et al.   RNA

miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay

(2012) S. Djuranovic et al.   SCIENCE

Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish

(2012) A. A. Bazzini et al.   SCIENCE

The code within the code: microRNAs target coding regions

(2011) Joshua J. Forman et al.   CELL CYCLE

Mouse miRNA-709 directly regulates miRNA-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microRNA hierarchy system

(2011) Rui Tang et al.   CELL RESEARCH

miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA

(2011) Thomas B Hansen et al.   EMBO JOURNAL

Transcriptional regulation by miRNA mimics that target sequences downstream of gene termini

(2011) Scott T. Younger et al.   Molecular BioSystems

Expanding the action of duplex RNAs into the nucleus: redirecting alternative splicing

(2011) Jing Liu et al.   NUCLEIC ACIDS RESEARCH

Direct evidence of nuclear Argonaute distribution during transcriptional silencing links the actin cytoskeleton to nuclear RNAi machinery in human cells

(2011) Chantelle L. Ahlenstiel et al.   NUCLEIC ACIDS RESEARCH

Upregulation of Cyclin B1 by miRNA and its implications in cancer

(2011) Vera Huang et al.   NUCLEIC ACIDS RESEARCH

Mature microRNAs identified in highly purified nuclei from HCT116 colon cancer cells

(2011) Chang Won Park et al.   RNA Biology

Nuclear and cytoplasmic localization of neural stem cell microRNAs

(2011) C. D. Jeffries et al.   RNA

MicroRNA-205-directed transcriptional activation of tumor suppressor genes in prostate cancer

(2010) Shahana Majid et al.   CANCER

Mechanistic principles of chromatin remodeling guided by siRNAs and miRNAs

(2010) Susana Gonzalez et al.   CELL CYCLE

Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes

(2010) Anna Zampetaki et al.   CIRCULATION RESEARCH

Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes

(2010) K.-M. Schmitz et al.   GENES & DEVELOPMENT

A Splicing-Independent Function of SF2/ASF in MicroRNA Processing

(2010) Han Wu et al.   MOLECULAR CELL

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis

(2010) Sihem Cheloufi et al.   NATURE

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter

(2010) Yongjun Chu et al.   NUCLEIC ACIDS RESEARCH

Deep Sequencing of Human Nuclear and Cytoplasmic Small RNAs Reveals an Unexpectedly Complex Subcellular Distribution of miRNAs and tRNA 3′ Trailers

(2010) Jian-You Liao et al.   PLoS One

Predicting potential miRNA target sites within gene promoters

(2009) Scott T. Younger et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Transcriptional inhibition of Hoxd4 expression by noncoding RNAs in human breast cancer cells

(2009) Yuliang Tan et al.   BMC MOLECULAR BIOLOGY

Importin 8 Is a Gene Silencing Factor that Targets Argonaute Proteins to Distinct mRNAs

(2009) Lasse Weinmann et al.   CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

New class of microRNA targets containing simultaneous 5'-UTR and 3'-UTR interaction sites

(2009) I. Lee et al.   GENOME RESEARCH

An Integrated Approach for Experimental Target Identification of Hypoxia-induced miR-210

(2009) Pasquale Fasanaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Argonaute HITS-CLIP decodes microRNA–mRNA interaction maps

(2009) Sung Wook Chi et al.   NATURE

Control of alternative splicing through siRNA-mediated transcriptional gene silencing

(2009) Mariano Alló et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs

(2009) D. Castanotto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs with a nucleolar location

(2009) J. C. Ritland Politz et al.   RNA

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

(2009) N. T. Ingolia et al.   SCIENCE

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Antisense transcripts are targets for activating small RNAs

(2008) Jacob C Schwartz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy reveal the cytoplasmic origination of loaded nuclear RISC in vivo in human cells

(2008) Thomas Ohrt et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-directed transcriptional gene silencing in mammalian cells

(2008) D. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro reconstitution of the human RISC-loading complex

(2008) I. J. MacRae et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-373 induces expression of genes with complementary promoter sequences

(2008) R. F. Place et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A multifunctional human Argonaute2-specific monoclonal antibody

(2008) S. Rudel et al.   RNA

Bidirectional Transcription Directs Both Transcriptional Gene Activation and Suppression in Human Cells

(2008) Kevin V. Morris et al.   PLoS Genetics