Article
Biochemistry & Molecular Biology
Raviprasad Kuthethur, Divya Adiga, Amoolya Kandettu, Maria Sona Jerome, Sandeep Mallya, Kamalesh Dattaram Mumbrekar, Shama Prasada Kabekkodu, Sanjiban Chakrabarty
Summary: This study identified FOXM1 as a direct target of miR-4521 in breast cancer. Overexpression of miR-4521 significantly downregulated FOXM1 expression in breast cancer cells, inhibiting cell proliferation and DNA damage repair. The findings reveal the role of the miR-4521/FOXM1 pathway in breast cancer and provide a new therapeutic target for its treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Oncology
Yanbo Zhu, Fang Li, Yilong Wan, Hansi Liang, Si Li, Bo Peng, Liqun Shao, Yunyun Xu, Dong Jiang
Summary: MiR-620 inhibits ESCC malignancy and suppresses aerobic glycolysis in ESCC cells by targeting FOXM1 and HER2. Exosomal miR-620 is highly secreted in ESCC and can regulate aerobic glycolysis in HFL1 cells via the FOXM1/HER2 signaling pathway. Additionally, exosomal miR-620 can promote ESCC metastasis by reprogramming aerobic glycolysis in lung fibroblasts.
FRONTIERS IN ONCOLOGY
(2022)
Article
Toxicology
Zi-tan Peng, Pei Gu
Summary: MiR-4521 inhibits autophagy by targeting PIK3R3, leading to decreased proliferation and increased apoptosis in gastric carcinoma cells. Furthermore, sulforaphane exerts anti-cancer effects by repressing autophagy and growth in tumor cells, which can be weakened by miR-4521 inhibition or PIK3R3 over-expression.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Parasitology
Qian Yao, Ying-Ying Fan, Shuang Huang, Gui-Rong Hu, Jun-Ke Song, Xin Yang, Guang-Hui Zhao
Summary: This study found that the expression of miR-4521 was upregulated during C. parvum infection, and this upregulation was related to the TLR/NF-kappa B signal pathway. Additionally, miR-4521 promoted the propagation of C. parvum in HCT-8 cells by regulating BCL2-mediated cell apoptosis through targeting foxm1.
Article
Oncology
Min Su, Jinming Tang, Baihua Zhang, Desong Yang, Zhining Wu, Jie Wu, Yong Zhou, Qianjin Liao, Hui Wang, Wenxiang Wang, Yuhang Xiao
Summary: This study demonstrates that GACAT3 acts as an oncogene in ESCC by interacting with miR-149 to promote tumor progression, and also functions as a ceRNA to modulate FOXM1 expression. These findings suggest that GACAT3 may serve as a potential therapeutic target in ESCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Shi-Xiong Liu, Yun Zhou, Li Zhao, Ling -Shan Zhou, Jie Sun, Ge-Jing Liu, Ying-Shi Du, Yong-Ning Zhou
Summary: The study found that FOXM1 expression levels were significantly up-regulated in human gastric cancer cell lines and tissues, and its expression was higher in patients with metastasis. Suppression of FOXM1 with its inhibitor THIO significantly inhibited the proliferation of gastric cancer cells, induced apoptosis, and suppressed migration, invasion, and angiogenesis. Furthermore, THIO promoted drug-resistant gastric cancer cells to chemotherapies and inhibited the epithelial-mesenchymal transition (EMT) process. These findings suggest that FOXM1 is a promising therapeutic target for gastric cancer treatment and THIO has potential as a therapeutic agent for the disease.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ran-Ran Ma, Hui Zhang, Hong-Fang Chen, Guo-Hao Zhang, Ya-Ru Tian, Peng Gao
Summary: This study revealed that the decreased expression of KIF26A in gastric cancer patients is associated with disease progression, metastasis, and poor survival. By regulating the focal-adhesion pathway and suppressing the occurrence of epithelial-to-mesenchymal transition, KIF26A can inhibit tumor cell migration and invasion.
Article
Oncology
Zhipeng Jiang, Hao Hu, Wenli Hu, Zehui Hou, Wei Liu, Zhuomin Yu, Zhiqiang Liang, Shuang Chen
Summary: This study aimed to investigate the role of circ-RNF121 in colorectal cancer (CRC). The results showed that circ-RNF121 silencing inhibited cell proliferation, migration, invasion, and glycolysis while inducing cell apoptosis in CRC. Additionally, circ-RNF121 acted as a sponge for miR-1224-5p and was involved in tumor growth inhibition in vivo. This finding sheds new light on circRNA-mediated therapy for CRC.
CANCER CELL INTERNATIONAL
(2021)
Article
Immunology
Shupei Zhang, Diling Pan, Shaoyu Zhang, Qiumei Wu, Lan Zhen, Shihuang Liu, Jingjing Chen, Rong Lin, Qiuhua Hong, Xiangqin Zheng, Huan Yi
Summary: This study found that exosomal miR-543 participates in the proteoglycan pathway to suppress cell proliferation by targeting IGF2 in ovarian cancer.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Pina Fusco, Anna Fietta, Maria Rosaria Esposito, Luca Zanella, Sara Micheli, Angelica Bastianello, Lorenzo Bova, Giulia Borile, Giuseppe Germano, Elisa Cimetta
Summary: Tumor hypoxia stimulates release of extracellular vesicles (EVs) that facilitate short- and long-range intercellular communication and metastatization. The role of hypoxic EVs and their miR-210-3p cargo enrichment in promoting Neuroblastoma (NB) dissemination was investigated. The study found that hypoxic EVs were more potent in inducing NB cells migration and colony formation, and miR-210-3p was identified as the most abundant miRNA in the cargo of hypoxic EVs. Overexpression of miR-210-3p in normoxic EVs conferred them pro-metastatic features, while miR-210-3p silencing suppressed the metastatic ability of hypoxic EVs both in vitro and in vivo.
CELL AND BIOSCIENCE
(2023)
Article
Medicine, Research & Experimental
Lunpo Wu, Meng Xue, Sanchuan Lai, Jingyu Chen, Yifeng Lin, Ning Ding, Jing Zhong, Shujie Chen, Liangjing Wang
Summary: The study found that exosomes derived from colorectal cancer cells can be transferred to normoxic cells in a hypoxic microenvironment, promoting cell proliferation and migration. miRNA microarray analysis revealed that miR-4299 expression was significantly increased in hypoxic exosomes, and the upregulation of miR-4299 may depend on HIF-1α. Additionally, overexpression of miR-4299 promoted tumor growth and metastasis both in vitro and in vivo, and the expression level of its target gene ZBTB4 was decreased in tumor tissues.
Article
Biotechnology & Applied Microbiology
Jianjie Li, Xiaoyue Xu, Chunhui Liu, Xiaoxue Xi, Yang Wang, Xiaotang Wu, Hua Li
Summary: miR-181a-2-3p promotes GC cell progression by targeting MYLK and enhancing tumor growth. The promoting effect of miR-181a-2-3p on GC cells is reversed when miR-181a-2-3p and MYLK are simultaneously overexpressed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ying Wang, Kaijuan Lu, Weibing Li, Zhigang Wang, Jing Ding, Zeyu Zhu, Zhipeng Li
Summary: The study revealed a tumor-promoting role of miR-200c-3p in gastric cell carcinoma (GCC), which may be achieved by targeting KLF6 and regulating the growth and metastasis of GCC cells.
Article
Cell Biology
Shuo Ma, Xinliang Gu, Lei Shen, Yinhao Chen, Chen Qian, Xianjuan Shen, Shaoqing Ju
Summary: The specific circRNA circHAS2 was upregulated in gastric cancer tissues and cells, and was positively correlated with tumor metastasis. Knockdown of circHAS2 or addition of hsa-miR-944 mimics inhibited proliferation, migration, and invasion of GC cells. The circHAS2/hsa-miR-944/PPM1E axis may be involved in the progression of GC, suggesting circHAS2 as a potential biomarker and therapeutic target for GC.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Michelle Xin Liu, Kent-Man Chu
Summary: This study aims to investigate the functional roles of miR-410-3p in primary gastric cancer and the roles of exosomes in regulating miR-410-3p expression. It was found that miR-410-3p was downregulated in gastric cancer and its overexpression inhibited cancer cell proliferation, migration, and invasion. Exosomal miR-410-3p expression was significantly higher than its endogenous expression and exosomes from gastric cancer cells regulated miR-410-3p expression in other cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)