The Crossroads between RAS and RHO Signaling Pathways in Cellular Transformation, Motility and Contraction

The Ins and Outs of RAS Effector Complexes

(2021) Christina Kiel et al.   Biomolecules

Mechanotransduction of Strain Regulates an Invasive Phenotype in Newly Transformed Epithelial Cells

(2021) Sophie Chagnon-Lessard et al.   Frontiers in Physics

Oncogenic Signaling Alters Cell Shape and Mechanics to Facilitate Cell Division under Confinement

(2020) Helen K. Matthews et al.   DEVELOPMENTAL CELL

Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties

(2020) Tito Panciera et al.   NATURE MATERIALS

Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide

(2020) Rachel Jaber Chehayeb et al.   PLoS One

Effect of PAK Inhibition on Cell Mechanics Depends on Rac1

(2020) Claudia Tanja Mierke et al.   Frontiers in Cell and Developmental Biology

The Frequency of Ras Mutations in Cancer

(2020) Ian A. Prior et al.   CANCER RESEARCH

Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice

(2020) Shahidul Islam et al.   Journal of Physiological Sciences

The effects of mutant Ras proteins on the cell signalome

(2020) Tamás Takács et al.   CANCER AND METASTASIS REVIEWS

Tyrosine Phosphorylation of the Myosin Regulatory Light Chain Controls Non-muscle Myosin II Assembly and Function in Migrating Cells

(2020) Rocío Aguilar-Cuenca et al.   CURRENT BIOLOGY

RAS-targeted therapies: is the undruggable drugged?

(2020) Amanda R. Moore et al.   NATURE REVIEWS DRUG DISCOVERY

Linking the Landscape of MYH9-Related Diseases to the Molecular Mechanisms that Control Non-Muscle Myosin II-A Function in Cells

(2020) Gloria Asensio-Juárez et al.   Cells

KRAS: From undruggable to a druggable Cancer Target

(2020) Dipesh Uprety et al.   CANCER TREATMENT REVIEWS

RAS and RHO family GTPase mutations in cancer: twin sons of different mothers?

(2020) Richard G. Hodge et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

SOS GEFs in health and disease

(2020) Fernando C. Baltanás et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Myosin IIA Regulated Tight Junction in Oxygen Glucose-Deprived Brain Endothelial Cells Via Activation of TLR4/PI3K/Akt/JNK1/2/14-3-3ε/NF-κB/MMP9 Signal Transduction Pathway

(2019) Yanni Lv et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis

(2019) Hendrik A. Messal et al.   NATURE

Eph signaling controls mitotic spindle orientation and cell proliferation in neuroepithelial cells

(2019) Maribel Franco et al.   JOURNAL OF CELL BIOLOGY

RAF dimers control vascular permeability and cytoskeletal rearrangements at endothelial cell‐cell junctions

(2019) Coralie Dorard et al.   FEBS Journal

p90 ribosomal S6 kinase (RSK) phosphorylates myosin phosphatase and thereby controls edge dynamics during cell migration

(2019) Shiela C. Samson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase 1 study evaluating the safety, tolerability, pharmacokinetics (PK), and efficacy of AMG 510, a novel small molecule KRASG12C inhibitor, in advanced solid tumors.

(2019) Marwan Fakih et al.   JOURNAL OF CLINICAL ONCOLOGY

RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance

(2019) Daniël A. Lionarons et al.   CANCER CELL

SRC and ERK cooperatively phosphorylate DLC1 and attenuate its Rho-GAP and tumor suppressor functions

(2019) Brajendra K. Tripathi et al.   JOURNAL OF CELL BIOLOGY

Rac1 S71 Mediates the Interaction between Rac1 and 14-3-3 Proteins

(2019) Abdalla Abdrabou et al.   Cells

Role of PI3K/Akt and MEK/ERK Signalling in cAMP/Epac-Mediated Endothelial Barrier Stabilisation

(2019) Dursun Gündüz et al.   Frontiers in Physiology

ZIP kinase phosphorylated and activated by Rho kinase/ROCK contributes to cytokinesis in mammalian cultured cells

(2019) Kozue Hamao et al.   EXPERIMENTAL CELL RESEARCH

RHO GTPases in cancer: known facts, open questions, and therapeutic challenges

(2018) Xosé R. Bustelo   BIOCHEMICAL SOCIETY TRANSACTIONS

Control of Mechanotransduction by Molecular Clutch Dynamics

(2018) Alberto Elosegui-Artola et al.   TRENDS IN CELL BIOLOGY

Ras-Mediated Activation of the Raf Family Kinases

(2018) Elizabeth M. Terrell et al.   Cold Spring Harbor Perspectives in Medicine

Drak/STK17A drives neoplastic glial proliferation through modulation of MRLC signaling

(2018) Alexander S Chen et al.   CANCER RESEARCH

Myosin-18B Promotes the Assembly of Myosin II Stacks for Maturation of Contractile Actomyosin Bundles

(2018) Yaming Jiu et al.   CURRENT BIOLOGY

MYO18B promotes hepatocellular carcinoma progression by activating PI3K/AKT/mTOR signaling pathway

(2018) Zhenyu Zhang et al.   Diagnostic Pathology

Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility

(2018) Ana Angulo-Urarte et al.   Nature Communications

Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer

(2018) Miguel M. Murillo et al.   Cell Reports

RalB directly triggers invasion downstream Ras by mobilizing the Wave complex

(2018) Giulia Zago et al.   eLife

Receptor tyrosine kinase activation of RhoA is mediated by AKT phosphorylation of DLC1

(2017) Brajendra K. Tripathi et al.   JOURNAL OF CELL BIOLOGY

Rho GTPase signaling complexes in cell migration and invasion

(2017) Campbell D. Lawson et al.   JOURNAL OF CELL BIOLOGY

TRPV4 mediates the Ca2+influx required for the interaction between flightless-1 and non-muscle myosin, and collagen remodeling

(2017) Pamma D. Arora et al.   JOURNAL OF CELL SCIENCE

Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis

(2017) S Gerboth et al.   LEUKEMIA

Targeting group I p21-activated kinases to control malignant peripheral nerve sheath tumor growth and metastasis

(2017) G Semenova et al.   ONCOGENE

RAF1/BRAF dimerization integrates the signal from RAS to ERK and ROKα

(2017) Andrea Varga et al.   Science Signaling

PI3K: A Crucial Piece in the RAS Signaling Puzzle

(2017) Agata Adelajda Krygowska et al.   Cold Spring Harbor Perspectives in Medicine

RAF1/BRAF dimerization integrates the signal from RAS to ERK and ROKα

(2017) Andrea Varga et al.   Science Signaling

Symmetry breaking in spreading RAT2 fibroblasts requires the MAPK/ERK pathway scaffold RACK1 that integrates FAK, p190A-RhoGAP and ERK2 signaling

(2016) Zuzana Klímová et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Rap1-RIAM-talin axis of integrin activation and blood cell function

(2016) F. Lagarrigue et al.   BLOOD

Inhibition of PI3K promotes dilation of human small airways in a rho kinase-dependent manner

(2016) Cynthia J Koziol-White et al.   BRITISH JOURNAL OF PHARMACOLOGY

Myosin light chain kinase steady-state kinetics: comparison of smooth muscle myosin II and nonmuscle myosin IIB as substrates

(2016) Diego B. Alcala et al.   CELL BIOCHEMISTRY AND FUNCTION

Direct interaction between exocyst and Wave complexes promotes cell protrusions and motility

(2016) Marco Biondini et al.   JOURNAL OF CELL SCIENCE

Tissue mechanics promote IDH1-dependent HIF1α–tenascin C feedback to regulate glioblastoma aggression

(2016) Yekaterina A. Miroshnikova et al.   NATURE CELL BIOLOGY

Phosphorylation and Activation of RhoA by ERK in Response to Epidermal Growth Factor Stimulation

(2016) Junfeng Tong et al.   PLoS One

Actin and Actin-Binding Proteins

(2016) Thomas D. Pollard   Cold Spring Harbor Perspectives in Biology

RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression

(2016) Esther Castellano et al.   Nature Communications

An oncogenic KRAS transcription program activates the RHOGEF ARHGEF2 to mediate transformed phenotypes in pancreatic cancer

(2016) Oliver A. Kent et al.   Oncotarget

Integrin β1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer

(2016) Cheolwon Choi et al.   Oncotarget

Rho GTPase signalling in cell migration

(2015) Anne J Ridley   CURRENT OPINION IN CELL BIOLOGY

Ral GTPases: crucial mediators of exocytosis and tumourigenesis

(2015) R. Shirakawa et al.   JOURNAL OF BIOCHEMISTRY

ERK reinforces actin polymerization to power persistent edge protrusion during motility

(2015) Michelle C. Mendoza et al.   Science Signaling

NMMHC IIA inhibition impedes tissue factor expression and venous thrombosis via Akt/GSK3β-NF-κB signalling pathways in the endothelium

(2015) Kefeng Zhai et al.   THROMBOSIS AND HAEMOSTASIS

Signaling Networks that Regulate Cell Migration

(2015) Peter Devreotes et al.   Cold Spring Harbor Perspectives in Biology

RalB regulates contractility-driven cancer dissemination upon TGFβ stimulation via the RhoGEF GEF-H1

(2015) Marco Biondini et al.   Scientific Reports

ERK reinforces actin polymerization to power persistent edge protrusion during motility

(2015) Michelle C. Mendoza et al.   Science Signaling

Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame

(2014) Leanna R. Gentry et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Effect of 2-arachidonoylglycerol on myosin light chain phosphorylation and platelet activation: The role of phosphatidylinositol 3 kinase/AKT pathway

(2014) Maria Grazia Signorello et al.   BIOCHIMIE

The RhoGEF GEF-H1 Is Required for Oncogenic RAS Signaling via KSR-1

(2014) Jane Cullis et al.   CANCER CELL

Mesenchymal Chemotaxis Requires Selective Inactivation of Myosin II at the Leading Edge via a Noncanonical PLCγ/PKCα Pathway

(2014) Sreeja B. Asokan et al.   DEVELOPMENTAL CELL

SDF-1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II

(2014) Dong Soon Choi et al.   INTERNATIONAL JOURNAL OF CANCER

Functional Cross-talk between Ras and Rho Pathways

(2014) Mamta Jaiswal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epithelial repair is a two-stage process driven first by dying cells and then by their neighbours

(2014) D. Kuipers et al.   JOURNAL OF CELL SCIENCE

Growing knowledge of the mTOR signaling network

(2014) Kezhen Huang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Interaction of RhoD and ZIP kinase modulates actin filament assembly and focal adhesion dynamics

(2013) Vishal Nehru et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Requirement for Interaction of PI3-Kinase p110α with RAS in Lung Tumor Maintenance

(2013) Esther Castellano et al.   CANCER CELL

Skin Tumorigenesis Stimulated by Raf Inhibitors Relies Upon Raf Functions That Are Dependent and Independent of ERK

(2013) E. Doma et al.   CANCER RESEARCH

RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms

(2013) Ralph Fritsch et al.   CELL

The guanine nucleotide exchange factor Tiam1: A Janus-faced molecule in cellular signaling

(2013) P. Boissier et al.   CELLULAR SIGNALLING

In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling

(2013) P. Khoo et al.   Disease Models & Mechanisms

Ral GTPases in tumorigenesis: Emerging from the shadows

(2013) David F. Kashatus   EXPERIMENTAL CELL RESEARCH

Extracellular Signal-Regulated Kinase Regulates RhoA Activation and Tumor Cell Plasticity by Inhibiting Guanine Exchange Factor H1 Activity

(2013) Anne von Thun et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation of Rac1 T108 by Extracellular Signal-Regulated Kinase in Response to Epidermal Growth Factor: a Novel Mechanism To Regulate Rac1 Function

(2013) Junfeng Tong et al.   MOLECULAR AND CELLULAR BIOLOGY

The Ras-ERK pathway modulates cytoskeleton organization, cell motility and lung metastasis signature genes in MDA-MB-231 LM2

(2013) C Choi et al.   ONCOGENE

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

p120RasGAP-Mediated Activation of c-Src Is Critical for Oncogenic Ras to Induce Tumor Invasion

(2012) P.-C. Chan et al.   CANCER RESEARCH

Exo70 Stimulates the Arp2/3 Complex for Lamellipodia Formation and Directional Cell Migration

(2012) Jianglan Liu et al.   CURRENT BIOLOGY

FRET imaging and statistical signal processing reveal positive and negative feedback loops regulating the morphology of randomly migrating HT-1080 cells

(2012) K. Kunida et al.   JOURNAL OF CELL SCIENCE

The RalB Small GTPase Mediates Formation of Invadopodia through a GTPase-Activating Protein-Independent Function of the RalBP1/RLIP76 Effector

(2012) N. F. Neel et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion

(2012) Subhanjan Mondal et al.   MOLECULAR BIOLOGY OF THE CELL

Cooperative Activation of PI3K by Ras and Rho Family Small GTPases

(2012) Hee Won Yang et al.   MOLECULAR CELL

Essential, non-redundant roles of B-Raf and Raf-1 in Ras-driven skin tumorigenesis

(2012) F Kern et al.   ONCOGENE

Nf1 RasGAP Inhibition of LIMK2 Mediates a New Cross-Talk between Ras and Rho Pathways

(2012) Béatrice Vallée et al.   PLoS One

Understanding SOS (Son of Sevenless)

(2011) Stéphane Pierre et al.   BIOCHEMICAL PHARMACOLOGY

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

Different metastasis promotive potency of small G-proteins RalA and RalB in in vivo hamster tumor model

(2011) Vera A Rybko et al.   Cancer Cell International

Life at the Leading Edge

(2011) Anne J. Ridley   CELL

Angiogenic Sprouting Requires the Fine Tuning of Endothelial Cell Cohesion by the Raf-1/Rok-α Complex

(2011) Reiner Wimmer et al.   DEVELOPMENTAL CELL

Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation

(2011) Antonio Castro-Castro et al.   EMBO JOURNAL

Early Requirement of Rac1 in a Mouse Model of Pancreatic Cancer

(2011) Irina Heid et al.   GASTROENTEROLOGY

The Epidermal Growth Factor Receptor Mediates Tumor Necrosis Factor-α-induced Activation of the ERK/GEF-H1/RhoA Pathway in Tubular Epithelium

(2011) Eli Kakiashvili et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TOR kinase complexes and cell migration

(2011) Lunhua Liu et al.   JOURNAL OF CELL BIOLOGY

Macrophage Migration Inhibitory Factor and CD74 Regulate Macrophage Chemotactic Responses via MAPK and Rho GTPase

(2011) H. Fan et al.   JOURNAL OF IMMUNOLOGY

BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study

(2011) Eleni Makrodouli et al.   Molecular Cancer

ERK-MAPK Drives Lamellipodia Protrusion by Activating the WAVE2 Regulatory Complex

(2011) Michelle C. Mendoza et al.   MOLECULAR CELL

New Modularity of DAP-Kinases: Alternative Splicing of the DRP-1 Gene Produces a ZIPk-Like Isoform

(2011) Yishay Shoval et al.   PLoS One

K-Ras Mediated Murine Epidermal Tumorigenesis Is Dependent upon and Associated with Elevated Rac1 Activity

(2011) Michael S. Samuel et al.   PLoS One

Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia

(2011) B. K. Chauhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of Actin Filament Treadmilling in Cell Motility

(2010) Beáta Bugyi et al.   Annual Review of Biophysics

Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration

(2010) Margaret L. Gardel et al.   Annual Review of Cell and Developmental Biology

Generation of branched actin networks: assembly and regulation of the N-WASP and WAVE molecular machines

(2010) Emmanuel Derivery et al.   BIOESSAYS

Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival

(2010) Matthias Drosten et al.   EMBO JOURNAL

Manipulating signal delivery - plasma-membrane ERK activation in aPKC-dependent migration

(2010) K. Boeckeler et al.   JOURNAL OF CELL SCIENCE

Identification of the Rac-GEF P-Rex1 as an Essential Mediator of ErbB Signaling in Breast Cancer

(2010) Maria Soledad Sosa et al.   MOLECULAR CELL

A nucleator arms race: cellular control of actin assembly

(2010) Kenneth G. Campellone et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

E-cadherin negatively regulates neoplastic growth in non-small cell lung cancer: role of Rho GTPases

(2010) L Asnaghi et al.   ONCOGENE

Raf-1 Addiction in Ras-Induced Skin Carcinogenesis

(2009) Karin Ehrenreiter et al.   CANCER CELL

The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells

(2009) K. Paňková et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Focal adhesion-localization of START-GAP1/DLC1 is essential for cell motility and morphology

(2009) Katsuhisa Kawai et al.   GENES TO CELLS

PTEN is a mechanosensing signal transducer for myosin II localization inDictyosteliumcells

(2009) Md. Kamruzzaman Pramanik et al.   GENES TO CELLS

From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-α kinase activity

(2009) Théodora Niault et al.   JOURNAL OF CELL BIOLOGY

The pre-GAP-related domain of neurofibromin regulates cell migration through the LIM kinase/cofilin pathway

(2009) Sigal Starinsky-Elbaz et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinase

(2009) Frederick Kweh et al.   MOLECULAR CARCINOGENESIS

Src-Induced Disassembly of Adherens Junctions Requires Localized Phosphorylation and Degradation of the Rac Activator Tiam1

(2009) Simon A. Woodcock et al.   MOLECULAR CELL

Non-muscle myosin II takes centre stage in cell adhesion and migration

(2009) Miguel Vicente-Manzanares et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities

(2009) X-Y Yang et al.   ONCOGENE

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA

(2008) Shuh-hei Fujishiro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

P120-Ras GTPase activating protein (RasGAP): A multi-interacting protein in downstream signaling

(2008) Perayot Pamonsinlapatham et al.   BIOCHIMIE

The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells

(2008) D. J. J. de Gorter et al.   BLOOD

A Tripartite Complex Containing MRCK Modulates Lamellar Actomyosin Retrograde Flow

(2008) Ivan Tan et al.   CELL

Ral-regulated interaction between Sec5 and paxillin targets Exocyst to focal complexes during cell migration

(2008) K. S. Spiczka et al.   JOURNAL OF CELL SCIENCE

CRAF Autophosphorylation of Serine 621 Is Required to Prevent Its Proteasome-Mediated Degradation

(2008) Catherine Noble et al.   MOLECULAR CELL

Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner

(2008) Colin K. Choi et al.   NATURE CELL BIOLOGY

Regulation of cytokinesis by Rho GTPase flux

(2008) Ann L. Miller et al.   NATURE CELL BIOLOGY

PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils

(2008) Bryan Heit et al.   NATURE IMMUNOLOGY

Mechanisms of Disease: epithelial–mesenchymal transition—does cellular plasticity fuel neoplastic progression?

(2008) Eva A Turley et al.   Nature clinical practice. Oncology

B-RAF Regulation of Rnd3 Participates in Actin Cytoskeletal and Focal Adhesion Organization

(2007) R. Matthew Klein et al.   MOLECULAR BIOLOGY OF THE CELL