Ral GTPases: crucial mediators of exocytosis and tumourigenesis

Platelets Are Highly Activated in Patients of Chronic Thromboembolic Pulmonary Hypertension

(2014) Nobuhiro Yaoita et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins

(2014) Qiaoli Chen et al.   CELLULAR SIGNALLING

Ral GTPase Down-regulation Stabilizes and Reactivates p53 to Inhibit Malignant Transformation

(2014) Awet Tecleab et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ral and Rheb GTPase Activating Proteins Integrate mTOR and GTPase Signaling in Aging, Autophagy, and Tumor Cell Invasion

(2014) Timothy D. Martin et al.   MOLECULAR CELL

RalA signaling pathway as a therapeutic target in hepatocellular carcinoma (HCC)

(2014) Mohamad Ezzeldin et al.   Molecular Oncology

Discovery and characterization of small molecules that target the GTPase Ral

(2014) Chao Yan et al.   NATURE

κB-Ras Proteins Regulate Both NF-κB-Dependent Inflammation and Ral-Dependent Proliferation

(2014) Andrea Oeckinghaus et al.   Cell Reports

Ral mediates activity-dependent growth of postsynaptic membranes via recruitment of the exocyst

(2013) Rita O Teodoro et al.   EMBO JOURNAL

Negative Regulation of the RalGAP Complex by 14-3-3

(2013) Dara Leto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Small GTPase RALA Controls c-Jun N-terminal Kinase-mediated FOXO Activation by Regulation of a JIP1 Scaffold Complex

(2013) Maaike C. W. van den Berg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia

(2013) Pedro Monteiro et al.   JOURNAL OF CELL BIOLOGY

RalA promotes a direct exocyst-Par6 interaction to regulate polarity in neuronal development

(2013) A. Das et al.   JOURNAL OF CELL SCIENCE

Identification of a Novel Prenyl and Palmitoyl Modification at the CaaX Motif of Cdc42 That Regulates RhoGDI Binding

(2013) A. Nishimura et al.   MOLECULAR AND CELLULAR BIOLOGY

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

(2013) Jonathan M. Ostrem et al.   NATURE

The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response

(2013) Michal Simicek et al.   NATURE CELL BIOLOGY

Spatial regulation of VEGF receptor endocytosis in angiogenesis

(2013) Masanori Nakayama et al.   NATURE CELL BIOLOGY

In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction

(2013) F. Shima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

(2012) Qi Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

RALBP1/RLIP76 Depletion in Mice Suppresses Tumor Growth by Inhibiting Tumor Neovascularization

(2012) S. Lee et al.   CANCER RESEARCH

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Genetic Deletion of RALA and RALB Small GTPases Reveals Redundant Functions in Development and Tumorigenesis

(2012) Pascal Peschard et al.   CURRENT BIOLOGY

Phosphorylation by Protein Kinase Cα Regulates RalB Small GTPase Protein Activation, Subcellular Localization, and Effector Utilization

(2012) Timothy D. Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Anti-inflammatory TIPE2 Is an Inhibitor of the Oncogenic Ras

(2012) Yael Gus-Brautbar et al.   MOLECULAR CELL

Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer

(2012) R Saito et al.   ONCOGENE

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

(2012) T. Maurer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation and Involvement of Ral GTPases in Colorectal Cancer

(2011) T. D. Martin et al.   CANCER RESEARCH

RalB and the Exocyst Mediate the Cellular Starvation Response by Direct Activation of Autophagosome Assembly

(2011) Brian O. Bodemann et al.   CELL

Control of Secondary Granule Release in Neutrophils by Ral GTPase

(2011) Celia X.-J. Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase D Mediates Nutrient Input to Mammalian Target of Rapamycin Complex 1 (mTORC1)

(2011) Limei Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 and its mutants in tumor cell migration and invasion

(2011) Patricia A. J. Muller et al.   JOURNAL OF CELL BIOLOGY

Ral GTPases Regulate Cell-Mediated Cytotoxicity in NK Cells

(2011) J. Sanchez-Ruiz et al.   JOURNAL OF IMMUNOLOGY

Direct binding of RalA to PKCη and its crucial role in morphological change during keratinocyte differentiation

(2011) Yasuhito Shirai et al.   MOLECULAR BIOLOGY OF THE CELL

RALA and RALBP1 regulate mitochondrial fission at mitosis

(2011) David F. Kashatus et al.   NATURE CELL BIOLOGY

The human Rgr oncogene is overexpressed in T-cell malignancies and induces transformation by acting as a GEF for Ras and Ral

(2011) K Osei-Sarfo et al.   ONCOGENE

Phosphorylation of RalB Is Important for Bladder Cancer Cell Growth and Metastasis

(2010) H. Wang et al.   CANCER RESEARCH

Aberrant Overexpression of the Rgl2 Ral Small GTPase-specific Guanine Nucleotide Exchange Factor Promotes Pancreatic Cancer Growth through Ral-dependent and Ral-independent Mechanisms

(2010) Dominico Vigil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action

(2010) Xiao-Wei Chen et al.   MOLECULAR BIOLOGY OF THE CELL

Sec5 and Exo84 Foster Oncogenic Ras-Mediated Tumorigenesis

(2010) S. H. Issaq et al.   MOLECULAR CANCER RESEARCH

An oncogene–tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-κB

(2010) Junxia Min et al.   NATURE MEDICINE

Dissection of RAS downstream pathways in melanomagenesis: a role for Ral in transformation

(2010) P J Mishra et al.   ONCOGENE

Ral activation promotes melanomagenesis

(2010) P A Zipfel et al.   ONCOGENE

RalA-Exocyst Complex Regulates Integrin-Dependent Membrane Raft Exocytosis and Growth Signaling

(2009) Nagaraj Balasubramanian et al.   CURRENT BIOLOGY

Tuberous Sclerosis Tumor Suppressor Complex-like Complexes Act as GTPase-activating Proteins for Ral GTPases

(2009) Ryutaro Shirakawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ral Overactivation in Malignant Peripheral Nerve Sheath Tumors

(2009) V. Bodempudi et al.   MOLECULAR AND CELLULAR BIOLOGY

Aurora-A Phosphorylates, Activates, and Relocalizes the Small GTPase RalA

(2009) K.-H. Lim et al.   MOLECULAR AND CELLULAR BIOLOGY

The Role of the Exocyst in Matrix Metalloproteinase Secretion and Actin Dynamics during Tumor Cell Invadopodia Formation

(2009) Jianglan Liu et al.   MOLECULAR BIOLOGY OF THE CELL

M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex

(2009) Koji Hase et al.   NATURE CELL BIOLOGY

Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion

(2008) Tetsuya SAITO et al.   BIOMEDICAL RESEARCH-TOKYO

The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells

(2008) D. J. J. de Gorter et al.   BLOOD

Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells

(2008) M. G. Rondaij et al.   BLOOD

Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs

(2008) Ilaria Cascone et al.   EMBO JOURNAL

The Rap–RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues

(2008) Andrea Scrima et al.   EMBO JOURNAL

RalA Functions as an Indispensable Signal Mediator for the Nutrient-sensing System

(2008) Tomohiko Maehama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The RalA GTPase Is a Central Regulator of Insulin Exocytosis from Pancreatic Islet Beta Cells

(2008) Jamie A. Lopez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ral-regulated interaction between Sec5 and paxillin targets Exocyst to focal complexes during cell migration

(2008) K. S. Spiczka et al.   JOURNAL OF CELL SCIENCE

RalGDS Couples Growth Factor Signaling to Akt Activation

(2008) Y. Hao et al.   MOLECULAR AND CELLULAR BIOLOGY