Essential, non-redundant roles of B-Raf and Raf-1 in Ras-driven skin tumorigenesis

RASMutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors

(2012) Fei Su et al.   NEW ENGLAND JOURNAL OF MEDICINE

c-Raf, but Not B-Raf, Is Essential for Development of K-Ras Oncogene-Driven Non-Small Cell Lung Carcinoma

(2011) Rafael B. Blasco et al.   CANCER CELL

Targeting RAF: trials and tribulations

(2011) Julian Downward   NATURE MEDICINE

Resistance to BRAF Inhibition in Melanomas

(2011) David B. Solit et al.   NEW ENGLAND JOURNAL OF MEDICINE

Raf kinases in cancer–roles and therapeutic opportunities

(2011) G Maurer et al.   ONCOGENE

C-Raf Is Required for the Initiation of Lung Cancer by K-Ras G12D

(2011) Florian A. Karreth et al.   Cancer Discovery

Ras and Raf pathways in epidermis development and carcinogenesis

(2010) F Kern et al.   BRITISH JOURNAL OF CANCER

Targets of Raf in tumorigenesis

(2010) T. S. Niault et al.   CARCINOGENESIS

Autocrine VEGF Signaling Synergizes with EGFR in Tumor Cells to Promote Epithelial Cancer Development

(2010) Beate M. Lichtenberger et al.   CELL

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

(2010) Sonja J. Heidorn et al.   CELL

BRAF Inhibitors: Research Accelerates in Wake of Positive Findings

(2010) V. Brower   JNCI-Journal of the National Cancer Institute

Drug discovery: Inhibitors that activate

(2010) Karen Cichowski et al.   NATURE

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

(2010) Poulikos I. Poulikakos et al.   NATURE

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

(2010) Georgia Hatzivassiliou et al.   NATURE

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

(2010) Gideon Bollag et al.   NATURE

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

(2010) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Partner exchange: protein–protein interactions in the Raf pathway

(2010) Reiner Wimmer et al.   TRENDS IN BIOCHEMICAL SCIENCES

Raf-1 Addiction in Ras-Induced Skin Carcinogenesis

(2009) Karin Ehrenreiter et al.   CANCER CELL

Selective Role for Mek1 but not Mek2 in the Induction of Epidermal Neoplasia

(2009) F. A. Scholl et al.   CANCER RESEARCH

Erk1/2 MAP kinases are required for epidermal G2/M progression

(2009) Phillip A. Dumesic et al.   JOURNAL OF CELL BIOLOGY

Mek1/2 gene dosage determines tissue response to oncogenic Ras signaling in the skin

(2009) F A Scholl et al.   ONCOGENE

Distinct Roles for ROCK1 and ROCK2 in the Regulation of Keratinocyte Differentiation

(2009) Frances E. Lock et al.   PLoS One

Elevated CRAF as a Potential Mechanism of Acquired Resistance to BRAF Inhibition in Melanoma

(2008) C. Montagut et al.   CANCER RESEARCH