Receptor tyrosine kinase activation of RhoA is mediated by AKT phosphorylation of DLC1

Targeting CDK4/6 in patients with cancer

(2016) Erika Hamilton et al.   CANCER TREATMENT REVIEWS

RhoA/Rho-Kinase in the Cardiovascular System

(2016) Hiroaki Shimokawa et al.   CIRCULATION RESEARCH

Proteogenomics connects somatic mutations to signalling in breast cancer

(2016) Philipp Mertins et al.   NATURE

RhoA/Rho kinase in spinal cord injury

(2016) Xiao-ming Xu et al.   Neural Regeneration Research

Attenuating the p53 Pathway in Human Cancers: Many Means to the Same End

(2016) Amanda R. Wasylishen et al.   Cold Spring Harbor Perspectives in Medicine

Rho regulation: DLC proteins in space and time

(2015) Anja C. Braun et al.   CELLULAR SIGNALLING

EGF-stimulated AKT activation is mediated by EGFR recycling via an early endocytic pathway in a gefitinib-resistant human lung cancer cell line

(2015) YUKIO NISHIMURA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)

(2015) GEORGE MIHAI NITULESCU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Epidermal growth factor–stimulated Akt phosphorylation requires clathrin or ErbB2 but not receptor endocytosis

(2015) Camilo Garay et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of RhoA Activity by Adhesion Molecules and Mechanotransduction

(2014) R.J. Marjoram et al.   CURRENT MOLECULAR MEDICINE

Functional Cross-talk between Ras and Rho Pathways

(2014) Mamta Jaiswal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidermal Growth Factor Activates the Rho GTPase-activating Protein (GAP) Deleted in Liver Cancer 1 via Focal Adhesion Kinase and Protein Phosphatase 2A

(2014) Archna Ravi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CDK5 is a major regulator of the tumor suppressor DLC1

(2014) Brajendra K. Tripathi et al.   JOURNAL OF CELL BIOLOGY

Cell Type-specific Signaling Function of RhoA GTPase: Lessons from Mouse Gene Targeting

(2013) Xuan Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis

(2013) Frankie Chi Fat Ko et al.   Nature Communications

Protein Purification-free Method of Binding Affinity Determination by Microscale Thermophoresis

(2013) Lyuba Khavrutskii et al.   Jove-Journal of Visualized Experiments

Lysophospholipid receptor activation of RhoA and lipid signaling pathways

(2012) Sunny Yang Xiang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

(2012) Susanne A.I. Seidel et al.   METHODS

Differential regulation of the activity of deleted in liver cancer 1 (DLC1) by tensins controls cell migration and transformation

(2012) X. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

The 'invisible hand': regulation of RHO GTPases by RHOGDIs

(2011) Rafael Garcia-Mata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)

(2011) G. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deleted in liver cancer protein family in human malignancies (Review)

(2011) E. Wilczek   Oncology Letters

Akt Phosphorylation of Deleted in Liver Cancer 1 Abrogates Its Suppression of Liver Cancer Tumorigenesis and Metastasis

(2010) Frankie Chi Fat Ko et al.   GASTROENTEROLOGY

MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo

(2010) H. Hirai et al.   MOLECULAR CANCER THERAPEUTICS

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

(2007) Kevin D. Healy et al.   MOLECULAR CARCINOGENESIS