Amyloid β-dependent mitochondrial toxicity in mouse microglia requires P2X7 receptor expression and is prevented by nimodipine

Toward a New Concept of Alzheimer’s Disease Models: A Perspective from Neuroinflammation

(2018) Antonia Gutierrez et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglia-Mediated Synapse Loss in Alzheimer's Disease

(2018) Lawrence Rajendran et al.   JOURNAL OF NEUROSCIENCE

New role of P2X7 receptor in an Alzheimer’s disease mouse model

(2018) Elodie Martin et al.   MOLECULAR PSYCHIATRY

Novel targets in Alzheimer’s disease: A special focus on microglia

(2018) Claudia Balducci et al.   PHARMACOLOGICAL RESEARCH

P2X7 as a scavenger receptor for innate phagocytosis in the brain

(2018) Ben J Gu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondria in innate immune signaling

(2018) Balaji Banoth et al.   Translational Research

The P2X7 Receptor in Infection and Inflammation

(2017) Francesco Di Virgilio et al.   IMMUNITY

Nimodipine fosters remyelination in a mouse model of multiple sclerosis and induces microglia-specific apoptosis

(2017) Andrea Schampel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting microglia for the treatment of Alzheimer's Disease

(2016) Paul D. Wes et al.   GLIA

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer’s disease

(2016) Simon J. Beck et al.   Nature Communications

Role of Mitochondria in Neurodegenerative Diseases: Mitochondria as a Therapeutic Target in Alzheimer's Disease

(2016) P. Hemachandra Reddy   CNS SPECTRUMS

P2X7Receptor Regulates Internalization of Antimicrobial Peptide LL-37 by Human Macrophages That Promotes Intracellular Pathogen Clearance

(2015) Xiao Tang et al.   JOURNAL OF IMMUNOLOGY

The L-type voltage-gated calcium channel modulates microglial pro-inflammatory activity

(2015) J.F. Espinosa-Parrilla et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology

(2013) Grietje Krabbe et al.   PLoS One

Nimodipine inhibits IL-1β release stimulated by amyloid β from microglia

(2012) JM Sanz et al.   BRITISH JOURNAL OF PHARMACOLOGY

P2X7 Receptor-mediated Scavenger Activity of Mononuclear Phagocytes toward Non-opsonized Particles and Apoptotic Cells Is Inhibited by Serum Glycoproteins but Remains Active in Cerebrospinal Fluid

(2012) Ben J. Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's disease: Effects of β-amyloid on mitochondria

(2010) Laurent Tillement et al.   MITOCHONDRION

Neuroinflammation – An Early Event in Both the History and Pathogenesis of Alzheimer’s Disease

(2010) Piet Eikelenboom et al.   Neurodegenerative Diseases

The Genetics of Alzheimer Disease: Back to the Future

(2010) Lars Bertram et al.   NEURON

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta

(2009) Heng Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The P2X7-nonmuscle myosin membrane complex regulates phagocytosis of nonopsonized particles and bacteria by a pathway attenuated by extracellular ATP

(2009) B. J. Gu et al.   BLOOD

Activation of Microglia by Amyloid   Requires P2X7 Receptor Expression

(2009) J. M. Sanz et al.   JOURNAL OF IMMUNOLOGY

Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-β

(2009) Alessandro Michelucci et al.   JOURNAL OF NEUROIMMUNOLOGY

Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells

(2009) Mariusz R Wieckowski et al.   Nature Protocols

Nimodipine protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation

(2008) Yachen Li et al.   NEUROPHARMACOLOGY

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA