Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 787, Issue -, Pages 134-142Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2016.03.064
Keywords
Glaucoma; Retinal ganglion cells; Neuroinflammation; Glial cells; Neurodegeneration; Neuroprotection; Antiinflammatory
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Funding
- PRIN [20109MXHMR_008]
- University of Calabria
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In clinical glaucoma, as well as in experimental models, the loss of retinal ganglion cells occurs by apoptosis. This final event is preceded by inflammatory responses involving the activation of innate and adaptive immunity, with retinal and optic nerve resident glial cells acting as major players. Here we review the current literature on the role of neuroinflammation in neurodegeneration, focusing on the inflammatory molecular mechanisms involved in the pathogenesis and progression of the optic neuropathy. (C) 2016 Elsevier B.V. All rights reserved.
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