Neuronal P2X7 receptor-induced reactive oxygen species production contributes to nociceptive behavior in mice

Expression level of P2X7 receptor is a determinant of ATP-induced death of mouse cultured neurons

(2016) A. Ohishi et al.   NEUROSCIENCE

Distinct contributions of reactive oxygen species in amygdala to bee venom-induced spontaneous pain-related behaviors

(2016) Yun-Fei Lu et al.   NEUROSCIENCE LETTERS

N-acetyl-cysteine attenuates neuropathic pain by suppressing matrix metalloproteinases

(2016) Jiajie Li et al.   PAIN

P2X7 receptor is critical in α-synuclein–mediated microglial NADPH oxidase activation

(2015) Tianfang Jiang et al.   NEUROBIOLOGY OF AGING

ROS Production via P2Y1-PKC-NOX2 Is Triggered by Extracellular ATP after Electrical Stimulation of Skeletal Muscle Cells

(2015) Alexis Díaz-Vegas et al.   PLoS One

Cellular Levels of 8-Oxoguanine in either DNA or the Nucleotide Pool Play Pivotal Roles in Carcinogenesis and Survival of Cancer Cells

(2014) Yusaku Nakabeppu   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Native store-operated calcium channels are functionally expressed in mouse spinal cord dorsal horn neurons and regulate resting calcium homeostasis

(2014) Jingsheng Xia et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of ATP-Gated P2X Channels: From Redox Signaling to Interactions with Other Proteins

(2013) Stanko S. Stojilkovic et al.   ANTIOXIDANTS & REDOX SIGNALING

Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluid

(2013) Henrik E. Poulsen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The NADPH Oxidase Pathway Is Dysregulated by the P2X7 Receptor in the SOD1-G93A Microglia Model of Amyotrophic Lateral Sclerosis

(2013) S. Apolloni et al.   JOURNAL OF IMMUNOLOGY

P2X7 receptor-induced death of motor neurons by a peroxynitrite/FAS-dependent pathway

(2013) Mandi Gandelman et al.   JOURNAL OF NEUROCHEMISTRY

P2X7 receptor activation regulates microglial cell death during oxygen-glucose deprivation

(2013) Ukpong B. Eyo et al.   NEUROPHARMACOLOGY

Regulation of P2X7-dependent inflammatory functions by P2X4 receptor in mouse macrophages

(2012) Ayumi Kawano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NADPH Oxidase and Neurodegeneration

(2012) Marina S. Hernandes et al.   Current Neuropharmacology

P2X7receptor in the trigeminal sensory nuclear complex contributes to tactile allodynia/hyperalgesia following trigeminal nerve injury

(2012) G. Ito et al.   EUROPEAN JOURNAL OF PAIN

Microglial neurotransmitter receptors trigger superoxide production in microglia; consequences for microglial-neuronal interactions

(2012) Emma L. Mead et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial dysfunction is involved in P2X7 receptor-mediated neuronal cell death

(2012) Kentaro Nishida et al.   JOURNAL OF NEUROCHEMISTRY

N-Acetyl-Cysteine Causes Analgesia by Reinforcing the Endogenous Activation of Type-2 Metabotropic Glutamate Receptors

(2012) Matteo Bernabucci et al.   Molecular Pain

A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases

(2011) Nishkantha Arulkumaran et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Roles of reactive oxygen and nitrogen species in pain

(2011) Daniela Salvemini et al.   FREE RADICAL BIOLOGY AND MEDICINE

There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells

(2011) Guy C. Brown et al.   MITOCHONDRION

P2X7 receptor blockade prevents ATP excitotoxicity in neurons and reduces brain damage after ischemia

(2011) Joana Arbeloa et al.   NEUROBIOLOGY OF DISEASE

Central sensitization of nociceptive neurons in rat medullary dorsal horn involves purinergic P2X7 receptors

(2011) K. Itoh et al.   NEUROSCIENCE

Reactive oxygen species contribute to neuropathic pain by reducing spinal GABA release

(2011) June Yowtak et al.   PAIN

Involvement of microglial P2X7 receptors and downstream signaling pathways in long-term potentiation of spinal nociceptive responses

(2010) Yu-Xia Chu et al.   BRAIN BEHAVIOR AND IMMUNITY

Extracellular ATP and the P2X7 receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis

(2010) Mandi Gandelman et al.   Journal of Neuroinflammation

P2X7-Dependent Release of Interleukin-1  and Nociception in the Spinal Cord following Lipopolysaccharide

(2010) A. K. Clark et al.   JOURNAL OF NEUROSCIENCE

DNA polymerases involved in the incorporation of oxidized nucleotides into DNA: Their efficiency and template base preference

(2010) Atsushi Katafuchi et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Activation of Microglia by Amyloid   Requires P2X7 Receptor Expression

(2009) J. M. Sanz et al.   JOURNAL OF IMMUNOLOGY

P2X7and P2Y13purinergic receptors mediate intracellular calcium responses to BzATP in rat cerebellar astrocytes

(2009) Luz María G. Carrasquero et al.   JOURNAL OF NEUROCHEMISTRY

The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore

(2009) M. Monif et al.   JOURNAL OF NEUROSCIENCE

Purinoceptors on Neuroglia

(2009) Alexei Verkhrasky et al.   MOLECULAR NEUROBIOLOGY

Physiological and pathological functions of P2X7 receptor in the spinal cord

(2009) Maria Luisa Cotrina et al.   Purinergic Signalling

Requirement of Reactive Oxygen Species-dependent Activation of ASK1-p38 MAPK Pathway for Extracellular ATP-induced Apoptosis in Macrophage

(2008) Takuya Noguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apocynin: Molecular Aptitudes

(2008) J. Stefanska et al.   MEDIATORS OF INFLAMMATION

Selective P2X7 receptor antagonists for chronic inflammation and pain

(2008) William A. Carroll et al.   Purinergic Signalling