Mechanosensitive release of adenosine 5′-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: A mechanism for purinergic involvement in chronic strain

SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel

(2014) Zhaozhu Qiu et al.   CELL

Identification of LRRC8 Heteromers as an Essential Component of the Volume-Regulated Anion Channel VRAC

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Astrocytes inhibit nitric oxide-dependent Ca2+dynamics in activated microglia: Involvement of ATP released via pannexin 1 channels

(2013) Juan A. Orellana et al.   GLIA

CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes

(2013) Akiyuki Taruno et al.   NATURE

TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity

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The biochemistry and function of pannexin channels

(2012) Silvia Penuela et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication

(2012) Federico Abascal et al.   BIOESSAYS

The effect of changes in intraocular pressure on the risk of primary open-angle glaucoma in patients with ocular hypertension: an application of latent class analysis

(2012) Feng Gao et al.   BMC Medical Research Methodology

Connexin and pannexin hemichannels in inflammatory responses of glia and neurons

(2012) Michael V.L. Bennett et al.   BRAIN RESEARCH

Heterosynaptic long-term depression mediated by ATP released from astrocytes

(2012) Jiadong Chen et al.   GLIA

Increased astrocytic ATP release results in enhanced excitability of the hippocampus

(2012) Hae Ung Lee et al.   GLIA

The Importance of astrocyte-derived purines in the modulation of sleep

(2012) Tamara Blutstein et al.   GLIA

ATP signaling is deficient in cultured pannexin1-null mouse astrocytes

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Splice variants of the P2X7 receptor reveal differential agonist dependence and functional coupling with pannexin-1

(2012) X. J. Xu et al.   JOURNAL OF CELL SCIENCE

Neurons respond directly to mechanical deformation with pannexin-mediated ATP release and autostimulation of P2X7receptors

(2012) Jingsheng Xia et al.   JOURNAL OF PHYSIOLOGY-LONDON

Imaging and characterization of stretch-induced ATP release from alveolar A549 cells

(2012) Ryszard Grygorczyk et al.   JOURNAL OF PHYSIOLOGY-LONDON

Genetic Ablation of Pannexin1 Protects Retinal Neurons from Ischemic Injury

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Critical pathogenic events underlying progression of neurodegeneration in glaucoma

(2012) David J. Calkins   PROGRESS IN RETINAL AND EYE RESEARCH

Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats

(2011) Lana J Mawhinney et al.   BMC NEUROSCIENCE

Expression and Roles of Pannexins in ATP Release in the Pituitary Gland

(2011) Shuo Li et al.   ENDOCRINOLOGY

Sustained elevation of extracellular ATP in aqueous humor from humans with primary chronic angle-closure glaucoma

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Rho Signaling Regulates Pannexin 1-mediated ATP Release from Airway Epithelia

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Pannexin 3 functions as an ER Ca2+channel, hemichannel, and gap junction to promote osteoblast differentiation

(2011) Masaki Ishikawa et al.   JOURNAL OF CELL BIOLOGY

Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma

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Circadian Regulation of ATP Release in Astrocytes

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Stimulation of the P2X7 receptor kills rat retinal ganglion cells in vivo

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A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma

(2010) Claude F. Burgoyne   EXPERIMENTAL EYE RESEARCH

Basal Release of ATP: An Autocrine-Paracrine Mechanism for Cell Regulation

(2010) R. Corriden et al.   Science Signaling

Both sides now: multiple interactions of ATP with pannexin-1 hemichannels. Focus on “A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP”

(2009) George R. Dubyak   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Extracellular osmolarity modulates G protein-coupled receptor-dependent ATP release from 1321N1 astrocytoma cells

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Biomechanics of the optic nerve head

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Expression and function of P2Y receptors on Müller cells of the postnatal rat retina

(2009) Antje Wurm et al.   GLIA

The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes

(2009) William R. Silverman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pannexin 1: The Molecular Substrate of Astrocyte "Hemichannels"

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Uniquely Hominid Features of Adult Human Astrocytes

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Tripartite synapses: Roles for astrocytic purines in the control of synaptic physiology and behavior

(2009) Michael M. Halassa et al.   NEUROPHARMACOLOGY

Maxi-anion channel as a candidate pathway for osmosensitive ATP release from mouse astrocytes in primary culture

(2008) Hong-Tao Liu et al.   CELL RESEARCH

Mechanical lesion activates newly identified NFATc1 in primary astrocytes: implication of ATP and purinergic receptors

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Pharmacological “cross-inhibition” of connexin hemichannels and swelling activated anion channels

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Pharmacological Characterization of Pannexin-1 Currents Expressed in Mammalian Cells

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Elevated pressure triggers a physiological release of ATP from the retina: Possible role for pannexin hemichannels

(2008) D. Reigada et al.   NEUROSCIENCE