Metabolic regulation of T cells in the tumor microenvironment by nutrient availability and diet
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Metabolic regulation of T cells in the tumor microenvironment by nutrient availability and diet
Authors
Keywords
Immunometabolism, Cancer metabolism, Tumor microenvironment, Immuno-oncology, Immunotherapy, T cells
Journal
SEMINARS IN IMMUNOLOGY
Volume -, Issue -, Pages 101485
Publisher
Elsevier BV
Online
2021-08-29
DOI
10.1016/j.smim.2021.101485
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion
- (2021) Nicole E. Scharping et al. NATURE IMMUNOLOGY
- CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability
- (2021) Xingzhe Ma et al. Cell Metabolism
- Metabolic support of tumour-infiltrating regulatory T cells by lactic acid
- (2021) McLane J. Watson et al. NATURE
- Lipid signalling enforces functional specialization of Treg cells in tumours
- (2021) Seon Ah Lim et al. NATURE
- Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cells
- (2021) Ilkka Liikanen et al. JOURNAL OF CLINICAL INVESTIGATION
- Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors
- (2021) Shihao Xu et al. IMMUNITY
- Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming
- (2020) Dominic G. Roy et al. Cell Metabolism
- CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors
- (2020) Haiping Wang et al. NATURE IMMUNOLOGY
- Cellular adaptation to hypoxia through hypoxia inducible factors and beyond
- (2020) Pearl Lee et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells
- (2020) Sicheng Fu et al. Nature Communications
- The cellular function of SCAP in metabolic signaling
- (2020) Sun Hee Lee et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Dietary modifications for enhanced cancer therapy
- (2020) Naama Kanarek et al. NATURE
- Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I
- (2020) Keisuke Yamamoto et al. NATURE
- Metabolic Reprogramming in CD8+ T Cells During Acute Viral Infections
- (2020) Shubhranshu S. Gupta et al. Frontiers in Immunology
- Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies
- (2020) Devikala Gurusamy et al. CANCER CELL
- Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells
- (2020) Teresa Manzo et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen
- (2020) Santosha A. Vardhana et al. NATURE IMMUNOLOGY
- Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy
- (2020) Lukas F. Mager et al. SCIENCE
- Cytotoxic CD8+ T cells in cancer and cancer immunotherapy
- (2020) Hans Raskov et al. BRITISH JOURNAL OF CANCER
- Dietary Regulation of Immunity
- (2020) Aileen H. Lee et al. IMMUNITY
- Cancer SLC43A2 alters T cell methionine metabolism and histone methylation
- (2020) Yingjie Bian et al. NATURE
- Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion
- (2020) Yi-Ru Yu et al. NATURE IMMUNOLOGY
- Cytotoxic T-cells mediate exercise-induced reductions in tumor growth
- (2020) Helene Rundqvist et al. eLife
- Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity
- (2020) Alison E. Ringel et al. CELL
- Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade
- (2020) Eduardo Bonavita et al. IMMUNITY
- Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells
- (2019) Sema Kurtulus et al. IMMUNITY
- Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy
- (2019) Imran Siddiqui et al. IMMUNITY
- Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycle
- (2019) Wan-Chen Cheng et al. NATURE IMMUNOLOGY
- Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8 T cells
- (2019) Katie Hurst et al. Cancer Immunology Research
- Obesity: global epidemiology and pathogenesis
- (2019) Matthias Blüher Nature Reviews Endocrinology
- Regulatory T cells in cancer immunosuppression — implications for anticancer therapy
- (2019) Yosuke Togashi et al. Nature Reviews Clinical Oncology
- Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
- (2019) Brian C. Miller et al. NATURE IMMUNOLOGY
- FXR Regulates Intestinal Cancer Stem Cell Proliferation
- (2019) Ting Fu et al. CELL
- CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer
- (2019) Laura M. McLane et al. Annual Review of Immunology
- Lipid metabolism in cancer cells under metabolic stress
- (2019) Rimsha Munir et al. BRITISH JOURNAL OF CANCER
- Lipid mediators in immune regulation and resolution
- (2019) Derek W. Gilroy et al. BRITISH JOURNAL OF PHARMACOLOGY
- Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment
- (2019) Xingzhe Ma et al. Cell Metabolism
- The diversity of gut microbiome is associated with favorable responses to anti-PD-1 immunotherapy in Chinese non-small cell lung cancer patients
- (2019) Yueping Jin et al. Journal of Thoracic Oncology
- Antigen receptor control of methionine metabolism in T cells
- (2019) Linda V Sinclair et al. eLife
- Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability
- (2019) Mark R Sullivan et al. eLife
- The PPARγ Agonist Rosiglitazone Suppresses Syngeneic Mouse SCC (Squamous Cell Carcinoma) Tumor Growth through an Immune-Mediated Mechanism
- (2019) Raymond L. Konger et al. MOLECULES
- TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection
- (2019) Francesca Alfei et al. NATURE
- TOX is a critical regulator of tumour-specific T cell differentiation
- (2019) Andrew C. Scott et al. NATURE
- Dietary methionine influences therapy in mouse cancer models and alters human metabolism
- (2019) Xia Gao et al. NATURE
- TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
- (2019) Omar Khan et al. NATURE
- Fatty acids distribution and content in oral squamous cell carcinoma tissue and its adjacent microenvironment
- (2019) Ludmiła Halczy-Kowalik et al. PLoS One
- TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion
- (2019) Hyungseok Seo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of Adaptive Immune Cells by Sirtuins
- (2019) Jonathan L. Warren et al. Frontiers in Endocrinology
- Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance
- (2019) Dayana B. Rivadeneira et al. IMMUNITY
- A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice
- (2019) Sarah Lévesque et al. OncoImmunology
- STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth
- (2019) Chunyan Zhang et al. Cell Metabolism
- Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells
- (2019) Eric H. Ma et al. IMMUNITY
- Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion
- (2019) Robert D. Leone et al. SCIENCE
- Linkage of CD8+ T cell exhaustion with high-fat diet-induced tumourigenesis
- (2019) Tomonobu Kado et al. Scientific Reports
- Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy
- (2019) Kathrin Renner et al. Cell Reports
- Metabolic Control of Epigenetics and Its Role in CD8+ T Cell Differentiation and Function
- (2019) Cansu Yerinde et al. Frontiers in Immunology
- Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer
- (2019) Marteinn Thor Snaebjornsson et al. Cell Metabolism
- LXR-inverse agonism stimulates immune-mediated tumor destruction by enhancing CD8 T-cell activity in triple negative breast cancer
- (2019) Katherine J. Carpenter et al. Scientific Reports
- Connections Between Metabolism and Epigenetics in Programming Cellular Differentiation
- (2018) Danielle A. Chisolm et al. Annual Review of Immunology
- CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions
- (2018) Masao Hashimoto et al. Annual Review of Medicine
- NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control
- (2018) Jan P. Böttcher et al. CELL
- Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer
- (2018) Xianmin Mu et al. CELL CYCLE
- Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance
- (2018) Camila Rubio-Patiño et al. Cell Metabolism
- Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment
- (2018) Pernille Hojman et al. Cell Metabolism
- Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation
- (2018) Brenda Raud et al. Cell Metabolism
- High-Fat Diet-Induced Inflammation Accelerates Prostate Cancer Growth via IL6 Signaling
- (2018) Takuji Hayashi et al. CLINICAL CANCER RESEARCH
- Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells
- (2018) Bertram Bengsch et al. IMMUNITY
- Fatty acid metabolism in CD8+ T cell memory: Challenging current concepts
- (2018) Brenda Raud et al. IMMUNOLOGICAL REVIEWS
- Role of prostanoids in gastrointestinal cancer
- (2018) Dingzhi Wang et al. JOURNAL OF CLINICAL INVESTIGATION
- Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis
- (2018) Jennifer L McQuade et al. LANCET ONCOLOGY
- Mitochondrial activity in T cells
- (2018) Gabriela Desdín-Micó et al. MITOCHONDRION
- A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade
- (2018) Daniela S. Thommen et al. NATURE MEDICINE
- Reactive Oxygen Species: Involvement in T Cell Signaling and Metabolism
- (2018) Davide G. Franchina et al. TRENDS IN IMMUNOLOGY
- Differential Reliance on Lipid Metabolism as a Salvage Pathway Underlies Functional Differences of T Cell Subsets in Poor Nutrient Environments
- (2018) Christopher Ecker et al. Cell Reports
- Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions
- (2018) Ashley V. Menk et al. Cell Reports
- Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes
- (2018) Jia-Ren Lin et al. eLife
- PPARγ Contributes to Immunity Induced by Cancer Cell Vaccines That Secrete GM-CSF
- (2018) Girija Goyal et al. Cancer Immunology Research
- The Role of Lipid Metabolism in T Lymphocyte Differentiation and Survival
- (2018) Duncan Howie et al. Frontiers in Immunology
- The effect of fasting or calorie restriction on autophagy induction: A review of the literature
- (2018) Mohammad Bagherniya et al. AGEING RESEARCH REVIEWS
- Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection
- (2018) Sue Tsai et al. Cell Metabolism
- Targeting the IDO1 pathway in cancer: from bench to bedside
- (2018) Ming Liu et al. Journal of Hematology & Oncology
- Cutting Edge: Elevated Leptin during Diet-Induced Obesity Reduces the Efficacy of Tumor Immunotherapy
- (2018) Katherine A. Murphy et al. JOURNAL OF IMMUNOLOGY
- Suppression of insulin feedback enhances the efficacy of PI3K inhibitors
- (2018) Benjamin D. Hopkins et al. NATURE
- PPAR-induced fatty acid oxidation in T cells increases the number of tumor-reactive CD8+ T cells and facilitates anti-PD-1 therapy
- (2018) Partha S. Chowdhury et al. Cancer Immunology Research
- Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression
- (2018) Christopher Groth et al. BRITISH JOURNAL OF CANCER
- Activation of peroxisome proliferator-activated receptors α and δ synergizes with inflammatory signals to enhance adoptive cell therapy
- (2018) Samuel D Saibil et al. CANCER RESEARCH
- Reinforce the antitumor activity of CD8+ T cells via glutamine restriction
- (2018) Shogo Nabe et al. CANCER SCIENCE
- Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy
- (2018) Priyamvada Jayaprakash et al. JOURNAL OF CLINICAL INVESTIGATION
- Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade
- (2018) Ziming Wang et al. NATURE MEDICINE
- Store-Operated Ca 2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming
- (2017) Martin Vaeth et al. IMMUNITY
- CCCTC-Binding Factor Translates Interleukin 2- and α-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene Programs
- (2017) Danielle A. Chisolm et al. IMMUNITY
- Modulating the therapeutic response of tumours to dietary serine and glycine starvation
- (2017) Oliver D. K. Maddocks et al. NATURE
- Chromatin states define tumour-specific T cell dysfunction and reprogramming
- (2017) Mary Philip et al. NATURE
- Tumor-Associated Fibroblasts and Microvessels Contribute to the Expression of Immunosuppressive Factor Indoleamine 2, 3-Dioxygenase in Human Esophageal Cancers
- (2017) Guanglin Cui et al. PATHOLOGY & ONCOLOGY RESEARCH
- Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients
- (2017) V. Gopalakrishnan et al. SCIENCE
- The Role of Oxysterols in Human Cancer
- (2017) Alzbeta Kloudova et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Prostaglandin E2 and PD-1 mediated inhibition of antitumor CTL responses in the human tumor microenvironment
- (2017) Jie Miao et al. Oncotarget
- Culturing CTLs under Hypoxic Conditions Enhances Their Cytolysis and Improves Their Anti-tumor Function
- (2017) Yael Gropper et al. Cell Reports
- Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population
- (2017) Reiner K. W. Mailer et al. Scientific Reports
- Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet
- (2016) Danielle M. Lussier et al. BMC CANCER
- Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance
- (2016) Federico Pietrocola et al. CANCER CELL
- Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity
- (2016) Stefano Di Biase et al. CANCER CELL
- Upregulated Glucose Metabolism Correlates Inversely with CD8 + T-cell Infiltration and Survival in Squamous Cell Carcinoma
- (2016) Christian H. Ottensmeier et al. CANCER RESEARCH
- Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming
- (2016) Michael D. Buck et al. CELL
- From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
- (2016) Ara Koh et al. CELL
- L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
- (2016) Roger Geiger et al. CELL
- Metabolic Heterogeneity in Human Lung Tumors
- (2016) Christopher T. Hensley et al. CELL
- Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution
- (2016) Line Pedersen et al. Cell Metabolism
- Obesity and cancer: inflammation bridges the two
- (2016) Ryan Kolb et al. CURRENT OPINION IN PHARMACOLOGY
- Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells
- (2016) Aaron M. Hosios et al. DEVELOPMENTAL CELL
- T Cell Factor 1-Expressing Memory-like CD8 + T Cells Sustain the Immune Response to Chronic Viral Infections
- (2016) Daniel T. Utzschneider et al. IMMUNITY
- The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction
- (2016) Nicole E. Scharping et al. IMMUNITY
- Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion
- (2016) Bertram Bengsch et al. IMMUNITY
- RhoA orchestrates glycolysis for T H 2 cell differentiation and allergic airway inflammation
- (2016) Jun-Qi Yang et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism
- (2016) Wei Yang et al. NATURE
- Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy
- (2016) Se Jin Im et al. NATURE
- S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate
- (2016) Petros A. Tyrakis et al. NATURE
- Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism
- (2016) M. Peng et al. SCIENCE
- Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
- (2016) K. E. Pauken et al. SCIENCE
- Metabolic pathways in T cell activation and lineage differentiation
- (2016) Luís Almeida et al. SEMINARS IN IMMUNOLOGY
- PPARgene: A Database of Experimentally Verified and Computationally Predicted PPAR Target Genes
- (2016) Li Fang et al. PPAR Research
- Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia
- (2016) Nicole E. Scharping et al. Cancer Immunology Research
- Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia
- (2015) Muhammad Zaeem Noman et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance
- (2015) Philip C. Calder BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy
- (2015) Shari Pilon-Thomas et al. CANCER RESEARCH
- Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
- (2015) Ping-Chih Ho et al. CELL
- Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
- (2015) Chih-Hao Chang et al. CELL
- Phenotypic switch of CD8+T cells reactivated under hypoxia toward IL-10 secreting, poorly proliferative effector cells
- (2015) Romain Vuillefroy de Silly et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Effects of extracellular pH and hypoxia on the function and development of antigen-specific cytotoxic T lymphocytes
- (2015) Yohko Nakagawa et al. IMMUNOLOGY LETTERS
- Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection
- (2015) Jonathan H Chen et al. NATURE MEDICINE
- T cell exclusion, immune privilege, and the tumor microenvironment
- (2015) J. A. Joyce et al. SCIENCE
- Sestrin2 is a leucine sensor for the mTORC1 pathway
- (2015) R. L. Wolfson et al. SCIENCE
- Overcoming T cell exhaustion in infection and cancer
- (2015) Kristen E. Pauken et al. TRENDS IN IMMUNOLOGY
- PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
- (2015) Nikolaos Patsoukis et al. Nature Communications
- Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response
- (2014) S R McKeown BRITISH JOURNAL OF RADIOLOGY
- The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection
- (2014) Matthew M. Staron et al. IMMUNITY
- Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development
- (2014) David O’Sullivan et al. IMMUNITY
- PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
- (2014) Muhammad Zaeem Noman et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways
- (2014) S. R. Jacobs et al. JOURNAL OF IMMUNOLOGY
- Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A
- (2014) Guillermo Mariño et al. MOLECULAR CELL
- De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
- (2014) Luciana Berod et al. NATURE MEDICINE
- Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications - a review
- (2014) Bogna Grygiel-Górniak Nutrition Journal
- Caloric restriction and cancer: molecular mechanisms and clinical implications
- (2014) Ophélie Meynet et al. TRENDS IN MOLECULAR MEDICINE
- Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism
- (2014) Bryan G. Allen et al. Redox Biology
- Adipose tissue and adipocytes support tumorigenesis and metastasis
- (2013) Kristin M. Nieman et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Acidic extracellular microenvironment and cancer
- (2013) Yasumasa Kato et al. Cancer Cell International
- A Mechanism of Hypoxia-Mediated Escape from Adaptive Immunity in Cancer Cells
- (2013) I. B. Barsoum et al. CANCER RESEARCH
- Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
- (2013) Chih-Hao Chang et al. CELL
- T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming
- (2013) Kai Yang et al. IMMUNITY
- Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling
- (2013) Laura A. Sena et al. IMMUNITY
- Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
- (2013) Madhusudhanan Sukumar et al. JOURNAL OF CLINICAL INVESTIGATION
- LAT1 Is a Critical Transporter of Essential Amino Acids for Immune Reactions in Activated Human T Cells
- (2013) K. Hayashi et al. JOURNAL OF IMMUNOLOGY
- Myeloid-Derived Suppressor Cells Suppress Antitumor Immune Responses through IDO Expression and Correlate with Lymph Node Metastasis in Patients with Breast Cancer
- (2013) J. Yu et al. JOURNAL OF IMMUNOLOGY
- Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
- (2013) Yoko Kidani et al. NATURE IMMUNOLOGY
- Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
- (2013) Linda V Sinclair et al. NATURE IMMUNOLOGY
- Arginase II Expressed in Cancer-Associated Fibroblasts Indicates Tissue Hypoxia and Predicts Poor Outcome in Patients with Pancreatic Cancer
- (2013) Yoshinori Ino et al. PLoS One
- Interstitial Fluid Flow and Drug Delivery in Vascularized Tumors: A Computational Model
- (2013) Michael Welter et al. PLoS One
- CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability
- (2013) G. J. W. van der Windt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma
- (2013) F. Guillaumond et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Proinflammatory and Immunoregulatory Roles of Eicosanoids in T Cells
- (2013) Anna Mari Lone et al. Frontiers in Immunology
- Laboratory animals as surrogate models of human obesity
- (2012) Cecilia Nilsson et al. ACTA PHARMACOLOGICA SINICA
- Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes
- (2012) A. Calcinotto et al. CANCER RESEARCH
- Metabolic switching and fuel choice during T-cell differentiation and memory development
- (2012) Gerritje J. W. Windt et al. IMMUNOLOGICAL REVIEWS
- Cholesterol and Sphingomyelin Drive Ligand-independent T-cell Antigen Receptor Nanoclustering
- (2012) Eszter Molnár et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PGC1 and mitochondrial metabolism - emerging concepts and relevance in ageing and neurodegenerative disorders
- (2012) S. Austin et al. JOURNAL OF CELL SCIENCE
- Malonyl-CoA: the regulator of fatty acid synthesis and oxidation
- (2012) Daniel W. Foster JOURNAL OF CLINICAL INVESTIGATION
- The effect of interstitial pressure on tumor growth: Coupling with the blood and lymphatic vascular systems
- (2012) Min Wu et al. JOURNAL OF THEORETICAL BIOLOGY
- Indoleamine 2,3 dioxygenase and metabolic control of immune responses
- (2012) David H. Munn et al. TRENDS IN IMMUNOLOGY
- Activated human CD4+ T cells express transporters for both cysteine and cystine
- (2012) Trine Bøegh Levring et al. Scientific Reports
- Inflammatory Mechanisms in Obesity
- (2011) Margaret F. Gregor et al. Annual Review of Immunology
- Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO
- (2011) Tuanjie Li et al. CANCER LETTERS
- Global Proteomic Assessment of the Classical Protein-Tyrosine Phosphatome and “Redoxome”
- (2011) Robert Karisch et al. CELL
- The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
- (2011) Ruoning Wang et al. IMMUNITY
- HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells
- (2011) Lewis Z. Shi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
- (2011) R. D. Michalek et al. JOURNAL OF IMMUNOLOGY
- Sirtuin-1 Targeting Promotes Foxp3+ T-Regulatory Cell Function and Prolongs Allograft Survival
- (2011) U. H. Beier et al. MOLECULAR AND CELLULAR BIOLOGY
- Tumor angiogenesis: molecular pathways and therapeutic targets
- (2011) Sara M Weis et al. NATURE MEDICINE
- Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression
- (2010) Eek Joong Park et al. CELL
- Diet-Induced Obesity Impairs the T Cell Memory Response to Influenza Virus Infection
- (2010) E. A. Karlsson et al. JOURNAL OF IMMUNOLOGY
- Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation
- (2010) E. L. Carr et al. JOURNAL OF IMMUNOLOGY
- Obesity and leptin resistance: distinguishing cause from effect
- (2010) Martin G. Myers et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- T Cell Activation
- (2009) Jennifer E. Smith-Garvin et al. Annual Review of Immunology
- Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization
- (2009) J. van Loosdregt et al. BLOOD
- Obesity accelerates thymic aging
- (2009) H. Yang et al. BLOOD
- Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine
- (2009) M. K. Srivastava et al. CANCER RESEARCH
- Hypoxia induces T-cell apoptosis by inhibiting chemokine C receptor 7 expression: the role of adenosine receptor A2
- (2009) Jintang Sun et al. Cellular & Molecular Immunology
- Diabetes and cancer
- (2009) Paolo Vigneri et al. ENDOCRINE-RELATED CANCER
- Enhancing CD8 T-cell memory by modulating fatty acid metabolism
- (2009) Erika L. Pearce et al. NATURE
- Tumor-mediated liver X receptor-α activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses
- (2009) Eduardo J Villablanca et al. NATURE MEDICINE
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response
- (2008) Steven J. Bensinger et al. CELL
- Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells
- (2008) Candace M. Cham et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
- (2008) Pierre Sonveaux et al. JOURNAL OF CLINICAL INVESTIGATION
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now