Phenotypic switch of CD8+T cells reactivated under hypoxia toward IL-10 secreting, poorly proliferative effector cells

NF-κB enhances hypoxia-driven T-cell immunosuppression via upregulation of adenosine A2A receptors

(2014) Laurie Bruzzese et al.   CELLULAR SIGNALLING

Tumor Plasticity Interferes with Anti-Tumor Immunity

(2014) Salem Chouaib et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Molecular aspects of cancer cell resistance to chemotherapy

(2013) Magali Rebucci et al.   BIOCHEMICAL PHARMACOLOGY

Targeting the HIF pathway in inflammation and immunity

(2013) Carsten C Scholz et al.   CURRENT OPINION IN PHARMACOLOGY

Pathophysiological hypoxia affects the redox state and IL-2 signalling of human CD4+T cells and concomitantly impairs survival and proliferation

(2013) Timo Gaber et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Hypoxia-induced and A2A adenosine receptor-independent T-cell suppression is short lived and easily reversible

(2013) Akio Ohta et al.   INTERNATIONAL IMMUNOLOGY

Hypoxia Enhances Stemness of Cancer Stem Cells in Glioblastoma: An In Vitro Study

(2013) Pengcheng Li et al.   International Journal of Medical Sciences

HIF1α and HIF2α independently activate SRC to promote melanoma metastases

(2013) Sara C. Hanna et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen

(2013) Andrew L Doedens et al.   NATURE IMMUNOLOGY

GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling

(2013) Yunqi Wang et al.   NATURE IMMUNOLOGY

Clonal Expansions of CD8+ T Cells with IL-10 Secreting Capacity Occur during Chronic Mycobacterium tuberculosis Infection

(2013) Joshua C. Cyktor et al.   PLoS One

Oxygen tension level and human viral infections

(2013) Frédéric Morinet et al.   VIROLOGY

Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism

(2012) Eun Chan Park et al.   EMBO JOURNAL

Genetic deletion of the HIF-1α isoform I.1 in T cells enhances antibacterial immunity and improves survival in a murine peritonitis model

(2012) Peter Georgiev et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function

(2012) Eóin N. McNamee et al.   IMMUNOLOGIC RESEARCH

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+T cells

(2012) David K. Finlay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

(2012) E. T. Clambey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response

(2012) G. Perona-Wright et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The HIF-1α Hypoxia Response in Tumor-Infiltrating T Lymphocytes Induces Functional CD137 (4-1BB) for Immunotherapy

(2012) Asís Palazón et al.   Cancer Discovery

IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance

(2011) John B. Mumm et al.   CANCER CELL

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Molecular Pathways: Hypoxia Response in Immune Cells Fighting or Promoting Cancer

(2011) Asis Palazón et al.   CLINICAL CANCER RESEARCH

CD8+ T Cells: Foot Soldiers of the Immune System

(2011) Nu Zhang et al.   IMMUNITY

Interleukin 10 in the tumor microenvironment: a target for anticancer immunotherapy

(2011) Takami Sato et al.   IMMUNOLOGIC RESEARCH

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

(2011) Aude Carreau et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Highly Activated Cytotoxic CD8 T Cells Express Protective IL-10 at the Peak of Coronavirus-Induced Encephalitis

(2011) K. Trandem et al.   JOURNAL OF IMMUNOLOGY

Orientation and expression of methicillin-resistant Staphylococcus aureus small RNAs by direct multiplexed measurements using the nCounter of NanoString technology

(2011) Marie Beaume et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential Dependence on Cysteine from Transsulfuration versus Transport During T Cell Activation

(2010) Sanjay K. Garg et al.   ANTIOXIDANTS & REDOX SIGNALING

Differentiation and Persistence of Memory CD8+ T Cells Depend on T Cell Factor 1

(2010) Xinyuan Zhou et al.   IMMUNITY

Effects of hypoxia and/or lack of glucose on cellular energy metabolism and cytokine production in stimulated human CD4+ T lymphocytes

(2010) R. Dziurla et al.   IMMUNOLOGY LETTERS

Tumor masses support naive T cell infiltration, activation, and differentiation into effectors

(2010) Elizabeth D. Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage Migration Inhibitory Factor Counterregulates Dexamethasone-Mediated Suppression of Hypoxia-Inducible Factor-1  Function and Differentially Influences Human CD4+ T Cell Proliferation under Hypoxia

(2010) T. Gaber et al.   JOURNAL OF IMMUNOLOGY

Knock down of HIF-1α in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres

(2010) Olga Méndez et al.   Molecular Cancer

Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation

(2010) Shane Crotty et al.   NATURE IMMUNOLOGY

T-Cell Activation under Hypoxic Conditions Enhances IFN-γ Secretion

(2009) Jessica Roman et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

Hypoxia but not cigarette smoke modulates VEGF secretion from human T cells

(2009) Mikael Mikko et al.   GROWTH FACTORS

Hypoxia or in situ normoxia: The stem cell paradigm

(2009) Zoran Ivanovic   JOURNAL OF CELLULAR PHYSIOLOGY

Induction of HIF-1α and the glycolytic pathway alters apoptotic and differentiation profiles of activated human T cells

(2009) Anis Larbi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10

(2009) Jie Sun et al.   NATURE MEDICINE

CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses

(2009) J. J. Obar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD28− T cells: their role in the age-associated decline of immune function

(2009) Nan-ping Weng et al.   TRENDS IN IMMUNOLOGY

Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells

(2008) Candace M. Cham et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

c-Maf increases apoptosis in peripheral CD8 cells by transactivatingCaspase 6

(2008) Siying Peng et al.   IMMUNOLOGY

Direct multiplexed measurement of gene expression with color-coded probe pairs

(2008) Gary K Geiss et al.   NATURE BIOTECHNOLOGY