Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells

Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression

(2019) Pieter Goossens et al.   Cell Metabolism

Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

(2019) Xingzhe Ma et al.   Cell Metabolism

Immune regulation by CD8+ Treg cells: novel possibilities for anticancer immunotherapy

(2018) Shuping Zhang et al.   Cellular & Molecular Immunology

Anticancer efficacy of noble metal nanoparticles relies on reprogramming tumor-associated macrophages through redox pathways and pro-inflammatory cytokine cascades

(2018) Mahuya Sengupta et al.   Cellular & Molecular Immunology

Cholesterol negatively regulates IL-9–producing CD8+T cell differentiation and antitumor activity

(2018) Xingzhe Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enhanced Anti-lymphoma Activity of CAR19-iNKT Cells Underpinned by Dual CD19 and CD1d Targeting

(2018) Antonia Rotolo et al.   CANCER CELL

PPARγ in dendritic cells and T cells drives pathogenic type-2 effector responses in lung inflammation

(2017) Samuel Philip Nobs et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Reciprocal Crosstalk between Dendritic Cells and Natural Killer T Cells: Mechanisms and Therapeutic Potential

(2017) Christian W. Keller et al.   Frontiers in Immunology

Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

(2016) Wei Yang et al.   NATURE

Lactic acid in tumor microenvironments causes dysfunction of NKT cells by interfering with mTOR signaling

(2016) Di Xie et al.   Science China-Life Sciences

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

(2016) Vinit Kumar et al.   TRENDS IN IMMUNOLOGY

Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells

(2016) Mulki Angela et al.   Nature Communications

Metabolic Reprogramming of Immune Cells in Cancer Progression

(2015) Subhra K. Biswas   IMMUNITY

Invariant NKT cells with chimeric antigen receptor provide a novel platform for safe and effective cancer immunotherapy

(2014) A. Heczey et al.   BLOOD

Regulatory T cells in cancer immunotherapy

(2014) Hiroyoshi Nishikawa et al.   CURRENT OPINION IN IMMUNOLOGY

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development

(2014) David O’Sullivan et al.   IMMUNITY

IFN- -Producing Human Invariant NKT Cells Promote Tumor-Associated Antigen-Specific Cytotoxic T Cell Responses

(2014) M. Moreno et al.   JOURNAL OF IMMUNOLOGY

Invariant NKT Cells Promote CD8+ Cytotoxic T Cell Responses by Inducing CD70 Expression on Dendritic Cells

(2014) V. Y. Taraban et al.   JOURNAL OF IMMUNOLOGY

Regulator of Fatty Acid Metabolism, Acetyl Coenzyme A Carboxylase 1, Controls T Cell Immunity

(2014) J. Lee et al.   JOURNAL OF IMMUNOLOGY

Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue

(2014) Lydia Lynch et al.   NATURE IMMUNOLOGY

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

(2014) Luciana Berod et al.   NATURE MEDICINE

Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia

(2014) W.-Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic Inflammation and Cytokines in the Tumor Microenvironment

(2014) Glauben Landskron et al.   Journal of Immunology Research

Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review

(2013) Asfar S. Azmi et al.   CANCER AND METASTASIS REVIEWS

Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

(2013) Yoko Kidani et al.   NATURE IMMUNOLOGY

SREBP: a novel therapeutic target

(2012) X. Xiao et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Clinical regressions and broad immune activation following combination therapy targeting human NKT cells in myeloma

(2012) J. Richter et al.   BLOOD

Links between metabolism and cancer

(2012) C. V. Dang   GENES & DEVELOPMENT

Cholesterol and Sphingomyelin Drive Ligand-independent T-cell Antigen Receptor Nanoclustering

(2012) Eszter Molnár et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

(2012) Daniela Cipolletta et al.   NATURE

Comparison of Clinical and Immunological Effects of Intravenous and Intradermal Administration of  -GalactosylCeramide (KRN7000)-Pulsed Dendritic Cells

(2011) A. J. Nicol et al.   CLINICAL CANCER RESEARCH

Peroxisome Proliferator-Activated Receptor  -Regulated Cathepsin D Is Required for Lipid Antigen Presentation by Dendritic Cells

(2011) B. Nakken et al.   JOURNAL OF IMMUNOLOGY

Regulation of Cholesterol and Fatty Acid Synthesis

(2011) J. Ye et al.   Cold Spring Harbor Perspectives in Biology

Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A

(2010) Carmela De Santo et al.   NATURE IMMUNOLOGY

A Phase I-II Study of  -Galactosylceramide-Pulsed IL-2/GM-CSF-Cultured Peripheral Blood Mononuclear Cells in Patients with Advanced and Recurrent Non-Small Cell Lung Cancer

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Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

Repression of interferon-γ expression in T cells by Prospero-related Homeobox protein

(2008) Linfang Wang et al.   CELL RESEARCH

The BTB–zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions

(2008) Damian Kovalovsky et al.   NATURE IMMUNOLOGY