Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection

The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection

(2014) Matthew M. Staron et al.   IMMUNITY

PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells

(2013) Erin E. West et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials

(2012) Annemijn M Algra et al.   LANCET ONCOLOGY

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection

(2012) M. A. Paley et al.   SCIENCE

Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells

(2011) N. Obermajer et al.   BLOOD

Modulation of T cell immune functions by the prostaglandin E2 - cAMP pathway in chronic inflammatory states

(2011) Kristoffer Watten Brudvik et al.   BRITISH JOURNAL OF PHARMACOLOGY

Prostaglandin E2 and T cells: friends or foes?

(2011) Vinatha Sreeramkumar et al.   IMMUNOLOGY AND CELL BIOLOGY

Increased Expression of the Pro-apoptotic Protein BIM, a Mechanism for cAMP/Protein Kinase A (PKA)-induced Apoptosis of Immature T Cells

(2011) Alexander C. Zambon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients

(2011) Lukas Baitsch et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of Immune Responses by Prostaglandin E2

(2011) P. Kalinski   JOURNAL OF IMMUNOLOGY

An Exploratory Trial of Cyclooxygenase Type 2 Inhibitor in HIV-1 Infection: Downregulated Immune Activation and Improved T Cell-Dependent Vaccine Responses

(2011) F. O. Pettersen et al.   JOURNAL OF VIROLOGY

The role of IL-10 in immune regulation during M. tuberculosis infection

(2011) P S Redford et al.   Mucosal Immunology

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models

(2010) Shuntaro Hara et al.   BIOCHIMIE

Receptor desensitization and blockade of the suppressive effects of prostaglandin E2 and adenosine on the cytotoxic activity of human melanoma-infiltrating T lymphocytes

(2010) Yunyun Su et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim

(2010) Diane Moujalled et al.   EMBO REPORTS

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

(2010) Kaori Sakuishi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

(2010) H.-T. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redefining Chronic Viral Infection

(2009) Herbert W. Virgin et al.   CELL

Cell-Intrinsic Transforming Growth Factor-β Signaling Mediates Virus-Specific CD8+ T Cell Deletion and Viral Persistence In Vivo

(2009) Roberto Tinoco et al.   IMMUNITY

Bim-mediated deletion of antigen-specific CD8+ T cells in patients unable to control HBV infection

(2008) A. Ross Lopes et al.   JOURNAL OF CLINICAL INVESTIGATION

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

Selective expansion of a subset of exhausted CD8 T cells by  PD-L1 blockade

(2008) S. D. Blackburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA