Naturally occurring coumestans from plants, their biological activities and therapeutic effects on human diseases
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Naturally occurring coumestans from plants, their biological activities and therapeutic effects on human diseases
Authors
Keywords
Coumestan, Natural products, Pharmacological activity, Mechanisms, Bone diseases, Organ damages
Journal
PHARMACOLOGICAL RESEARCH
Volume 169, Issue -, Pages 105615
Publisher
Elsevier BV
Online
2021-04-19
DOI
10.1016/j.phrs.2021.105615
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Osteoporosis and the Potential of Cell-Based Therapeutic Strategies
- (2020) Iratxe Macías et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Inhibition of CYP2C9 by natural products: insight into the potential risk of herb-drug interactions
- (2020) Kai Wang et al. DRUG METABOLISM REVIEWS
- Response surface methodology for the extraction of wedelolactone from Eclipta alba using aqueous two-phase extraction
- (2020) Neha N. Gharat et al. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
- Potent Inhibitors of Organic Anion Transporters 1 and 3 From Natural Compounds and Their Protective Effect on Aristolochic Acid Nephropathy
- (2020) Caiyu Li et al. TOXICOLOGICAL SCIENCES
- Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety
- (2020) Abdullah Shaito et al. Frontiers in Pharmacology
- Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis
- (2020) Hao Pan et al. CELL PROLIFERATION
- Isolation and Identification of Antiarthritic Constituents from Glycine tabacina and Network Pharmacology-Based Prediction of Their Protective Mechanisms against Rheumatoid Arthritis
- (2020) Yanbei Tu et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Dolichosin A, a coumestan isolated from Glycine tabacina, inhibits IL-1β-induced inflammation in SW982 human synovial cells and suppresses RANKL-induced osteoclastogenesis: From network pharmacology to experimental pharmacology
- (2020) Yanbei Tu et al. JOURNAL OF ETHNOPHARMACOLOGY
- Synergistic Cytotoxic Effect from Combination of Wedelolactone and Cisplatin in HeLa Cell Line: A Novel Finding
- (2020) Sadia Sarwar et al. Drug Design Development and Therapy
- Ultra-high pressure-assisted extraction of wedelolactone and isodemethylwedelolactone from Ecliptae Herba and purification by high-speed counter-current chromatography
- (2019) Hongwei Zhao et al. BIOMEDICAL CHROMATOGRAPHY
- Wedelolactone Attenuates Pulmonary Fibrosis Partly Through Activating AMPK and Regulating Raf-MAPKs Signaling Pathway
- (2019) Jin-yu Yang et al. Frontiers in Pharmacology
- Effect and mechanism of psoralidin on promoting osteogenesis and inhibiting adipogenesis
- (2019) Hui-juan Cao et al. PHYTOMEDICINE
- Phenolic compounds from cultivated Glycyrrhiza uralensis and their PD-1/PD-L1 inhibitory activities
- (2019) Fang Bao et al. NATURAL PRODUCT RESEARCH
- Isoflavones
- (2019) Ludmila Křížová et al. MOLECULES
- Development and Validation of an Ultra-Performance Liquid Chromatography Method for the Determination of Wedelolactone in Rat Plasma and its Application in a Pharmacokinetic Study
- (2019) Qing Chen et al. MOLECULES
- A new bioactive coumestan from the seeds of Psoralea corylifolia
- (2019) Ming-Yan Chai JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
- Anti-inflammatory pterocarpanoids from the roots of Pongamia pinnata
- (2019) Ran Wen et al. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
- Phytoestrogen coumestrol: Antioxidant capacity and its loading in albumin nanoparticles
- (2019) Guillermo Montero et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Isolation, structural elucidation and in vitro hepatoprotective activity of flavonoids from Glycyrrhiza uralensis
- (2019) Ming Cheng et al. Journal of Natural Medicines
- New cathepsin V inhibitor from stems of Bowdichia virgilioides
- (2019) Taynara L. Silva et al. Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy
- Wedelolactone alleviates doxorubicin-induced inflammation and oxidative stress damage of podocytes by IκK/IκB/NF-κB pathway
- (2019) Mao-mao Zhu et al. BIOMEDICINE & PHARMACOTHERAPY
- Wedelolactone suppresses IL-1β maturation and neutrophil infiltration in Aspergillus fumigatus keratitis
- (2019) Min Cheng et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- A chemo-photothermal synergetic antitumor drug delivery system: Gold nanoshell coated wedelolactone liposome
- (2019) Xuwu Zhang et al. Materials Science & Engineering C-Materials for Biological Applications
- Glycyrol exerts potent therapeutic effect on lung cancer via directly inactivating T-LAK cell-originated protein kinase
- (2019) Shangyun Lu et al. PHARMACOLOGICAL RESEARCH
- Mechanisms explaining the efficacy of psoralidin in cancer and osteoporosis, a review
- (2019) Zhenlong Xin et al. PHARMACOLOGICAL RESEARCH
- The combined effect of oleonuezhenide and wedelolactone on proliferation and osteoblastogenesis of bone marrow mesenchymal stem cells
- (2019) Xue Deng et al. PHYTOMEDICINE
- Natural product derived privileged scaffolds in drug discovery
- (2019) Emma K Davison et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Anti-diabetic compounds from the seeds of Psoralea corylifolia
- (2019) Gaohui Zhu et al. FITOTERAPIA
- Synergistic anti-colon cancer effect of glycyrol and butyrate is associated with the enhanced activation of caspase-3 and structural features of glycyrol
- (2019) Shangyun Lu et al. FOOD AND CHEMICAL TOXICOLOGY
- Regulation of Inflammatory Response in Human Osteoarthritic Chondrocytes by Novel Herbal Small Molecules
- (2019) Ziadlou et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Antiproliferative Pterocarpans and Coumestans from Lespedeza bicolor
- (2019) Nguyen Thi Thanh Thuy et al. JOURNAL OF NATURAL PRODUCTS
- Wedelolactone-Loaded Micelles Ameliorate Doxorubicin-Induced Oxidative Injury in Podocytes by Improving Permeability and Bioavailability
- (2019) Liang Feng et al. Frontiers in Bioengineering and Biotechnology
- Wedelolactone inhibits human cytomegalovirus replication by targeting distinct steps of the viral replication cycle
- (2019) Adriana Svrlanska et al. ANTIVIRAL RESEARCH
- Phytoestrogen coumestrol attenuates brain mitochondrial dysfunction and long‐term cognitive deficits following neonatal hypoxia–ischemia
- (2019) Janine Beatriz Ramos Anastacio et al. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
- Antiobesity effects of coumestrol through expansion and activation of brown adipose tissue metabolism
- (2019) Sang-Nam Kim et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Antidiabetic Activity of Gold Nanoparticles Synthesized Using Wedelolactone in RIN-5F Cell Line
- (2019) Vinayagam Ramachandran et al. Antioxidants
- Hepatoprotective Effect of Wedelolactone against Concanavalin A-Induced Liver Injury in Mice
- (2018) Qingqiong Luo et al. AMERICAN JOURNAL OF CHINESE MEDICINE
- The higher osteoprotective activity of psoralidin in vivo than coumestrol is attributed by its presence of an isopentenyl group and through activated PI3K/Akt axis
- (2018) Yuankun Zhai et al. BIOMEDICINE & PHARMACOTHERAPY
- Coumestrol/hydroxypropyl-β-cyclodextrin association incorporated in hydroxypropyl methylcellulose hydrogel exhibits wound healing effect: in vitro and in vivo study
- (2018) Sara E. Bianchi et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Wedelolactone inhibits osteoclastogenesis but enhances osteoblastogenesis through altering different semaphorins production
- (2018) Xue Deng et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery
- (2018) Nicholas Thomford et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Impact of wedelolactone in the anti-glycation and anti-diabetic activity in experimental diabetic animals
- (2018) Uzma Shahab et al. IUBMB LIFE
- Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis
- (2018) Wei Zhang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Pharmacological and Nutritional Effects of Natural Coumarins and Their Structure-Activity Relationships
- (2018) Jing-Jing Zhu et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Comparative Evaluation of the Antioxidant and Anti-Alzheimer’s Disease Potential of Coumestrol and Puerarol Isolated from Pueraria lobata Using Molecular Modeling Studies
- (2018) Prashamsa Koirala et al. MOLECULES
- Wedelolactone Enhances Osteoblastogenesis through ERK- and JNK-mediated BMP2 Expression and Smad/1/5/8 Phosphorylation
- (2018) Di Zhu et al. MOLECULES
- Effect of wedelolactone and gallic acid on quinolinic acid-induced neurotoxicity and impaired motor function: significance to sporadic amyotrophic lateral sclerosis
- (2018) Maya S et al. NEUROTOXICOLOGY
- The potential beneficial role of isoflavones in type 2 diabetes mellitus
- (2018) K.C. Duru et al. NUTRITION RESEARCH
- Deconvoluting the dual hypoglycemic effect of wedelolactone isolated from Wedelia calendulacea: investigation via experimental validation and molecular docking
- (2018) Vikas Kumar et al. RSC Advances
- Evaluation of neuroprotective effects of wedelolactone and gallic acid on aluminium-induced neurodegeneration: Relevance to sporadic amyotrophic lateral sclerosis
- (2018) S. Maya et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Prenylated Flavonoids from Roots of Glycyrrhiza uralensis Induce Differentiation of B16-F10 Melanoma Cells
- (2018) Yunfeng Zheng et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Wedelolactone suppresses cell proliferation and migration through Akt and AMPK signaling in melanoma
- (2018) Ya-guang Peng et al. JOURNAL OF DERMATOLOGICAL TREATMENT
- Effect of hydroxyapatite nanoparticles and wedelolactone on osteoblastogenesis from bone marrow mesenchymal stem cells
- (2018) Peipei Dong et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
- Psoralidin Stimulates Expression of Immediate-Early Genes and Synapse Development in Primary Cortical Neurons
- (2018) Seojin Hwang et al. NEUROCHEMICAL RESEARCH
- Four new flavonoids with DGAT inhibitory activity from Psoralea corylifolia
- (2018) Hao-Ze Li et al. Phytochemistry Letters
- α-Glucosidase Inhibitory and Anti-Inflammatory Coumestans from the Roots of Dolichos trilobus
- (2018) Meng-Yuan Jiang et al. PLANTA MEDICA
- Psoralidin, a prenylated coumestan, as a novel anti-osteoporosis candidate to enhance bone formation of osteoblasts and decrease bone resorption of osteoclasts
- (2017) Yuankun Zhai et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Wedelolactone, a plant coumarin, prevents vascular smooth muscle cell proliferation and injury-induced neointimal hyperplasia through Akt and AMPK signaling
- (2017) Lu Peng et al. EXPERIMENTAL GERONTOLOGY
- Cytotoxic activity of soy phytoestrogen coumestrol against human breast cancer MCF-7 cells: Insights into the molecular mechanism
- (2017) Atif Zafar et al. FOOD AND CHEMICAL TOXICOLOGY
- Isotrifoliol inhibits pro-inflammatory mediators by suppression of TLR/NF-κB and TLR/MAPK signaling in LPS-induced RAW264.7 cells
- (2017) Hua Li et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Psoralidin suppresses osteoclastogenesis in BMMs and attenuates LPS-mediated osteolysis by inhibiting inflammatory cytokines
- (2017) Lingbo Kong et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Dietary intake of isoflavones and coumestrol and the risk of prostate cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
- (2017) Michael K. Reger et al. INTERNATIONAL JOURNAL OF CANCER
- Coumestrol Epigenetically Suppresses Cancer Cell Proliferation: Coumestrol Is a Natural Haspin Kinase Inhibitor
- (2017) Jong-Eun Kim et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Wedelolactone Acts as Proteasome Inhibitor in Breast Cancer Cells
- (2017) Tereza Nehybová et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The free radical scavenging activity of lespedezacoumestan toward ˙OH radical: A quantum chemical and computational kinetics study
- (2017) Ahmad Bayat et al. JOURNAL OF PHYSICAL ORGANIC CHEMISTRY
- Coumestrol induces mitochondrial dysfunction by stimulating ROS production and calcium ion influx into mitochondria in human placental choriocarcinoma cells
- (2017) Whasun Lim et al. MOLECULAR HUMAN REPRODUCTION
- New coumestan and coumaronochromone derivatives from Dalbergia boehmii Taub. (Fabaceae)
- (2017) Jean Pierre Abdou et al. Phytochemistry Letters
- Protective effects of coumestrol on lipopolysaccharide-induced acute lung injury via the inhibition of proinflammatory mediators and NF-κB activation
- (2017) Heung Joo Yuk et al. Journal of Functional Foods
- Phytoestrogen coumestrol improves mitochondrial activity and decreases oxidative stress in the brain of ovariectomized Wistar-Han rats
- (2017) Ana C. Moreira et al. Journal of Functional Foods
- Effect and mechanism of wedelolactone as antioxidant-coumestan on OH-treated mesenchymal stem cells
- (2017) Xican Li et al. Arabian Journal of Chemistry
- Synergic effect of combination of glycyrol and fluconazole against experimental cutaneous candidiasis due to Candida albicans
- (2016) Zheong-Imm Rhew et al. ARCHIVES OF PHARMACAL RESEARCH
- The molecular pathway of psoralidin-induced apoptosis in HepG2 cell line
- (2016) Bin Yu et al. Chinese Journal of Integrative Medicine
- The therapeutic potential of plant flavonoids on rheumatoid arthritis
- (2016) Samuel D. Hughes et al. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
- LPS-stimulated inflammation inhibits BMP-9-induced osteoblastic differentiation through crosstalk between BMP/MAPK and Smad signaling
- (2016) Lu Daigang et al. EXPERIMENTAL CELL RESEARCH
- Coumestrol Counteracts Interleukin-1β-Induced Catabolic Effects by Suppressing Inflammation in Primary Rat Chondrocytes
- (2016) Jae-Seek You et al. INFLAMMATION
- Protective effect of wedelolactone against CCl 4 -induced acute liver injury in mice
- (2016) Yang Lu et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Nanoencapsulation of psoralidin via chitosan and Eudragit S100 for enhancement of oral bioavailability
- (2016) Juntao Yin et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Comparison of the in vitro metabolism of psoralidin among different species and characterization of its inhibitory effect against UDP- glucuronosyltransferase (UGT) or cytochrome p450 (CYP450) enzymes
- (2016) Xianbao Shi et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Synthesis of Coumestrol and Aureol
- (2016) Jianfei Sheng et al. JOURNAL OF NATURAL PRODUCTS
- Wedelolactone, an Anti-inflammatory Botanical, Interrupts c-Myc Oncogenic Signaling and Synergizes with Enzalutamide to Induce Apoptosis in Prostate Cancer Cells
- (2016) S. Sarveswaran et al. MOLECULAR CANCER THERAPEUTICS
- On-demand drug release of ICG-liposomal wedelolactone combined photothermal therapy for tumor
- (2016) Xuwu Zhang et al. Nanomedicine-Nanotechnology Biology and Medicine
- Syntheses of pterocarpenes and coumestans via regioselective cyclodehydration
- (2016) Maloy Nayak et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Cyclization of 4-Phenoxy-2-coumarins and 2-Pyrones via a Double C–H Activation
- (2016) Katrina Mackey et al. ORGANIC LETTERS
- Psoralidin induced reactive oxygen species (ROS)-dependent DNA damage and protective autophagy mediated by NOX4 in breast cancer cells
- (2016) Guowen Ren et al. PHYTOMEDICINE
- Wedelolactone metabolism in rats through regioselective glucuronidation catalyzed by uridine diphosphate-glucuronosyltransferases 1As (UGT1As)
- (2016) Liang Li et al. PHYTOMEDICINE
- Chemical Constituents from Campylotropis hirtella
- (2016) Yang-Guo Xie et al. PLANTA MEDICA
- Synthesis of Psoralidin derivatives and their anticancer activity: first synthesis of Lespeflorin I1
- (2016) Pallab Pahari et al. TETRAHEDRON
- Psoralidin inhibits proliferation and enhances apoptosis of human esophageal carcinoma cells via NF-κB and PI3K/Akt signaling pathways
- (2016) Zhiliang Jin et al. Oncology Letters
- Coumestrol inhibits autoantibody production through modulating Th1 response in experimental autoimmune thyroiditis
- (2016) Xiaojing Jin et al. Oncotarget
- Wedelolactone enhances osteoblastogenesis by regulating Wnt/β-catenin signaling pathway but suppresses osteoclastogenesis by NF-κB/c-fos/NFATc1 pathway
- (2016) Yan-Qiu Liu et al. Scientific Reports
- Wedelolactone Enhances Osteoblastogenesis but Inhibits Osteoclastogenesis through Sema3A/NRP1/PlexinA1 Pathway
- (2016) Yan-Qiu Liu et al. Frontiers in Pharmacology
- Flt3 is a target of coumestrol in protecting against UVB-induced skin photoaging
- (2015) Gaeun Park et al. BIOCHEMICAL PHARMACOLOGY
- Coumestrol inhibits carotid sinus baroreceptor activity by cAMP/PKA dependent nitric oxide release in anesthetized male rats
- (2015) Haitao Liu et al. BIOCHEMICAL PHARMACOLOGY
- Wedelolactone protects human bronchial epithelial cell injury against cigarette smoke extract-induced oxidant stress and inflammation responses through Nrf2 pathway
- (2015) Shumin Ding et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Metabolites identification of glycyrin and glycyrol, bioactive coumarins from licorice
- (2015) Qi Wang et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Coumestrol suppresses proliferation of ES2 human epithelial ovarian cancer cells
- (2015) Whasun Lim et al. JOURNAL OF ENDOCRINOLOGY
- The treatment of rheumatoid arthritis using Chinese medicinal plants: From pharmacology to potential molecular mechanisms
- (2015) Shaowa Lü et al. JOURNAL OF ETHNOPHARMACOLOGY
- Bioactive Metabolites from the Fruits of Psoralea corylifolia
- (2015) Tae Hyung Won et al. JOURNAL OF NATURAL PRODUCTS
- Wedelolactone induces growth of breast cancer cells by stimulation of estrogen receptor signalling
- (2015) Tereza Nehybova et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Cartilage damage in osteoarthritis and rheumatoid arthritis—two unequal siblings
- (2015) Thomas Pap et al. Nature Reviews Rheumatology
- Prenylated flavonoids, promising nutraceuticals with impressive biological activities
- (2015) Xiaoman Yang et al. TRENDS IN FOOD SCIENCE & TECHNOLOGY
- Differential effect of psoralidin in enhancing apoptosis of colon cancer cells via nuclear factor-κB and B-cell lymphoma-2/B-cell lymphoma-2-associated X protein signaling pathways
- (2015) ZHILIANG JIN et al. Oncology Letters
- Bone-Immune Cell Crosstalk: Bone Diseases
- (2015) Giorgio Mori et al. Journal of Immunology Research
- Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy
- (2014) Tereza Nehybova et al. Anti-Cancer Agents in Medicinal Chemistry
- Psoralidin, a coumestan analogue, as a novel potent estrogen receptor signaling molecule isolated from Psoralea corylifolia
- (2014) Xiyuan Liu et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Antitumor activity of glycyrol via induction of cell cycle arrest, apoptosis and defective autophagy
- (2014) Mei-Ying Xu et al. FOOD AND CHEMICAL TOXICOLOGY
- Wedelolactone inhibits breast cancer-induced osteoclastogenesis by decreasing Akt/mTOR signaling
- (2014) CHIA-JUNG HSIEH et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Coumestan Inhibits Radical-Induced Oxidation of DNA: Is Hydroxyl a Necessary Functional Group?
- (2014) Gao-Lei Xi et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Inhibitory effect of Ecliptae herba extract and its component wedelolactone on pre-osteoclastic proliferation and differentiation
- (2014) Yan-Qiu Liu et al. JOURNAL OF ETHNOPHARMACOLOGY
- Anti-hepatitis C virus compounds obtained fromGlycyrrhiza uralensis and otherGlycyrrhizaspecies
- (2014) Myrna Adianti et al. MICROBIOLOGY AND IMMUNOLOGY
- Identification of Licopyranocoumarin and Glycyrurol from Herbal Medicines as Neuroprotective Compounds for Parkinson's Disease
- (2014) Takahiro Fujimaki et al. PLoS One
- Glycyrol Suppresses Collagen-Induced Arthritis by Regulating Autoimmune and Inflammatory Responses
- (2014) Yanxia Fu et al. PLoS One
- Psoralidin induces autophagy through ROS generation which inhibits the proliferation of human lung cancer A549 cells
- (2014) Wenhui Hao et al. PeerJ
- Non-isoflavone phytoestrogenic compound contents of various legumes
- (2013) Nevzat Konar EUROPEAN FOOD RESEARCH AND TECHNOLOGY
- Wedelolactone exhibits anti-fibrotic effects on human hepatic stellate cell line LX-2
- (2013) Yanzhe Xia et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Coumestrol induces senescence through protein kinase CKII inhibition-mediated reactive oxygen species production in human breast cancer and colon cancer cells
- (2013) Young-Hoon Lee et al. FOOD CHEMISTRY
- A current review of molecular mechanisms regarding osteoarthritis and pain
- (2013) Andrew S. Lee et al. GENE
- Phytoestrogens mediated anti-inflammatory effect through suppression of IRF-1 and pSTAT1 expressions in lipopolysaccharide-activated microglia
- (2013) Nattinee Jantaratnotai et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Wedelolactone, a Naturally Occurring Coumestan, Enhances Interferon-γ Signaling through Inhibiting STAT1 Protein Dephosphorylation
- (2013) Zhimin Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds ofPsoralea corylifolia
- (2013) Dae Wook Kim et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Compounds isolated fromPsoralea corylifoliaseeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells
- (2013) Christian Limper et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Coumestrol treatment prevents Na+, K+-ATPase inhibition and affords histological neuroprotection to male rats receiving cerebral global ischemia
- (2013) Cibele Canal Castro et al. NEUROLOGICAL RESEARCH
- Synthesis and biological activity of coumestan derivatives (Review)
- (2013) V. A. Tuskaev PHARMACEUTICAL CHEMISTRY JOURNAL
- Coumestrol and its metabolite in mares' plasma after ingestion of phytoestrogen-rich plants: Potent endocrine disruptors inducing infertility
- (2013) G. Ferreira-Dias et al. THERIOGENOLOGY
- Coumestrol from the national cancer Institute’s natural product library is a novel inhibitor of protein kinase CK2
- (2013) Shu Liu et al. BMC Pharmacology & Toxicology
- Coumestrol has neuroprotective effects before and after global cerebral ischemia in female rats
- (2012) Cibele Canal Castro et al. BRAIN RESEARCH
- Synthesis, Stereochemistry, Structural Classification, and Chemical Reactivity of Natural Pterocarpans
- (2012) Atul Goel et al. CHEMICAL REVIEWS
- Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice
- (2012) Yean-Jang Lee et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt
- (2012) SIVALOKANATHAN SARVESWARAN et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Wedelolactone inhibits adipogenesis through the ERK pathway in human adipose tissue-derived mesenchymal stem cells
- (2012) Seyoung Lim et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Identification and evaluation of anti Hepatitis C virus phytochemicals from Eclipta alba
- (2012) Dinesh Manvar et al. JOURNAL OF ETHNOPHARMACOLOGY
- The Coumarin Psoralidin Enhances Anticancer Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
- (2012) Joanna Bronikowska et al. MOLECULES
- Semaphorins in bone development, homeostasis, and disease
- (2012) Sujin Kang et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Psoralidin, a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation
- (2011) Hee Jung Yang et al. BIOCHEMICAL PHARMACOLOGY
- Sulphur compounds from the aerial parts of Eclipta prostrata
- (2011) Chao-Feng Zhang et al. BIOCHEMICAL SYSTEMATICS AND ECOLOGY
- Dietary Phytoestrogens and the Risk of Ovarian Cancer in the Women's Lifestyle and Health Cohort Study
- (2011) M. Hedelin et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Inhibition of topoisomerase IIα: Novel function of wedelolactone
- (2011) Petr Benes et al. CANCER LETTERS
- Development and characterization of phyto-vesicles of wedelolactone for hepatoprotective activity
- (2011) Kirti Upadhyay et al. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
- A new coumestan with immunosuppressive activities from Flemingia philippinensis
- (2011) Li. Li et al. FITOTERAPIA
- Antithrombotic phenolic compounds from Glycyrrhiza uralensis
- (2011) Wei-Wei Tao et al. FITOTERAPIA
- Dietary phytochemicals induce p53- and caspase-independent cell death in human neuroblastoma cells
- (2011) Sangeetha Sukumari-Ramesh et al. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
- Solalyratins A and B, new anti-inflammatory metabolites from Solanum lyratum
- (2011) De-Wu Zhang et al. Journal of Natural Medicines
- The protective effects of coumestrol against amyloid-beta peptide- and lipopolysaccharide-induced toxicity on mice astrocytes
- (2011) Man-Hai Liu et al. NEUROLOGICAL RESEARCH
- Phenolic compounds from Pueraria lobata protect PC12 cells against Aβ-induced toxicity
- (2010) Yun-hyeok Choi et al. ARCHIVES OF PHARMACAL RESEARCH
- Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis
- (2010) Young Bae Ryu et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Psoralidin inhibits LPS-induced iNOS expression via repressing Syk-mediated activation of PI3K-IKK-IκB signaling pathways
- (2010) Wen-Fei Chiou et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- AMP-Activated Protein Kinase (AMPK) Activation by Benzofurans and Coumestans Isolated fromErythrina abyssinica
- (2010) Phi-Hung Nguyen et al. JOURNAL OF NATURAL PRODUCTS
- Activating Stress-Activated Protein Kinase-Mediated Cell Death and Inhibiting Epidermal Growth Factor Receptor Signaling: A Promising Therapeutic Strategy for Prostate Cancer
- (2010) R. Kumar et al. MOLECULAR CANCER THERAPEUTICS
- Two new phenolic compounds from the roots ofFicus hirta
- (2010) Ji Ya et al. NATURAL PRODUCT RESEARCH
- Immunosuppressive activity on the murine immune responses of glycyrol fromGlycyrrhiza uralensisvia inhibition of calcineurin activity
- (2010) Jiayu Li et al. PHARMACEUTICAL BIOLOGY
- Glycyrol Induces Apoptosis in Human Jurkat T Cell Lymphocytes via the Fas-FasL/Caspase-8 Pathway
- (2010) Eun Shin et al. PLANTA MEDICA
- Inhibiting TNF-mediated signaling: a novel therapeutic paradigm for androgen independent prostate cancer
- (2009) Sowmyalakshmi Srinivasan et al. APOPTOSIS
- Hirtellanines A and B, a pair of isomeric isoflavonoid derivatives from Campylotropis hirtella and their immunosuppressive activities
- (2009) Qing Yao Shou et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Psoralidin, an Herbal Molecule, Inhibits Phosphatidylinositol 3-Kinase-Mediated Akt Signaling in Androgen-Independent Prostate Cancer Cells
- (2009) R. Kumar et al. Cancer Prevention Research
- Coumestrol promotes proliferation and osteoblastic differentiation in rat bone marrow stromal cells
- (2009) Xiao-tao Wu et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
- Inhibition of the α1β1 Isoform of the Na, K-ATPase by 8-methoxycoumestrol Without Positive Inotropic Effect in Human Myocardium-Novel Aspects of Cardiac Glycoside Pharmacology
- (2009) T Potter et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Melanin Synthesis Inhibitors fromLespedeza floribunda
- (2009) Maya Mori-Hongo et al. JOURNAL OF NATURAL PRODUCTS
- Total Synthesis of Psoralidin, an Anticancer Natural Product
- (2009) Pallab Pahari et al. JOURNAL OF ORGANIC CHEMISTRY
- Recent developments in anti-inflammatory natural products
- (2009) Raju Gautam et al. MEDICINAL RESEARCH REVIEWS
- Wnt and PPARγ signaling in osteoblastogenesis and adipogenesis
- (2009) Ichiro Takada et al. Nature Reviews Rheumatology
- INHIBITION OF NFκB REDUCES CELLULAR VIABILITY IN GH3 PITUITARY ADENOMA CELLS
- (2009) John R. Vender et al. NEUROSURGERY
- Ability of a synthetic coumestan to antagonize Bothrops snake venom activities
- (2009) Paulo A. Melo et al. TOXICON
- Osteogenic activity of constituents from Butea monosperma
- (2008) Rakesh Maurya et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Natural products in drug discovery
- (2008) A HARVEY DRUG DISCOVERY TODAY
- Anti-inflammatory effects of glycyrol isolated from Glycyrrhiza uralensis in LPS-stimulated RAW264.7 macrophages
- (2008) Eun Myoung Shin et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Studies on coumestrol/β-cyclodextrin association: Inclusion complex characterization
- (2008) Camila Franco et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Antioxidant 2-Phenylbenzofurans and a Coumestan fromLespedeza virgata
- (2008) Yan Chen et al. JOURNAL OF NATURAL PRODUCTS
- Cytotoxic benzil and coumestan derivatives from Tephrosia calophylla
- (2008) Seru Ganapaty et al. PHYTOCHEMISTRY
- The first total synthesis of glycyrol
- (2008) Ying Lan Jin et al. TETRAHEDRON LETTERS
- Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair?
- (2008) Gillian Murphy et al. Nature clinical practice. Rheumatology
- The Phytoestrogen Coumestrol Is a Naturally Occurring Antagonist of the Human Pregnane X Receptor
- (2007) Hongwei Wang et al. MOLECULAR ENDOCRINOLOGY
- Antidepressant-like effects of psoralidin isolated from the seeds of Psoralea Corylifolia in the forced swimming test in mice
- (2007) Li-Tao Yi et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation