Coumestrol induces mitochondrial dysfunction by stimulating ROS production and calcium ion influx into mitochondria in human placental choriocarcinoma cells

Cytotoxic activity of soy phytoestrogen coumestrol against human breast cancer MCF-7 cells: Insights into the molecular mechanism

(2017) Atif Zafar et al.   FOOD AND CHEMICAL TOXICOLOGY

Curcumin Suppresses Proliferation and Migration and Induces Apoptosis on Human Placental Choriocarcinoma Cells via ERK1/2 and SAPK/JNK MAPK Signaling Pathways

(2016) W. Lim et al.   BIOLOGY OF REPRODUCTION

Luteolin Inhibits Proliferation and Induces Apoptosis of Human Placental Choriocarcinoma Cells by Blocking the PI3K/AKT Pathway and Regulating Sterol Regulatory Element Binding Protein Activity

(2016) W. Lim et al.   BIOLOGY OF REPRODUCTION

Curcumin induces apoptosis by inhibiting sarco/endoplasmic reticulum Ca2+ ATPase activity in ovarian cancer cells

(2016) Jeong-ah Seo et al.   CANCER LETTERS

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

Coumestrol Counteracts Interleukin-1β-Induced Catabolic Effects by Suppressing Inflammation in Primary Rat Chondrocytes

(2016) Jae-Seek You et al.   INFLAMMATION

Coumestrol Inhibits Proliferation and Migration of Prostate Cancer Cells by Regulating AKT, ERK1/2, and JNK MAPK Cell Signaling Cascades

(2016) Whasun Lim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibitory Effects of Quercetin on Progression of Human Choriocarcinoma Cells Are Mediated Through PI3K/AKT and MAPK Signal Transduction Cascades

(2016) Whasun Lim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cu(II)-coumestrol interaction leads to ROS-mediated DNA damage and cell death: a putative mechanism for anticancer activity

(2016) Atif Zafar et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Delphinidin suppresses proliferation and migration of human ovarian clear cell carcinoma cells through blocking AKT and ERK1/2 MAPK signaling pathways

(2016) Whasun Lim et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Green tea (-)-epigallocatechin gallate induced growth inhibition of human placental choriocarcinoma cells

(2016) Li-Jane Shih et al.   PLACENTA

Chrysophanic acid reduces testosterone-induced benign prostatic hyperplasia in rats by suppressing 5α-reductase and extracellular signal-regulated kinase

(2016) Dong-Hyun Youn et al.   Oncotarget

Changes of intracellular Ca2+in quercetin-induced autophagy progression

(2015) Xiaodong Cui et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Flt3 is a target of coumestrol in protecting against UVB-induced skin photoaging

(2015) Gaeun Park et al.   BIOCHEMICAL PHARMACOLOGY

Mitochondrial apoptosis: killing cancer using the enemy within

(2015) J Lopez et al.   BRITISH JOURNAL OF CANCER

The switch from ER stress-induced apoptosis to autophagy via ROS-mediated JNK/p62 signals: A survival mechanism in methotrexate-resistant choriocarcinoma cells

(2015) Yun Shen et al.   EXPERIMENTAL CELL RESEARCH

Mitochondria and the hallmarks of cancer

(2015) Evangelos Giampazolias et al.   FEBS Journal

Coumestrol suppresses proliferation of ES2 human epithelial ovarian cancer cells

(2015) Whasun Lim et al.   JOURNAL OF ENDOCRINOLOGY

CXCL12–CXCR7 Signaling Activates ERK and Akt Pathways in Human Choriocarcinoma Cells

(2014) Vishwas Tripathi et al.   CELL COMMUNICATION AND ADHESION

AKR1C3 Overexpression Mediates Methotrexate Resistance in Choriocarcinoma Cells

(2014) Jing Zhao et al.   International Journal of Medical Sciences

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Coumestrol induces senescence through protein kinase CKII inhibition-mediated reactive oxygen species production in human breast cancer and colon cancer cells

(2013) Young-Hoon Lee et al.   FOOD CHEMISTRY

Quercetin Suppresses Intracellular ROS Formation, MMP Activation, and Cell Motility in Human Fibrosarcoma Cells

(2013) Dong Eun Lee et al.   JOURNAL OF FOOD SCIENCE

BID Preferentially Activates BAK while BIM Preferentially Activates BAX, Affecting Chemotherapy Response

(2013) Kristopher A. Sarosiek et al.   MOLECULAR CELL

Coumestrol treatment prevents Na+, K+-ATPase inhibition and affords histological neuroprotection to male rats receiving cerebral global ischemia

(2013) Cibele Canal Castro et al.   NEUROLOGICAL RESEARCH

Achieving the Balance between ROS and Antioxidants: When to Use the Synthetic Antioxidants

(2013) Borut Poljsak et al.   Oxidative Medicine and Cellular Longevity

Natural products: An evolving role in future drug discovery

(2011) Bhuwan B. Mishra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Withaferin A-Induced Apoptosis in Human Breast Cancer Cells Is Mediated by Reactive Oxygen Species

(2011) Eun-Ryeong Hahm et al.   PLoS One

Gestational trophoblastic disease II: classification and management of gestational trophoblastic neoplasia

(2010) John R. Lurain   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin

(2010) Lara Gibellini et al.   Cancers

Vanilloid-Induced Conduction Analgesia: Selective, Dose-Dependent, Long-Lasting, with a Low Level of Potential Neurotoxicity

(2009) Igor Kissin   ANESTHESIA AND ANALGESIA

Mitochondrial calcium and the permeability transition in cell death

(2009) John J. Lemasters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Apoptosis and glutathione: beyond an antioxidant

(2009) R Franco et al.   CELL DEATH AND DIFFERENTIATION

Potentiation of a Topoisomerase I Inhibitor, Karenitecin, by the Histone Deacetylase Inhibitor Valproic Acid in Melanoma: Translational and Phase I/II Clinical Trial

(2009) A. I. Daud et al.   CLINICAL CANCER RESEARCH

Bax Contains Two Functional Mitochondrial Targeting Sequences and Translocates to Mitochondria in a Conformational Change- and Homo-oligomerization-driven Process

(2009) Nicholas M. George et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of diverse dietary phytoestrogens on cell growth, cell cycle and apoptosis in estrogen-receptor-positive breast cancer cells

(2009) Takako Sakamoto et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Inositol trisphosphate and calcium signalling mechanisms

(2008) Michael J. Berridge   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Expression and activity of vitamin D receptor in the human placenta and in choriocarcinoma BeWo and JEG-3 cell lines

(2008) Katerina Pospechova et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY