Coumestrol Epigenetically Suppresses Cancer Cell Proliferation: Coumestrol Is a Natural Haspin Kinase Inhibitor

Flt3 is a target of coumestrol in protecting against UVB-induced skin photoaging

(2015) Gaeun Park et al.   BIOCHEMICAL PHARMACOLOGY

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Coumestrol suppresses hypoxia inducible factor 1α by inhibiting ROS mediated sphingosine kinase 1 in hypoxic PC-3 prostate cancer cells

(2014) Sung-Yun Cho et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Curcumin Suppresses Proliferation of Colon Cancer Cells by Targeting CDK2

(2014) T.-G. Lim et al.   Cancer Prevention Research

Ovarian Cancer Spheroid Cells with Stem Cell-Like Properties Contribute to Tumor Generation, Metastasis and Chemotherapy Resistance through Hypoxia-Resistant Metabolism

(2014) Jianqun Liao et al.   PLoS One

Esculetin Suppresses Proliferation of Human Colon Cancer Cells by Directly Targeting  -Catenin

(2013) S.-Y. Lee et al.   Cancer Prevention Research

Coumestrol induces senescence through protein kinase CKII inhibition-mediated reactive oxygen species production in human breast cancer and colon cancer cells

(2013) Young-Hoon Lee et al.   FOOD CHEMISTRY

Coumestrol from the national cancer Institute’s natural product library is a novel inhibitor of protein kinase CK2

(2013) Shu Liu et al.   BMC Pharmacology & Toxicology

Structure–activity relationship study of beta-carboline derivatives as haspin kinase inhibitors

(2012) Gregory D. Cuny et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Coumestrol has neuroprotective effects before and after global cerebral ischemia in female rats

(2012) Cibele Canal Castro et al.   BRAIN RESEARCH

Identification and characterization of plant Haspin kinase as a histone H3 threonine kinase

(2011) Daisuke Kurihara et al.   BMC PLANT BIOLOGY

Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin

(2011) D Huertas et al.   ONCOGENE

Structure–activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors

(2010) Gregory D. Cuny et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of prenylated pterocarpans and other isoflavonoids in Rhizopus spp. elicited soya bean seedlings by electrospray ionisation mass spectrometry

(2010) Rudy Simons et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Estrogenic Activity of Coumestrol, DDT, and TCDD in Human Cervical Cancer Cells

(2010) Kenneth Ndebele et al.   International Journal of Environmental Research and Public Health

Haspin: a newly discovered regulator of mitotic chromosome behavior

(2009) Jonathan M. G. Higgins   CHROMOSOMA

Studies of haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion

(2009) J. Dai et al.   JOURNAL OF CELL SCIENCE

Structure and functional characterization of the atypical human kinase haspin

(2009) J. Eswaran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenes and Cancer

(2008) Carlo M. Croce   NEW ENGLAND JOURNAL OF MEDICINE