Cartilage damage in osteoarthritis and rheumatoid arthritis—two unequal siblings

The role of inflammation in the initiation of osteoarthritis after meniscal damage

(2015) Shannon N Edd et al.   JOURNAL OF BIOMECHANICS

Stroma: Fertile soil for inflammation

(2014) Rikesh Patel et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Aberrant histone acetylation contributes to elevated interleukin-6 production in rheumatoid arthritis synovial fibroblasts

(2014) Takuma Tsuzuki Wada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Citrullination of collagen II affects integrin-mediated cell adhesion in a receptor-specific manner

(2014) Kalle Sipilä et al.   FASEB JOURNAL

SUMO-Conjugating Enzyme UBC9 Promotes Proliferation and Migration of Fibroblast-like Synoviocytes in Rheumatoid Arthritis

(2014) Faxin Li et al.   INFLAMMATION

Epigenome Analysis Reveals TBX5 as a Novel Transcription Factor Involved in the Activation of Rheumatoid Arthritis Synovial Fibroblasts

(2014) Emmanuel Karouzakis et al.   JOURNAL OF IMMUNOLOGY

Epigenetic differences in human cartilage between mild and severe OA

(2014) Florentine C. Moazedi-Fuerst et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Of mice and men: how animal models advance our understanding of T-cell function in RA

(2014) Tamás Kobezda et al.   Nature Reviews Rheumatology

In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis

(2014) N.H. Lim et al.   OSTEOARTHRITIS AND CARTILAGE

TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading

(2014) C. J. O'Conor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice

(2014) Oksana Kehoe et al.   ARTHRITIS RESEARCH & THERAPY

Association of Reduced Type IX Collagen Gene Expression in Human Osteoarthritic Chondrocytes With Epigenetic Silencing by DNA Hypermethylation

(2014) Kei Imagawa et al.   Arthritis & Rheumatology

Characterization of the Cartilage DNA Methylome in Knee and Hip Osteoarthritis

(2014) Michael D. Rushton et al.   Arthritis & Rheumatology

Regulation of matrixmetalloproteinase-3 and matrixmetalloproteinase-13 by SUMO-2/3 through the transcription factor NF-κB

(2013) Svetlana Frank et al.   ANNALS OF THE RHEUMATIC DISEASES

Regulation of DNA Methylation in Rheumatoid Arthritis Synoviocytes

(2013) K. Nakano et al.   JOURNAL OF IMMUNOLOGY

Parallel evolution of OA phenotypes and therapies

(2013) Philip G. Conaghan   Nature Reviews Rheumatology

Mechanisms of the placebo response in pain in osteoarthritis

(2013) A. Abhishek et al.   OSTEOARTHRITIS AND CARTILAGE

Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development

(2013) Y. Hosaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual Role of Autophagy in Stress-Induced Cell Death in Rheumatoid Arthritis Synovial Fibroblasts

(2013) Masaru Kato et al.   Arthritis & Rheumatology

Early structural changes in cartilage and bone are required for the attachment and invasion of inflamed synovial tissue during destructive inflammatory arthritis

(2012) Adelheid Korb-Pap et al.   ANNALS OF THE RHEUMATIC DISEASES

DNA methylome signature in rheumatoid arthritis

(2012) Kazuhisa Nakano et al.   ANNALS OF THE RHEUMATIC DISEASES

Stress-induced cartilage degradation does not depend on the NLRP3 inflammasome in human osteoarthritis and mouse models

(2012) Carole Bougault et al.   ARTHRITIS AND RHEUMATISM

Syndecan 4 supports bone fracture repair, but not fetal skeletal development, in mice

(2012) Jessica Bertrand et al.   ARTHRITIS AND RHEUMATISM

Sox9 Directs Hypertrophic Maturation and Blocks Osteoblast Differentiation of Growth Plate Chondrocytes

(2012) Peter Dy et al.   DEVELOPMENTAL CELL

The postnatal role of Sox9 in cartilage

(2012) Stephen P Henry et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Changes in the epigenetic status of theSOX-9promoter in human osteoarthritic cartilage

(2012) Kyung-Il Kim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Tackling obesity in knee osteoarthritis

(2012) Anita E. Wluka et al.   Nature Reviews Rheumatology

Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors

(2012) Nunzio Bottini et al.   Nature Reviews Rheumatology

Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)

(2012) F. Berenbaum   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis as a disease of mechanics

(2012) D.T. Felson   OSTEOARTHRITIS AND CARTILAGE

Association of MMP-3 (-1612 5A/6A) polymorphism with knee osteoarthritis in Thai population

(2012) Sittisak Honsawek et al.   RHEUMATOLOGY INTERNATIONAL

Citrullination of fibronectin modulates synovial fibroblast behavior

(2012) Miriam A Shelef et al.   ARTHRITIS RESEARCH & THERAPY

Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis

(2011) Meina Wang et al.   Annals of the New York Academy of Sciences

Extra domain A of fibronectin primes leukotriene biosynthesis and stimulates neutrophil migration through activation of Toll-like receptor 4

(2011) Julie S. Lefebvre et al.   ARTHRITIS AND RHEUMATISM

Contributions of angiogenesis to inflammation, joint damage, and pain in a rat model of osteoarthritis

(2011) Sadaf Ashraf et al.   ARTHRITIS AND RHEUMATISM

The loss of α2β1 integrin suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis

(2011) Marvin A. Peters et al.   ARTHRITIS AND RHEUMATISM

Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: Effects of short-term exercise

(2011) Timothy M. Griffin et al.   ARTHRITIS AND RHEUMATISM

Metabolic stress-induced inflammation plays a major role in the development of osteoarthritis in mice

(2011) L. M. Gierman et al.   ARTHRITIS AND RHEUMATISM

Proteases involved in cartilage matrix degradation in osteoarthritis

(2011) Linda Troeberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Inflammation in osteoarthritis

(2011) Mary B. Goldring et al.   CURRENT OPINION IN RHEUMATOLOGY

C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes

(2011) Makoto Hirata et al.   HUMAN MOLECULAR GENETICS

TNF-α and IL-1β Promote a Disintegrin-like and Metalloprotease with Thrombospondin Type I Motif-5-mediated Aggrecan Degradation through Syndecan-4 in Intervertebral Disc

(2011) Jianru Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAMTS-4 and ADAMTS-5: Key enzymes in osteoarthritis

(2011) Priyanka Verma et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Adamts5 (aggrecanase-2) is widely expressed in the mouse musculoskeletal system and is induced in specific regions of knee joint explants by inflammatory cytokines

(2011) James D. Wylie et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Replication studies in various ethnic populations do not support the association of the HIF-2α SNP rs17039192 with knee osteoarthritis

(2011) Masahiro Nakajima et al.   NATURE MEDICINE

Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development

(2011) Elisa Araldi et al.   NATURE MEDICINE

Identification of a central role for complement in osteoarthritis

(2011) Qian Wang et al.   NATURE MEDICINE

Summary of the OA biomarkers workshop 2010 – genetics and genomics: new targets in OA

(2011) I. Meulenbelt et al.   OSTEOARTHRITIS AND CARTILAGE

Integrins and their ligands in rheumatoid arthritis

(2011) Torsten Lowin et al.   ARTHRITIS RESEARCH & THERAPY

SOX9 Governs Differentiation Stage-Specific Gene Expression in Growth Plate Chondrocytes via Direct Concomitant Transactivation and Repression

(2011) Victor Y. L. Leung et al.   PLoS Genetics

Therapeutic opportunities in fibroblasts in inflammatory arthritis

(2010) Marianne Niedermeier et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Heparan Sulfate-Dependent Signaling of Fibroblast Growth Factor 18 by Chondrocyte-Derived Perlecan

(2010) Christine Y. Chuang et al.   BIOCHEMISTRY

Epigenetics and rheumatoid arthritis: The role of SENP1 in the regulation of MMP-1 expression

(2010) Hanna Maciejewska-Rodrigues et al.   JOURNAL OF AUTOIMMUNITY

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium

(2010) H.J.M. Kerkhof et al.   OSTEOARTHRITIS AND CARTILAGE

Hypertrophic differentiation of chondrocytes in osteoarthritis: the developmental aspect of degenerative joint disorders

(2010) Rita Dreier   ARTHRITIS RESEARCH & THERAPY

Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis

(2009) Shi-Lu Chia et al.   ARTHRITIS AND RHEUMATISM

DNA hypomethylation in rheumatoid arthritis synovial fibroblasts

(2009) Emmanuel Karouzakis et al.   ARTHRITIS AND RHEUMATISM

Membrane type 1 matrix metalloproteinase is a crucial promoter of synovial invasion in human rheumatoid arthritis

(2009) Mary-Clare Miller et al.   ARTHRITIS AND RHEUMATISM

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium

(2009) G Zhai et al.   JOURNAL OF MEDICAL GENETICS

Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

(2009) Stephanie Lefèvre et al.   NATURE MEDICINE

Modulating hedgehog signaling can attenuate the severity of osteoarthritis

(2009) Alvin C Lin et al.   NATURE MEDICINE

Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis

(2009) Frank Echtermeyer et al.   NATURE MEDICINE

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

The “placebo” response in osteoarthritis and its implications for clinical practice

(2009) M. Doherty et al.   OSTEOARTHRITIS AND CARTILAGE

Gene expression in human chondrocytes in late osteoarthritis is changed in both fibrillated and intact cartilage without evidence of generalised chondrocyte hypertrophy

(2008) C J Brew et al.   ANNALS OF THE RHEUMATIC DISEASES

Increased expression of matrilin-3 not only in osteoarthritic articular cartilage but also in cartilage-forming tumors, and down-regulation of SOX9 via epidermal growth factor domain 1-dependent signaling

(2008) Jean-Baptiste Vincourt et al.   ARTHRITIS AND RHEUMATISM

CXCR2‐specific chemokines mediate leukotriene B4–dependent recruitment of neutrophils to inflamed joints in mice with antigen‐induced arthritis

(2008) Renata Grespan et al.   ARTHRITIS AND RHEUMATISM

Notch1, Jagged1, and HES5 Are Abundantly Expressed in Osteoarthritis

(2008) C. Karlsson et al.   CELLS TISSUES ORGANS

Evidence that cytokines play a role in rheumatoid arthritis

(2008) Fionula M. Brennan et al.   JOURNAL OF CLINICAL INVESTIGATION

SOX Gene Expression in Human Osteoarthritic Cartilage

(2008) Jochen Haag et al.   PATHOBIOLOGY